Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 10.649
Filtrar
1.
Life Sci ; 255: 117830, 2020 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-32450172

RESUMO

Advanced glycation end products (AGEs) are heterogeneous products of the non-enzymatic interaction between proteins and reducing sugars. Numerous studies have shown that AGEs are associated with senescence, diabetes, vascular disease, aging and kidney disease. Infertility has been affected approximately 10 to15% of couples of reproductive ages. AGEs accumulation has been shown to play a crucial role in pathogenesis of infertility-related diseases. The present review provides the generation process, mechanism and pathological significance of AGEs and the novel treatment targeting AGEs for infertility.


Assuntos
Produtos Finais de Glicação Avançada/metabolismo , Infertilidade/fisiopatologia , Animais , Feminino , Humanos , Infertilidade/epidemiologia , Masculino
2.
Reprod Biomed Online ; 41(1): 1-5, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-32451301

RESUMO

The emergence of the novel coronavirus infection that arose in Wuhan, China in December 2019 has resulted in an epidemic that has quickly expanded to become one of the most significant public health threats in recent times. Unfortunately, the disease has spread globally. On March 11th (2020) World Health Organization (WHO) declared Covid-19 a pandemic and has called governments to take urgent and aggressive action to change the course of the outbreak. Within the context of Assisted Reproduction, both reproductive medicine professionals and patients are also fighting against this unprecedented viral pandemic. In view of events, most of us had to make serious decisions, some of them with a lack of scientific evidence due to the circumstances and with the only objective of ensuring the safe care of our patients, reduce non-essential contacts and prevent possible maternal and fetal complications in future pregnancies. Pregnant women should not be considered at high risk for developing severe infection. Up to date, there are no reported deaths in pregnant women with Covid-19, while in the cases that have presented pneumonia because of Covid-19, the symptoms have been moderate and with a good prognosis in recovery.


Assuntos
Infecções por Coronavirus/epidemiologia , Clínicas de Fertilização , Pneumonia Viral/epidemiologia , Serviços de Saúde Reprodutiva , Feminino , Guias como Assunto , Humanos , Infertilidade/terapia , Itália , Idade Materna , Pandemias , Assistência ao Paciente , Gravidez , Técnicas de Reprodução Assistida , Espanha , Fatores de Tempo
3.
Reprod Biomed Online ; 41(1): 89-95, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-32466994

RESUMO

The outbreak of 2019 novel coronavirus disease (COVID-19) has become a major pandemic threat worldwide. Such a public health emergency can greatly impact various aspects of people's health and lives. This paper focuses on its potential risks for reproductive health, including the reproductive system and its functioning, as well as gamete and embryo development, which could be affected by the virus itself, drug treatments, chemical disinfectants and psychological effects related to panic during the COVID-19 outbreak.


Assuntos
Infecções por Coronavirus/psicologia , Pneumonia Viral/psicologia , Antivirais/efeitos adversos , Infecções por Coronavirus/tratamento farmacológico , Infecções por Coronavirus/epidemiologia , Infecções por Coronavirus/fisiopatologia , Feminino , Humanos , Infertilidade/virologia , Masculino , Pandemias , Pneumonia Viral/tratamento farmacológico , Pneumonia Viral/epidemiologia , Pneumonia Viral/fisiopatologia , Gravidez , Complicações Infecciosas na Gravidez/epidemiologia , Complicações Infecciosas na Gravidez/terapia , Saúde Reprodutiva , Estresse Psicológico
4.
DNA Cell Biol ; 39(6): 1012-1022, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32352843

RESUMO

Kisspeptin has been identified as a key regulatory protein in the release of gonadotropin-releasing hormone (GnRH), which subsequently increases gonadotropin secretion during puberty to establish reproductive function and regulate the hypothalamic-pituitary-gonadal axis. The effects of variants in the KISS1, KISS1R, and GNRHR genes and their possible association with assisted reproduction outcomes remain to be elucidated. In this study, we used next-generation sequencing to investigate the associations of the genetic diversity at the candidate loci for KISS1, KISS1R, and GNRHR with the hormonal profiles and reproductive outcomes in 86 women who underwent in vitro fertilization treatments. Variants in the KISS1 and KISS1R genes were associated with luteinizing hormone (rs35431622:T>C), anti-Mullerian hormone (rs71745629delT), follicle-stimulating hormone (rs73507529:C>A), and estradiol (rs73507527:G>A, rs350130:A>G, and rs73507529:C>A) levels, as well as with reproductive outcomes such as the number of oocytes retrieved (s35431622:T>C), metaphasis II oocytes (rs35431622:T>C), and embryos (rs1132506:G>C). Additionally, variants in the GNRHR UTR3' (rs1038426:C>A, rs12508464:A>C, rs13150734:C>A, rs17635850:A>G, rs35683646:G>A, rs35610027:C>G, rs35845954:T>C, rs17635749:C>T, and rs7666201:C>T) were associated with low prolactin levels. A conjoint analysis of clinical, hormonal, and genetic variables using a generalized linear model identified two variants of the KISS1 gene (rs71745629delT and rs1132506:G>C) that were significantly associated with hormonal variations and reproductive outcomes. The findings suggest that variants in KISS1, KISS1R, and GNRHR genes can modulate hormone levels and reproductive outcomes.


Assuntos
Variação Genética , Hormônio Liberador de Gonadotropina/metabolismo , Kisspeptinas/genética , Receptores de Kisspeptina-1/genética , Receptores LHRH/genética , Reprodução/genética , Adulto , Feminino , Loci Gênicos/genética , Sequenciamento de Nucleotídeos em Larga Escala , Humanos , Infertilidade/genética
5.
Reprod Biomed Online ; 40(6): 755-759, 2020 06.
Artigo em Inglês | MEDLINE | ID: mdl-32354663

RESUMO

The COVID-19 pandemic is an unprecedented global situation. As assisted reproductive technology (ART) specialists, we should be cautious, carefully monitoring the situation while contributing by sharing novel evidence to counsel our patients, both pregnant women and would-be mothers. Time to egg collection and drop-out rates are critical parameters for scheduling treatments once the curve of infections has peaked and plateaued in each country. In order to reduce the values for these two parameters, infertile patients now require even more support from their IVF team: urgent oocyte collection for oncology patients must be guaranteed, and oocyte retrievals for women of advanced maternal age and/or reduced ovarian reserve cannot be postponed indefinitely. This document represents the position of the Italian Society of Fertility and Sterility and Reproductive Medicine (SIFES-MR) in outlining ART priorities during and after this emergency.


Assuntos
Infecções por Coronavirus , Pandemias , Pneumonia Viral , Técnicas de Reprodução Assistida , Feminino , Humanos , Infertilidade , Itália , Gravidez
7.
Nurse Pract ; 45(5): 48-54, 2020 05.
Artigo em Inglês | MEDLINE | ID: mdl-32332233

RESUMO

Infertility is a growing issue for couples. Primary care NPs can manage initial treatment as well as address the emotional and financial burdens of patients experiencing infertility. NPs can provide timely access to investigations and treatment, helping patients achieve their goal of pregnancy sooner.


Assuntos
Infertilidade/enfermagem , Profissionais de Enfermagem , Enfermagem de Atenção Primária , Técnicas de Laboratório Clínico , Feminino , Humanos , Infertilidade/tratamento farmacológico , Masculino , Anamnese , Exame Físico/enfermagem , Encaminhamento e Consulta
8.
Urol Clin North Am ; 47(2): 193-204, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32272991

RESUMO

Although infertility is now recognized as a disease by multiple organizations including the World Health Organization and the American Medical Association, private insurance companies rarely include coverage for infertility treatments. In this review, the authors assess the current state of care delivery for male infertility care in the United States. They discuss the scope of male infertility as well as the unique burdens it places on patients and review emerging market forces that could affect the future of care delivery for male infertility.


Assuntos
Assistência à Saúde/métodos , Assistência à Saúde/tendências , Infertilidade Masculina/diagnóstico , Infertilidade Masculina/terapia , Cobertura do Seguro/legislação & jurisprudência , Seguro Saúde/legislação & jurisprudência , Comorbidade , Assistência à Saúde/estatística & dados numéricos , Previsões , Política de Saúde/legislação & jurisprudência , Humanos , Infertilidade/diagnóstico , Infertilidade/economia , Infertilidade/terapia , Infertilidade Masculina/economia , Infertilidade Masculina/epidemiologia , Masculino , Estados Unidos/epidemiologia
9.
Urol Clin North Am ; 47(2): 205-210, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32272992

RESUMO

Qualitative research methods represent a valuable tool for investigating the entirety of the experience of male infertility evaluation, diagnosis, and treatment. Qualitative research is rigorous and thorough and well adapted for studying the complex field of infertility and reproductive health. Knowledge gained from qualitative research methods can undoubtedly inform clinical practice and improve support for individuals and couples affected by male factor infertility.


Assuntos
Infertilidade Masculina , Pesquisa Qualitativa , Pesquisa Biomédica/métodos , Feminino , Recursos em Saúde , Acesso aos Serviços de Saúde , Humanos , Infertilidade/diagnóstico , Infertilidade/etiologia , Infertilidade/terapia , Infertilidade Masculina/diagnóstico , Infertilidade Masculina/etiologia , Infertilidade Masculina/terapia , Masculino
10.
Proc Biol Sci ; 287(1925): 20192468, 2020 04 29.
Artigo em Inglês | MEDLINE | ID: mdl-32290801

RESUMO

Human populations in many countries have undergone a phase of demographic transition, characterized by a major reduction in fertility at a time of increased resource availability. A key stylized fact is that the reduction in fertility is preceded by a reduction in mortality and a consequent increase in population density. Various theories have been proposed to account for the demographic transition process, including maladaptation, increased parental investment in fewer offspring, and cultural evolution. None of these approaches, including formal cultural evolutionary models of the demographic transitions, have addressed a possible direct causal relationship between a reduction in mortality and the subsequent decline in fertility. We provide mathematical models in which low mortality favours the cultural selection of low-fertility traits. This occurs because reduced mortality slows turnover in the model, which allows the cultural transmission advantage of low-fertility traits to outrace their reproductive disadvantage. For mortality to be a crucial determinant of outcome, a cultural transmission bias is required where slow reproducers exert higher social influence. Computer simulations of our models that allow for exogenous variation in the death rate can reproduce the central features of the demographic transition process, including substantial reductions in fertility within only one to three generations. A model assuming continuous evolution of reproduction rates through imitation errors predicts fertility to fall below replacement levels if death rates are sufficiently low. This can potentially explain the very low preferred family sizes in Western Europe.


Assuntos
Evolução Biológica , Evolução Cultural , Fertilidade , Coeficiente de Natalidade , Europa (Continente) , Características da Família , Humanos , Infertilidade , Modelos Teóricos , Dinâmica Populacional , Reprodução
11.
An Bras Dermatol ; 95(3): 271-277, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32317131

RESUMO

Finasteride is a 5α-reductase enzyme inhibitor that has been approved for the treatment of male androgenic alopecia since 1997. Over time, it has been considered a safe and well-tolerated drug with rare and reversible side effects. Recently there have been reports of adverse drug-related reactions that persisted for at least three months after discontinuation of this drug, and the term post-finasteride syndrome arose. It includes persistent sexual, neuropsychiatric, and physical symptoms. Studies to date cannot refute or confirm this syndrome as a nosological entity. If it actually exists, it seems to occur in susceptible people, even if exposed to small doses and for short periods, and symptoms may persist for long periods. Based on currently available data, the use of 5α-reductase inhibitors in patients with a history of depression, sexual dysfunction, or infertility should be carefully and individually assessed.


Assuntos
Inibidores de 5-alfa Redutase/efeitos adversos , Finasterida/efeitos adversos , Disfunções Sexuais Fisiológicas/induzido quimicamente , Doenças Cardiovasculares/induzido quimicamente , Humanos , Infertilidade/induzido quimicamente , Masculino , Transtornos Mentais/induzido quimicamente , Doenças Metabólicas/induzido quimicamente , Fatores de Risco , Espermatozoides/efeitos dos fármacos , Síndrome
12.
PLoS One ; 15(3): e0229904, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32142542

RESUMO

The placental epigenome plays a critical role in regulating mammalian growth and development. Alterations to placental methylation, often observed at imprinted genes, can lead to adverse pregnancy complications such as intrauterine growth restriction and preterm birth. Similar associations have been observed in offspring derived from advanced paternal age fathers. As parental age at time of conception continues to rise, the impact of advanced paternal age on these reproductive outcomes is a growing concern, but limited information is available on the molecular mechanisms affected in utero. This longitudinal murine research study thus investigated the impact of paternal aging on genomic imprinting in viable F1 embryonic portions of the placentas derived from the same paternal males when they were young (4-6 months) and when they aged (11-15 months). The use of a controlled outbred mouse model enabled analysis of offspring throughout the natural lifetime of the same paternal males and excluded confounding factors like female age or infertility. Firstly, paternal age significantly impacted embryonic placental weight, fetal weight and length. Targeted bisulfite sequencing was utilized to examine imprinted methylation at the Kcnq1ot1 imprinting control region, with significant hypermethylation observed upon natural paternal aging. Quantitative real-time PCR assessed imprinted gene expression levels at various imprinting clusters, resulting in transcript level alterations attributable to advanced paternal age. In summary, our results demonstrate a paternal age effect with dysregulation at numerous imprinted loci, providing a mechanism for future adverse placental and offspring health conditions.


Assuntos
Epigênese Genética , Impressão Genômica/genética , Idade Paterna , Reprodução/genética , Animais , Metilação de DNA/genética , Epigenoma/genética , Pai , Feminino , Humanos , Infertilidade/genética , Infertilidade/patologia , Masculino , Camundongos , Placenta/metabolismo , Placenta/patologia , Gravidez
13.
Pediatrics ; 145(3)2020 03.
Artigo em Inglês | MEDLINE | ID: mdl-32071259

RESUMO

Many cancers presenting in children and adolescents are curable with surgery, chemotherapy, and/or radiotherapy. Potential adverse consequences of treatment include sterility, infertility, or subfertility as a result of gonad removal, damage to germ cells as a result of adjuvant therapy, or damage to the pituitary and hypothalamus or uterus as a result of irradiation. In recent years, treatment of solid tumors and hematologic malignancies has been modified in an attempt to reduce damage to the gonadal axis. Simultaneously, advances in assisted reproductive technology have led to new possibilities for the prevention and treatment of infertility. This clinical report reviews the medical aspects and ethical considerations that arise when considering fertility preservation in pediatric and adolescent patients with cancer.


Assuntos
Sobreviventes de Câncer , Preservação da Fertilidade , Infertilidade/etiologia , Neoplasias/terapia , Adolescente , Antineoplásicos/efeitos adversos , Criança , Aconselhamento , Criopreservação , Preservação da Fertilidade/ética , Humanos , Cobertura do Seguro , Seguro Saúde , Masculino , Oócitos/citologia , Radioterapia/efeitos adversos , Espermatozoides
15.
BMC Psychol ; 8(1): 6, 2020 Jan 29.
Artigo em Inglês | MEDLINE | ID: mdl-31996245

RESUMO

BACKGROUND: Infertility can have a powerful impact on marital quality. The Revised Dyadic Adjustment Scale (RDAS) is a widely used measure of marital quality. This scale has not been validated in infertile patients. Therefore, this study aimed to evaluate the reliability and validity of the RDAS in a sample of infertile patients. METHODS: The sample of this methodological study consisted of 254 infertile patients referring to a referral infertility clinic in Tehran, Iran. A battery of questionnaires was administered to the participants, including a demographic/fertility questionnaire, the RDAS, the Relationship Assessment Scale (RAS), the Kansas Marital Satisfaction Scale (KMSS), the Couples Satisfaction Index- 4 Item (CSI-4), the Hospital Anxiety and Depression Scale (HADS), and the Perceived Stress Scale-4 Item (PSS-4). Internal consistency of the scale was assessed with Cronbach's alpha, construct validity was investigated using confirmatory factor analysis (CFA), and convergent validity was examined by correlating the RDAS with RAS, KMSS, CSI-4, HADS, and PSS-4 instruments. RESULTS: The mean total RDAS score was 49.26 ± 9.34, and 100 patients (39.4%) had marital distress based on the cut-off value of < 48. The second-order three-factor model of the RDAS exhibited an excellent fit to the data, as indicated by χ2/df = 2.26; CFI = 0.96; GFI = 0.91; NFI = 0.93; IFI = 0.96; RMSEA = 0.071 and SRMR = 0.050. The RDAS and its subscales revealed satisfactory internal consistency that ranged from 0.664 to 0.847. Convergent validity was confirmed by strong correlations between RDAS scores and scores on the RAS, KMSS, and CSI-4. These correlations also tended to be larger than correlations with measures of HADS-anxiety, HADS-depression, and PSS-4. Among demographic/fertility variables, only infertility duration was found to be correlated to the RDAS. CONCLUSION: The RDAS is a reliable and valid inventory for measuring marital quality in infertile patients. Further validation studies are needed to generalize the underlying structure of the scale in various populations.


Assuntos
Infertilidade/psicologia , Casamento/psicologia , Testes Psicológicos , Adulto , Análise Fatorial , Feminino , Humanos , Irã (Geográfico) , Masculino , Satisfação Pessoal , Reprodutibilidade dos Testes , Inquéritos e Questionários
16.
Gynecol Oncol ; 156(3): 611-615, 2020 03.
Artigo em Inglês | MEDLINE | ID: mdl-31983516

RESUMO

OBJECTIVE: Risk factors for ovarian borderline tumors and low-grade serous carcinoma (LGSC) are poorly understood. The aim of this study was to examine the association between infertility, pelvic inflammatory disease (PID), endometriosis, ectopic pregnancy, hysterectomy, tubal ligation and parity and the risk of serous borderline tumor (SBT), mucinous borderline tumor (MBT) and LGSC. METHODS: This was a population-based cohort study using linked administrative and hospital data. Participants were 441,382 women born between 1945 and 1975 who had been admitted to hospital in Western Australia between 1 January 1980 and 30 June 2014. We used Cox regression to estimate hazard ratios (HRs). RESULTS: We observed an increased rate of SBT associated with infertility, PID and ectopic pregnancy (HRs and 95% CIs were, respectively, 1.98 (1.20-3.26); 1.95 (1.22-3.10) and 2.44 (1.20-4.96)). We did not detect an association between any of the factors under study and the rate of MBT. A diagnosis of PID was associated with an increased rate of LGSC (HR 2.90, 95% CI 1.21-6.94). CONCLUSIONS: The association with PID supports the hypothesis that inflammatory processes within the upper gynaecological tract and/or peritoneum may predispose to the development of SBT and LGSC.


Assuntos
Cistadenocarcinoma Seroso/epidemiologia , Infertilidade/epidemiologia , Neoplasias Císticas, Mucinosas e Serosas/epidemiologia , Neoplasias Ovarianas/epidemiologia , Doença Inflamatória Pélvica/epidemiologia , Gravidez Ectópica/epidemiologia , Adulto , Estudos de Coortes , Cistadenocarcinoma Seroso/patologia , Feminino , Humanos , Pessoa de Meia-Idade , Gradação de Tumores , Neoplasias Císticas, Mucinosas e Serosas/patologia , Neoplasias Ovarianas/patologia , Gravidez , Austrália Ocidental/epidemiologia
17.
Support Care Cancer ; 28(2): 809-817, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31154532

RESUMO

PURPOSE: Impaired fertility in cancer patients and survivors of reproductive age (15-45 years) may lead to psychological distress and poor mental health outcomes, and may negatively impact quality of life. Limited research has focused on the fertility experiences of those who have had access to supportive oncofertility care. This study aims to explore the fertility-care experiences and reproductive concerns of reproductive age cancer patients at the time of their cancer diagnosis who have had access to oncofertility care. METHODS: The qualitative data from a larger mixed method study is presented, comprising 30 semi-structured telephone interviews with newly diagnosed cancer patients across Australia and New Zealand, undertaken between April 2016 and April 2018. RESULTS: Interviews were undertaken with 9 male patients and 21 female patients aged between 15 and 44 years. All patients recalled a discussion about fertility and majority underwent some form of fertility preservation. Thematic analysis identified five main themes: (i) satisfaction with oncofertility care, (ii) a need for individualised treatment and support, (iii) desire for parenthood, (iv) fertility treatment can be challenging, and (v) fertility preservation provides a safety net for the future. CONCLUSIONS: Participants who access supportive oncofertility care report low emotional impact of threatened future infertility at the time of cancer diagnosis. These results suggest that such services may assist in lowering the emotional burden of potential infertility in survivors. Long-term research is needed to assess the longitudinal benefits for different models of care.


Assuntos
Preservação da Fertilidade/métodos , Preservação da Fertilidade/psicologia , Infertilidade/psicologia , Neoplasias/psicologia , Sistemas de Apoio Psicossocial , Adolescente , Adulto , Austrália , Feminino , Fertilidade/fisiologia , Humanos , Infertilidade/patologia , Masculino , Saúde Mental , Neoplasias/terapia , Nova Zelândia , Pesquisa Qualitativa , Qualidade de Vida/psicologia , Sobreviventes , Adulto Jovem
20.
Arch Biochem Biophys ; 679: 108222, 2020 01 15.
Artigo em Inglês | MEDLINE | ID: mdl-31816311

RESUMO

Aquaporins (AQPs) are a family of transmembrane channel proteins responsible for the transport of water and small uncharged molecules. Thirteen distinct isoforms of AQPs have been identified in mammals (AQP0-12). Throughout the male reproductive tract, AQPs greatly enhance water transport across all biological barriers, providing a constant and expeditious movement of water and playing an active role in the regulation of water and ion homeostasis. This regulation of fluids is particularly important in the male reproductive tract, where proper fluid composition is directly linked with a healthy and competent spermatozoa production. For instance, in the testis, fluid regulation is essential for spermatogenesis and posterior spermatozoa transport into the epididymal ducts, while maintaining proper ionic conditions for their maturation and storage. Alterations in the expression pattern of AQPs or their dysfunction is linked with male subfertility/infertility. Thus, AQPs are important for male reproductive health. In this review, we will discuss the most recent data on the expression and function of the AQPs isoforms in the human, mouse and rat male reproductive tract. In addition, the regulation of AQPs expression and dysfunction linked with male infertility will be discussed.


Assuntos
Aquaporinas/genética , Aquaporinas/metabolismo , Fertilidade/genética , Regulação da Expressão Gênica , Infertilidade/genética , Infertilidade/metabolismo , Animais , Humanos , Infertilidade/fisiopatologia , Masculino , Reprodução
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA