Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 2.661
Filtrar
1.
Artigo em Inglês | MEDLINE | ID: mdl-32785056

RESUMO

The COVID-19 pandemic has affected lives and professions worldwide. We aimed to determine the behavior of dentists during the lockdown in Central Italy through an online survey. We demonstrated that the most frequent of urgencies, not otherwise manageable through telemedicine, was dental pulp inflammation. Although a statistically significant increase in the use of some of the personal protective equipment (PPE) from pre to during lockdown was shown, dentists were afraid of being infected during the dental procedures. Moreover, we showed that digital dentistry, telemedicine, use of the rubber dam, distancing of the appointments and further structural changes at the dental office are necessary to reduce the contagion among dentists and patients. No significant differences were shown between gender.


Assuntos
Infecções por Coronavirus/epidemiologia , Consultórios Odontológicos/organização & administração , Consultórios Odontológicos/estatística & dados numéricos , Pneumonia Viral/epidemiologia , Betacoronavirus , Controle de Doenças Transmissíveis/organização & administração , Doenças da Polpa Dentária/epidemiologia , Medo , Humanos , Itália/epidemiologia , Pandemias , Equipamento de Proteção Individual/provisão & distribução , Inquéritos e Questionários , Telemedicina/organização & administração
2.
J Am Dent Assoc ; 151(5): 358-367, 2020 05.
Artigo em Inglês | MEDLINE | ID: mdl-32209245

RESUMO

BACKGROUND: Teeth with dens evaginatus (DE) are more commonly observed in Western countries than previously. This is due to the increase in populations of patients of Asian origin, in whom DE is more common than in people of European origin. The interest in DE has also increased with the introduction of a procedure called regenerative endodontics. CASE DESCRIPTION: A narrative review of treatment options for teeth with DE is presented, based on pulpal conditions and maturity of the teeth. PRACTICAL IMPLICATIONS: Early recognition of teeth with DE allows for treatment choices that generally lead to good outcomes and can aid in preserving developing teeth in young patients.


Assuntos
Doenças da Polpa Dentária , Anormalidades Dentárias , Dente Pré-Molar , Humanos , Incisivo , Coroa do Dente
3.
Int J Paediatr Dent ; 30(3): 360-369, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-31803975

RESUMO

BACKGROUND: Trauma-induced adverse reactions may trigger complications when moving teeth orthodontically. AIM: The purpose of this study was to evaluate the knowledge of dental practitioners about this topic. DESIGN: A questionnaire survey was organized among general dentists, paediatric dentists, and orthodontists in Flanders (Belgium). Three clinical cases describing trauma-induced tooth damage (tooth ankylosis, apical root resorption, and pulp/root canal obliteration) were presented, followed by a set of questions. RESULTS: The questionnaire was completed by 121 general dentists (GD), 47 paediatric dentists (PD), and 99 orthodontic specialists (OS). In the case with ankylosis, impossibility to move the tooth orthodontically was reported as most frequent adverse reaction (82.8% of GD, 95.7% of PD, and 100.0% of OS) (P < .001). In the situation of apical root resorption, the most frequently reported adverse event was progressive apical root resorption (78.9%, 85.7%, and 88.8% respectively; P = .265). Most frequently mentioned adverse reaction in the case with pulp and root canal obliteration was tooth discoloration (64.1%, 57.1%, and 78.3%; P = .055), followed by apical root resorption (57.4%, 56.8%, and 68.7%; P = .283). Orthodontic treatment recommendation differed among specific clinical situations but also among groups of dental practitioners. CONCLUSIONS: Important knowledge gaps exist regarding the orthodontic managment of traumatized teeth. This topic requires more attention in undergraduate training, specialist training, and continuing education.


Assuntos
Doenças da Polpa Dentária , Reabsorção da Raiz , Criança , Odontólogos , Humanos , Especialização , Inquéritos e Questionários
4.
Zhonghua Kou Qiang Yi Xue Za Zhi ; 54(9): 584-590, 2019 Sep 09.
Artigo em Chinês | MEDLINE | ID: mdl-31550780

RESUMO

Pulp regeneration in a tooth with pulp necrosis is the research hotspot in current clinical treatment of endodontic diseases. Up to now, the revascularization therapy, which is one of the regenerative endodontic treatment, and the most extensive and effective method in clinical practice, can partially achieve the goal of pulp regeneration and root development in young permanent immature teeth. In order to standardize the technique and improve the curative effect, this atticle discusses the indications, pre-treatment preparation, treatment procedure and the rapeutic evaluation of pulp revascularization therapy.


Assuntos
Doenças da Polpa Dentária , Polpa Dentária , Doenças da Polpa Dentária/terapia , Necrose da Polpa Dentária/terapia , Humanos , Prognóstico , Regeneração
5.
Eur J Clin Microbiol Infect Dis ; 38(11): 2005-2019, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31372904

RESUMO

Human oral cavity (mouth) hosts a complex microbiome consisting of bacteria, archaea, protozoa, fungi and viruses. These bacteria are responsible for two common diseases of the human mouth including periodontal (gum) and dental caries (tooth decay). Dental caries is caused by plaques, which are a community of microorganisms in biofilm format. Genetic and peripheral factors lead to variations in the oral microbiome. It has known that, in commensalism and coexistence between microorganisms and the host, homeostasis in the oral microbiome is preserved. Nonetheless, under some conditions, a parasitic relationship dominates the existing situation and the rise of cariogenic microorganisms results in dental caries. Utilizing advanced molecular biology techniques, new cariogenic microorganisms species have been discovered. The oral microbiome of each person is quite distinct. Consequently, commonly taken measures for disease prevention cannot be exactly the same for other individuals. The chance for developing tooth decay in individuals is dependent on factors such as immune system and oral microbiome which itself is affected by the environmental and genetic determinants. Early detection of dental caries, assessment of risk factors and designing personalized measure let dentists control the disease and obtain desired results. It is necessary for a dentist to consider dental caries as a result of a biological process to be targeted than treating the consequences of decay cavities. In this research, we critically review the literature and discuss the role of microbial biofilms in dental caries.


Assuntos
Biofilmes/crescimento & desenvolvimento , Cárie Dentária/microbiologia , Microbiota/fisiologia , Boca/microbiologia , Bactérias/isolamento & purificação , Bactérias/patogenicidade , Cárie Dentária/genética , Cárie Dentária/prevenção & controle , Doenças da Polpa Dentária/genética , Doenças da Polpa Dentária/microbiologia , Doenças da Polpa Dentária/prevenção & controle , Gengiva/microbiologia , Gengiva/fisiologia , Humanos , Doenças Periodontais/genética , Doenças Periodontais/microbiologia , Doenças Periodontais/prevenção & controle , Saliva/química
6.
PLoS One ; 14(7): e0219599, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31291645

RESUMO

INTRODUCTION: Enterococcus faecalis is a key pathogen recovered from root canals when conventional treatment fails. Phage therapy has generated new interest in combating pathogens. A sustained-release formulation using specific phages against E. faecalis may offer an alternative approach. OBJECTIVES: To evaluate the efficacy of anti-E. faecalis phages formulated in a thermo- sustained-release system against E. faecalis in vitro and in vivo. METHODS: EFDG1 and EFLK1 phages were formulated with poloxamer P407. Gelation time, phage survival, activity and toxicity were evaluated. Lytic activity was evaluated in vitro against E. faecalis at various growth phases, including anti-biofilm activity. Methods included viable bacterial count (CFU/mL), biofilm biomass determination and electron microscopy (live/dead staining). Further evaluation included infected incisors in an in vivo rat model. Anti-E. faecalis phage-cocktail suspension and sustained-release phage formulation were evaluated by viable bacterial count (CFU/mL), histology, scanning electron microscopy (SEM) and 16S genome sequencing of the microbiota of the root canal. RESULTS: Gelation time for clinical use was established. Low toxicity and a high phage survival rate were recorded. Sustained-release phages reduced E. faecalis in logarithmic (4 logs), stationary (3 logs) and biofilm (4 logs) growth phases. Prolonged anti-biofilm activity of 88% and 95% reduction in biomass and viable counts, respectively, was recorded. Reduction of intracanal viable bacterial counts was observed (99% of enterococci) also seen in SEM. Phage treatment increased Proteobacteria and decreased Firmicutes. Histology showed reduced periapical inflammation and improved healing following phage treatment. CONCLUSION: Poloxamer P407 formulated with phages has an effective and long-lasting effect in vitro and in vivo targeting E. faecalis.


Assuntos
Bacteriófagos , Terapia Biológica/métodos , Doenças da Polpa Dentária/terapia , Enterococcus faecalis/virologia , Tratamento do Canal Radicular/métodos , Animais , Antibacterianos , Carga Bacteriana , Biofilmes/crescimento & desenvolvimento , Preparações de Ação Retardada/administração & dosagem , Cavidade Pulpar/microbiologia , Doenças da Polpa Dentária/microbiologia , Modelos Animais de Doenças , Enterococcus faecalis/isolamento & purificação , Firmicutes/isolamento & purificação , Humanos , Masculino , Proteobactérias/isolamento & purificação , Ratos , Ratos Wistar
7.
J Endod ; 45(9): 1114-1118, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31280911

RESUMO

INTRODUCTION: Acute and chronic apical abscesses are 2 dramatic ways that periradicular tissues may react to pulpal infection and necrosis. Although both of these clinical states are the response to pulpal infection, their clinical manifestations are significantly different. It is not clear why the body responds to root canal infection in one way or another. The objective of this study was to evaluate the size and pattern of bone loss in patients with acute apical abscess (AAA) and chronic apical abscess (CAA) using cone-beam computed tomographic images. METHODS: Twenty-three cone-beam computed tomographic images of cases with AAA and 25 cases with CAA were selected and evaluated. The presence and location of fenestration and the volume and pattern of the periradicular lesions were recorded and compared between the 2 groups using the Fisher exact and Mann-Whitney U tests. RESULTS: One hundred percent of cases with CAA had cortical fenestration, but only 47% of cases with AAA had cortical fenestration (P < .05). The median volume of the lesions was 233 mm3 in the CAA group and 109 mm3 in the AAA group (P > .05). CAA cases, in comparison with the AAA group, had a relatively larger cortical disruptions. CONCLUSIONS: Cortical fenestration is fundamental for the development of CAA. However, periradicular lesions without evident cortical fenestration can still cause AAA and fascial space involvement.


Assuntos
Abscesso , Doenças da Polpa Dentária , Doenças Periapicais , Periodontite Periapical , Abscesso/diagnóstico por imagem , Osso e Ossos , Tomografia Computadorizada de Feixe Cônico , Humanos , Periodontite Periapical/diagnóstico por imagem , Tratamento do Canal Radicular
9.
J Int Med Res ; 47(6): 2381-2393, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30991868

RESUMO

OBJECTIVE: To evaluate dentist-related factors associated with the use of vital pulp therapy (VPT) for the treatment of pulp exposures in permanent teeth. METHODS: This survey-based study sent an online questionnaire to collect data on the demographics of the respondents, the use of VPT and the choice of materials for VPT, to all members of the Society of Endodontology of Guangdong, China. RESULTS: A total 183 of 380 members responded (48.2%). The majority (89.6%; 164 of 183) had performed direct pulp capping (DPC) while 55.2% (101 of 183) had performed partial pulpotomy (PP) at least once. The most-cited reason for not performing VPT was unfamiliarity with the technique. Mineral trioxide aggregate was the most commonly used material for both DPC (67.1%; 110 of 164) and PP (73.3%; 74 of 101). Endodontists, compared with general practitioners, preferred to perform DPC and chose calcium silicate materials (CSMs) for VPT (odds ratios 5.81 and 8.07, respectively). DPC and CSMs for VPT were also favoured more by respondents who had practised for > 5 years. Senior respondents were more likely to use PP. CONCLUSIONS: Speciality, years of practise and age of dentists influenced the decision making and the choice of materials for VPT. Continuing education is essential to promote the clinical use of VPT.


Assuntos
Compostos de Alumínio/uso terapêutico , Compostos de Cálcio/uso terapêutico , Capeamento da Polpa Dentária/métodos , Doenças da Polpa Dentária/terapia , Odontólogos/estatística & dados numéricos , Óxidos/uso terapêutico , Pulpotomia/métodos , Silicatos/uso terapêutico , Adulto , China/epidemiologia , Doenças da Polpa Dentária/epidemiologia , Combinação de Medicamentos , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Prognóstico , Inquéritos e Questionários
11.
Pediatr Dent ; 41(2): 107-111, 2019 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-30992107

RESUMO

Purpose: The purpose of this study was to compare the success of pulpotomies in primary molars using a new type of mineral trioxide aggregate (MTA; NeoMTA Plus) with a conventional MTA (ProRoot MTA) as a pulpotomy medicament in primary molars. Methods: Eighty primary teeth in 28 patients were divided randomly, with 40 teeth in a control group (ProRoot MTA) and 40 teeth in an experimental group (NeoMTA Plus). A standardized pulpotomy technique was performed for each tooth. Clinical and radiographic follow-up examinations were conducted at three, six, and 12 months. Results: At 12 months, the clinical success for ProRoot MTA was 97.4 percent (38 out of 39) and the radiographic success was 94.9 percent (37 out of 39); for NeoMTA Plus, the clinical success was 100 percent (40 out of 40) and the radiographic success was 97.5 percent (39 out of 40). No significant differences were found between the two groups at all follow-up evaluations. Conclusions: NeoMTA Plus showed a high percent success, similar to that of ProRoot MTA. NeoMTA Plus is a potential pulpotomy medicament for primary teeth.


Assuntos
Compostos de Alumínio/administração & dosagem , Compostos de Cálcio/administração & dosagem , Cimentos Dentários , Dente Molar , Óxidos/administração & dosagem , Pulpotomia/métodos , Silicatos/administração & dosagem , Dente Decíduo , Criança , Doenças da Polpa Dentária/etiologia , Combinação de Medicamentos , Feminino , Humanos , Masculino , Reabsorção da Raiz
12.
Compend Contin Educ Dent ; 40(1): 27-31; quiz 32, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30601019

RESUMO

Maintaining dental pulp vitality should be among the clinical goals of any restorative treatment. By obtaining a pretreatment pulpal and periradicular diagnosis before performing restorative treatment, the clinician will be better able to proceed with treatment of the pulp, especially if it is exposed during caries excavation. A pretreatment pulpal and periapical diagnosis may be effectively attained by performing five objective clinical tests: pulp sensibility, percussion (which may include bite testing), palpation, periodontal probing/ tooth mobility, and updated radiography. This article provides a description of these five clinical tests and gives an overview of current terminologies used when obtaining a pulpal and periradicular diagnosis.


Assuntos
Doenças da Polpa Dentária/diagnóstico , Doenças Periapicais/diagnóstico , Restauração Dentária Permanente , Humanos
13.
J Mater Sci Mater Med ; 30(2): 17, 2019 Jan 22.
Artigo em Inglês | MEDLINE | ID: mdl-30671677

RESUMO

Enterococcus faecalis (E. faecalis), a Gram-positive facultative anaerobe, is reported to take responsibility for a large portion of refractory root canal infections and root canal re-infections of human teeth. Chlorhexidine is a strong bactericide against E. faecalis but cannot infiltrate into dentinal tubules. On the other hand, a common negative effect of root canal medicaments is the decrease of dentin microhardness. In this study, poly(D,L-lactic-co-glycolide) (PLGA) submicron particles were applied as delivery carriers to load and release the chlorhexidine as well as calcium and phosphorus. The release profiles, antibacterial ability against E. faecalis, infiltration ability into dentinal tubules, biocompatibility and effects on dentin microhardness of these particles were investigated. Results revealed that encapsulated chemicals could be released in a sustained manner from the particles. The particles also exhibited excellent biocompatibility on MC3T3-E1 cells and significant antimicrobial property against E. faecalis. On dentin slices, the particles could be driven into dentinal tubules by ultrasonic activiation and inhibit E. faecalis colonization. Besides, dentin slices medicated with the particles displayed an increase in microhardness. In conclusion, PLGA submicron particles carrying chlorhexidine, calcium and phosphorus could be developed into a new intra-canal disinfectant for dental treatments.


Assuntos
Cálcio/química , Clorexidina/administração & dosagem , Dentina/química , Enterococcus faecalis/efeitos dos fármacos , Infecções por Bactérias Gram-Positivas/tratamento farmacológico , Fósforo/química , Células 3T3 , Animais , Antibacterianos , Hidróxido de Cálcio/química , Doenças da Polpa Dentária/tratamento farmacológico , Dentina/efeitos dos fármacos , Portadores de Fármacos , Dureza , Humanos , Camundongos , Copolímero de Ácido Poliláctico e Ácido Poliglicólico/química , Irrigantes do Canal Radicular/farmacologia , Dente/efeitos dos fármacos
14.
Int Endod J ; 52(4): 451-460, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30284721

RESUMO

AIM: To characterize the proteome of 20 root canals in teeth with post-treatment endodontic disease using mass spectrometry and to correlate the identified proteins with clinical features. METHODOLOGY: Twenty patients with radiographic evidence of apical periodontitis and need for root canal re-treatment were selected. Samples from the root canal contents were collected and processed using two-dimensional capillary nano-flow liquid chromatography and electrospray ionization tandem mass spectrometry. The acquired spectra were separately searched against specific protein database. The results obtained were analysed using descriptive statistics. Additionally, Pearson's chi-square test or one-sided Fisher's exact test, as appropriate, was chosen to examine the null hypothesis that there is no relationship between each clinical feature and the presence of specific microbial or human proteins. Significance levels were set at 5% (P < 0.05). RESULTS: A total of 1153 human and 720 microbial UniProt accession numbers corresponding to proteins were recovered. The greater prevalence of proteins was related to biological functions, such as cellular and metabolic processes. A considerable number of microbial proteins with clinical relevance functions, such as pathogenesis/virulence, proteolysis, cell adhesion and drug resistance, were detected. Common endodontic pathogens related to post-treatment endodontic disease such as Enterococcus spp., Propionibacterium spp. and Streptococcus spp. were associated with 23, 40 and 94 distinct proteins, respectively. As for human proteins, many factors related to the immune system process were detected. No significant correlations were found between microbial and human proteins and the clinical features investigated (P > 0.05). CONCLUSIONS: A considerable number of microbial and human proteins were identified using proteomic analyses, being mainly related to processes indicating cell viability. No significant correlation was found between proteins and clinical features. These findings suggest a network of important microbial pathogenic functions that may be responsible for the host immune system response.


Assuntos
Doenças da Polpa Dentária , Periodontite Periapical , Cavidade Pulpar , Humanos , Proteômica , Tratamento do Canal Radicular
15.
Braz Oral Res ; 32: e120, 2018 Nov 29.
Artigo em Inglês | MEDLINE | ID: mdl-30517429

RESUMO

The present study aims to evaluate the longitudinal effects of induced experimental infections in gnotoxenic animals on the expression of inflammatory chemokines and their receptors in periradicular tissues. The null hypothesis tested was that Enterococcus faecalis and Fusobacterium nucleatum had no effect on CCR5, CCL5, CXCL10, CCL2/MCP-1, CXCR2 and CCR1 expression. Two groups of five animals (n = 5) aged between 8 and 12 weeks were used in this study. The animals were anaesthetized, and coronary access was performed in the first molar on the right and left sides. Microorganisms were inoculated into the left molar, and the right molar was sealed without contamination to function as a control. Animals were sacrificed 7 and 14 days after infection, and periapical tissues were collected. The cytokine mRNA expression levels were assessed using real-time PCR. The chemokine mRNA expression levels demonstrated that the experimental infection was capable of inducing increased chemokine expression on day 7 compared to that on day 14, except for CCR5 and CCL5, which showed no changes. The gnotoxenic animal model proved to be effective and allowed evaluation of the immune response against a known infection. Additionally, this study demonstrates that gene expression of chemokines and their receptors against the experimental infection preferentially prevailed during the initial phase of induction of the periradicular alteration (i.e., on day 7 post-infection).


Assuntos
Quimiocinas/análise , Cavidade Pulpar/imunologia , Doenças da Polpa Dentária/imunologia , Infecções por Fusobacterium/imunologia , Vida Livre de Germes , Infecções por Bactérias Gram-Positivas/imunologia , Receptores de Quimiocinas/análise , Animais , Quimiocinas/genética , Cavidade Pulpar/microbiologia , Doenças da Polpa Dentária/microbiologia , Expressão Gênica , Camundongos , Doenças Periapicais/imunologia , Doenças Periapicais/microbiologia , Reação em Cadeia da Polimerase em Tempo Real , Receptores de Quimiocinas/genética , Valores de Referência , Fatores de Tempo
16.
Minerva Stomatol ; 67(6): 225-230, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30499284

RESUMO

BACKGROUND: Many techniques have been evolved for the purpose of managing discoloured non-vital tooth such as dental bleaching, restorative and prosthetic treatment. In order to achieve better control on the patients, in-office and intra-coronal bleaching procedures were introduced in clinical practice. Such techniques usually use higher whitening agent concentrations activated by means of heat or light sources, resulting in improved color stability in the long term. The aim of this study was to evaluate the color stability, after 25 years, of endodontically-treated teeth subjected to in-office and walking bleach dental treatments with carbamide peroxide. METHODS: A population of patients with a single endodontic treatment on an incisor teeth was recruited. All the teeth selected for the study were subjected to both in-office intra-coronal dental bleaching and walking bleach technique with 10% carbamide peroxide gel. The patients were recalled at follow-up every 12 months for a total observational period of 25 years. RESULTS: After 25 years of clinical service on 40 patients, an optimal tooth color stability in relation to adjacent teeth was evidenced in 34 patients, while 6 patients were classified as failures, since a color mismatch of two or more shades were noticed. Consequently, a success rate of 85% was reported after 25 years. CONCLUSIONS: Ten percent carbamide peroxide proved to be an effective dental whitening agent in the long-term for endodontically-treated.


Assuntos
Peróxido de Carbamida , Doenças da Polpa Dentária/terapia , Visita a Consultório Médico , Clareadores Dentários , Clareamento Dental , Feminino , Seguimentos , Humanos , Masculino , Fatores de Tempo
17.
Gen Dent ; 66(6): 30-38, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30444704

RESUMO

Pulp therapy for pediatric patients aims to alleviate pulpal infection, relieve associated symptoms, and, ultimately, preserve the tooth. Primary teeth adequately retain space for their successors and have been described as "the best space maintainers." Therefore, the decision to extract a primary tooth should take into consideration occlusal growth and development as well as the potential outcome of pulp therapy. Maintaining pulpal vitality in young permanent teeth is essential for continued root formation; if vitality is lost, the root will cease growth and remain at an unfavorable length. A systematic approach to diagnosis and treatment planning is imperative, and a good history of signs and symptoms and a detailed evaluation of radiographs are prerequisites to accurate diagnosis. The purpose of this review is to aid dental professionals in correctly establishing a pulpal diagnosis and selecting the appropriate method of pulp therapy to achieve a successful outcome. The article discusses contemporary views on indications and pulp medicaments and presents step-by-step descriptions of pulp treatments for both primary and immature permanent teeth.


Assuntos
Doenças da Polpa Dentária/terapia , Apexificação , Criança , Capeamento da Polpa Dentária , Doenças da Polpa Dentária/diagnóstico , Dentição Permanente , Humanos , Pulpectomia , Pulpotomia , Endodontia Regenerativa , Dente Decíduo
18.
Pak J Pharm Sci ; 31(5(Special)): 2303-2306, 2018 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-30463830

RESUMO

To evaluate and compare the clinical efficacy and safety between articaine and lidocaine in the anaesthesia management of tooth pulp disease. The 160 patients with tooth pulp disease treated at our hospital were enrolled. After informed consent was obtained, patients were randomly assigned to study group and control group, with 80 patients in each group. Of those, lidocaine was administered to the control group while articaine was given to the study group. The onset time, analgesic effect and adverse events were recorded. Compared with control group, the onset time was significantly reduced in study group (p<0.05). Patients treated with articaine had better analgesic effect than patients in control group (p<0.05). And the incidence of adverse events was notably lower in study group (p<0.05). Compared with lidocaine, articaine presents higher analgesic efficacy and safety for patients with tooth pulp disease.


Assuntos
Anestésicos Locais/uso terapêutico , Carticaína/uso terapêutico , Doenças da Polpa Dentária/tratamento farmacológico , Lidocaína/uso terapêutico , Adulto , Idoso , Anestesia/métodos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Medição da Dor/métodos , Resultado do Tratamento , Adulto Jovem
19.
Braz Oral Res ; 32(suppl 1): e68, 2018 Oct 18.
Artigo em Inglês | MEDLINE | ID: mdl-30365609

RESUMO

Endodontic medicine, which addresses the bidirectional relationship between endodontic infections and systemic diseases, has gained prominence in the field of endodontics. There is much evidence showing that while systemic disease may influence the pathogenesis of endodontic infection, endodontic infection can also cause systemic alterations. These alterations include more severe bone resorption and inflammation in the periapical area as well as enhanced systemic disease symptoms. Similarly, many reports have described the impact of systemic diseases on the tissue responses to dental materials. Conversely, the local use of dental materials may show systemic effects in the form of altered production of biomarkers. Thus, studies to better understand the mechanisms related to those connections are extremely important. In this context, the objective of this review was to analyze and discuss the current literature regarding the connections among these three factors-systemic diseases, endodontic infection, and endodontic dental materials-and determine how these connections may interfere in the systemic health status and the endodontic treatment outcomes, which are represented by periapical wound healing.


Assuntos
Doenças Cardiovasculares/fisiopatologia , Polpa Dentária/efeitos dos fármacos , Diabetes Mellitus/fisiopatologia , Periodontite Periapical/fisiopatologia , Materiais Restauradores do Canal Radicular/farmacologia , Tela Subcutânea/efeitos dos fármacos , Compostos de Alumínio/farmacologia , Compostos de Cálcio/farmacologia , Doenças da Polpa Dentária/fisiopatologia , Combinação de Medicamentos , Humanos , Doenças Metabólicas/fisiopatologia , Óxidos/farmacologia , Fatores de Risco , Silicatos/farmacologia
20.
Braz Oral Res ; 32(suppl 1): e69, 2018 Oct 18.
Artigo em Inglês | MEDLINE | ID: mdl-30365610

RESUMO

Evidence shows the polymicrobial etiology of endodontic infections, in which bacteria and their products are the main agents for the development, progression, and dissemination of apical periodontitis. Microbial factors in necrotic root canals (e.g., endotoxin) may spread into apical tissue, evoking and supporting a chronic inflammatory load. Thus, apical periodontitis is the result of the complex interplay between microbial factors and host defense against invasion of periradicular tissues. This review of the literature aims to discuss the complex network between endodontic infectious content and host immune response in apical periodontitis. A better understanding of the relationship of microbial factors with clinical symptomatology is important to establish appropriate therapeutic procedures for a more predictable outcome of endodontic treatment.


Assuntos
Cavidade Pulpar/microbiologia , Doenças da Polpa Dentária/complicações , Doenças da Polpa Dentária/microbiologia , Periodontite Periapical/microbiologia , Infecções Bacterianas/complicações , Infecções Bacterianas/microbiologia , Citocinas/análise , Citocinas/fisiologia , Cavidade Pulpar/patologia , Doenças da Polpa Dentária/patologia , Endotoxinas/fisiologia , Humanos , Lipopolissacarídeos/fisiologia , Metaloproteinases da Matriz/análise , Metaloproteinases da Matriz/fisiologia , Periodontite Periapical/patologia
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA