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1.
Med Lav ; 111(2): 126-132, 2020 Feb 27.
Artigo em Italiano | MEDLINE | ID: mdl-32352426

RESUMO

BACKGROUND: The Tuscan Regional Operating Center (ROC) of Malignant Mesotheliomas has identified a cluster of 11 cases of malignant mesothelioma occurred in a textile plant manufacturing sewing thread. Using the common research method, the ROC had not previously been able to identify the specific sources of asbestos exposure causing such a large cluster. OBJECTIVES: The ROC's objective was to review all cases of the cluster and to better identify their occupational asbestos exposures. METHODS: The cases' occupational histories of asbestos exposure have been reviewed, using information deriving from the annual reports sent to the Tuscany Region since 1988 by all the asbestos removal companies according to the Law no. 257/1992, article 9, and from interviews to former employees of the plant. RESULTS: The work cycle has been reconstructed and enriched with the new information about the asbestos presence and its uses in the plant. The eleven cases were all reclassified as "certainly occupational exposed" given that the new collected information depicted a widespread asbestos pollution of the workplace during the period of employment of all cases. CONCLUSIONS: Using different sources of information, in addition to those traditionally collected through questionnaires, to reconstruct past asbestos exposuresallowed us to clarify the existence of the cluster of mesothelioma cases and the highest level of occupational asbestos exposure was attributed to all cases with consequent activation of the medico-legal procedure.


Assuntos
Asbestos , Neoplasias Pulmonares , Mesotelioma , Exposição Ocupacional , Neoplasias Pleurais , Asbestos/toxicidade , Humanos , Neoplasias Pulmonares/epidemiologia , Mesotelioma/epidemiologia , Doenças Profissionais , Neoplasias Pleurais/epidemiologia
2.
Sci Total Environ ; 729: 138925, 2020 Aug 10.
Artigo em Inglês | MEDLINE | ID: mdl-32371204

RESUMO

Based on a large body of evidence asbestos minerals have been classified as carcinogens. Despite the Italian ban on asbestos in 1992 and the subsequent remediation activities, latent sources of contamination may still represent a hazard where asbestos were particularly used. Using wild rats as sentinel animals, this study aimed at uncovering sites with the greatest potential for non-occupational exposure to asbestos in the city of Casale Monferrato (Piedmont Region, Italy), where the largest Italian manufacturing plant of asbestos-cement had been active. During the study period (2013-2015) a total of 40 wild rats were captured from 16 sampling capture points. The lungs of wild rats have been investigated by using scanning electron microscopy (SEM) with energy dispersive spectroscopy (EDS). The SEM-EDS detected the presence of asbestos fibers (tremolite/actinolite, amosite, and chrysotile) in rats' lungs from 11 sampling points. The hypothetical rats' home-range and the observed site-specific concentration of asbestos fibers per gram of dry lung tissue were used to identify areas to be targeted by additional search of latent sources of asbestos. In conclusion, our results showed that the use of wild rats as sentinel animals may effectively integrate the strategies currently in use to reduce the exposure to asbestos.


Assuntos
Asbestos , Animais , Carcinógenos , Itália , Pulmão , Ratos
3.
Internist (Berl) ; 61(6): 626-633, 2020 Jun.
Artigo em Alemão | MEDLINE | ID: mdl-32328688

RESUMO

Rare work-related illnesses do not usually meet the requirements to be recognised and compensated as a legal occupational disease. However, common diseases (e.g. ovarian carcinoma) are sometimes caused by occupational influences (e.g. asbestos), making the occupational disease ovarian cancer caused by occupational exposure to asbestos a rare disease. Since in our modern working world the occupational influences that are harmful to health are decreasing qualitatively (substitutes) and quantitatively (limit values), the diseases they cause are also becoming increasingly rare.


Assuntos
Asbestos/efeitos adversos , Asbestose , Doenças Profissionais , Exposição Ocupacional , Neoplasias Ovarianas/induzido quimicamente , Feminino , Humanos , Doenças Raras
4.
Cancer Sci ; 111(6): 2016-2027, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32248600

RESUMO

Malignant mesothelioma (MM) is one of the most lethal tumors in humans. The onset of MM is linked to exposure to asbestos, which generates reactive oxygen species (ROS). ROS are believed to be derived from the frustrated phagocytosis and the iron in asbestos. To explore the pathogenesis of MM, peritoneal MM was induced in rats by the repeated intraperitoneal injection of iron saccharate and nitrilotriacetate. In the present study, we used microarray techniques to screen the microRNA (miR) expression profiles of these MM. We observed that the histological subtype impacted the hierarchical clustering of miR expression profiles and determined that miR-199/214 is a distinctive feature of iron saccharate-induced sarcomatoid mesothelioma (SM). Twist1, a transcriptional regulator of the epithelial-mesenchymal transition, has been shown to activate miR-199/214 transcription; thus, the expression level of Twist1 was examined in iron-induced and asbestos-induced mesotheliomas in rats. Twist1 was exclusively expressed in iron saccharate-induced SM but not in the epithelioid subtype. The Twist1-miR-199/214 axis is activated in iron saccharate-induced and asbestos-induced SM. The expression levels of miR-214 and Twist1 were correlated in an asbestos-induced MM cell line, suggesting that the Twist1-miR-199/214 axis is preserved. MeT5A, an immortalized human mesothelial cell line, was used for the functional analysis of miR. The overexpression of miR-199/214 promoted cellular proliferation, mobility and phosphorylation of Akt and ERK in MeT5A cells. These results indicate that miR-199/214 may affect the aggressive biological behavior of SM.


Assuntos
Neoplasias Pulmonares/patologia , Mesotelioma/patologia , MicroRNAs/biossíntese , Neoplasias Peritoneais/patologia , Proteína 1 Relacionada a Twist/biossíntese , Animais , Asbestos/toxicidade , Linhagem Celular , Regulação Neoplásica da Expressão Gênica/genética , Humanos , Ferro/toxicidade , Neoplasias Pulmonares/genética , Neoplasias Pulmonares/metabolismo , Mesotelioma/genética , Mesotelioma/metabolismo , Neoplasias Peritoneais/genética , Neoplasias Peritoneais/metabolismo , Ratos
5.
Waste Manag ; 106: 184-192, 2020 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-32229415

RESUMO

This paper presented a new method of preparing porous glass-ceramics by high-temperature pore-forming using coal fly ash and asbestos tailings as raw materials. The effects of the content of asbestos tailings and sintering temperature on the phase composition, microstructure and properties of the porous glass-ceramics had been systematically discussed, furthermore, the pore formation mechanism was also expounded. Compared with T0, porous glass-ceramics from T1, T2 and T3 experienced more violent self-expansion during the sintering process due to the addition of asbestos tailings. The porosity of porous glass-ceramics from T3 was 51%, the bulk density was 1.42 g/cm3, the flexure strength was 19 MPa, the main crystal phase was indialite, along with several secondary phases such as anorthite, enstatite, and forsterite. Due to the high strength, the material was expected to be used as a porous construction material with load-bearing function. This work provided a convenient and promising method for the utilization of coal fly ash and asbestos tailings to prepare porous glass-ceramics without adding foaming agents.


Assuntos
Asbestos , Cinza de Carvão , Cerâmica , Carvão Mineral , Porosidade , Temperatura
6.
Environ Pollut ; 263(Pt B): 114384, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32234644

RESUMO

The present investigation represents a new approach useful to evaluate the general population risk correlated with environmental exposure to air dispersed inorganic fibers. The used method is based on the evaluation of the respirable inorganic fibers both air dispersed in a big city and contained in lungs of the general population following their respiration. Moreover, these data allow to identify the sources of dispersion (anthropogenic or natural) in air of the inorganic fibers and therefore to apply strategies to improve air quality. To describe this approach, we investigated air samples from a big city in NW Italy and lung inorganic burden of people here lived. This paper reports the data of the airborne inorganic fibers detected in two sampling campaign (2014 and 2016), in 24 districts of Torino (Piemonte - NW Italy), and in some autoptic lungs of general population lived here. The airborne fibers (collected on mixed-cellulose esters membrane) were characterized by SEMEDS. The identified inorganic fiber species were assigned to 5 classes, one of these including 2 types of asbestos. These last are grouped as tremolite/actinolite asbestos. They are dispersed from natural sources (i.e. certain kinds of rocks outcropping in the city surrounding areas). In no-one of the 24 districts of Torino their concentration highlighted a situation of asbestos pollution in place. A correlation with inorganic fibers (collected on mixed-cellulose esters membrane and characterized by SEM-EDS) detected in lung tissue samples of 10 subjects lived in Torino all their life and without professional exposure to asbestos were attempted. The only types of fibers identified as asbestos are tremolite/actinolite asbestos, and they match those detected in air sampling. The number of fibers per 1 g of tissue dry weight is lower than the quantities reported as indicative of significant asbestos exposure. We observed interesting gender differences.


Assuntos
Poluição do Ar , Asbestos , Cidades , Humanos , Itália , Pulmão/química
7.
Am J Physiol Lung Cell Mol Physiol ; 318(5): L1084-L1096, 2020 05 01.
Artigo em Inglês | MEDLINE | ID: mdl-32209025

RESUMO

Alveolar epithelial cell (AEC) apoptosis, arising from mitochondrial dysfunction and mitophagy defects, is important in mediating idiopathic pulmonary fibrosis (IPF). Our group established a role for the mitochondrial (mt) DNA base excision repair enzyme, 8-oxoguanine-DNA glycosylase 1 (mtOGG1), in preventing oxidant-induced AEC mtDNA damage and apoptosis and showed that OGG1-deficient mice have increased lung fibrosis. Herein, we determined whether mice overexpressing the mtOGG1 transgene (mtOgg1tg) are protected against lung fibrosis and whether AEC mtOGG1 preservation of mtDNA integrity mitigates phosphatase and tensin homolog-induced putative kinase 1 (PINK1) deficiency and apoptosis. Compared with wild type (WT), mtOgg1tg mice have diminished asbestos- and bleomycin-induced pulmonary fibrosis that was accompanied by reduced lung and AEC mtDNA damage and apoptosis. Asbestos and H2O2 promote the MLE-12 cell PINK1 deficiency, as assessed by reductions in the expression of PINK1 mRNA and mitochondrial protein expression. Compared with WT, Pink1-knockout (Pink1-KO) mice are more susceptible to asbestos-induced lung fibrosis and have increased lung and alveolar type II (AT2) cell mtDNA damage and apoptosis. AT2 cells from Pink1-KO mice and PINK1-silenced (siRNA) MLE-12 cells have increased mtDNA damage that is augmented by oxidative stress. Interestingly, mtOGG1 overexpression attenuates oxidant-induced MLE-12 cell mtDNA damage and apoptosis despite PINK1 silencing. mtDNA damage is increased in the lungs of patients with IPF as compared with controls. Collectively, these findings suggest that mtOGG1 maintenance of AEC mtDNA is crucial for preventing PINK1 deficiency that promotes apoptosis and lung fibrosis. Given the key role of AEC apoptosis in pulmonary fibrosis, strategies aimed at preserving AT2 cell mtDNA integrity may be an innovative target.


Assuntos
Células Epiteliais Alveolares/efeitos dos fármacos , Asbestose/genética , DNA Glicosilases/genética , Pulmão/efeitos dos fármacos , Mitocôndrias/efeitos dos fármacos , Proteínas Quinases/genética , Fibrose Pulmonar/genética , Células Epiteliais Alveolares/metabolismo , Células Epiteliais Alveolares/patologia , Animais , Apoptose/efeitos dos fármacos , Apoptose/genética , Asbestos/administração & dosagem , Asbestose/etiologia , Asbestose/metabolismo , Asbestose/patologia , Bleomicina/administração & dosagem , Dano ao DNA , DNA Glicosilases/deficiência , DNA Mitocondrial/genética , DNA Mitocondrial/metabolismo , Feminino , Regulação da Expressão Gênica , Peróxido de Hidrogênio/farmacologia , Pulmão/metabolismo , Pulmão/patologia , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Transgênicos , Mitocôndrias/metabolismo , Cultura Primária de Células , Proteínas Quinases/metabolismo , Fibrose Pulmonar/induzido quimicamente , Fibrose Pulmonar/metabolismo , Fibrose Pulmonar/patologia , RNA Interferente Pequeno/genética , RNA Interferente Pequeno/metabolismo , Transdução de Sinais , Titânio/administração & dosagem
8.
Bull Cancer ; 107(4): 428-437, 2020 Apr.
Artigo em Francês | MEDLINE | ID: mdl-32204890

RESUMO

INTRODUCTION: An in-patient clinical service has been set up in March 2016 in the Occupational Diseases Center of Brest University Hospital, France, to seek for work-relatedness of diseases in patients hospitalized into the oncology and hematology departments. We present here data after two years of existence. METHODS: All cases of cancers or malignant hematological diseases (ICD-10 codes C00 to C97 and D37 to D48) seen between March 1, 2016, and March 1, 2018, have been identified. We present sociodemographic data, occupational exposures, occupation, business sector, and tobacco consumption. The causation level between the disease and each of the occupational exposures has been rated as strong, intermediate, weak or null by the occupational medicine specialist of the Occupational Diseases Center. RESULTS: Among the 196 patients encountered, there are 127 work-related diseases and 82 of these had one occupational exposure rated as strong or intermediate. The most frequent occupational hazards were asbestos (48 cases) and ionizing radiation (23 cases). The most frequent business sectors were metallurgy, mechanical engineering, and agriculture. Lung cancer was the most frequently reported disease (49 cases). DISCUSSION: . We identified well-known couples with occupational exposures and diseases, such as asbestos and lung cancer. We also identified a link between pesticides and leukemias. This in-patient clinical service is helpful to identify work-related exposures and in helping patients to get compensated.


Assuntos
Neoplasias/etiologia , Doenças Profissionais/etiologia , Exposição Ocupacional/efeitos adversos , Adulto , Idoso , Idoso de 80 Anos ou mais , Asbestos/toxicidade , Carcinógenos/toxicidade , Feminino , França , Hospitais Universitários , Humanos , Leucemia/induzido quimicamente , Neoplasias Pulmonares/etiologia , Linfoma/etiologia , Masculino , Pessoa de Meia-Idade , Mieloma Múltiplo/etiologia , Exposição Ocupacional/classificação , Serviços de Saúde do Trabalhador/organização & administração , Ocupações , Praguicidas/toxicidade , Exposição à Radiação/efeitos adversos , Radiação Ionizante , Neoplasias da Bexiga Urinária/etiologia , Adulto Jovem
9.
Artigo em Inglês | MEDLINE | ID: mdl-32213819

RESUMO

Thank you for the possibility of enabling us to provide a response to the comment on our paper "Environmental and Occupational Exposure to Asbestos as a Result of Consumption and Use in Poland" [...].


Assuntos
Asbestos , Exposição Ocupacional , Polônia , Saúde Pública
11.
13.
Waste Manag ; 105: 180-189, 2020 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-32070821

RESUMO

In the second half of the 20th century, asbestos extraction was up to 4 Mt/year. Due to its high strength and insulation properties, this mineral was used as an additive in building materials. Over time these materials were destroyed by the process of weathering and leaching. Asbestos fibers in dust form penetrate the respiratory system causing diseases. This article proposes the binding of hazardous asbestos fibers in a polymer matrix formed from waste cooking oil. Compact materials were produced by heating catalyzed waste cooking oil and asbestos waste, and the process of obtaining these materials was optimized and their physicochemical and strength properties were determined. Oil-asbestos blocks contained sulfuric acid in a mass ratio of 0.05-0.30, being the mass of waste cooking oil, invariable mass of filling and 20% of waste cooking oil to the mass of the whole mixture. The materials were characterized by a compact structure and high hardness. The best mechanical strength above 140 N/mm was obtained for blocks with low acid to oil mass ratio ranging from 0.05 to 0.1125.


Assuntos
Asbestos , Materiais de Construção , Culinária
14.
Cancer Sci ; 111(4): 1180-1192, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32080953

RESUMO

The onset of malignant mesothelioma (MM) is linked to exposure to asbestos fibers. Asbestos fibers are classified as serpentine (chrysotile) or amphibole, which includes the crocidolite, amosite, anthophyllite, tremolite, and actinolite types. Although few studies have been undertaken, anthophyllite has been shown to be associated with mesothelioma, and tremolite, a contaminant in talc and chrysotile, is a risk factor for carcinogenicity. Here, after characterizing the length and width of these fibers by scanning electron microscopy, we explored the cytotoxicity induced by tremolite and anthophyllite in cells from an immortalized human mesothelial cell line (MeT5A), murine macrophages (RAW264.7), and in a rat model. Tremolite and short anthophyllite fibers were phagocytosed and localized to vacuoles, whereas the long anthophyllite fibers were caught on the pseudopod of the MeT5A and Raw 264.7 cells, according to transmission electron microscopy. The results from a 2-day time-lapse study revealed that tremolite was engulfed and damaged the MeT5A and RAW264.7 cells, but anthophyllite was not cytotoxic to these cells. Intraperitoneal injection of tremolite in rats induced diffuse serosal thickening, whereas anthophyllite formed focal fibrosis and granulomas on peritoneal serosal surfaces. Furthermore, the loss of Cdkn2a/2b, which are the most frequently lost foci in human MM, were observed in 8 cases of rat MM (homozygous deletion [5/8] and loss of heterozygosity [3/8]) by array-based comparative genomic hybridization techniques. These results indicate that tremolite initiates mesothelial injury and persistently frustrates phagocytes, causing subsequent peritoneal fibrosis and MM. The possible mechanisms of carcinogenicity based on fiber diameter/length are discussed.


Assuntos
Asbestos/toxicidade , Inibidor de Quinase Dependente de Ciclina p15/genética , Inibidor p16 de Quinase Dependente de Ciclina/genética , Neoplasias Pulmonares/genética , Mesotelioma/genética , Animais , Amiantos Anfibólicos/toxicidade , Asbesto Crocidolita/toxicidade , Asbestos Serpentinas/toxicidade , Hibridização Genômica Comparativa , Homozigoto , Humanos , Neoplasias Pulmonares/induzido quimicamente , Neoplasias Pulmonares/patologia , Mesotelioma/induzido quimicamente , Mesotelioma/patologia , Ratos , Fatores de Risco , Deleção de Sequência/genética
15.
Occup Environ Med ; 77(3): 151-159, 2020 03.
Artigo em Inglês | MEDLINE | ID: mdl-32054819

RESUMO

OBJECTIVES: This study provides a detailed analysis of the global and regional burden of cancer due to occupational carcinogens from the Global Burden of Disease 2016 study. METHODS: The burden of cancer due to 14 International Agency for Research on Cancer Group 1 occupational carcinogens was estimated using the population attributable fraction, based on past population exposure prevalence and relative risks from the literature. The results were used to calculate attributable deaths and disability-adjusted life years (DALYs). RESULTS: There were an estimated 349 000 (95% Uncertainty Interval 269 000 to 427 000) deaths and 7.2 (5.8 to 8.6) million DALYs in 2016 due to exposure to the included occupational carcinogens-3.9% (3.2% to 4.6%) of all cancer deaths and 3.4% (2.7% to 4.0%) of all cancer DALYs; 79% of deaths were of males and 88% were of people aged 55 -79 years. Lung cancer accounted for 86% of the deaths, mesothelioma for 7.9% and laryngeal cancer for 2.1%. Asbestos was responsible for the largest number of deaths due to occupational carcinogens (63%); other important risk factors were secondhand smoke (14%), silica (14%) and diesel engine exhaust (5%). The highest mortality rates were in high-income regions, largely due to asbestos-related cancers, whereas in other regions cancer deaths from secondhand smoke, silica and diesel engine exhaust were more prominent. From 1990 to 2016, there was a decrease in the rate for deaths (-10%) and DALYs (-15%) due to exposure to occupational carcinogens. CONCLUSIONS: Work-related carcinogens are responsible for considerable disease burden worldwide. The results provide guidance for prevention and control initiatives.


Assuntos
Carga Global da Doença/estatística & dados numéricos , Carga Global da Doença/tendências , Expectativa de Vida , Neoplasias/epidemiologia , Exposição Ocupacional/estatística & dados numéricos , Adolescente , Adulto , Distribuição por Idade , Idoso , Idoso de 80 Anos ou mais , Asbestos/efeitos adversos , Carcinógenos , Pessoas com Deficiência/estatística & dados numéricos , Feminino , Saúde Global/estatística & dados numéricos , Saúde Global/tendências , Humanos , Neoplasias Pulmonares/mortalidade , Masculino , Mesotelioma , Pessoa de Meia-Idade , Neoplasias/mortalidade , Doenças Profissionais/epidemiologia , Exposição Ocupacional/efeitos adversos , Anos de Vida Ajustados por Qualidade de Vida , Medição de Risco , Fatores de Risco , Distribuição por Sexo , Fatores Socioeconômicos , Adulto Jovem
16.
BMJ Case Rep ; 13(1)2020 Jan 02.
Artigo em Inglês | MEDLINE | ID: mdl-31900296

RESUMO

Malignant mesothelioma is an uncommon form of neoplastic transformation of the mesothelial cells that line the serosal surfaces of the body. It most commonly affects the pleura and is often associated with pleural effusions and pleural-based masses. The annual incidence in the United States is only 3300 cases, representing less than 0.3% of all cancers worldwide, although this is likely underestimated. We present a case of diffuse epithelioid malignant pleural mesothelioma in a patient with remote, short-term asbestos exposure complicated by recurrent left-sided hydropneumothoraces and pleural-based invasion of the T12 vertebral body, which represent two rare coexisting complications. This case illustrates the importance of maintaining a broad differential for hydropneumothorax, particularly as the risk factors may be decades removed and the degree of asbestos exposure to induce a malignant mesothelioma may be smaller than has been traditionally thought.


Assuntos
Asbestos/efeitos adversos , Hidropneumotórax/cirurgia , Neoplasias Pulmonares/terapia , Mesotelioma/terapia , Neoplasias Pleurais/terapia , Neoplasias Torácicas/terapia , Idoso , Diagnóstico Diferencial , Humanos , Masculino , Invasividade Neoplásica , Neoplasias Torácicas/secundário
17.
Artigo em Inglês | MEDLINE | ID: mdl-31963324

RESUMO

Indonesia has limited data on asbestos-related diseases despite abundant use. This study investigated the risk of occupational asbestos exposure for lung cancer development, utilizing a hospital-based case-control study. Subjects were patients who received a thoracic CT scan at Persahabatan Hospital, Jakarta. The cases had primary lung cancer confirmed by histology, the controls were negative for lung cancer. The cumulative occupational asbestos exposure was calculated by multiplying the exposure intensity by the years of exposure. The exposure intensity was obtained by adopting the weighted arithmetic mean value of asbestos exposure from a job-exposure matrix developed in Korea. The primary data analysis was based on logistic regression. The study included 696 subjects, with 336 cases and 360 controls. The chance of lung cancer for subjects exposed to asbestos was doubled (OR = 2.04, 95% CI = 1.21-3.42) compared with unexposed, and subjects with a cumulative asbestos exposure of 10 fiber-years or more even showed an OR of 3.08 (95% CI = 1.01-9.46). The OR of the combined effect between smoking and asbestos was 8.7 (95% CI = 1.71-44.39); the interaction was consistent with an additive and multiplicative risk model. Asbestos exposure is associated with a higher chance of lung cancer. Improved policies are needed to protect the population from asbestos hazards.


Assuntos
Asbestos/toxicidade , Neoplasias Pulmonares/induzido quimicamente , Neoplasias Pulmonares/epidemiologia , Exposição Ocupacional/estatística & dados numéricos , Adulto , Estudos de Casos e Controles , Feminino , Hospitais , Humanos , Indonésia/epidemiologia , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Fatores de Risco , Fumar Tabaco , Tomografia Computadorizada por Raios X
18.
Am J Respir Crit Care Med ; 201(1): 57-62, 2020 01 01.
Artigo em Inglês | MEDLINE | ID: mdl-31433952

RESUMO

Rationale: Asbestos exposure is associated with a dose-dependent risk of lung cancer. The association between lung cancer and the presence of pleural plaques remains controversial.Objectives: To define the relationship between pleural plaques and lung cancer risk.Methods: Subjects were from two cohorts: 1) crocidolite mine and mill workers and Wittenoom Township residents and 2) a mixed-asbestos-fiber, mixed-occupation group. All subjects underwent annual review since 1990, chest X-ray or low-dose computed tomography scan, and outcome linkage to national cancer and mortality registry data. Cox regression, with adjustment for age (as the underlying matching time variable), was used to estimate hazard ratios (HRs) for lung cancer incidence by sex, tobacco smoking, asbestos exposure, presence of asbestosis, and pleural plaques.Measurements and Main Results: For all 4,240 subjects, mean age at follow up was 65.4 years, 3,486 (82.0%) were male, 1,315 (31.0%) had pleural plaques, and 1,353 (32.0%) had radiographic asbestosis. Overall, 3,042 (71.7%) were ever-smokers with mean tobacco exposure of 33 pack-years. In total, 200 lung cancers were recorded. Risk of lung cancer increased with cumulative exposure to cigarettes, asbestos, and presence of asbestosis. Pleural plaques did not confer any additional lung cancer risk in either cohort (cohort 1: HR, 1.03; 95% confidence interval, 0.64-1.67; P = 0.89; cohort 2: HR, 0.75; 95% confidence interval, 0.45-1.25; P = 0.28).Conclusions: The presence of pleural plaques on radiologic imaging does not confer additional increase in the risk of lung cancer. This result is consistent across two cohorts with differing asbestos fiber exposures and intensity.


Assuntos
Asbestos/efeitos adversos , Asbestose/fisiopatologia , Neoplasias Pulmonares/fisiopatologia , Exposição Ocupacional/efeitos adversos , Doenças Pleurais/fisiopatologia , Adulto , Asbestose/epidemiologia , Estudos de Coortes , Feminino , Humanos , Incidência , Neoplasias Pulmonares/epidemiologia , Masculino , Pessoa de Meia-Idade , Doenças Pleurais/epidemiologia , Modelos de Riscos Proporcionais , Fatores de Risco
20.
Am J Surg Pathol ; 44(3): 293-304, 2020 03.
Artigo em Inglês | MEDLINE | ID: mdl-31876584

RESUMO

We reviewed 354 cases of malignant diffuse mesothelioma (MM) in women from a database of 2858 histologically confirmed MM cases. There was a pleural predominance with 78% pleural MM and 22% peritoneal MM. The pleural tumors consisted of 72% epithelioid, 19% biphasic, and 9% sarcomatoid variant. The peritoneal tumors consisted of 82% epithelioid, 13% biphasic, and 5% sarcomatoid. The immunohistochemical profile was typical of what is well-accepted and previously described for MM. When examining tumor subtype and location, there was a trend toward epithelioid subtype and peritoneal location; however, this did not reach statistical significance. Age at the time of diagnosis ranged from 19 to 93 years with a mean of 60 years. The median age at time of diagnosis for pleural MM was 65 years and for peritoneal MM was 52 years. A further look at age and histologic subtype showed no statistically significant difference in age between MM subtypes. Survival was greatest for epithelioid variant, and this was magnified in the peritoneum. A majority of our cases were exposed to asbestos through a household contact. Asbestosis and parietal pleural plaque were present in 5% and 50% of cases with data, respectively. Fiber analysis data was available in 67 cases; 38 cases had elevated asbestos fiber burden, and tremolite was the most common asbestos fiber type detected. Commercial and noncommercial amphibole asbestos fibers were elevated in nearly equal numbers of cases.


Assuntos
Neoplasias Pulmonares/patologia , Mesotelioma/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Asbestos/toxicidade , Carcinógenos/toxicidade , Bases de Dados Factuais , Exposição Ambiental/efeitos adversos , Feminino , Humanos , Neoplasias Pulmonares/induzido quimicamente , Neoplasias Pulmonares/diagnóstico , Neoplasias Pulmonares/mortalidade , Mesotelioma/induzido quimicamente , Mesotelioma/diagnóstico , Mesotelioma/mortalidade , Pessoa de Meia-Idade , Prognóstico , Análise de Sobrevida , Estados Unidos/epidemiologia
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