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1.
BMC Vet Res ; 16(1): 5, 2020 Jan 06.
Artigo em Inglês | MEDLINE | ID: mdl-31906934

RESUMO

BACKGROUND: Traditionally, wide lateral surgical margins of 3 cm and one fascial plane deep have been recommended for resection of canine cutaneous mast cell tumor (MCT). Several studies have been published assessing surgical margins of less than this traditional recommendation. The objective of this systematic review was to determine if resection MCT with lateral surgical margins < 3 cm results in low rates of incomplete resection and local tumor recurrence. Systematic searches of digital bibliographic databases were performed with two authors (AR & LES) screening abstracts to identify relevant scientific articles. Studies regarding surgical treatment of dogs with cutaneous MCT were reviewed. Data abstraction was performed and the quality of individual studies and the strength of the body of evidence for utilization of surgical margins < 3 cm for removal of MCTs was assessed. RESULTS: From the initial 78 citations identified through the database searches, four articles were retained for data abstraction after both relevance screenings were performed. Two studies were retrospective observational studies, one was a prospective case series and one was a prospective clinical trial. Assessment of the quality level of the body of evidence identified using the GRADE system was low. Excision of MCT at 2 cm and 3 cm was associated with comparably low rates of incomplete excision and recurrence. CONCLUSIONS: Despite the low quality of the overall body of evidence, a recommendation can be made that resection of canine cutaneous MCTs (< 4 cm) of Patnaik grade I and II with 2 cm lateral margins and 1 fascial plane deep results in low rates of incomplete excision and local tumor recurrence.


Assuntos
Doenças do Cão/cirurgia , Margens de Excisão , Sarcoma de Mastócitos/veterinária , Neoplasias Cutâneas/veterinária , Animais , Cães , Sarcoma de Mastócitos/cirurgia , Recidiva Local de Neoplasia/prevenção & controle , Recidiva Local de Neoplasia/veterinária , Neoplasias Cutâneas/cirurgia , Resultado do Tratamento
2.
J Vet Med Sci ; 81(8): 1133-1143, 2019 Aug 24.
Artigo em Inglês | MEDLINE | ID: mdl-31257236

RESUMO

Cutaneous tumors are commonly found in dogs. To date, few studies have investigated the epidemiology of canine cutaneous tumors in Asian countries. The present study aims to report the prevalence of canine cutaneous tumors in Japan, and assess the association of breed, age, sex, and anatomical locations with the development of common tumor types. A total of 1,435 cases of cutaneous tumors were examined, of which 813 (56.66%) cases were malignant, and 622 (43.34%) were benign. Soft tissue sarcomas (18.40%), mast cell tumor (16.24%), lipoma (9.69%), hair follicle tumors (9.34%), and benign sebaceous tumors (8.50%) outnumbered the other tumor types. Tumors were commonly found on the head (13.87%), hindlimb (10.52%), forelimb (8.01%), chest (5.78%), and neck (5.57%). The risk of developing cutaneous tumors increased significantly in dogs aged 11-year and above (P<0.001). Mixed-breed dogs (14.63%), Miniature Dachshund (9.90%), and Labrador Retriever (8.01%) were the three most presented breeds; while Boxer, Bernese Mountain Dog, and Golden Retriever had an increased risk of cutaneous tumor development in comparison to mixed-breed dogs (P<0.05). Epidemiological information from the present study will serve as a useful reference for regional veterinarians to establish a preliminary diagnosis of canine cutaneous tumors.


Assuntos
Doenças do Cão/patologia , Neoplasias Cutâneas/veterinária , Animais , Doenças do Cão/epidemiologia , Cães , Feminino , Japão/epidemiologia , Lipoma/veterinária , Masculino , Sarcoma de Mastócitos/veterinária , Prevalência , Estudos Retrospectivos , Fatores de Risco , Sarcoma/veterinária , Neoplasias das Glândulas Sebáceas/veterinária , Neoplasias Cutâneas/epidemiologia
3.
Aust Vet J ; 97(5): 162-165, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-31025329

RESUMO

CASE REPORT: A 7-year-old female-neutered Maltese Terrier × Papillon dog was presented with tachypnoea and weight loss following 12 months of therapy with toceranib phosphate for a metastatic, histologically-low-grade mast cell tumour. The dog was diagnosed with Pneumocystis canis based on PCR with supportive clinical, radiographic and cytological findings. No other clinical evidence of immunocompromise was identified through assessment of haematology and immunoglobulin quantification. Clinical signs completely resolved with a short course of potentiated sulfonamides and discontinuation of the toceranib. CONCLUSION: To the authors' knowledge this represents the first case of Pneumocystis in a dog secondary to immunomodulatory drug therapy. It is also the first case of opportunist infection secondary to a tyrosine kinase inhibitor in dogs.


Assuntos
Doenças do Cão/induzido quimicamente , Indóis/efeitos adversos , Pneumonia por Pneumocystis/veterinária , Pirróis/efeitos adversos , Animais , Cães , Combinação de Medicamentos , Feminino , Sarcoma de Mastócitos/tratamento farmacológico , Sarcoma de Mastócitos/veterinária , Pneumonia por Pneumocystis/induzido quimicamente , Pneumonia por Pneumocystis/diagnóstico por imagem , Pneumonia por Pneumocystis/tratamento farmacológico , Sulfadoxina/uso terapêutico , Resultado do Tratamento , Trimetoprima/uso terapêutico
6.
Vet Comp Oncol ; 16(2): 188-193, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-28560846

RESUMO

Prognosis of feline gastrointestinal mast cell tumours (FGIMCT), based on limited available literature, is described as guarded to poor, which may influence treatment recommendations and patient outcome. The purpose of this study is to describe the clinical findings, treatment response, and outcome of FGIMCT. Medical records of 31 cats diagnosed with and treated for FGIMCT were retrospectively reviewed. Data collected included signalment, method of diagnosis, tumour location (including metastatic sites), treatment type, cause of death and survival time. Mean age was 12.9 y. Diagnosis was made via cytology (n = 15), histopathology (n = 13) or both (n = 3). Metastatic sites included abdominal lymph node (n = 10), abdominal viscera (n = 4) and both (n = 2). Therapeutic approaches included chemotherapy alone (n = 15), surgery and chemotherapy (n = 7), glucocorticoid only (n = 6) and surgery and glucocorticoid (n = 3). Lomustine (n = 15) and chlorambucil (n = 12) were the most commonly used chemotherapy drugs. Overall median survival time was 531 d (95% confidence interval 334, 982). Gastrointestinal location, diagnosis of additional cancers, and treatment type did not significantly affect survival time. Cause of death was tumour-related or unknown (n = 12) and unrelated (n = 8) in the 20 cats dead at the time of analysis. The prognosis for cats with FGIMCT may be better than previously reported, with 26% of cats deceased from an unrelated cause. Surgical and medical treatments (including prednisolone alone) were both associated with prolonged survival times. Treatment other than prednisolone may not be necessary in some cats. Continued research into prognostic factors and most effective treatment strategies are needed.


Assuntos
Doenças do Gato/patologia , Doenças do Gato/terapia , Neoplasias Gastrointestinais/terapia , Neoplasias Gastrointestinais/veterinária , Sarcoma de Mastócitos/veterinária , Animais , Antineoplásicos/uso terapêutico , Gatos , Bases de Dados Factuais , Feminino , Neoplasias Gastrointestinais/patologia , Hospitais Veterinários , Estimativa de Kaplan-Meier , Masculino , Mastócitos/efeitos dos fármacos , Mastócitos/patologia , Sarcoma de Mastócitos/patologia , Sarcoma de Mastócitos/terapia , Estadiamento de Neoplasias , Estudos Retrospectivos , Faculdades de Medicina Veterinária , Sobrevida , Resultado do Tratamento , Estados Unidos
7.
Clin Neuropathol ; 37(1): 28-35, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-28992848

RESUMO

In this report, we present a 53-year-old woman with primary mast cell sarcoma of the thoracic spine vertebrae. Mast cell sarcoma is an aggressive and rare cancer. To date, no cases of primary mast cell sarcoma have been reported in the spinal vertebrae. The patient initially presented with a 1-month history of pelvic and abdominal pain. Inconclusive gynecological evaluation resulted in a CT of the abdomen and pelvis, demonstrating a destructive lesion centered at the 11th thoracic vertebral body. The patient underwent a two-stage spine operation for T11 corpectomy and T7-L3 posterior spinal fusion. Histopathological, immunohistochemical, and flow cytometry studies of the resection specimens showed the tumor to be mostly composed of CD117-positive and mast cell tryptase-positive cells with features consistent with mast cell sarcoma. This is the first reported case of primary vertebral mast cell sarcoma, which may mimic other destructive lesions of the spine including osteomyelitis, vertebral tuberculosis, or plasmacytoma.
.


Assuntos
Sarcoma de Mastócitos/patologia , Sarcoma de Mastócitos/cirurgia , Neoplasias da Coluna Vertebral/cirurgia , Vértebras Torácicas/cirurgia , Feminino , Humanos , Sarcoma de Mastócitos/diagnóstico , Pessoa de Meia-Idade , Procedimentos Neurocirúrgicos/métodos , Neoplasias da Coluna Vertebral/patologia , Vértebras Torácicas/patologia , Resultado do Tratamento
8.
Vet Comp Oncol ; 16(2): 214-219, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-28857446

RESUMO

Mast cell tumours (MCTs) are common tumours of the canine skin, and are estimated to represent up to 20% of all skin tumours in dogs. Tumour grade has a major impact on the incidence of local recurrence and metastatic potential. In addition to helping the clinician with surgical planning, knowledge of the tumour grade also assists in proper prognostication and client education. For pre-treatment biopsies to be useful, there must exist a high level of correlation between the histopathological grade obtained from the pre-treatment biopsy and the actual histopathological grade from the excisional biopsy. The aim of this study was to determine concordance of tumour grade between various biopsy techniques (wedge, punch, needle core) and the "gold standard" excisional biopsy method. We found an overall concordance rate of 96% based on the Patnaik grading system, and an overall concordance rate of 92% based on the Kiupel grading system. The accuracy of the various biopsy techniques (wedge, punch and needle core) when compared with excisional biopsy was 92%, 100% and 100%, respectively, based on the Patnaik grading system, and 90%, 95% and 100%, respectively, based on the Kiupel grading system. Of the cases with discordant results, the pre-treatment biopsies tended to underestimate the grade of the tumour. Based on these results, we conclude that pre-treatment biopsies are sufficiently accurate for differentiating low-grade from high-grade MCTs, regardless of biopsy technique or tumour location.


Assuntos
Biópsia/veterinária , Doenças do Cão/diagnóstico , Doenças do Cão/patologia , Sarcoma de Mastócitos/diagnóstico , Sarcoma de Mastócitos/patologia , Neoplasias Cutâneas/veterinária , Animais , Austrália , Biópsia/métodos , Cães , Modelos Logísticos , Mastócitos , Estadiamento de Neoplasias , Reprodutibilidade dos Testes , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/patologia
9.
J Comp Pathol ; 157(4): 231-240, 2017 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-29169616

RESUMO

Stromal invasion is identified commonly in cutaneous malignancies; however, invasive patterns are defined inconsistently and their clinical relevance is uncertain. This study aimed to define objective, quantifiable histomorphological invasive patterns in low-grade canine mast cell tumours (MCTs) and grade I/II soft tissue sarcomas (STSs), and correlate invasive patterns with overall excisional status. Haematoxylin and eosin-stained glass slides prepared for routine histopathology of surgically-excised tumours from client-owned dogs were evaluated for invasion beyond their subgross edge, asymmetrical invasion, satellite lesions, lymphovascular invasion, perineurovascular growth, growth along fascial planes, intramuscular invasion and multicompartmental involvement. Digital histological tumour-free margins <1 mm in any direction were considered to represent an incomplete excision. Fifty-one dogs with 69 tumours (50 MCTs and 19 STSs) were included in the study. Invasion in both circumferential and deep directions was significantly greater in MCTs compared with STSs (exact 2-tailed P <0.0001 circumferential; P = 0.0095 deep). Within the MCT group, circumferential invasion was greater than deep invasion (P = 0.0076). Multivariate logistic regression analysis found two variables that were significantly associated with incomplete MCT excision: intraoperative grossly normal circumferential surgical margin size (odds ratio of 0.776, 95% confidence interval: 0.651-0.925) and asymmetry invasion index (odds ratio of 1.318, 95% confidence interval: 1.039-1.671). These data may help create evidence-based strategies for planning surgical resections of cutaneous malignancies. Presence of asymmetrical microscopical invasion might prompt pathologists to perform more comprehensive surgical margin evaluation.


Assuntos
Doenças do Cão/patologia , Sarcoma de Mastócitos/veterinária , Sarcoma/veterinária , Neoplasias de Tecidos Moles/veterinária , Animais , Cães
10.
J Am Vet Med Assoc ; 251(7): 804-813, 2017 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-28967819

RESUMO

OBJECTIVE To evaluate the effects of IV diphenhydramine hydrochloride administration on cardiorespiratory variables in anesthetized dogs undergoing mast cell tumor (MCT) excision. DESIGN Randomized, blinded clinical trial. ANIMALS 16 client-owned dogs with MCTs. PROCEDURES In a standardized isoflurane anesthesia session that included mechanical ventilation, dogs received diphenhydramine hydrochloride (1 mg/kg [0.45 mg/lb], IV; n = 8) or an equivalent volume of saline (0.9% NaCl) solution (IV; control treatment; 8) 10 minutes after induction. Cardiorespiratory variables were recorded throughout anesthesia and MCT excision, and blood samples for determination of plasma diphenhydramine and histamine concentrations were collected prior to premedication (baseline), throughout anesthesia, and 2 hours after extubation. RESULTS Cardiorespiratory values in both treatment groups were acceptable for anesthetized dogs. Mean ± SD diastolic arterial blood pressure was significantly lower in the diphenhydramine versus control group during tumor dissection (52 ± 10 mm Hg vs 62 ± 9 mm Hg) and surgical closure (51 ± 10 mm Hg vs 65 ± 9 mm Hg). Mean arterial blood pressure was significantly lower in the diphenhydramine versus control group during surgical closure (65 ± 12 mm Hg vs 78 ± 11 mm Hg), despite a higher cardiac index value. Plasma histamine concentrations were nonsignificantly higher than baseline during maximal manipulation of the tumor and surgical preparation in the diphenhydramine group and during surgical dissection in the control group. CONCLUSIONS AND CLINICAL RELEVANCE IV administration of diphenhydramine prior to MCT excision had no clear clinical cardiorespiratory benefits over placebo in isoflurane-anesthetized dogs.


Assuntos
Difenidramina/farmacologia , Doenças do Cão/cirurgia , Sarcoma de Mastócitos/veterinária , Anestésicos Inalatórios , Animais , Pressão Sanguínea/efeitos dos fármacos , Difenidramina/efeitos adversos , Cães , Feminino , Frequência Cardíaca/efeitos dos fármacos , Isoflurano , Masculino , Sarcoma de Mastócitos/cirurgia
11.
J Vet Intern Med ; 31(6): 1796-1803, 2017 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-28941306

RESUMO

BACKGROUND: Low blood 25-hydroxyvitamin D (25(OH)D) concentrations have been associated with cancer in dogs. Little research has examined what other factors may affect 25(OH)D concentrations. OBJECTIVES: (1) To determine whether the presence of cancer (lymphoma, osteosarcoma, or mast cell tumor [MCT]) in dogs is associated with plasma 25(OH)D concentrations and (2) identify other factors related to plasma 25(OH)D concentrations in dogs. ANIMALS: Dogs newly diagnosed with osteosarcoma (n = 21), lymphoma (n = 27), and MCT (n = 21) presented to a tertiary referral oncology center, and healthy, client-owned dogs (n = 23). METHODS: An observational study design was used. Dietary vitamin D intake, sex, age, body condition score (BCS), muscle condition score (MCS), and plasma concentrations of 25(OH)D, 24,25-dihydroxyvitamin D (24,25(OH)2 D) (a marker of CYP24A1 activity), as well as ionized calcium (ICa), parathyroid hormone, and parathyroid hormone-related protein concentrations were measured. An analysis of covariance was used to model plasma 25(OH)D concentrations. RESULTS: Cancer type (P = 0.004), plasma 24,25(OH)2 D concentrations (P < 0.001), and plasma ICa concentrations (P = 0.047) had significant effects on plasma 25(OH)D concentrations. Effects of age, sex, body weight, BCS, MCS, and plasma PTH concentrations were not identified. A significant interaction between ICa and cancer was found (P = 0.005). Plasma 25(OH)D concentrations increased as ICa concentrations increased in dogs with cancer, whereas plasma 25(OH)D concentrations decreased as ICa concentrations increased in healthy dogs. CONCLUSIONS AND CLINICAL IMPORTANCE: Results support a relationship between cancer and altered vitamin D metabolism in dogs, mediated by plasma ICa concentrations. The CYP24A1 activity and plasma ICa should be measured in studies examining plasma 25(OH)D concentrations in dogs.


Assuntos
Cálcio/sangue , Doenças do Cão/sangue , Neoplasias/veterinária , Vitamina D/análogos & derivados , Animais , Cães , Feminino , Linfoma/sangue , Linfoma/veterinária , Masculino , Sarcoma de Mastócitos/sangue , Sarcoma de Mastócitos/veterinária , Neoplasias/sangue , Osteossarcoma/sangue , Osteossarcoma/veterinária , Hormônio Paratireóideo/sangue , Vitamina D/sangue , Vitamina D3 24-Hidroxilase/sangue
12.
Can Vet J ; 58(9): 931-935, 2017 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-28878416

RESUMO

Mast cell tumors (MCTs) are commonly encountered in dogs and have been reported in cutaneous, conjunctival, oral mucosal, and gastrointestinal locations, but not in an intramuscular location. Medical records at 2 referral centers in the UK were examined to find cases of MCTs in this location. Seven dogs were identified as having an intramuscular MCT by a combination of fine-needle aspirate cytology and computed tomography or ultrasound. None of the dogs had evidence of local lymph node metastasis. Six dogs had no evidence of distant metastasis and surgery was carried out as the primary treatment option. Three of those dogs also had adjunctive chemotherapy due to a high Ki67 value or high mitotic index. All 6 dogs that had had surgery were alive at follow-up with a minimum elapsed time of 7 months. One dog had a course of chemotherapy due to the location, size, and evidence of biological activity of the tumor and died 23 days afterwards. The prognosis of intramuscular mast cell tumors appears to be favorable in most cases.


Assuntos
Doenças do Cão/diagnóstico , Sarcoma de Mastócitos/veterinária , Animais , Cães , Sarcoma de Mastócitos/diagnóstico , Estadiamento de Neoplasias/veterinária , Prognóstico
13.
Can Vet J ; 58(8): 851-854, 2017 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-28761193

RESUMO

The medical records of 4 dogs with histologically confirmed intranasal mast cell tumors (MCTs) were retrospectively evaluated to determine their biological behavior. Information on signalment, presenting clinical signs, tumor grade, treatment administered, and survival times was obtained from the medical record. All 4 patients had high grade tumors and received chemotherapy. Survival times ranged from 27 to 134 days. All 4 dogs showed signs of local or distant disease progression, suggestive of an aggressive behavior of intranasal MCTs.


Assuntos
Doenças do Cão/diagnóstico , Sarcoma de Mastócitos/veterinária , Neoplasias Nasais/veterinária , Animais , Intervalo Livre de Doença , Doenças do Cão/mortalidade , Cães , Sarcoma de Mastócitos/diagnóstico , Sarcoma de Mastócitos/mortalidade , Recidiva Local de Neoplasia/veterinária , Estadiamento de Neoplasias/veterinária , Neoplasias Nasais/diagnóstico , Neoplasias Nasais/mortalidade , Prognóstico , Estudos Retrospectivos , Resultado do Tratamento
14.
Can Vet J ; 58(6): 591-596, 2017 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-28588331

RESUMO

Two dogs were presented, each with a large solitary pulmonary mass, and cytology confirmed mast cell tumor (MCT) in each dog. One dog was euthanized following diagnosis. Thoracic computed tomography scan and exploratory thoracotomy of the second dog revealed a right pulmonary mass that would require a radical lung resection. The patient was euthanized and histopathology confirmed a poorly granulated MCT with characteristics suggestive of epitheliotropism, an uncommon finding with MCT. These represent the first reported cases of presumptive primary pulmonary MCT in dogs.


Assuntos
Doenças do Cão/diagnóstico , Neoplasias Pulmonares/veterinária , Sarcoma de Mastócitos/veterinária , Animais , Cães , Evolução Fatal , Neoplasias Pulmonares/diagnóstico , Sarcoma de Mastócitos/diagnóstico
19.
J Comp Pathol ; 156(1): 14-20, 2017 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-27889201

RESUMO

Fibroblast activating protein (FAP) is a membrane serine protease expressed by activated fibroblasts, particularly tumour associated fibroblasts (TAFs). FAP expression has not been reported in canine mast cell tumours (MCTs). The objective of this study was to evaluate the expression of FAP in TAFs and its correlation with histological grade, mitotic index and Ki67 expression in canine MCTs. FAP expression was evaluated by immunohistochemistry (IHC) in 30 canine MCTs. Twenty-eight (90%) of the MCTs expressed FAP in the stroma, 16 cases showed low to intermediate FAP score and 14 cases had a high FAP score. FAP was correlated positively with both Patnaik (P = 0.007) and Kiupel (P = 0.008) grading systems, mitotic index (P = 0.0008) and Ki67 expression (P = 0.009). High stromal FAP expression could be a potential negative prognostic factor in canine MCTs.


Assuntos
Doenças do Cão/patologia , Fibroblastos/patologia , Gelatinases/biossíntese , Sarcoma de Mastócitos/veterinária , Mastocitoma/veterinária , Proteínas de Membrana/biossíntese , Serina Endopeptidases/biossíntese , Animais , Doenças do Cão/metabolismo , Cães , Imuno-Histoquímica , Antígeno Ki-67/biossíntese , Índice Mitótico , Gradação de Tumores
20.
Oncotarget ; 7(40): 66299-66309, 2016 10 04.
Artigo em Inglês | MEDLINE | ID: mdl-27602777

RESUMO

Mast cell sarcoma (MCS) is a rare form of mastocytosis characterized by the presence of solid tumor(s) comprising malignant mast cells that harbor destructive infiltration capability and metastatic potential. Here, we present an extensive literature review and report on 23 cases of MCS, including 3 new cases from the French National Reference Center for Mastocytosis. From our analysis, it appears that MCS can occur at any age. It can manifest de novo or, to a lesser extent, may evolve from a previously established mastocytosis. Bone tumor is a frequent manifestation, and symptoms of mast cell activation are rare. Histological diagnosis can be difficult because MCS is frequently composed of highly atypical neoplastic mast cells and can thus mimic other tumors. Unexpectedly, the canonical KIT D816V mutation is found in only 21% of MCS; therefore, complete KIT gene sequencing is required. The prognosis of patients with MCS is poor, with a median survival time of less than 18 months, and progression to mast cell leukemia is not unusual. Because conventional chemotherapies usually fail, the role of targeted therapies and bone marrow transplantation warrants further investigation in such aggressive neoplasms.


Assuntos
Sarcoma de Mastócitos/patologia , Sarcoma de Mastócitos/terapia , Progressão da Doença , Humanos , Prognóstico
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