Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 734
Filtrar
1.
Tech Vasc Interv Radiol ; 22(4): 100628, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31864528

RESUMO

Ongoing discovery regarding the origin and treatment of vascular anomalies requires standardized nomenclature which itself must undergo iterative updating. This article introduces the 2018 International Society for the Study of Vascular Anomalies (ISSVA) classification, emphasizing the biologic basis of vascular anomalies, summarizing the key features of commonly encountered entities, and serving as a foundation for subsequent articles presented herein. Vascular tumors are discussed to highlight their distinction from vascular malformations which will receive greater attention with respect to management and technical considerations within the issue.


Assuntos
Neoplasias de Tecido Vascular/classificação , Neoplasias de Tecido Vascular/diagnóstico por imagem , Radiologistas , Terminologia como Assunto , Malformações Vasculares/classificação , Malformações Vasculares/diagnóstico por imagem , Humanos , Neoplasias de Tecido Vascular/terapia , Valor Preditivo dos Testes , Prognóstico , Malformações Vasculares/terapia
2.
Tech Vasc Interv Radiol ; 22(4): 100629, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31864536

RESUMO

Vascular anomalies are classified as either tumors or malformations based on clinical findings rendered through radiologic evaluation, physical exam, and histologic interpretation. These findings comprise the phenotype of the disorder. Recently, advances in the molecular genetics of vascular anomalies have shed light on the genotype of these disorders. These phenotype/genotype characterizations will provide a more precise classification of vascular anomalies and identify potential therapeutic targets for expanded treatment options in the future. In this chapter, we will review the phenotype/genotype characterizations and the possible therapeutic pathways for targeted pharmacologic therapy.


Assuntos
Técnicas de Diagnóstico Molecular , Neoplasias de Tecido Vascular/genética , Malformações Vasculares/genética , Antineoplásicos/uso terapêutico , Predisposição Genética para Doença , Humanos , Terapia de Alvo Molecular , Neoplasias de Tecido Vascular/diagnóstico por imagem , Neoplasias de Tecido Vascular/tratamento farmacológico , Fenótipo , Medicina de Precisão , Valor Preditivo dos Testes , Malformações Vasculares/diagnóstico por imagem , Malformações Vasculares/tratamento farmacológico
3.
Zhonghua Bing Li Xue Za Zhi ; 48(8): 620-625, 2019 Aug 08.
Artigo em Chinês | MEDLINE | ID: mdl-31422593

RESUMO

Objective: To study the clinicopathological features, diagnosis, and differential diagnosis of atypical epithelioid hemangioendothelioma (EHE). Methods: Eight cases of atypical EHEs were collected from Jiangsu Province Hospital (the First Affiliated Hospital of Nanjing Medical University) between 2010 and 2018. EnVision method and fluorescence in situ hybridization (FISH) were used to detect immunophenotype, WWTR1-CAMTA1 and TFE3 gene rearrangement, respectively. Results: There were 4 males and 4 females, ranging from 42 to 59 years (median 47.5 years). The tumors located in soft tissue (3 cases), lung (3 cases), liver (1 case) and chest wall (1 case). One soft tissue EHE involved also adjacent fibula and pleural involvement was present in all three lung cases at the diagnosis. Regional lymph node metastases were present in two cases (one involving soft tissue tumor and one involving liver). Morphologically, the tumor cells were epithelioid with abundant eosinophilic cytoplasm, moderate to marked nuclear pleomorphism, irregular nuclear membrane, unevenly chromatin, and prominent nucleoli. The cells arranged in cords, small nests or solid pattern. The mitotic rate was 4.3 mitoses/2 mm(2) on average (ranging 2 to 9). Tumor necrosis was seen in every case. Among all 8 cases, blister cells were found upon careful observation. Myxohyaline stroma was present in 6 cases. Immunohistochemically, tumor cells expressed CD31 (8/8), CD34 (7/8), ERG (8/8), CKpan (2/7), and CAMTA1 (4/6). None of the tested cases stained for TFE3 (0/6). WWTR1-CAMTA1 fusion gene by FISH was found in all tested 6 cases and TFE3 gene rearrangement was not detected in any. Available clinical follow-up was obtained in 7 cases and the intervals range from 6 to 55 months (average 19.6 months). Six patients had metastasis and 3 patients died of disease. One patient was alive with no evidence of disease. Conclusions: Atypical EHE is a more aggressive tumor than classic EHE, with histological features including high nuclear grade, increased mitotic activity, the presence of solid growth pattern and tumor necrosis. The differential diagnoses include epithelioid angiosarcoma, carcinoma and epithelioid sarcoma.


Assuntos
Hemangioendotelioma Epitelioide , Neoplasias de Tecido Vascular , Adulto , Biomarcadores Tumorais , Proteínas de Ligação ao Cálcio , Feminino , Humanos , Hibridização in Situ Fluorescente , Masculino , Pessoa de Meia-Idade , Transativadores
5.
Ann Thorac Surg ; 108(5): e325-e327, 2019 11.
Artigo em Inglês | MEDLINE | ID: mdl-30926474

RESUMO

This case report describes a primary cardiac tumor, classified as venous malformation, diagnosed in an asymptomatic child. The tumor was located in the left atrium near the mitral valve without affecting the mitral valve's functioning. Complete resection of the lesion was performed because of the risk of systemic embolism. The lesion consisted of fibrous tissue with multiple venous vascular channels. The patient did not have similar lesions in other locations. Vascular primary cardiac tumors are extremely rare. Hemangiomas and lymphangiomas have been described previously, but to our knowledge, this is the first primary cardiac tumor identified as a venous malformation.


Assuntos
Átrios do Coração , Neoplasias Cardíacas , Neoplasias de Tecido Vascular , Adolescente , Feminino , Neoplasias Cardíacas/diagnóstico , Neoplasias Cardíacas/cirurgia , Humanos , Neoplasias de Tecido Vascular/diagnóstico , Neoplasias de Tecido Vascular/cirurgia
6.
Adv Anat Pathol ; 26(3): 186-197, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-30762622

RESUMO

Vascular tumors are a diagnostically challenging area. This is particularly true in the case of epithelioid vascular tumors. Not only is the distinction between different epithelioid vascular tumors challenging, but also the differential diagnosis may be substantially expanded by the inclusion of melanoma, carcinomas, and other epithelioid soft tissue tumors. Recently developed immunohistochemical markers and more comprehensive genetic characterizations continue to advance our understanding of epithelioid vascular tumors. The present paper briefly reviews and updates basic concepts with regard to the following epithelioid vascular tumors: epithelioid hemangioma, epithelioid angiomatous nodule, pseudomyogenic hemangioendothelioma, composite hemangioendothelioma, epithelioid hemangioendothelioma, and epithelioid angiosarcoma.


Assuntos
Neoplasias de Tecido Vascular/patologia , Humanos
8.
J Hand Surg Eur Vol ; 44(3): 233-241, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30380989

RESUMO

Vascular anomalies are common in the upper extremities, but there continues to be a relative paucity of information about them in publications dealing with surgery in the hands and upper limbs. The wide spectrum of pathology and an inconsistent use of terminology make vascular anomalies susceptible to incorrect diagnosis and as a result, to misdirected management. This article aims to provide an update on vascular anomalies relevant to the upper limbs, focusing on significant advances in pathogenesis and genetics, classification systems, diagnosis and treatment.


Assuntos
Neoplasias de Tecido Vascular/diagnóstico , Neoplasias de Tecido Vascular/terapia , Extremidade Superior/irrigação sanguínea , Malformações Vasculares/diagnóstico , Malformações Vasculares/terapia , Classe I de Fosfatidilinositol 3-Quinases/genética , Humanos , Anormalidades Musculoesqueléticas/genética , Mutação , Malformações Vasculares/classificação
9.
BMC Cancer ; 18(1): 993, 2018 Oct 19.
Artigo em Inglês | MEDLINE | ID: mdl-30340559

RESUMO

BACKGROUND: Epithelioid hemangioendothelioma is an exceedingly rare sarcoma often occurring as an indolent angiocentric vascular tumor at various anatomic sites. Few reports have evaluated large case series of epithelioid hemangioendothelioma. METHODS: We conducted a retrospective analysis of the clinical data of 42 consecutive patients with epithelioid hemangioendothelioma who were pathologically diagnosed between 1990 and 2014 at 13 Japanese tertiary hospitals. We analyzed their clinical characteristics, tumor features and prognostic factors. RESULTS: The study included 22 men and 20 women, with a median age of 54 (range, 18-78) years. Pain was the most common symptom, occurring in 15 (68%) of the 22 symptomatic patients. The median maximum tumor diameter was 4.0 (range, 1.0-12.8) cm. The most commonly involved organs were the liver (81%), lungs (57%), and bones (12%). The overall survival rates were 79.5% at 1 year and 72.0% at 5 years. Substantially better survival was observed in asymptomatic patients than in symptomatic patients (P = 0.03), and better survival was also ovserved in patients with Ki-67 index ≤10% than in those with Ki-67 index > 10% (P = 0.04). By multivariate analysis, tumor size > 3.0 cm was associated with decreased survival (P = 0.049, hazard ratio 13.33). CONCLUSIONS: This study showed the clinical characteristics of Japanese patients with epithelioid hemangioendothelioma. Tumor size > 3.0 cm is an independent indicator of a poor prognosis in epithelioid hemangioendothelioma. The presence of symptoms at the time of diagnosis and high Ki-67 index implied poor survival.


Assuntos
Neoplasias Ósseas/diagnóstico , Neoplasias Ósseas/mortalidade , Hemangioendotelioma Epitelioide/diagnóstico , Hemangioendotelioma Epitelioide/mortalidade , Neoplasias de Tecidos Moles/diagnóstico , Neoplasias de Tecidos Moles/mortalidade , Adolescente , Adulto , Idoso , Feminino , Humanos , Japão/epidemiologia , Masculino , Pessoa de Meia-Idade , Neoplasias de Tecido Vascular/diagnóstico , Neoplasias de Tecido Vascular/mortalidade , Estudos Retrospectivos , Taxa de Sobrevida/tendências , Adulto Jovem
10.
Int J Hematol ; 108(6): 637-639, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30196477

RESUMO

We describe a patient who presented with large cardiac diffuse large B-cell lymphoma (DLBCL) and adrenal masses. The patient also had subcutaneous intravascular lymphoma lesions which were detected by random skin biopsy. Although ambiguous, minimal extravascular location of lymphoma cells is permitted for the diagnosis of intravascular large B-cell lymphoma (IVLBCL) in the WHO definition, a number of rare cases have been reported as having concomitant tumours in other organs, such as the adrenal gland, brain, and penis. We assume that IVLBCL might be a peculiar feature of DLBCL characterised by preferential localisation of lymphoma cells within the capillaries rather than a distinct disease entity of DLBCL.


Assuntos
Neoplasias Cardíacas/complicações , Neoplasias Cardíacas/diagnóstico , Linfoma Difuso de Grandes Células B/complicações , Linfoma Difuso de Grandes Células B/diagnóstico , Neoplasias de Tecido Vascular/complicações , Neoplasias de Tecido Vascular/diagnóstico , Tela Subcutânea/patologia , Idoso , Biomarcadores , Biópsia , Terapia Combinada , Diagnóstico Diferencial , Feminino , Neoplasias Cardíacas/terapia , Humanos , Linfoma Difuso de Grandes Células B/terapia , Imagem Multimodal/métodos , Neoplasias de Tecido Vascular/terapia , Resultado do Tratamento
11.
Ugeskr Laeger ; 180(36)2018 Sep 03.
Artigo em Dinamarquês | MEDLINE | ID: mdl-30187855

RESUMO

The classification of vascular anomalies has been revised, as physicians and researchers have recognised an increasing number of vascular anomalies. The International Society for the Study of Vascular Anomalies presents a classification distinguishing between tumours and malformations. Over the years, an inaccurate application of the term haemangioma has been used, which has led to confusion among physicians. By using the classification and combining it with a thorough history and objective examination a classification of the most common vascular anomalies should be possible.


Assuntos
Neoplasias de Tecido Vascular/classificação , Malformações Vasculares/classificação , Hemangioma/classificação , Hemangioma/diagnóstico por imagem , Hemangioma/patologia , Humanos , Neoplasias de Tecido Vascular/patologia , Mancha Vinho do Porto/classificação , Mancha Vinho do Porto/patologia , Malformações Vasculares/patologia
12.
Am J Surg Pathol ; 42(9): 1201-1207, 2018 09.
Artigo em Inglês | MEDLINE | ID: mdl-29975248

RESUMO

Hepatic small vessel neoplasm (HSVN) is a recently described infiltrative vascular neoplasm of the liver, composed of small vessels. Although the infiltrative nature can mimic angiosarcoma, HSVN are thought to be benign or low-grade neoplasms because they lack cytologic atypia and increased proliferation. To characterize the molecular pathogenesis of HSVN, we performed both targeted panel sequencing and exome sequencing on 18 benign or low-grade vascular neoplasms in the liver including 8 HSVN, 6 classic cavernous hemangioma (CH), and 4 variant lesions (VL) with overlapping features between HSVN and CH. All 18 lesions had simple genomes without copy number alterations. In total, 75% (6/8) of HSVN demonstrated known activating hotspot mutations in GNAQ (2/8, p.Q209H) or GNA14 (4/8, p.Q205L), and the remaining 2 had the same missense mutation in GNAQ, p.G48L, which has not been previously described. 25% (1/4) of VL had a hotspot GNAQ p.Q209H mutation and another VL had a GNAQ p.G48L mutation. Known pathogenic mutations were not identified in any of the 6 CH. These data suggest that HSVN share a similar molecular biology to several other vascular lesions (congenital hemangioma, tufted angioma, anastomosing hemangioma, lobular capillary hemangioma, and kaposiform hemangioendothelioma) recently reported to have GNAQ, GNA11, or GNA14 mutations.


Assuntos
Subunidades alfa Gq-G11 de Proteínas de Ligação ao GTP/genética , Neoplasias Hepáticas/genética , Neoplasias de Tecido Vascular/genética , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Mutação
13.
J Neurooncol ; 139(3): 679-688, 2018 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-29846895

RESUMO

INTRODUCTION: Stereotactic radiation technique is widely reported as an effective treatment for various types of benign intracranial tumors. However, single fraction radiosurgery (SRS) is not recommended for tumors located close to the optic apparatus due to the restricted radiation tolerance dose of the optic pathway. Recent advances in radiotherapy include advanced frameless radiosurgery using hypofractionated stereotactic radiotherapy (HSRT), and this has become an attractive treatment option for perioptic tumors within 2-3 mm of the optic pathway. Accordingly, the aim of this study was to investigate the clinical outcomes of perioptic tumors treated with HSRT using CyberKnife® (CK) robotic radiosurgery system relative to tumor control, vision preservation and toxicity. METHODS: This retrospective analysis of prospectively collected data included consecutive 100 patients that were diagnosed with and treated for perioptic tumor at the Radiosurgery center, Ramathibodi Hospital during the January 2009 to December 2012 study period. RESULTS: The median tumor volume was 6.81 cm3 (range 0.37-51.6), and the median prescribed dose was 25 Gy (range 20-35) in 5 fractions (range 3-5). After the median follow-up time of 37.5 months (range 21-103), two patients developed tumor progression at 6 and 34 months post-HSRT. The 5-year overall survival was 97%, and the 5-year local control was 97.5%. At the last follow-up, no vision deterioration or newly developed hypopituitarism was detected in our study. CONCLUSIONS: Although a longer follow-up is needed, HSRT yields a high level of local control and vision preservation, and should be considered a treatment of choice for perioptic tumor located close to the optic apparatus.


Assuntos
Neoplasias Meníngeas/radioterapia , Neoplasias de Tecido Vascular/radioterapia , Neoplasias do Sistema Nervoso/radioterapia , Neoplasias Hipofisárias/radioterapia , Radiocirurgia , Adolescente , Adulto , Idoso , Olho , Feminino , Seguimentos , Humanos , Masculino , Neoplasias Meníngeas/mortalidade , Pessoa de Meia-Idade , Neoplasias de Tecido Vascular/mortalidade , Neoplasias do Sistema Nervoso/mortalidade , Neoplasias Hipofisárias/mortalidade , Estudos Prospectivos , Hipofracionamento da Dose de Radiação , Radiocirurgia/efeitos adversos , Estudos Retrospectivos , Resultado do Tratamento , Adulto Jovem
14.
Ophthalmic Surg Lasers Imaging Retina ; 49(5): 356-359, 2018 05 01.
Artigo em Inglês | MEDLINE | ID: mdl-29772046

RESUMO

The authors report a case of a 57-year-old male with high myopia, extensive bilateral myelination of the retinal nerve fiber layer, bilateral vitreous cysts, and a solitary vasoproliferative tumor in the right eye. He underwent pars plana vitrectomy and multiple transpupillary thermotherapy treatments for recurrent vitreous hemorrhages and subretinal exudation from the vasoproliferative tumor. To the authors' knowledge, this is the first description of this constellation of findings and suggests this represents a new syndrome. [Ophthalmic Surg Lasers Imaging Retina. 2018;49:356-359.].


Assuntos
Neoplasias Oculares/patologia , Neoplasias de Tecido Vascular/patologia , Fibras Nervosas Mielinizadas/patologia , Corpo Vítreo/patologia , Cistos , Humanos , Masculino , Pessoa de Meia-Idade , Síndrome
15.
Bull Cancer ; 105(6): 610-625, 2018 Jun.
Artigo em Francês | MEDLINE | ID: mdl-29571951

RESUMO

Superficial vascular anomalies constitute a large group of malformative and tumoral conditions developed from all types of vessels. Vascular tumors are the result of cellular hyperplasia, whereas vascular malformations (VMs) are constituted of dysplastic vessels. The classification from International Society for the Study of Vascular Anomalies (ISSVA) is based on this pathogenic difference. The most common vascular tumor is infantile hemangioma, which treatment, when necessary, is propranolol. Congenital hemangiomas and tumors that might be complicated with Kasabach-Merritt phenomenon, i.e. deep thrombocytopenia, are much rarer. Management of Kasabach-Merritt phenomenon is now largely based on sirolimus. Low-flow VMs include capillary, venous and lymphatic malformations; arteriovenous malformations are high-flow malformations. These different types of VMs might be combined. Currently, there is an increasing work in delineating the different entities based on molecular findings. Treatment of VMs depends on the impairment linked to them, and is decided case by case, in pluridisciplinary consultations. Interventional treatments, especially surgery and sclerotherapy, are usually partially efficient, and management of patients with VMs increasingly involves medical drugs. First-line treatment of coagulation disorders associated with venous malformations is based on low molecular weight heparin; sirolimus seems efficient in hemorrhagic complications refractory to usual treatment. Sirolimus is about to become the standard treatment in painful inflammatory manifestations of mixed and/or complicated lymphatic malformations.


Assuntos
Neoplasias de Tecido Vascular , Doenças Raras , Adolescente , Antagonistas de Receptores Adrenérgicos alfa 1/uso terapêutico , Malformações Arteriovenosas/classificação , Malformações Arteriovenosas/terapia , Criança , Pré-Escolar , Hemangioma/complicações , Hemangioma/tratamento farmacológico , Humanos , Lactente , Síndrome de Kasabach-Merritt/tratamento farmacológico , Neoplasias de Tecido Vascular/classificação , Neoplasias de Tecido Vascular/complicações , Neoplasias de Tecido Vascular/terapia , Propranolol/uso terapêutico , Doenças Raras/classificação , Doenças Raras/complicações , Doenças Raras/terapia , Sirolimo/uso terapêutico , Malformações Vasculares/classificação , Malformações Vasculares/terapia , Vasodilatadores/uso terapêutico
16.
Hum Pathol ; 78: 159-162, 2018 08.
Artigo em Inglês | MEDLINE | ID: mdl-29366622

RESUMO

Hepatic small vessel neoplasm (HSVN) is a recently described vascular neoplasm of the adult liver. The neoplastic cells are positive for markers of vascular lineage (CD31, CD34, FLI-1). The distinctive morphology and infiltrative borders separate HSVN from benign vascular tumors such as cavernous hemangioma, while lack of atypical morphologic features, low to absent mitotic activity and low proliferation index distinguish it from malignant vascular tumors such as epithelioid hemangioendothelioma and angiosarcoma. Due to its infiltrative nature and lack of adequate follow-up information, the benign versus low-grade nature of this tumor is currently uncertain. We present a patient with resected HSVN involving all but the right posterior section of the liver, making this case the largest reported in the current literature.


Assuntos
Neoplasias Hepáticas/patologia , Recidiva Local de Neoplasia/patologia , Neoplasias de Tecido Vascular/patologia , Neoplasias Vasculares/patologia , Biomarcadores Tumorais/análise , Diagnóstico Diferencial , Humanos , Fígado/patologia , Neoplasias Hepáticas/diagnóstico , Masculino , Pessoa de Meia-Idade , Recidiva Local de Neoplasia/diagnóstico , Neoplasias de Tecido Vascular/diagnóstico , Neoplasias Vasculares/diagnóstico
17.
Hum Pathol ; 72: 153-159, 2018 02.
Artigo em Inglês | MEDLINE | ID: mdl-28855107

RESUMO

Epithelioid hemangioendothelioma (EHE) is a malignant neoplasm with vascular differentiation that most frequently occurs within soft tissues, bone, lung, and liver. It is histologically typified by epithelioid or spindle cells present singly or in cords or clusters, many with cytoplasmic vacuoles that can contain intraluminal erythrocytes (in keeping with primitive vascular differentiation), within myxohyaline or sclerotic matrix. Up to 50% present with synchronous lesions as multifocal disease. The WWTR1-CAMTA1 fusion has been demonstrated in EHEs at a variety of sites and is considered to represent its genetic hallmark. We describe a case of EHE in a patient who initially presented with multiple liver and pulmonary deposits, was found to have a soft tissue lesion in the foot, and then presented with further lesions on the nasal bridge and the arm approximately 6 years after initial presentation. Interestingly, the case showed diffuse CAMTA1 expression but negative TFE3 immunohistochemically, but in contrast showed TFE3 gene rearrangement with fluorescence in situ hybridization but no evidence of WWTR1-CAMTA1 translocation. The clinical behavior of EHE is unpredictable, and this case highlights unusual anatomic, immunohistochemical, and molecular cytogenetic findings. Characterization of the genetics of EHE is important because targeted therapies toward products of the specific WWTR1-CAMTA1 gene fusion may have an impact in the near future.


Assuntos
Fatores de Transcrição de Zíper de Leucina e Hélice-Alça-Hélix Básicos/genética , Hemangioendotelioma Epitelioide/genética , Hemangioendotelioma Epitelioide/patologia , Neoplasias de Tecido Vascular/genética , Adulto , Biomarcadores Tumorais/genética , Proteínas de Ligação ao Cálcio/metabolismo , Feminino , Hemangioendotelioma Epitelioide/diagnóstico , Humanos , Peptídeos e Proteínas de Sinalização Intracelular/metabolismo , Neoplasias de Tecido Vascular/patologia , Proteínas de Fusão Oncogênica/genética , Proteínas de Fusão Oncogênica/metabolismo , Transativadores/metabolismo , Fatores de Transcrição , Translocação Genética/genética
18.
Otolaryngol Clin North Am ; 51(1): 89-97, 2018 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-29217070

RESUMO

Vascular tumors are benign neoplasms, which result from proliferating endothelial cells. These lesions present during infancy or childhood, may affect any location, and exhibit postnatal growth. Local complications include bleeding, tissue destruction, and pain whereas systemic sequelae include thrombocytopenia, congestive heart failure, and death. Vascular tumors should be differentiated from vascular malformations, which present at birth, have a quiescent endothelium, and grow in proportion to the child. Together, vascular tumors and malformations comprise the field of vascular anomalies.


Assuntos
Neoplasias de Tecido Vascular/congênito , Neoplasias de Tecido Vascular/diagnóstico , Neoplasias de Tecido Vascular/terapia , Diagnóstico Diferencial , Granuloma Piogênico/diagnóstico , Granuloma Piogênico/terapia , Humanos , Miofibroma/diagnóstico , Miofibroma/terapia , Malformações Vasculares
19.
Zhonghua Bing Li Xue Za Zhi ; 46(11): 760-763, 2017 Nov 08.
Artigo em Chinês | MEDLINE | ID: mdl-29136688

RESUMO

Objective: To investigate the expression of ERG, Fli-1, CD34, CD31 and factor Ⅷ-related antigen(FⅧRAg) in hepatic malignant vascular tumors. Methods: A retrospective analysis was conducted on 63 cases of primary hepatic malignant vascular tumors and 31 cases of hepatic other malignant spindle cell tumors collected during January 1986 to January 2014. EnVision method was used to detect the expression of ERG, Fli-1, CD34, CD31, FⅧRAg. Results: Sixty-three cases of malignant vascular tumors, including 24 cases of angiosarcoma, 38 cases of epithelioid hemangioendothelioma and 1 case of hepatic Kaposi's sarcoma. All of the cases were positive for ERG(100.0%, 63/63). Positive rate of Fli-1, CD34, CD31, FⅧRAg was 96.8% (61/63), 87.3% (55/63), 81.0% (51/63) and 41.3% (26/63), respectively. In other hepatic malignant spindle cell tumors, the positive rate of ERG, Fli-1, CD34, CD31 and FⅧRAg was 3.2% (1/31), 19.4% (6/31), 19.4% (6/31), 9.7%(3/31) and 3.2%(1/31), respectively.The sensitivity of ERG, Fli-1, CD34, CD31, FⅧRAg was 100.0%, 96.8%, 87.3%, 81.0% and 41.3%, respectively.The specificity was 96.8%, 80.6%, 80.6%, 90.3% and 96.8%, respectively. Conclusion: ERG is a more sensitive and specific diagnostic marker for hepatic malignant vascular tumors in comparison to Fli-1, CD34, CD31 and FⅧRAg.


Assuntos
Antígenos CD34/metabolismo , Hemangioendotelioma Epitelioide/metabolismo , Neoplasias Hepáticas/metabolismo , Neoplasias de Tecido Vascular/metabolismo , Molécula-1 de Adesão Celular Endotelial a Plaquetas/metabolismo , Proteína Proto-Oncogênica c-fli-1/metabolismo , Fator de von Willebrand/metabolismo , Biomarcadores Tumorais/metabolismo , Hemangiossarcoma/metabolismo , Humanos , Imuno-Histoquímica , Estudos Retrospectivos , Sarcoma de Kaposi/metabolismo , Sensibilidade e Especificidade , Regulador Transcricional ERG/metabolismo
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA