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1.
MMW Fortschr Med ; 162(4): 34, 2020 03.
Artigo em Alemão | MEDLINE | ID: mdl-32124354

Assuntos
Glossite , Língua , Humanos
4.
J Formos Med Assoc ; 119(3): 720-727, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31630933

RESUMO

BACKGROUND/PURPOSE: Our previous study found that 56 of 1064 atrophic glossitis (AG) patients have vitamin B12 deficiency. This study assessed whether the AG patients with vitamin B12 deficiency (B12D/AG patients) had significantly higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity than healthy control subjects. METHODS: The blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 56 B12D/AG patients and 532 healthy control subjects were measured and compared. RESULTS: We found that 56 B12D/AG patients had significantly lower mean blood Hb and serum iron levels as well as significantly higher mean corpuscular volume (MCV) and mean serum homocysteine level than healthy control subjects (all P-values < 0.05). Moreover, 56 B12D/AG patients had significantly higher frequencies of macrocytosis (53.6%), blood Hb (64.3%), iron (26.8%), and folic acid (3.6%) deficiencies, hyperhomocysteinemia (89.3%), and serum GPCA positivity (55.4%) than 532 healthy control subjects (all P-values < 0.005). In addition, of 36 anemic B12D/AG patients, 22 (61.1%) had pernicious anemia (PA), 6 (16.7%) had macrocytic anemia other than PA, 4 (11.1%) had normocytic anemia, 3 (8.3%) had iron deficiency anemia (IDA), and one (2.8%) had microcytic anemia other than IDA and thalassemia trait-induced anemia. CONCLUSION: We conclude that B12D/AG patients have significantly higher frequencies of macrocytosis, blood Hb, iron, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity than healthy control subjects. PA is the most common type of anemia in our B12D/AG patients.


Assuntos
Anemia/epidemiologia , Deficiência de Ácido Fólico/epidemiologia , Glossite/epidemiologia , Hiper-Homocisteinemia/epidemiologia , Deficiência de Vitamina B 12/epidemiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Anemia/sangue , Autoanticorpos/sangue , Estudos de Casos e Controles , Comorbidade , Índices de Eritrócitos , Feminino , Ácido Fólico/sangue , Deficiência de Ácido Fólico/sangue , Hematínicos , Hemoglobinas/análise , Humanos , Hiper-Homocisteinemia/sangue , Ferro/sangue , Masculino , Pessoa de Meia-Idade , Células Parietais Gástricas/imunologia , Vitamina B 12/sangue , Deficiência de Vitamina B 12/sangue
6.
J Vet Diagn Invest ; 31(5): 783-787, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31347467

RESUMO

Rhodococcus equi infection in horses is common and is characterized by pyogranulomatous pneumonia and ulcerative enterocolitis. R. equi clinical disease in cattle, however, is rare and typically manifests as granulomatous lymphadenitis discovered in the abattoir. A 19-mo-old female Santa Gertrudis had a history of intermittent inappetence and weight loss for a 3-mo period before euthanasia. Gross and histologic examination revealed severe, chronic, ulcerative, and granulomatous inflammation in the tongue, pharynx, and small intestine. Also, the heifer had severe, granulomatous pharyngeal and mesenteric lymphadenitis. Bacterial cultures from the ileum, tongue, and liver yielded numerous-to-moderate numbers of R. equi. PCR analysis of the isolate detected the linear virulence plasmid vapN, which is often identified in bovine isolates (traA- and vapN-positive). The bacteria also lack the circular plasmids vapA and vapB that are associated with virulence in horses and swine, respectively. We report herein an atypical and unusual clinical presentation of R. equi infection in cattle, which has zoonotic potential.


Assuntos
Infecções por Actinomycetales/veterinária , Doenças dos Bovinos/diagnóstico , Enterite/veterinária , Glossite/veterinária , Rhodococcus equi/isolamento & purificação , Infecções por Actinomycetales/diagnóstico , Infecções por Actinomycetales/microbiologia , Animais , Bovinos , Doenças dos Bovinos/microbiologia , Enterite/diagnóstico , Enterite/microbiologia , Evolução Fatal , Feminino , Glossite/diagnóstico , Glossite/microbiologia , Granuloma/diagnóstico , Granuloma/microbiologia , Granuloma/veterinária , Úlcera/diagnóstico , Úlcera/microbiologia , Úlcera/veterinária
7.
J Formos Med Assoc ; 118(11): 1515-1521, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31324439

RESUMO

BACKGROUND/PURPOSE: Macrocytosis is defined as having the mean corpuscular volume (MCV) â‰§ 100 fL. This study evaluated whether 41 atrophic glossitis (AG) patients with macrocytosis had significantly higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity than 532 healthy control subjects or 1064 AG patients. METHODS: Complete blood count, serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 41 AG patients with macrocytosis, 1064 AG patients, and 532 healthy control subjects were measured and compared. RESULTS: We found that 73.2%, 22.0%, 73.2%, 4.9%, 80.5%, and 56.1% of 41 AG patients with macrocytosis were diagnosed as having blood hemoglobin, iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity, respectively. Moreover, 41 AG patients with macrocytosis had significantly higher frequencies of blood hemoglobin and serum vitamin B12 deficiencies, hyperhomocysteinemia, and serum GPCA positivity than 532 healthy control subjects or 1064 AG patients (all P-values < 0.001). In addition, 41 AG patients with macrocytosis also had significantly higher frequencies of serum iron and folic acid deficiencies than 532 healthy control subjects (both P-values < 0.001). Pernicious anemia was found in 22 AG patients with macrocytosis. CONCLUSION: There are significantly higher frequencies of anemia and serum iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity in AG patients with macrocytosis than in healthy control subjects. AG patients with macrocytosis also have significantly higher frequencies of blood hemoglobin and serum vitamin B12 deficiencies, hyperhomocysteinemia, and serum GPCA positivity than AG patients.


Assuntos
Anemia Macrocítica/sangue , Autoanticorpos/sangue , Glossite/sangue , Hematínicos/sangue , Doenças Hematológicas/sangue , Hiper-Homocisteinemia/etiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Anemia/etiologia , Anemia Macrocítica/complicações , Anemia Macrocítica/imunologia , Atrofia , Estudos de Casos e Controles , Índices de Eritrócitos , Feminino , Ácido Fólico/sangue , Glossite/complicações , Glossite/imunologia , Doenças Hematológicas/complicações , Doenças Hematológicas/imunologia , Hemoglobinas/análise , Homocisteína/sangue , Humanos , Ferro/sangue , Masculino , Pessoa de Meia-Idade , Células Parietais Gástricas/imunologia , Língua/patologia , Vitamina B 12/sangue , Adulto Jovem
8.
J Formos Med Assoc ; 118(10): 1401-1407, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31242967

RESUMO

BACKGROUND/PURPOSE: Microcytosis is defined as having mean corpuscular volume (MCV) < 80 fL. This study evaluated whether 79 atrophic glossitis (AG) patients with microcytosis and 985 AG patient without microcytosis had higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity than 532 healthy control subjects. METHODS: Complete blood count, serum iron, vitamin B12, folic acid, homocysteine, and serum GPCA levels in 79 AG patients with microcytosis, 985 AG patient without microcytosis, and 532 healthy control subjects were measured and compared. RESULTS: We found that 69.6%, 43.0%, 5.1%, 3.8%, 11.4%, and 22.8% of 79 AG patients with microcytosis and 14.9%, 14.8%, 5.3%, 2.1%, 12.0%, and 27.0% of 985 AG patients without microcytosis were diagnosed as having blood hemoglobin, iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity, respectively. Both 79 AG patients with microcytosis and 985 AG patients without microcytosis had significantly higher frequencies of blood hemoglobin, iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity than 532 healthy control subjects (all P-values < 0.01). Moreover, 79 AG patients with microcytosis had significantly higher frequencies of blood hemoglobin and iron deficiencies than 985 AG patients without microcytosis. CONCLUSION: There are significantly higher frequencies of anemia, serum iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity in AG patients with or without microcytosis than in healthy control subjects. AG patients with microcytosis have significantly higher frequencies of blood hemoglobin and iron deficiencies than AG patients without microcytosis.


Assuntos
Anemia/etiologia , Autoanticorpos/sangue , Glossite/sangue , Glossite/complicações , Hiper-Homocisteinemia/etiologia , Células Parietais Gástricas/imunologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Anemia/sangue , Atrofia/sangue , Estudos de Casos e Controles , Índices de Eritrócitos , Eritropoese , Feminino , Ácido Fólico/sangue , Deficiência de Ácido Fólico/sangue , Deficiência de Ácido Fólico/etiologia , Glossite/patologia , Hemoglobinas/metabolismo , Homocisteína/sangue , Humanos , Hiper-Homocisteinemia/sangue , Ferro/sangue , Ferro/deficiência , Masculino , Pessoa de Meia-Idade , Língua/patologia , Vitamina B 12/sangue , Deficiência de Vitamina B 12/sangue , Deficiência de Vitamina B 12/etiologia , Adulto Jovem
9.
J Formos Med Assoc ; 118(8): 1218-1224, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31005374

RESUMO

BACKGROUND/PURPOSE: Our previous study found that 304 of 1064 atrophic glossitis (AG) patients have thyroglobulin antibody (TGA) positivity and/or thyroid microsomal antibody (TMA) positivity but without gastric parietal cell antibody positivity (GPCAÖ¾TGA+/TMA+AG patients). This study mainly assessed whether the serum TGA/TMA positivity was significantly associated with anemia, hematinic deficiencies, and hyperhomocysteinemia in GPCAÖ¾TGA+/TMA+AG patients. METHODS: The mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between 304 GPCAÖ¾TGA+/TMA+AG patients and 476 GPCA-negative, TGA-negative, and TMA-negative AG patients (GPCAÖ¾TGAÖ¾TMAÖ¾AG patients) or 532 healthy control subjects. RESULTS: We found significantly lower MCV and lower mean blood Hb and iron levels as well as significantly greater frquencies of microcytosis, macrocytosis, blood Hb, iron, vitamin B12, and folic acid deficiencies and hyperhomocysteinemia in 304 GPCAÖ¾TGA+/TMA+AG patients than in 532 healthy control subjects. However, no significant differences in the MCV and mean blood Hb, iron, vitamin B12, folic acid, and homocysteine leve1s as well as no significant differences in the frequencies of microcytosis, macrocytosis, blood Hb, iron, and folic acid deficiencies, and hyperhomocysteinemia were discovered between 304 GPCAÖ¾TGA+/TMA+AG patients and 476 GPCAÖ¾TGAÖ¾TMAÖ¾AG patients. The 304 GPCAÖ¾TGA+/TMA+AG patients had a significantly greater frquency of serum vitamin B12 deficiency than 476 GPCAÖ¾TGAÖ¾TMAÖ¾AG patients. CONCLUSION: The disease of AG itself plays a significant role in causing anemia, hematinic deficiencies, and hyperhomocysteinemia in GPCAÖ¾TGA+/TMA+AG patients. However, the serum TGA/TMA-positivity is not significantly associated with anemia, serum iron and folic acid deficiencies, and hyperhomocysteinemia in GPCAÖ¾TGA+/TMA+AG patients.


Assuntos
Anemia/etiologia , Autoanticorpos/sangue , Glossite/sangue , Células Parietais Gástricas/imunologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Atrofia , Índices de Eritrócitos , Feminino , Ácido Fólico/sangue , Hemoglobinas/análise , Humanos , Hiper-Homocisteinemia/sangue , Ferro/sangue , Masculino , Pessoa de Meia-Idade , Taiwan , Vitamina B 12/sangue
10.
J Formos Med Assoc ; 118(7): 1114-1121, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-30979649

RESUMO

BACKGROUND/PURPOSE: Our previous study found that 177 of 1064 atrophic glossitis (AG) patients have serum gastric parietal cell antibody (GPCA) positivity only (so-called GPCA+AG patients). This study assessed whether serum GPCA positivity or AG itself was a significant factor causing hematinic deficiencies and hyperhomocysteinemia in GPCA+AG or GPCA-negative, thyroglobulin antibody (TGA)-negative, and thyroid microsomal antibody (TMA)-negative AG (GPCAÖ¾TGAÖ¾TMAÖ¾AG) patients. METHODS: The mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between any two of three groups of 177 GPCA+AG patients, 476 GPCAÖ¾TGAÖ¾TMAÖ¾AG patients, and 532 healthy control subjects. RESULTS: GPCA+AG patients had significantly lower mean blood Hb and iron (for women only) levels and a significantly higher mean serum homocysteine level than healthy control subjects. Moreover, GPCA+AG patients had significantly greater frequencies of blood Hb, iron, and vitamin B12 deficiencies and hyperhomocysteinemia than healthy control subjects. GPCA+AG patients have a lower mean serum vitamin B12 level and a significantly higher mean serum homocysteine level as well as significantly greater frequencies of vitamin B12 deficiency and hyperhomocysteinemia than GPCAÖ¾TGAÖ¾TMAÖ¾AG patients. Moreover, GPCAÖ¾TGAÖ¾TMAÖ¾AG patients did have significantly lower mean blood Hb and iron levels and significantly greater frequencies of blood Hb, iron, vitamin B12, and folic acid deficiencies and hyperhomocysteinemia than healthy control subjects. CONCLUSION: The GPCA is a major factor causing vitamin B12 deficiency and hyperhomocyteinemia in GPCA+AG patients. AG itself does play a significant role in causing anemia, hematinic deficiencies, and hyperhomocysteinemia in both GPCA+AG and GPCAÖ¾TGAÖ¾TMAÖ¾AG patients.


Assuntos
Anemia/etiologia , Autoanticorpos/sangue , Glossite/sangue , Hiper-Homocisteinemia/sangue , Células Parietais Gástricas/imunologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Atrofia , Índices de Eritrócitos , Feminino , Ácido Fólico/sangue , Hemoglobinas/análise , Humanos , Ferro/sangue , Masculino , Pessoa de Meia-Idade , Taiwan , Vitamina B 12/sangue , Adulto Jovem
11.
J Formos Med Assoc ; 118(6): 973-978, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30736997

RESUMO

BACKGROUND/PURPOSE: Gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) are organ-specific autoantibodies. This study mainly assessed the frequencies of presence of serum GPCA, TGA, and TMA in atrophic glossitis (AG) patients. METHODS: Serum GPCA, TGA, and TMA levels were measured in 1064 AG patients and in 532 age- and sex-matched healthy control subjects. RESULTS: We found that 26.7%, 28.4%, and 29.8% of 1064 AG patients and 2.3%, 2.1%, and 2.6% of 532 healthy control subjects had the serum GPCA, TGA, and TMA positivities, respectively. AG patients had a significantly higher frequency of GPCA, TGA, or TMA positivity than healthy control subjects (all P-values < 0.001). We also found that 67 (6.3%), 181 (17.0%), and 340 (32.0%) AG patients and 3 (0.6%), 10 (1.9%), and 8 (1.5%) healthy control subjects had the presence of three (GPCA + TGA + TMA), two (GPCA + TGA, GPCA + TMA, or TGA + TMA), or one (GPCA only, TGA only, or TMA only) organ-specific autoantibody in their sera, respectively. Of 373 TGA/TMA-positive AG patients whose serum thyroid-stimulating hormone (TSH) levels were measured, 78.6%, 8.0%, and 13.4% of these TGA/TMA-positive AG patients had normal, lower, and higher serum TSH levels, respectively. CONCLUSION: Approximately 55.3% of 1064 AG patients have serum GPCA/TGA/TMA positivity. Because part of GPCA-positive AG patients may develop pernicious anemia, autoimmune atrophic gastritis, and gastric carcinoma, and part of TGA/TMA-positive AG patients may have thyroid dysfunction such as hyperthyroidism and hypothyroidism, these autoantibody-positive AG patients should be referred to medical doctors for further management.


Assuntos
Autoanticorpos/sangue , Glossite/sangue , Células Parietais Gástricas/imunologia , Glândula Tireoide/fisiopatologia , Tireotropina/sangue , Adulto , Idoso , Idoso de 80 Anos ou mais , Estudos de Casos e Controles , Feminino , Humanos , Hipertireoidismo/complicações , Hipotireoidismo/complicações , Masculino , Pessoa de Meia-Idade , Adulto Jovem
12.
J Vet Med Sci ; 81(2): 274-278, 2019 Feb 28.
Artigo em Inglês | MEDLINE | ID: mdl-30606907

RESUMO

Five-day-old neonatal piglets presented with debilitation and ananastasia. At the necropsy of one piglet, the apex of the tongue was found to be discolored dark red, and disseminated white foci were found on the cut surface. Many white foci were also found in the lungs and on the serosa of the liver and spleen. Histopathological findings revealed multifocal necrotic glossitis and pneumonia with Gram-negative bacilli. The bacilli were identified as Actinobacillus suis through immunohistochemical, biochemical, and genetic tests, including 16S rRNA gene sequencing. Although A. suis usually causes inflammation in thoracic and abdominal organs, lesions were also found in the tongue in the present case. This study is the first report of glossitis caused by A. suis.


Assuntos
Infecções por Actinobacillus/veterinária , Actinobacillus suis , Glossite/veterinária , Sepse/veterinária , Infecções por Actinobacillus/diagnóstico , Infecções por Actinobacillus/patologia , Actinobacillus suis/genética , Animais , Animais Recém-Nascidos/microbiologia , Glossite/microbiologia , Glossite/patologia , Necrose , RNA Ribossômico 16S/genética , Sepse/diagnóstico , Sepse/microbiologia , Sepse/patologia , Análise de Sequência de RNA/veterinária , Língua/patologia
13.
J Formos Med Assoc ; 118(2): 565-571, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30581105

RESUMO

BACKGROUND/PURPOSE: Approximately 27% of atrophic glossitis (AG) patients have the serum gastric parietal cell antibody (GPCA) positivity. This study assessed whether the serum GPCA or AG itself was a significant factor causing anemia, hematinic deficiencies, and hyperhomocysteinemia in GPCA-positive AG (GPCA+AG) and GPCA-negative AG (GPCA-AG) patients. METHODS: The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between any two of three groups of 284 GPCA+AG, 780 GPCA-AG patients, and 532 healthy control subjects. RESULTS: Both 284 GPCA+AG and 780 GPCA-AG patients had significantly higher frequencies of microcytosis, macrocytosis, blood Hb, iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia than 532 healthy control subjects. Moreover, 284 GPCA+AG patients had significantly higher frequencies of macrocytosis, vitamin B12 deficiency, and hyperhomocysteinemia than 780 GPCA-AG patients. Sixty-three (22.2%) of 284 GPCA+AG patients and 139 (17.8%) of 780 GPCA-AG patients had anemia. The normocytic anemia (42.9%), pernicious anemia (34.9%), and iron deficiency anemia (15.9%) were the three most common types of anemia in the 63 anemic GPCA+AG patients. Moreover, the normocytic anemia (64.8%), iron deficiency anemia (14.4%), and thalassemia trait-induced anemia (13.7%) were the three most common types of anemia in 139 anemic GPCA-AG patients. CONCLUSION: The disease of AG itself is a significant factor causing anemia, hematinic deficiencies, and hyperhomocysteinemia in both GPCA+AG and GPCA-AG patients. The serum GPCA also plays a significant role in causing macrocytosis, vitamin B12 deficiency, and hyperhomocysteinemia in GPCA+AG patients.


Assuntos
Anemia/etiologia , Autoanticorpos/sangue , Glossite/sangue , Hiper-Homocisteinemia/sangue , Células Parietais Gástricas/imunologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Atrofia , Estudos de Casos e Controles , Contagem de Eritrócitos , Índices de Eritrócitos , Feminino , Ácido Fólico/sangue , Hemoglobinas/análise , Humanos , Ferro/sangue , Masculino , Pessoa de Meia-Idade , Taiwan , Vitamina B 12/sangue , Adulto Jovem
15.
Morphologie ; 102(339): 250-254, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30219545

RESUMO

Diabetes mellitus (DM) is a metabolic disorder resulting with many different complications including soft tissue abnormalities in the oral cavity such as periodontitis and salivary and taste dysfunction. Previous studies also reported fungal and bacterial infections in oral cavity in these patients. This study aims to represent three dimentional morphologic ultrastructural changes of the diabetic rat tongue via scanning electron microscopy. Twenty-four (24) adult male Spraque-Dawley rats, (weight ranging between 200-250g) included in the study were randomly assigned into two groups: control rats were injected with intraperitoneally saline alone, experimental diabetes group received streptozotocin (STZ) (80mg/kg) administrated intraperitoneally. On month four, by the end of experimental period, all animals of each group were anesthetised. All tongues were dissected totally, postfixed in 2% osmium tetroxide and then dried by critical point drying before SEM analysis. Finally, superficial epithelial configurations of the lingual papillae in experimental diabetic rats were examined by scanning electron microscopy. Diabetes mellitus caused thickness, hyperceratosis and different epithelial changes, We observed yeast-like structures and bacterial colonisations on the papillar and epithelial structure of the tongue. The morphological atrophic changes of lingual mucosa and the median rhomboid glossitis (which is primary finding of candidal infection) are characteristic observations on the lingual mucosa of the streptozotocin treated rats.


Assuntos
Candidíase/patologia , Diabetes Mellitus Experimental/patologia , Glossite/patologia , Mucosa Bucal/ultraestrutura , Língua/ultraestrutura , Animais , Atrofia/patologia , Candida/isolamento & purificação , Candidíase/microbiologia , Diabetes Mellitus Experimental/induzido quimicamente , Diabetes Mellitus Experimental/complicações , Glossite/microbiologia , Humanos , Hifas/isolamento & purificação , Masculino , Microscopia Eletrônica de Varredura , Mucosa Bucal/microbiologia , Mucosa Bucal/patologia , Ratos , Ratos Sprague-Dawley , Estreptozocina/toxicidade , Língua/microbiologia , Língua/patologia
16.
J Formos Med Assoc ; 117(12): 1065-1071, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30087017

RESUMO

BACKGROUND/PURPOSE: Atrophic glossitis (AG) patients are prone to have anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity. This study evaluated whether 1064 AG patients had significantly higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum GPCA positivity than 532 healthy control subjects. METHODS: The complete blood count, serum iron, vitamin B12, folic acid, homocysteine, and serum GPCA levels in 1064 AG patients and 532 age- and sex-matched healthy control subjects were measured and compared. RESULTS: We found that 7.4%, 3.9%, 19.0%, 16.9%, 5.3%, 2.3%, 11.9%, and 26.7% of 1064 AG patients were diagnosed as having microcytosis, macrocytosis, hemoglobin, iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity, respectively. Moreover, 1064 AG patients had significantly higher frequencies of microcytosis, macrocytosis, hemoglobin, iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity than 532 healthy control subjects (all P-values < 0.005). Of the 202 anemic AG patients, 22 had pernicious anemia, eight had macrocytic anemia rather than pernicious anemia, 117 had normocytic anemia, 30 had iron deficiency anemia, and 21 had thalassemia trait-induced anemia, and four had microcytic anemia rather than iron deficiency anemia and thalassemia trait-induced anemia. CONCLUSION: There are significantly higher frequencies of anemia, serum iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity in AG patients than in healthy control subjects. The normocytic anemia and iron deficiency anemia are the two most common types of anemia in our 1064 AG patients.


Assuntos
Anemia/etiologia , Autoanticorpos/sangue , Glossite/sangue , Hiper-Homocisteinemia/sangue , Células Parietais Gástricas/imunologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Atrofia , Estudos de Casos e Controles , Contagem de Eritrócitos , Índices de Eritrócitos , Feminino , Ácido Fólico/sangue , Hemoglobinas/análise , Humanos , Ferro/sangue , Masculino , Pessoa de Meia-Idade , Taiwan , Vitamina B 12/sangue , Adulto Jovem
17.
Acta Dermatovenerol Croat ; 26(2): 125-132, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29989868

RESUMO

The aim of this study was to evaluate zinc gluconate as a treatment option in patients with symptomatic migratory glossitis (MG). Using simple random sampling, 28 non-psoriatic patients with symptomatic MG were divided into a test and control group. The test group took 20 mg/day of chelated zinc gluconate for one month, and was put on a diet rich in zinc. The control group was only put on a diet rich in zinc. Changes in the size of red atrophied areas (width and length) and the intensity of symptoms were evaluated as primary and secondary outcomes, respectively, at baseline, after therapy, and one month later. In the test group, the mean value of the red atrophy area width and length displayed some significant reduction as a primary outcome. There were no significant changes in the size of red patches in the control group. Secondary outcome showed that the intensity of subjective symptoms in the test group significantly decreased (P=0.042) compared with controls. The filiform papillae had partially or completely regenerated in 85.7% of cases in the test group and in 23.1% of the controls (P=0.001). Red patches with raised keratotic rims may have healed spontaneously and reappeared in constantly changing patterns that are typical for MG. This phenomenon was not observed in patients supplemented with zinc, and new atrophy areas occurred in only one case. Low-dose zinc gluconate.


Assuntos
Glossite/tratamento farmacológico , Gluconatos/uso terapêutico , Adulto , Idoso , Epitélio/efeitos dos fármacos , Epitélio/patologia , Epitélio/fisiopatologia , Feminino , Glossite/complicações , Glossite/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Avaliação de Resultados em Cuidados de Saúde , Regeneração/efeitos dos fármacos , Método Simples-Cego , Avaliação de Sintomas , Adulto Jovem
18.
J Formos Med Assoc ; 117(8): 691-696, 2018 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-29653880

RESUMO

BACKGROUND/PURPOSE: Behcet's disease (BD) patients should have recurrent aphthous stomatitis (RAS) but they may or may not have atrophic glossitis (AG). This study mainly assessed the frequencies of serum gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) positivities in 30 AG-positive RAS/BD (AG+RAS/BD) and 33 AG-negative RAS/BD (AGÖ¾RAS/BD) patients. METHODS: The frequencies of serum GPCA, TGA, and TMA positivities in 30 AG+RAS/BD patients, 33 AGÖ¾RAS/BD patients, and 126 healthy control subjects were calculated and compared. RESULTS: We found that 20.0%, 30.0%, and 26.7% of 30 AG+RAS/BD patients, 9.1%, 12.1%, and 15.2% of 33 AGÖ¾RAS/BD patients, and 1.6%, 2.4%, and 2.4% of 126 healthy control subject had the presence of GPCA, TGA, and TMA in their sera, respectively. The 30 AG+RAS/BD patients had significantly higher frequencies of serum GPCA, TGA, and TMA positivities than healthy control subjects (all P-values < 0.001). The 33 AGÖ¾RAS/BD patients had a higher frequency of serum TGA positivity (P = 0.051, marginal significance) and a significantly higher frequency of serum TMA positivity (P = 0.011) than healthy control subjects. Although the 30 AG+RAS/BD patients had higher frequencies of serum GPCA, TGA, and TMA positivities than the 33 AGÖ¾RAS/BD patients, the differences were not significant. CONCLUSION: AG+RAS/BD patients do have significantly higher frequencies of serum GPCA, TGA, and TMA positivities than healthy control subjects. This finding indicates that the concomitant presence of AG may result in significantly elevated frequencies of serum GPCA, TGA, and TMA positivities in BD patients.


Assuntos
Autoanticorpos/sangue , Síndrome de Behçet/sangue , Glossite/sangue , Glossite/complicações , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Estudos de Casos e Controles , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Células Parietais Gástricas/imunologia , Taiwan , Tireoglobulina/imunologia , Glândula Tireoide/imunologia , Adulto Jovem
19.
J Formos Med Assoc ; 117(7): 559-565, 2018 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-29572125

RESUMO

BACKGROUND/PURPOSE: Behcet's disease (BD) patients should have recurrent aphthous stomatitis (RAS) but they may or may not have atrophic glossitis (AG). This study mainly assessed whether 30 AG-positive RAS/BD (AG+RAS/BD) patients had significantly higher frequencies of hemoglobin, iron, vitamin B12, and folic acid deficiencies and of hyperhomocysteinemia than 33 AG-negative RAS/BD (AGÖ¾RAS/BD) patients or 126 age- and sex-matched healthy control subjects. METHODS: The blood hemoglobin, iron, vitamin B12, folic acid, and homocysteine concentrations were measured and compared among 30 AG+RAS/BD patients, 33 AGÖ¾RAS/BD patients, and 126 healthy control subjects. RESULTS: We found that 43.3%, 33.3%, 13.3%, 6.7%, and 20.0% of 30 AG+RAS/BD patients and 18.2%, 36.4%, 0%, 6.1%, and 9.1% of 33 AGÖ¾RAS/BD patients had hemoglobin, iron, vitamin B12, and folic acid deficiencies and hyperhomocysteinemia, respectively. Moreover, 30 AG+RAS/BD patients had significantly higher frequencies of hemoglobin, iron, vitamin B12, and folic acid deficiencies and of hyperhomocysteinemia than healthy control subjects (all P-values < 0.05), and had a higher frequency of hemoglobin deficiency (P = 0.058, marginal significance) and a significantly higher frequency of vitamin B12 deficiency (P = 0.046) than 33 AGÖ¾RAS/BD patients. In addition, the 33 AGÖ¾RAS/BD patients had significantly higher frequencies of hemoglobin and iron deficiencies than healthy control subjects (both P-values < 0.001). CONCLUSION: We conclude that AG+RAS/BD patients do have significantly higher frequencies of hemoglobin, iron, vitamin B12, and folic acid deficiencies and of hyperhomocysteinemia than healthy control subjects and have significantly higher frequencies of hemoglobin and vitamin B12 deficiencies than AGÖ¾RAS/BD patients.


Assuntos
Síndrome de Behçet/complicações , Deficiência de Ácido Fólico/complicações , Hemoglobinas/deficiência , Hiper-Homocisteinemia/complicações , Ferro/deficiência , Deficiência de Vitamina B 12/complicações , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Atrofia , Síndrome de Behçet/sangue , Estudos de Casos e Controles , Feminino , Ácido Fólico/sangue , Glossite , Hemoglobinas/análise , Homocisteína/sangue , Humanos , Ferro/sangue , Masculino , Pessoa de Meia-Idade , Estomatite Aftosa , Taiwan , Vitamina B 12/sangue , Adulto Jovem
20.
Auris Nasus Larynx ; 45(3): 522-526, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-28882408

RESUMO

OBJECTIVE: In this study, we evaluated pathological changes in the tooth and pharynx of GERD rats to elucidate the association between gastric acid reflux and oral and pharyngeal diseases. METHODS: An experimental rat model of chronic acid reflux esophagitis was surgically created. The oral cavities were observed histologically every 2 weeks until 20 weeks after surgery. RESULTS: At 10 weeks after surgery, molar crown heights in GERD rats were shorter than that in control rats, and inflammatory cell infiltration by gastric acid reflux was found in the periodontal mucosa of GERD rats. Furthermore, dental erosion progressed in GERD rats at 20 weeks after surgery, and enamel erosion and dentin exposure were observed. During the same period, inflammatory cell infiltration was observed in the mucosa of the posterior part of the tongue. These findings suggest that gastric acid reflux may be one of the exacerbating factors of dental erosion, periodontitis and glossitis. CONCLUSION: We investigated oral changes in an experimental rat model of GERD and observed development of dental erosion, periodontitis and glossitis. Our findings suggested chronic gastric acid reflux may be involved in the pathogenesis of oral disease.


Assuntos
Esofagite Péptica/patologia , Glossite/patologia , Refluxo Laringofaríngeo/patologia , Mucosa Bucal/patologia , Periodontite/patologia , Faringe/patologia , Erosão Dentária/patologia , Animais , Esofagite Péptica/complicações , Glossite/etiologia , Refluxo Laringofaríngeo/complicações , Masculino , Boca/patologia , Periodontite/etiologia , Ratos , Ratos Wistar , Erosão Dentária/etiologia
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