Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 272
Filtrar
1.
Am J Med Sci ; 359(1): 42-50, 2020 01.
Artigo em Inglês | MEDLINE | ID: mdl-31902440

RESUMO

We report a case of liver transplant patient who presented with lung masses, found to be Mycobacterium spindle cell pseudotumors. The masses demonstrated hypermetabolic activities on positron emission tomography. Core biopsy revealed sheets of spindle histiocytic cells with abundant acid-fast bacilli identified as Mycobacterium avium-intracellulare complex. This finding is a rare presentation of Mycobacterium infection, mainly nontuberculous Mycobaterium. It is characterized by a benign, spindle cell mass-forming reaction. Most of the reported cases had acquired immune deficiency syndrome or organ transplant. Histopathology illustrating the proliferation of spindle cell shaped histiocytes containing numerous acid-fast bacilli is the gold standard for diagnosis. The standard treatment has not been well established; previously reported cases followed the standard treatment for Mycobacterium based on organ involvement. Our case is the first case to our knowledge that reports pulmonary Mycobacterium spindle cell pseudotumors in a liver transplant recipient.


Assuntos
Transplante de Fígado , Complexo Mycobacterium avium/isolamento & purificação , Infecção por Mycobacterium avium-intracellulare/patologia , Granuloma de Células Plasmáticas Pulmonar/microbiologia , Idoso , Antibacterianos/administração & dosagem , Antibacterianos/uso terapêutico , Antituberculosos/administração & dosagem , Antituberculosos/uso terapêutico , Azitromicina/administração & dosagem , Azitromicina/uso terapêutico , Etambutol/administração & dosagem , Etambutol/uso terapêutico , Feminino , Humanos , Infecção por Mycobacterium avium-intracellulare/tratamento farmacológico , Infecção por Mycobacterium avium-intracellulare/microbiologia , Granuloma de Células Plasmáticas Pulmonar/diagnóstico , Granuloma de Células Plasmáticas Pulmonar/tratamento farmacológico
2.
Transplant Proc ; 51(9): 2991-2994, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31611127

RESUMO

INTRODUCTION: Malignant diseases are well-known complications after lung transplantation (LT). Among these, inflammatory myofibroblastic tumor (IMT) is a rare neoplasm with a not well-known and often aggressive biological behavior. MATERIAL AND METHODS: We hereby describe 2 cases of cystic fibrosis patients who underwent bilateral sequential LT (BSLT) complicated by IMT. RESULTS: A 26-year-old man presented a right endobronchial lesion 6 months after BSLT. Two consecutive fiber bronchoscopic biopsies showed granulation tissue. For the persistent lesion growth, the patient underwent a transthoracic biopsy showing histologic diagnosis of IMT. Therefore, he underwent to right pneumonectomy that was unfortunately complicated after 6 months with a late bronchopleural fistula and empyema with exitus 6 months later. A 31-year-old woman 1 year after BSLT presented with a left voluminous pleural-parenchymal lesion; the histologic examination after biopsy revealed an IMT. She underwent a removal of the lesion with a macroscopic R0 resection. Histologic, immunophenotypic, and cytogenetic examinations showed a strong overexpression of anaplastic lymphoma kinase requiring biological adjuvant therapies; however, the patient refused it. Four years later, she presented a recurrence treated with debulking procedure and adjuvant radiotherapy. At last follow-up, the patient was alive with stable disease and optimal graft function. CONCLUSIONS: Although IMT is a rare complication after lung transplant, to obtain a careful diagnosis, an early and aggressive treatment is mandatory.


Assuntos
Hospedeiro Imunocomprometido , Transplante de Pulmão/efeitos adversos , Granuloma de Células Plasmáticas Pulmonar/imunologia , Adulto , Fibrose Cística/cirurgia , Feminino , Humanos , Masculino
3.
Ir Med J ; 112(4): 920, 2019 04 11.
Artigo em Inglês | MEDLINE | ID: mdl-31190516

RESUMO

Inflammatory myofibroblastic tumour (IMT) is a rare neoplasm derived from tissue of mesenchymal origin. This tumour occurs predominantly in the lung, though extrapulmonary sites have been documented throughout the body.1 Presentation can be variable depending on location of the tumour and can include constitutional symptoms (fever, weight loss), thrombocytosis, hypergammaglobulinemia, anemia, and mass effect on local structures.2 Majority of patients with intrapulmonary IMT remain asymptomatic but can have symptoms including chest pain, dyspnoea, cough or haemoptysis.3 Most cases of IMT present in younger individuals (under age 40).4 Although the aetiology of IMT is unclear, current hypotheses suggest an inflammatory response to infection or an underlying malignancy could promote such cellular changes. Alternatively, the inflammatory component itself may be a consequence of the development of these mesenchymal tumours.


Assuntos
Granuloma de Células Plasmáticas Pulmonar/diagnóstico por imagem , Adulto , Tosse/etiologia , Feminino , Humanos , Granuloma de Células Plasmáticas Pulmonar/complicações , Granuloma de Células Plasmáticas Pulmonar/patologia , Granuloma de Células Plasmáticas Pulmonar/cirurgia , Tomografia Computadorizada por Raios X
4.
Med Oncol ; 35(7): 102, 2018 Jun 04.
Artigo em Inglês | MEDLINE | ID: mdl-29869302

RESUMO

Inflammatory myofibroblastic tumor (IMT) is a mesenchymal neoplasm that may arise in soft tissues of nearly every organ. Although IMTs are the most common lung tumors in pediatric populations, these tumors are extremely rare in adults, constituting less than 1% of adult lung tumors. IMTs are characterized by proliferating spindle cells with variable inflammatory component. The biological behavior of lung IMTs in adults is highly unpredictable, which confounds diagnosis and treatment. We retrospectively investigated patients with pulmonary lesions and the histopathologic diagnosis of inflammatory myofibroblastic tumor or its synonymous names (Plasma Cell Granuloma, xanthogranuloma, inflammatory pseudotumor, fibroxanthoma, and fibrous histiocytoma) at the MD Anderson Cancer Institute in the period between August 2000 and August 2016. We describe 7 adult cases of IMT of the lung that were diagnosed at MD Anderson Cancer Center. These cases highlight the tumor's variability in terms of clinical presentation, histopathology, and biologic behavior, and underscore the challenges in the management of these rare lung neoplasms.


Assuntos
Neoplasias Pulmonares/diagnóstico , Granuloma de Células Plasmáticas Pulmonar/diagnóstico , Idoso , Biomarcadores Tumorais/análise , Institutos de Câncer , Diagnóstico Diferencial , Feminino , Humanos , Neoplasias Pulmonares/diagnóstico por imagem , Neoplasias Pulmonares/patologia , Neoplasias Pulmonares/terapia , Masculino , Pessoa de Meia-Idade , Granuloma de Células Plasmáticas Pulmonar/diagnóstico por imagem , Granuloma de Células Plasmáticas Pulmonar/patologia , Granuloma de Células Plasmáticas Pulmonar/terapia , Estudos Retrospectivos , Texas , Resultado do Tratamento , Adulto Jovem
6.
Asian Cardiovasc Thorac Ann ; 26(4): 317-319, 2018 May.
Artigo em Inglês | MEDLINE | ID: mdl-29649880

RESUMO

Pulmonary inflammatory myofibroblastic tumor is a rare disease. Computed tomography in a 54-year-old woman showed a mass compressing the segmental bronchus of the left lung. Bronchoscopy indicated a mesenchymal tumor, hamartoma, or inflammatory myofibroblastic tumor. Because an inflammatory myofibroblastic tumor can potentially clog the segmental bronchus, we performed a left upper division segmentectomy. Pathologic examination revealed an inflammatory myofibroblastic tumor. In most cases, preoperative diagnosis is difficult because of the varied radiologic manifestations, and it can also be difficult to distinguish from malignancy in small tissue samples.


Assuntos
Granuloma de Células Plasmáticas Pulmonar/diagnóstico , Biópsia , Broncoscopia , Diagnóstico Diferencial , Feminino , Humanos , Imuno-Histoquímica , Neoplasias Pulmonares/diagnóstico , Pessoa de Meia-Idade , Granuloma de Células Plasmáticas Pulmonar/diagnóstico por imagem , Granuloma de Células Plasmáticas Pulmonar/patologia , Granuloma de Células Plasmáticas Pulmonar/cirurgia , Pneumonectomia , Valor Preditivo dos Testes , Tomografia Computadorizada por Raios X , Resultado do Tratamento
8.
Zentralbl Chir ; 143(1): 90-95, 2018 Feb.
Artigo em Alemão | MEDLINE | ID: mdl-28641331

RESUMO

INTRODUCTION: Pseudotumour of the lung is a collective term for various subentities. Some subgroups are considered to be intermediary malignant tumours. A pseudotumour is a rare condition, which makes it difficult to estimate its incidence and prevalence. METHODS: Retrospective analysis of all surgically treated patients between 2008 and 2015 diagnosed with a pseudotumour of the lung. The primary endpoint of this study was to estimate the rates of local recurrence and metastasis. Secondary endpoints were to determine the nomenclature, medical history, treatment, and the perioperative course. RESULTS: Out of 27 patients (10 females and 17 males) with a median age of 58 years, 19 patients (70%) had an inflammatory pseudotumour (IPT), and four patients (15%) had an inflammatory myofibroblastoma (IMT). Two patients had a pneumocytoma/histiocytoma. A preoperative pulmonary infection was present in 12 (44%) patients. The average tumour size was 2.1 cm (0.8 - 5.3 cm), with the lower pulmonary lobes being mostly affected (52%). One enucleation, 20 atypical wedge resections and six anatomical resections were performed. This was done in a minimally invasive procedure (VATS) in 48% of cases (13/27). R0 resection was achieved in 93% of cases (25/27). Complications occurred in seven (26%) patients. The difference between the duration of hospital stay (mean duration 8 days) after open resection and VATS was minimal (8.8 vs. 7.2 days). Patients were followed up over a period of 4 years, during which time only one patient developed a tumour recurrence, which led to the patient's death, although she had had a R0 resection of an IMT. CONCLUSIONS: The treatment of choice for pseudotumours of the lung is R0 resection, preferably with VATS. Most patients have a benign course of disease, although relapses are possible in some cases, especially in IMT. Follow-up monitoring is necessary for IMT. The application of a uniform nomenclature and classification would be a sensible approach.


Assuntos
Granuloma de Células Plasmáticas Pulmonar/cirurgia , Adulto , Idoso , Feminino , Seguimentos , Humanos , Tempo de Internação , Neoplasias Pulmonares/diagnóstico , Neoplasias Pulmonares/mortalidade , Neoplasias Pulmonares/cirurgia , Masculino , Pessoa de Meia-Idade , Granuloma de Células Plasmáticas Pulmonar/diagnóstico , Granuloma de Células Plasmáticas Pulmonar/mortalidade , Pneumonectomia/métodos , Complicações Pós-Operatórias/etiologia , Lesões Pré-Cancerosas/diagnóstico , Lesões Pré-Cancerosas/mortalidade , Lesões Pré-Cancerosas/cirurgia , Recidiva , Estudos Retrospectivos , Análise de Sobrevida , Cirurgia Torácica Vídeoassistida/métodos
9.
J Coll Physicians Surg Pak ; 27(9): S68-S70, 2017 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-28969727

RESUMO

Inflammatory myofibroblastic tumor (IMT), also called pseudo-tumor, is a very rare condition and accounts for less than 1% of primary lung tumor. It is most common benign tumor of lung in children. This case is reported with the objective of highlighting the role of manual trans-tracheal high frequency positive pressure ventilation (HFPPV) in facilitating surgical resection with maintenance of adequate oxygenation and a little compromised ventilation. A9-year boy, weighing 21 kg, was diagnosed as a case of IMTof left main bronchus on biopsy and was successfully treated by surgical excision through left thoracotomy. HFPPV through improvised technique was used for ventilation and oxygenation during surgery. Total Intravenous anaesthesia with propofol infusion and increments of fentanyl was used during HFPPV. After the completion of the surgery, conventional positive pressure ventilation (PPV) was continued through the endotracheal tube (ETT) to check any bronchial stump leak. After the surgery, patient was weaned and extubated in the operating room. Hospital course remained uneventful and the patient was discharged after 6 days. HFPPV with manually improvised technique is applicable in carinal surgery for optimization of oxygenation, ventilation, and uninterrupted surgical resection.


Assuntos
Ventilação de Alta Frequência , Neoplasias Pulmonares/cirurgia , Granuloma de Células Plasmáticas Pulmonar/cirurgia , Toracotomia/métodos , Traqueia/cirurgia , Criança , Humanos , Masculino , Resultado do Tratamento
10.
Asian Cardiovasc Thorac Ann ; 25(9): 653-655, 2017 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-29022826

RESUMO

Inflammatory myofibroblastic tumors of the lung are rare in adults but common among pediatric lung tumors. A 4-year-old girl was evaluated for respiratory symptoms, dysphagia, and weight loss. Radiology revealed a right hilar mass that persisted despite antibiotic treatment. On exploration, a hilar mass involving the pulmonary vasculature, diaphragm and gastroesophageal junction was found. Aggressive surgical excision including a right pneumonectomy was performed. Histopathology confirmed an inflammatory myofibroblastic tumor with no features of malignancy. At the 2-year follow-up, the child was clinically stable with no recurrence. Dysphagia is a very rare presentation of such tumors.


Assuntos
Transtornos de Deglutição/etiologia , Granuloma de Células Plasmáticas Pulmonar/complicações , Biópsia , Pré-Escolar , Transtornos de Deglutição/diagnóstico , Feminino , Humanos , Granuloma de Células Plasmáticas Pulmonar/diagnóstico por imagem , Granuloma de Células Plasmáticas Pulmonar/cirurgia , Pneumonectomia , Tomografia Computadorizada por Raios X , Resultado do Tratamento
11.
Asian Cardiovasc Thorac Ann ; 25(6): 440-445, 2017 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-28605954

RESUMO

Background Pulmonary inflammatory pseudotumors are rare lesions that remain problematic in several aspects, especially regarding the therapeutic strategy. The goal of this study was to evaluate long-term survival in a multicenter series of patients who required surgery for pulmonary inflammatory pseudotumors. Methods Thirty-six cases of pulmonary inflammatory pseudotumors, operated on in 3 French thoracic surgery departments between 1989 and 2015, were studied retrospectively. We recorded pre-, peri- and postoperative data for each patient, and long-term survival was analyzed. Results There were 22 men and 14 women. Mean age was 53.5 years (range 14-81 years). Three pneumonectomies, 1 bilobectomy, 19 lobectomies, 2 segmentectomies, 10 wedge resections, and 1 biopsy were performed. Complete resection was carried out in 32 (88.8%) patients. Median follow-up was 76 months. Five-year and 10-year survival rates were respectively 86.8% and 81.7% (96% and 90% for patients with R0 resection). Conclusions Long-term survival was excellent for patients with pulmonary inflammatory pseudotumors who benefited from surgery, especially when surgical resection was complete. These results confirm that surgical resection must be proposed as the first-line treatment for patients with pulmonary inflammatory pseudotumors.


Assuntos
Granuloma de Células Plasmáticas Pulmonar/cirurgia , Pneumonectomia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , França , Humanos , Estimativa de Kaplan-Meier , Masculino , Pessoa de Meia-Idade , Granuloma de Células Plasmáticas Pulmonar/diagnóstico por imagem , Granuloma de Células Plasmáticas Pulmonar/mortalidade , Pneumonectomia/efeitos adversos , Pneumonectomia/mortalidade , Estudos Retrospectivos , Fatores de Tempo , Tomografia Computadorizada por Raios X , Resultado do Tratamento , Adulto Jovem
13.
Pediatr Int ; 58(10): 1087-1089, 2016 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-27804248

RESUMO

Inflammatory myofibroblastic tumor (IMT) is an uncommon solid tumor that was originally described in the lung. A 4-year-old girl was admitted to hospital with urticarial rash. On chest radiographs, an opacity was seen in the inferior zone of the left lung, and computed tomography showed a mass in the left lower lobe. Left lower sleeve lobectomy was performed, and the diagnosis was confirmed as IMT. Sleeve resection is the best option in lesions located in the mainstem bronchus or secondary carina. Herein, we present a rare case of IMT of the lung that was successfully treated with sleeve lobectomy. There have been fewer than 15 childhood cases of IMT reported in the literature, and the present 4-year-old patient is one of the youngest.


Assuntos
Pulmão/diagnóstico por imagem , Granuloma de Células Plasmáticas Pulmonar/cirurgia , Pneumonectomia/métodos , Biópsia , Pré-Escolar , Feminino , Humanos , Granuloma de Células Plasmáticas Pulmonar/diagnóstico , Radiografia Torácica , Tomografia Computadorizada por Raios X
14.
World J Pediatr ; 12(4): 498-500, 2016 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-27286690

RESUMO

BACKGROUND: Inflammatory myofibroblastic tumor (IMT) is a rare and mostly benign tumor that has the possibility of malignant change. METHODS: Radiological findings revealed a huge mass that filled most of the right hemithorax of a 17-monthold female infant. Tumor extirpation was stopped due to massive bleeding and limited exposure of the tumor. Embolization was conducted to obstruct the arteries feeding the mass. Complete resection was performed. RESULTS: Histopathologic examination led to the diagnosis of IMT. Postoperative recovery was uneventful. CONCLUSION: Hypervascularity of IMT should be considered. Preoperative embolization can be effective to reduce intraoperative blood loss and facilitate the surgical procedure.


Assuntos
Neoplasias Pulmonares/diagnóstico por imagem , Neoplasias Pulmonares/cirurgia , Granuloma de Células Plasmáticas Pulmonar/diagnóstico por imagem , Granuloma de Células Plasmáticas Pulmonar/cirurgia , Tomografia Computadorizada por Raios X/métodos , Embolização Terapêutica/métodos , Feminino , Seguimentos , Humanos , Lactente , Neoplasias Pulmonares/patologia , Invasividade Neoplásica/patologia , Estadiamento de Neoplasias , Granuloma de Células Plasmáticas Pulmonar/patologia , Pneumonectomia/métodos , Cuidados Pré-Operatórios/métodos , Radiografia Torácica/métodos , Doenças Raras , Medição de Risco , Toracotomia/métodos , Resultado do Tratamento
15.
J Coll Physicians Surg Pak ; 26(4): 331-3, 2016 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-27097710

RESUMO

Inflammatory myofibroblastic tumor of the lung is a rare condition, with a reported incidence between 0.04 - 1.2% of all tumors of the lung. We present a case of inflammatory myofibroblastic tumor of the lung. A61-year man presented to the outpatient department complaining of cough and blood-streaked sputum for 5 days. The computed tomography scan of the chest demonstrated a 4.5 x 4 cm, calcified pulmonary mass in the anterior segment of the right upper lobe. Bronchoscophy and computed tomography-guided transthoracic fine needle aspiration was inconclusive. The tumor was removed via wedge resection. Histological and immunohistochemical findings were consistent with inflammatory myofibroblastic tumor of the lung.


Assuntos
Neoplasias Pulmonares/patologia , Neoplasias Pulmonares/cirurgia , Granuloma de Células Plasmáticas Pulmonar/patologia , Granuloma de Células Plasmáticas Pulmonar/cirurgia , Biópsia por Agulha Fina , Broncoscopia , Humanos , Pulmão/patologia , Masculino , Mediastinoscopia , Pessoa de Meia-Idade , Doenças Raras , Tomografia Computadorizada por Raios X , Resultado do Tratamento
16.
Histopathology ; 69(3): 510-5, 2016 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-26880345

RESUMO

AIMS: Anaplastic lymphoma kinase (ALK) functions as an oncogenic driver in a subset of haematopoietic, epithelial and mesenchymal neoplasms. Activation of ALK most commonly occurs through gene fusion events, the presence of which predicts response to ALK-targeted inhibitors in some tumour types. Echinoderm microtubule-associated protein-like 4 (EML4)-ALK fusions represent the majority of ALK rearrangements in lung adenocarcinomas and were, until recently, thought to be exclusive to that tumour type. However, recent work has identified EML4-ALK fusions in ~20% of inflammatory myofibroblastic tumours (IMTs), particularly in those arising in the lung. Here, we present a patient with an ALK-rearranged poorly differentiated lung adenocarcinoma with a predominant sarcomatoid component that was morphologically indistinguishable from IMT. METHODS AND RESULTS: Targeted next-generation sequencing revealed EML4-ALK rearrangements in both components, with identical fusion sequences. Copy number analysis demonstrated focal gain of the MYC gene in the IMT-like component. The findings support a diagnosis of ALK-rearranged lung adenocarcinoma with IMT-like dedifferentiation. CONCLUSIONS: Our findings suggest that ALK-driven epithelial and mesenchymal neoplasms exist on a morphological spectrum, and emphasize the need to consider translocation testing in pulmonary tumours with unusual sarcomatoid morphology.


Assuntos
Adenocarcinoma/genética , Adenocarcinoma/patologia , Neoplasias Pulmonares/genética , Neoplasias Pulmonares/patologia , Proteínas de Fusão Oncogênica/genética , Granuloma de Células Plasmáticas Pulmonar/genética , Granuloma de Células Plasmáticas Pulmonar/patologia , Adenocarcinoma de Pulmão , Adulto , Feminino , Sequenciamento de Nucleotídeos em Larga Escala , Humanos , Imuno-Histoquímica
17.
Microbes Infect ; 17(11-12): 795-8, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26342254

RESUMO

A 58-year-old man was admitted because of respiratory failure, episodic fever with chilling, cough, malaise, fatigue, myalgia and weight loss lasting for at least one month. Chest x-rays and CT scan of the chest showed bilateral pulmonary consolidations in upper lobes, the left lower lobe, and mediastinal lymphadenopathy. Bronchoscopy with cytology was unremarkable. A needle CT-guided lung biopsy documented an inflammatory pseudotumor, lymphoplasmacytic type. Serology showed high titer antibodies to phase II Coxiella burnetii infection. Therapy with doxycycline and hydroxychloroquine for three months led to a complete resolution of symptoms and radiological findings, and a marked decrease in titers to Q fever.


Assuntos
Coxiella burnetii/patogenicidade , Granuloma de Células Plasmáticas Pulmonar , Antibacterianos/uso terapêutico , Anticorpos Antibacterianos/sangue , Anticorpos Antibacterianos/imunologia , Coxiella burnetii/imunologia , Doxiciclina/uso terapêutico , Humanos , Hidroxicloroquina/uso terapêutico , Masculino , Pessoa de Meia-Idade , Granuloma de Células Plasmáticas Pulmonar/diagnóstico por imagem , Granuloma de Células Plasmáticas Pulmonar/tratamento farmacológico , Granuloma de Células Plasmáticas Pulmonar/microbiologia , Febre Q/tratamento farmacológico , Febre Q/microbiologia , Radiografia
18.
Pediatr Radiol ; 45(11): 1672-81, 2015 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-26135643

RESUMO

BACKGROUND: Inflammatory myofibroblastic tumor is a rare benign neoplasm and most commonly involves the lung but occurs in extrapulmonary locations. OBJECTIVE: To present imaging findings in inflammatory myofibroblastic tumors in children based on a single-centre experience. MATERIALS AND METHODS: We retrospectively reviewed CT and MRI findings of children diagnosed with inflammatory myofibroblastic tumor in a single institution. RESULTS: We identified 15 children (range: 1-17 years) with inflammatory myofibroblastic tumor. The tumor was localized to the lung (n = 5), mediastinum (n = 3), trachea (n = 1), bronchus (n = 1), abdomen (n = 2) and orbit (n = 3). All the extraorbital tumors were solid masses with homogeneous or heterogeneous enhancement. Four lung tumors and one posterior mediastinal tumor contained calcification. Local recurrence following surgical removal occurred in two children with invasion of the esophagus and of the left atrium in one. Localized masses were seen in all children with orbital tumour. Two of these had episcleritis and perineuritis; one had episcleritis, tendonitis, perineuritis, myositis and dacryoadenitis. CONCLUSION: The locations and imaging features of inflammatory myofibroblastic tumors are variable.


Assuntos
Granuloma de Células Plasmáticas/diagnóstico , Imagem por Ressonância Magnética/métodos , Pseudotumor Orbitário/diagnóstico , Granuloma de Células Plasmáticas Pulmonar/diagnóstico , Tomografia Computadorizada por Raios X/métodos , Adolescente , Criança , Pré-Escolar , História Antiga , Humanos , Lactente , Masculino
19.
Tumori ; 101(3): 249-56, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25983099

RESUMO

AIMS AND BACKGROUND: Inflammatory pseudotumor (IPT) and inflammatory myofibroblastic tumor (IMT) represent different entities. However, it is only in recent years that this has been taken into increasing consideration. Some authors still use both terms synonymously or interchangeably. Inflammatory myofibroblastic tumor is a real neoplasm because of the proliferation of myofibroblastic cells. Inflammatory pseudotumor is a more inflammatory reactive or regenerative entity and shows an overlapping with immunoglobulin G4-related disease. METHODS AND STUDY DESIGN: To analyze the current situation, 443 publications from the last 5 years (2009 to February 2014) were included. Reports involved 938 patients and 956 organ sites. The age distribution is twin peaked with one maximum in childhood and the other between 50 and 60 years of age. This distribution is questionable due to the more frequent occurrence of IPT in the liver and of IMT in the lung. Inflammatory pseudotumors mainly occur in older patients; IMTs in children and young adults. RESULTS AND CONCLUSIONS: The liver and biliary tract were the most commonly affected of all body regions, at 32%. This was followed by the lung, including the respiratory tract, at 27%, and by the gastrointestinal tract, at 10%. Lesions of the large bowel, as in the present case of a 9-year-old boy, are very rare. There were organ-related as well as nonspecific clinical symptoms, such as fever, weight loss, and fatigue. Laboratory test results revealed anemia and elevated inflammation-dependent parameters. The patterns in medical imaging are variable and nonspecific. Morphology often suggests a malignant process. For this reason, therapy in most cases is surgical, but this is required more often in IMTs. Many IPTs could be treated conservatively.


Assuntos
Neoplasias do Colo/diagnóstico , Neoplasias do Colo/cirurgia , Granuloma de Células Plasmáticas/diagnóstico , Granuloma de Células Plasmáticas/cirurgia , Miofibroblastos/patologia , Miofibroma/diagnóstico , Miofibroma/cirurgia , Adulto , Distribuição por Idade , Quinase do Linfoma Anaplásico , Biomarcadores Tumorais/análise , Criança , Neoplasias do Colo/química , Granuloma de Células Plasmáticas/epidemiologia , Humanos , Imagem por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Miofibroma/epidemiologia , Granuloma de Células Plasmáticas Pulmonar/diagnóstico , Receptores Proteína Tirosina Quinases/análise
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA