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1.
World Neurosurg ; 137: 247-251, 2020 05.
Artigo em Inglês | MEDLINE | ID: mdl-32068171

RESUMO

BACKGROUND: Meningioangiomatosis is an extremely rare meningovascular disease of the central nervous system that is characterized by the proliferation of leptomeninges, cortical vessels, and perivascular spindled cells. Although it is a benign, neoplastic disorder that carries a good prognosis after surgical excision, initial diagnosis may be challenging as radiologic findings are often variable and nonspecific. CASE DESCRIPTION: In this report, we describe an unusual presentation of meningioangiomatosis presenting as a symptomatic middle cranial fossa arachnoid cyst. CONCLUSIONS: In view of the unexpected diagnosis and infrequency of this condition, the case is discussed in collaboration with current literature and management strategies.


Assuntos
Angiomatose/diagnóstico , Angiomatose/cirurgia , Cistos Aracnóideos/diagnóstico por imagem , Cistos Aracnóideos/diagnóstico , Fossa Craniana Média/diagnóstico por imagem , Procedimentos Neurocirúrgicos/métodos , Angiomatose/diagnóstico por imagem , Transtornos Cerebrovasculares/diagnóstico , Transtornos Cerebrovasculares/patologia , Craniotomia , Diagnóstico Diferencial , Oftalmopatias/etiologia , Humanos , Lactente , Imagem por Ressonância Magnética , Masculino , Meninges/patologia , Resultado do Tratamento
2.
J Am Vet Med Assoc ; 256(2): 226-229, 2020 01 15.
Artigo em Inglês | MEDLINE | ID: mdl-31910088

RESUMO

CASE DESCRIPTION: A 1.5-year-old 4.0-kg (8.8-lb) castrated male mixed-breed cat was evaluated because of an 8-month history of repeated bleeding from a hole in the skin next to the left metatarsal pad. CLINICAL FINDINGS: The cat had swelling in the distal region of the left pelvic limb, and blood dripped from a 2-mm-diameter hole in the skin adjacent and proximal to the metatarsal pad. Radiographic findings for the distal aspect of the left pelvic limb were compatible with a soft tissue inflammatory process. Results of histologic examination of a wedge biopsy sample, including the affected skin and subcutaneous tissue, indicated cutaneous angiomatosis. Angiography revealed anomalous vessels in the metatarsal region. TREATMENT AND OUTCOME: Surgical resection of the skin, subcutaneous tissue, and anomalous vessels in the affected metatarsal region of the left pelvic limb was performed. However, similar abnormal clinical signs recurred and did not respond to treatment, including prednisolone (2.0 mg/kg [0.9 mg/lb], PO, q 12 h for 4 days) and doxycycline (10 mg/kg [4.5 mg/lb], PO, q 24 h). The left pelvic limb was amputated, and no recurrence of similar abnormalities in the cat's other limbs was evident within a 15-month follow-up period. CLINICAL RELEVANCE: Findings in the cat of the present report highlighted that cutaneous angiomatosis could recur in a short period of time and that amputation of the affected limb was a viable treatment option when surgical resection was not successful.


Assuntos
Angiomatose/veterinária , Doenças do Gato/diagnóstico , Ossos do Metatarso , Amputação/veterinária , Angiomatose/diagnóstico , Angiomatose/cirurgia , Animais , Doenças do Gato/cirurgia , Gatos , Masculino , Prednisolona , Pele
3.
Am J Case Rep ; 21: e919856, 2020 Jan 16.
Artigo em Inglês | MEDLINE | ID: mdl-31941879

RESUMO

BACKGROUND Pseudoangiomatous stromal hyperplasia (PASH) is an uncommon benign breast lesion. CASE REPORT PASH is reported in a young female in treatment for neurological diseases with multi-drug therapy (clonazepam, valproate and risperidone). Her menstrual cycles are irregular, and she reached menarche very late. CONCLUSIONS The higher PASH prevalence in premenopausal woman (the majority of whom are actively taking oral contraceptive pills), in 24% to 47% of men with gynecomastia and during pregnancy supports a hormonal etiology; the interaction between clonazepam, valproate, risperidone and progesterone could increase the level of progesterone that could stimulate PASH growth.


Assuntos
Angiomatose/diagnóstico , Doenças Mamárias/diagnóstico , Mama/patologia , Hiperplasia/diagnóstico , Células Estromais/patologia , Adulto , Angiomatose/etiologia , Angiomatose/cirurgia , Biópsia com Agulha de Grande Calibre , Mama/citologia , Doenças Mamárias/etiologia , Doenças Mamárias/cirurgia , Interações Medicamentosas , Feminino , Humanos , Hiperplasia/etiologia , Hiperplasia/cirurgia , Mastectomia Segmentar , Progesterona/metabolismo
6.
J Cutan Pathol ; 47(1): 27-30, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31589777

RESUMO

BACKGROUND: Although diffuse dermal angiomatosis (DDA), a rare acquired reactive cutaneous vascular disorder, has been previously reported in association with calciphylaxis (CP), the clinical significance of this relationship has not yet been elucidated. METHODS: A total of 24 cases of CP diagnosed from 2013 to 2018 were retrospectively reviewed for the presence of associated DDA. Pertinent clinical information for each patient was also collected, and statistical analysis was performed using multivariable logistic regression, Student t test and Fisher exact test. RESULTS: African American race and comorbid congestive heart failure were the only variables that demonstrated independent, statistically significant association with the presence of DDA. End-stage renal failure, diabetes mellitus, immunosuppressive and hypercoagulable states, arrhythmia, body mass index, hypertension, coronary artery disease, patient age, duration of CP symptoms, gender, time interval from biopsy to death, anticoagulation therapy and sodium thiosulfate administration at the time of biopsy did not demonstrate a statistically significant association with DDA. CONCLUSION: DDA does not appear to be associated with disease severity or prognosis in cases of CP; however, in our population CP with concurrent DDA was more prevalent in African Americans and individuals with congestive heart failure.


Assuntos
Afro-Americanos , Angiomatose , Calciofilaxia , Derme , Insuficiência Cardíaca , Dermatopatias Vasculares , Idoso , Angiomatose/etnologia , Angiomatose/metabolismo , Angiomatose/patologia , Calciofilaxia/etnologia , Calciofilaxia/metabolismo , Calciofilaxia/patologia , Derme/metabolismo , Derme/patologia , Feminino , Insuficiência Cardíaca/etnologia , Insuficiência Cardíaca/metabolismo , Insuficiência Cardíaca/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Dermatopatias Vasculares/etnologia , Dermatopatias Vasculares/metabolismo , Dermatopatias Vasculares/patologia
7.
Tokai J Exp Clin Med ; 44(4): 73-79, 2019 Dec 20.
Artigo em Inglês | MEDLINE | ID: mdl-31768994

RESUMO

A 49-year-old woman, with a medical history of rheumatism, was admitted to our hospital with chief complaints of bilateral enlargement and redness of breasts. She underwent weekly breast examinations. Mammography findings were reported as category 3 for both breasts. Breast ultrasonography, magnetic resonance imaging, and chest contrast computed tomography revealed a massive tumor in the left BD region, however, there were no findings for suspected malignancy. Needle biopsy did not yield histologically malignant cells in both breasts. Mammary interstitium was edematous, and capillary-like slit structures were observed. The stroma stained with alcian blue and destained with hyaluronidase treatment. Since the stroma tested positive for vimentin, calponin, and CD34 and negative for CD31, the patient was diagnosed as (PASH). Because both breasts had similar diagnosis based on histopathologic findings, bilateral mastectomy was performed. Details about the origin of bilateral PASH are unknown but it may be related to the development of rheumatoid arthritis. Additionally, systemic autoimmune diseases like rheumatism may be the reason for repeated contraction and enlargement of PASH.


Assuntos
Angiomatose/diagnóstico por imagem , Angiomatose/patologia , Doenças Mamárias/diagnóstico por imagem , Doenças Mamárias/patologia , Hiperplasia/diagnóstico por imagem , Hiperplasia/patologia , Angiomatose/complicações , Angiomatose/cirurgia , Artrite Reumatoide/complicações , Doenças Mamárias/complicações , Doenças Mamárias/cirurgia , Feminino , Humanos , Hiperplasia/complicações , Hiperplasia/cirurgia , Imagem por Ressonância Magnética , Mamografia , Mastectomia , Pessoa de Meia-Idade , Tomografia Computadorizada por Raios X , Ultrassonografia Mamária
9.
Acta Ortop Mex ; 33(1): 46-49, 2019.
Artigo em Espanhol | MEDLINE | ID: mdl-31480127

RESUMO

INTRODUCTION: Bone cystic angiomatosis is a disease with only 200 cases described, based on angiomatous nonmalignant proliferation, in bone tissue and viscera. It focuses on pelvis, long bones and scapular waist. Clinical evolution ranges from self-limiting forms to massive aggressive osteolysis (Gorham-Stout).Its diagnosis is of exclusion, with nonspecific clinical, radiological (lytic images) and histopathological findings. CLINICAL CASE: Our study is based on the clinical case of a 14-year-old man diagnosed with bone cystic angiomatosis, with disseminated bone involvement, who came to our center for pain and functional impotence in the right hip, diagnosing a pertrochanteric fracture. It was operated by open reduction and osteosynthesis with four-hole VERSA sliding plate screw. An allogeneic graft of cancellous bone was used from femoral head. The evolution was satisfactory, with ambulation at full load per month without requiring analgesic medication and control X-ray at eight months that showed signs of complete integration of the graft. The analgesic pain scale (visual analogue scale) showed a score of 2/10 per month. DISCUSSION: There is controversy regarding the treatment of these fractures by osteosynthesis with bone graft. We are facing a case without serious clinical criteria, but with multiple foci of osteolysis. It was decided not to intervene prophylactically the contraleteral hip, since it is asymptomatic and there are different patterns of evolution described in the literature and risks in surgery.


Assuntos
Angiomatose , Fixação Interna de Fraturas , Fraturas do Quadril , Adolescente , Placas Ósseas , Parafusos Ósseos , Fraturas do Quadril/diagnóstico , Fraturas do Quadril/cirurgia , Humanos , Masculino
10.
J Med Case Rep ; 13(1): 265, 2019 Aug 22.
Artigo em Inglês | MEDLINE | ID: mdl-31434569

RESUMO

BACKGROUND: We report a case of a patient with a rare clinical condition: cystic angiomatosis presenting as pleural effusion and multiple bone lesions mimicking a metastatic malignant neoplasia. With only about 50 such cases published in the literature, it is important to report the clinical presentation and proposed treatment and to share information about the clinical evolution in these patients. CASE PRESENTATION: We report a case of a 45-year-old white man who presented to our hospital with ventilator-dependent pain. Chest tomography detected pleural effusion and multiple osteolytic bone lesions. Oncologic investigation for metastatic malignant neoplasia was started after exclusion of an infectious process. Imaging examinations revealed diffuse osteolytic lesions as well as cystic lesions of the spleen, with discrete glycolytic hypermetabolism visualized by positron emission tomography. After negative results were obtained by investigation of the primary tumor site and a bone biopsy, a final diagnosis of cystic angiomatosis was made. CONCLUSIONS: In view of the fact that cystic angiomatosis is a heterogeneous disorder of unpredictable prognosis and uncertain treatment, it is necessary to disseminate new cases so that further studies may be undertaken to obtain further physiopathological findings and an effective treatment.


Assuntos
Angiomatose/diagnóstico , Osteólise/diagnóstico por imagem , Derrame Pleural/diagnóstico por imagem , Diagnóstico Diferencial , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias/diagnóstico , Esplenopatias/diagnóstico por imagem , Tomografia Computadorizada por Raios X
12.
J Cutan Pathol ; 46(11): 864-866, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31209887

RESUMO

Cutaneous epithelioid angiomatous nodule is an uncommon vascular lesion usually described as composed of epithelioid endothelial cells with vesicular nuclei and eosinophilic cytoplasm. A granular cell variant has not been previously described. Endothelial cells can present with granular cytoplasm as documented with reports of granular cell angiosarcoma. The granularity is thought to be due to increased intracytoplasmic lysosomes. We present a case of a benign superficial vascular lesion composed of a sheet-like proliferation of epithelioid endothelial cells with distinctly granular cytoplasm confirmed as of endothelial origin with positive staining for CD31 and ERG.


Assuntos
Angiomatose , Células Endoteliais , Hemangiossarcoma , Neoplasias Cutâneas , Pele , Adulto , Angiomatose/metabolismo , Angiomatose/patologia , Células Endoteliais/metabolismo , Células Endoteliais/patologia , Células Epitelioides/metabolismo , Células Epitelioides/patologia , Hemangiossarcoma/metabolismo , Hemangiossarcoma/patologia , Humanos , Masculino , Pele/metabolismo , Pele/patologia , Neoplasias Cutâneas/metabolismo , Neoplasias Cutâneas/patologia
14.
Clin Dermatol ; 37(3): 213-226, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31178104

RESUMO

Viral exanthems are frequent in children and are mostly self-limited. Early recognition and differentiation from other childhood illnesses are important to direct further investigations and treatment initiation. The clinical presentation of viral exanthems in children includes a polymorphic spectrum of skin eruptions ranging from classic viral exanthems to "atypical" presentations that can mimic nonviral diseases; thus, viral exanthems of childhood can be readily diagnosed on clinical grounds, but not rarely do they represent a diagnostic challenge. In this review, we focus on viral diseases in children that may be difficult to diagnose due to their clinical similarities with nonviral diseases, and we offer clues for the differential diagnosis and proper diagnostic testing in such cases.


Assuntos
Exantema/diagnóstico , Exantema/virologia , Pele/virologia , Acrodermatite , Angiomatose , Febre de Chikungunya , Criança , Pré-Escolar , Técnicas de Laboratório Clínico , Dengue , Diagnóstico Diferencial , Exantema/patologia , Feminino , Doença de Mão, Pé e Boca , Herpesvirus Humano 4 , Humanos , Hospedeiro Imunocomprometido , Lactente , Masculino , Testes Sorológicos , Pele/patologia , Zika virus
15.
Cutis ; 103(3): 181-184, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31039226

RESUMO

Diffuse dermal angiomatosis (DDA) is a benign and rare acquired, cutaneous, reactive, vascular disorder. We report a rare case of a 43-year-old man who presented with a large (15-cm diameter), indurated, hyperpigmented plaque covering the left buttock for 6 years. This report further discusses DDA with a review of the literature, including its classification, epidemiology, pathophysiology, etiology, histopathology, differential diagnosis, and current therapeutic approaches.


Assuntos
Angiomatose/diagnóstico , Dermatopatias Vasculares/diagnóstico , Adulto , Angiomatose/etiologia , Angiomatose/fisiopatologia , Angiomatose/terapia , Humanos , Masculino , Dermatopatias Vasculares/etiologia , Dermatopatias Vasculares/fisiopatologia , Dermatopatias Vasculares/terapia
16.
J Clin Pathol ; 72(9): 597-602, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31088938

RESUMO

AIMS: Mammary angiomatosis is a rare, benign vascular lesion that morphologically mimics low-grade angiosarcoma (LGAS). To date, only occasional reports of this entity have been published, none of which included analysis by immunohistochemistry. The purpose of this study was to further characterise mammary angiomatosis by clinical, histological, and immunohistochemical means while emphasising distinguishing features from LGAS. METHODS: Seven cases of primary mammary angiomatosis were evaluated. For one patient, a subsequent recurrence was also evaluated. RESULTS: All patients were female with a median age at presentation of 51 years (range: 19-58 years). The most common clinical presentation was that of a palpable abnormality or mass (5/8) and the median primary tumour size was 3.1 cm (range: 2-9 cm). Of the six patients with follow-up, one developed a recurrence 6 years after initial presentation. Histologically, all cases were composed of variably sized ectatic, thin-walled vessels lined by flat normochromic endothelium diffusely infiltrating mammary stroma. Where present, lesional vessels infiltrated between and around terminal duct lobular units but not into individual intralobular stroma. Most cases (6/8) showed a combination of lymphatic-appearing and haemangiomatous-appearing vessels. Lymphatic-appearing vessels were D2-40 positive in all but one case. D2-40 was negative or weak in haemangiomatous-appearing vessels. All lesional vessels were CD31 positive. Ki-67 indices were <1% in all but one case (5%). CONCLUSIONS: Mammary angiomatosis is a rare vascular lesion that shares clinical, morphological and immunohistochemical features with LGAS; however, certain key traits make the distinction possible.


Assuntos
Angiomatose/metabolismo , Antígenos de Neoplasias/análise , Doenças Mamárias/metabolismo , Neoplasias da Mama/química , Hemangiossarcoma/química , Imuno-Histoquímica , Imunofenotipagem/métodos , Molécula-1 de Adesão Celular Endotelial a Plaquetas/análise , Adulto , Angiomatose/patologia , Anticorpos Monoclonais Murinos , Biópsia , Doenças Mamárias/patologia , Neoplasias da Mama/patologia , Diagnóstico Diferencial , Feminino , Hemangiossarcoma/patologia , Humanos , Pessoa de Meia-Idade , Fenótipo , Valor Preditivo dos Testes , Prognóstico , Adulto Jovem
17.
A A Pract ; 13(4): 137-139, 2019 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-30973350

RESUMO

Cutaneomeningospinal angiomatosis, popularly known as Cobb syndrome, is a rare clinical disorder predominantly presenting with a vascular skin lesion and a spinal angioma at the same dermatomal level. Several case reports and case series have reported on the surgical management of this syndrome, but we failed to find any information about its anesthetic considerations in the Medline database. Our case report describes the perioperative anesthetic management of a 46-year-old man with Cobb syndrome.


Assuntos
Atracúrio/administração & dosagem , Fentanila/administração & dosagem , Isoflurano/administração & dosagem , Síndromes Neoplásicas Hereditárias/cirurgia , Anestésicos Gerais/administração & dosagem , Angiomatose/complicações , Angiomatose/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Síndromes Neoplásicas Hereditárias/complicações , Neoplasias Cutâneas/complicações , Neoplasias Cutâneas/cirurgia , Neoplasias da Coluna Vertebral/complicações , Neoplasias da Coluna Vertebral/cirurgia , Resultado do Tratamento
19.
Pathol Int ; 69(5): 300-305, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-30957322

RESUMO

Pseudoangiomatous stromal hyperplasia (PASH) of the breast is a benign lesion manifesting as myofibroblastic proliferation and anastomosing slit-like spaces. Atypical PASH is an extremely rare lesion characterized by cytological alteration of myofibroblast, presenting as myofibroblastic sarcoma arising from PASH. To our knowledge, only one other case has been reported since the first report of Rosen. We present a case of atypical PASH. A 39-year-old female presented with a round, elastic hard, painless mass in the left breast. Mammography and ultrasonography revealed no definitive sign of malignancy. Core needle biopsy report was suggestive of atypical PASH. Five months later, the mass had grown rapidly with pain. Considering the clinicopathological features, excision was performed. Pathological examination revealed the spindle cells proliferation in collagenous stroma. The spindle cell involved the adipose tissue and lobules and lined peudoangiomatous spaces. These cells exhibited marked cytological atypia and mitotic activity. Immunohistochemically, these spindle cells were positive for SMA, CD10, and bcl-2, and negative for podoplanin, p63, CD31, ERG and cytokeratins. The final diagnosis was atypical PASH. She is tumor-free on 12 months follow-up. The nature of atypical PASH remains unknown. Further studies are required for a clear definition, a new histological entity and diagnostic criteria.


Assuntos
Angiomatose/complicações , Angiomatose/patologia , Doenças Mamárias/complicações , Doenças Mamárias/patologia , Hiperplasia/complicações , Hiperplasia/patologia , Sarcoma/diagnóstico , Adulto , Biópsia com Agulha de Grande Calibre , Mama/patologia , Neoplasias da Mama , Feminino , Humanos , Pessoa de Meia-Idade , Miofibroblastos/patologia , Sarcoma/patologia , Sarcoma/cirurgia
20.
BMJ Case Rep ; 12(3)2019 Mar 08.
Artigo em Inglês | MEDLINE | ID: mdl-30852501

RESUMO

Parkes Weber syndrome (PWS) is a rare disorder characterised by arteriovenous (AV) fistula, along with capillary, lymphatic, venous malformations and limb hypertrophy. Stewart-Bluefarb syndrome is a variant of acroangiodermatitis, which is associated with congenital AV malformation/fistulas. It usually begins early in life, unilaterally over lower extremities presenting as violaceous to dusky coloured macules, papules or plaques with tendency to ulcerate. We are reporting a case of AV malformation fulfilling the triad of PWS and presenting with acroangiodermatitis.


Assuntos
Acrodermatite/etiologia , Angiomatose/etiologia , Fístula Arteriovenosa/etiologia , Malformações Arteriovenosas/etiologia , Síndrome de Sturge-Weber/complicações , Acrodermatite/patologia , Adolescente , Angiomatose/patologia , Fístula Arteriovenosa/patologia , Malformações Arteriovenosas/patologia , Humanos , Extremidade Inferior/irrigação sanguínea , Extremidade Inferior/patologia , Masculino
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