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1.
J Pharm Sci ; 107(1): 273-285, 2018 01.
Artigo em Inglês | MEDLINE | ID: mdl-29045887

RESUMO

The antibiotics family of sulfonamides has been used worldwide intensively in human therapeutics and farm livestock during decades. Intermolecular interactions of these sulfamides are important to understand their bioactivity and biodegradation. These interactions are also responsible for their supramolecular structures. The intermolecular interactions in the crystal polymorphs of the sulfonamides, sulfamethoxypyridazine, and sulfamethoxydiazine, as models of sulfonamides, have been studied by using quantum mechanical calculations. Different conformations in the sulphonamide molecules have been detected in the crystal polymorphs. Several intermolecular patterns have been studied to understand the molecular packing behavior in these antibiotics. Strong intermolecular hydrogen bonds and π-π interactions are the main driving forces for crystal packing in these sulfonamides. Different stability between polymorphs can explain the experimental behavior of these crystal forms. The calculated infrared spectroscopy frequencies explain the main intermolecular interactions in these crystals.


Assuntos
Sulfonamidas/química , Antibacterianos/química , Cristalização/métodos , Cristalografia por Raios X/métodos , Ligação de Hidrogênio , Modelos Moleculares , Conformação Molecular , Teoria Quântica , Análise Espectral/métodos , Sulfameter/química , Sulfametoxipiridazina/química , Sulfanilamida , Sulfanilamidas/química
2.
Environ Sci Pollut Res Int ; 23(19): 19921-30, 2016 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-27424205

RESUMO

Sulfonamide antibiotics (SAs) have been observed to undergo direct and indirect photodegradation in natural water environments. In this study, the density functional theory (DFT) method was employed for the study of direct and indirect photodegradation mechanisms of sulfameter (SME) with excited triplet states of dissolved organic matter ((3)DOM(*)) and metal ions. SME was adopted as a representative of SAs, and SO2 extrusion product was obtained with different energy paths in the triplet-sensitized photodegradation of the neutral (SME(0)) and the anionic (SME(-)) form of SME. The selected divalent metal ions (Ca(2+), Mg(2+), and Zn(2+)) promoted the triplet-sensitized photodegradation of SME(0) but showed an inhibitory effect in triplet-sensitized photodegradation of SME(-). The triplet-sensitized indirect photodegradation mechanism of SME was investigated with the three DOM analogues, i.e., 2-acetonaphthone (2-AN), fluorenone (FN), and thioxanthone (TN). Results indicated that the selected DOM analogues are highly responsible for the photodegradation via attacking on amine moiety of SME. According to the natural bond orbital (NBO) analysis, the triplet-sensitized photodegradation mechanism of SME(0) with 2-AN, FN, and TN was H-transfer, and the SME(-) was proton plus electron transfer with these DOM analogues.


Assuntos
Fotólise , Sulfameter , Poluentes Químicos da Água , Purificação da Água/métodos , Metais Pesados/química , Sulfameter/análise , Sulfameter/química , Sulfameter/efeitos da radiação , Poluentes Químicos da Água/análise , Poluentes Químicos da Água/química , Poluentes Químicos da Água/efeitos da radiação
3.
Food Chem ; 212: 635-40, 2016 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-27374578

RESUMO

This research aimed to monitor the concentrations of sulfamethoxydiazine (SMD), sulfamethazine (SMT), sulfamethoxazole (SMX) and sulfadiazine (SDZ) in imported Pangasius catfish products in Thailand. The residues of the four sulfonamides (SAs) were analyzed by extraction process and liquid chromatography coupled with tandem mass spectrometry. The highest concentrations found were 10.97ng/g for SMD, 6.23ng/g for SMT, 11.13ng/g for SDZ and 245.91ng/g for SMX, which was higher than the European Union (EU) standard (100ng/g). Moreover, all samples contaminated with SMX also contained SMT, indicating that more than one antibiotic was used for production in the country of origin. Because Thai standards for antibiotics in food have not been completely set, all contaminated discovered would not be considered to be an illegal food, in which antibiotic residues may affect human health in the long term. Therefore, antibiotic residues in Pangasius catfish products should be continually regulated and monitored.


Assuntos
Antibacterianos/análise , Produtos Pesqueiros/análise , Contaminação de Alimentos/análise , Análise de Perigos e Pontos Críticos de Controle/métodos , Sulfonamidas/análise , Espectrometria de Massas em Tandem/métodos , Animais , Peixes-Gato , Cromatografia Líquida/métodos , Sulfadiazina/análise , Sulfameter/análise , Sulfametazina/análise , Sulfametoxazol/análise , Tailândia
4.
Acta Crystallogr C Struct Chem ; 71(Pt 11): 944-53, 2015 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-26524165

RESUMO

The ability of the antibacterial agent sulfameter (SMT) to form solvates is investigated. The X-ray crystal structures of sulfameter solvates have been determined to be conformational polymorphs. Both 1,4-dioxane and tetrahydrofuran form solvates with sulfameter in a 1:1 molar ratio. 4-Amino-N-(5-methoxypyrimidin-2-yl)benzenesulfonamide (polymorph III), C11H12N4O3S, (1), has two molecules of sulfameter in the asymmetric unit cell. 4-Amino-N-(5-methoxypyrimidin-2-yl)benzenesulfonamide 1,4-dioxane monosolvate, C11H12N4O3S·C4H8O2, (2), and 4-amino-N-(5-methoxypyrimidin-2-yl)benzenesulfonamide tetrahydrofuran monosolvate, C11H12N4O3S·C4H8O, (3), crystallize in the imide form. Hirshfeld surface analyses and fingerprint analyses were performed to study the nature of the interactions and their quantitative contributions towards the crystal packing. Finally, Hirshfeld surfaces, fingerprint plots and structural overlays were employed for a comparison of the two independent molecules in the asymmetric unit of (1), and also for a comparison of (2) and (3) in the monoclinic crystal system. A three-dimensional hydrogen-bonding network exists in all three structures, involving one of the sulfone O atoms and the aniline N atom. All three structures are stabilized by strong intermolecular N-H···N interactions. The tetrahydrofuran solvent molecule also takes part in forming significant intermolecular C-H···O interactions in the crystal structure of (3), contributing to the stability of the crystal packing.


Assuntos
Antibacterianos/análise , Dioxanos/química , Furanos/química , Sulfameter/análise , Sulfonamidas/química , Antibacterianos/química , Cristalografia por Raios X , Ligação de Hidrogênio , Modelos Moleculares , Conformação Molecular , Sulfameter/química
5.
Talanta ; 123: 63-70, 2014 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-24725865

RESUMO

A novel porous molecularly imprinted monolithic capillary column (MIMCC) based on ternary porogen was synthesized by in situ technique with sulfaquinoxaline as the template molecule. The characteristics of the MIMCC were investigated by scanning electron microscopy, infrared spectrum, thermogravimetric analysis and solvent resistance test. The saturated adsorption amount of sulfaquinoxaline on MIMCC was 2.7 times over that on the non-imprinted monolithic capillary column (NIMCC). The MIMCC also exhibited good enrichment ability to its analogs and the enrichment factors were 46-211 for five antimicrobials. High permeability and imprinting factors as well as good stability, reproducibility and long lifetime were obtained. An on-line method based on MIMCC solid-phase microextraction coupled with high-performance liquid chromatography was developed for the determination of trace antimicrobials in complex samples. The good linearity for sulfametoxydiazine, sulamethoxazole and sulfaquinoxaline was 0.05-10 µg/L, the limits of detection (LODs) were 10.0-14.0 ng/L. The linear range for mequindox and quinocetone were 0.10-10.0 µg/L, the LODs were 20.0-27.0 ng/L respectively. The recoveries were 71.0-108.2% with relative standard deviation of 1.6-8.5%, correspondingly. The results showed that MIMCC could effectively enrich antimicrobials from complex matrices. The on-line method based on MIMCC and HPLC was selective, sensitive and convenient for trace determination of antimicrobials in complex samples.


Assuntos
Anti-Infecciosos/análise , Cromatografia Líquida de Alta Pressão/métodos , Análise de Alimentos/métodos , Extração em Fase Sólida/métodos , Animais , Anti-Infecciosos/química , Anti-Infecciosos/isolamento & purificação , Galinhas , Cromatografia Líquida de Alta Pressão/instrumentação , Ovos/análise , Carne/análise , Metacrilatos/química , Microscopia Eletrônica de Varredura , Impressão Molecular , Estrutura Molecular , Porosidade , Quinoxalinas/análise , Quinoxalinas/química , Quinoxalinas/isolamento & purificação , Reprodutibilidade dos Testes , Dióxido de Silício/química , Solventes/química , Espectrofotometria Infravermelho , Sulfameter/análise , Sulfameter/química , Sulfameter/isolamento & purificação , Sulfaquinoxalina/análise , Sulfaquinoxalina/química , Sulfaquinoxalina/isolamento & purificação , Suínos , Termogravimetria
6.
Spectrochim Acta A Mol Biomol Spectrosc ; 81(1): 544-7, 2011 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-21795101

RESUMO

Sulfamethoxydiazine (SMD), which is often used for animal disease treatment, is harmful to human health. No SMD residue should be detected in food in some countries, such as USA and Japan. Therefore, it is significant to develop a high-throughput, high-sensitivity and accurate method for the determination of the content of SMD in food. In this paper, chemiluminescence enzyme immunoassay (CLEIA) was developed for quantification of SMD. For this method, the limit of detection was 3.2 pg/ml, the linear range was from 10 to 2000 pg/ml, the within-day and inter-day precision were below 13% and below 18%, respectively, and the recovery was from 85% to 105%. Milk and egg were selected as samples to be examined with this method, and the result indicated that this CLEIA method was suitable for screening and quality control of food.


Assuntos
Medições Luminescentes/métodos , Sulfameter/análise , Animais , Anti-Infecciosos/análise , Calibragem , Ovos/análise , Análise de Alimentos/métodos , Contaminação de Alimentos/análise , Ensaios de Triagem em Larga Escala/métodos , Ensaios de Triagem em Larga Escala/normas , Humanos , Técnicas Imunoenzimáticas/métodos , Técnicas Imunoenzimáticas/normas , Limite de Detecção , Medições Luminescentes/normas , Leite/química , Sensibilidade e Especificidade
7.
Drug Test Anal ; 3(5): 300-5, 2011 May.
Artigo em Inglês | MEDLINE | ID: mdl-21287695

RESUMO

A novel chemiluminescence (CL) quenching method for the determination of sulfonamides is proposed. The CL reaction between Ag(III) complex [Ag(HIO6)2]5⁻ and luminol in alkaline solution was investigated. The quenching effect of sulfonamides on CL emission of [Ag(HIO6)2]5⁻-luminol system was found. Quenching degree of CL emission was proportional to sulfonamide concentration. The effects of the reaction conditions on CL emission and quenching were examined. Under optimal conditions, the detection limits (s/n = 3) were 7.2, 17 and 8.3 ng/mL for sulfadiazine, sulfameter, and sulfadimethoxine, respectively. The recoveries of the three drugs were in the range of 91.3-110% with RSDs of 1.9-2.7% for urine samples, and 106-112% with RSDs of 1.6-2.8% for serum samples. The proposed method was used for the determination of sulfadiazine at clinically relevant concentrations in real urine and serum samples with satisfactory results.


Assuntos
Medições Luminescentes/métodos , Sulfadiazina/análise , Sulfadimetoxina/análise , Sulfameter/análise , Anti-Infecciosos/análise , Anti-Infecciosos/sangue , Anti-Infecciosos/urina , Humanos , Luminol/química , Prata/química , Sulfadiazina/sangue , Sulfadiazina/urina , Sulfadimetoxina/sangue , Sulfadimetoxina/urina , Sulfameter/sangue , Sulfameter/urina
8.
J Pharm Sci ; 97(6): 2160-75, 2008 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-17975809

RESUMO

Solvates are often encountered in pharmaceutical solids and knowledge of their physical stability is necessary for their effective formulation. This work investigates the solid-state stability of five structurally related solvates of sulfameter (5-methoxysulfadiazine) by studying the kinetics of their desolvation reaction with thermogravimetric analysis, both isothermally and nonisothermally. Desolvation kinetic analysis was done isothermally by conventional model-fitting and nonisothermally by the complementary method. Calculated kinetic parameters (model, A and E(a)) were compared and related to the crystal structure of these solvates. A relationship was established between desolvation activation energy from isothermal results and solvent size; the larger the solvent molecule, the higher its solvate's desolvation activation energy. The best fitting solid-state reaction model correlated to single crystal structural features of sulfameter-solvates where solvent molecules occupied cavities in the unit cell. Finally, it was found that kinetic parameters obtained isothermally and nonisothermally were at variance. Therefore, kinetic results obtained from one method may not be extended to results form the other.


Assuntos
Anti-Infecciosos Urinários/química , Sulfameter/química , Química Farmacêutica , Cristalização , Estabilidade de Medicamentos , Cinética , Modelos Químicos , Solubilidade , Tecnologia Farmacêutica/métodos , Termogravimetria
9.
Se Pu ; 23(4): 397-400, 2005 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-16250451

RESUMO

The presence of sulfonamide (SA) residues in foods is largely due to the raising of animals with sulfonamide antibiotics added or polluted feedstuff. Because of interference from the matrices, the commonly used immunoassay or chromatographic method is not suitable for the analysis of multi-SAs in feedstuff. A high performance liquid chromatographic-electrospray tandem mass spectrometric (HPLC/ESI-MS-MS) method has been established for the simultaneous determination of multi-SAs including sulfadiazine (SD), sulfapyridine (SPD), sulfamerazine (SM1), sulfameter (SM), sulfamethazine (SM2), sulfamethoxypyridazine (SMP), sulfamethoxazole (SMZ), sulfamonomethoxine (SMM), sulfadimethoxine (SDM) and sulfaquinoxaline (SQX). After solvent extraction, solid phase extraction, dilution and reversed-phase HPLC separation, SAs were detected by ESI-MS-MS under multi-reaction monitoring mode. The qualification analysis was done by using retention time and distribution of diagnostic ion pairs, and the quantification was based on the peak intensity of common fragment ion m/z 156. The limits of quantification for 10 SAs were 0.5 - 2.0 microg/kg (S/N = 10). The correlation coefficient of linear calibration curve was over 0.9995 within the SAs concentration range 2.0 - 200 microg/L except for SDM and SQX. At the spiked level of 1.0 mg/kg, the average recoveries for the 10 SAs were between 70% and 92%, the relative standard deviations were under 10% for intra-day and under 15% for inter-day. Routine tests showed the method was fast, sensitive, specific, and practical for the SAs determination in feedstuff.


Assuntos
Ração Animal/análise , Cromatografia Líquida de Alta Pressão/métodos , Sulfonamidas/análise , Sulfonamidas/química , Espectrometria de Massas em Tandem/métodos , Animais , Espectrometria de Massas por Ionização por Electrospray , Sulfadimetoxina/análise , Sulfadimetoxina/química , Sulfameter/análise , Sulfameter/química , Sulfametazina/análise , Sulfametazina/química , Sulfametoxazol/análise , Sulfametoxazol/química , Sulfametoxipiridazina/análise , Sulfametoxipiridazina/química , Sulfamonometoxina/análise , Sulfamonometoxina/química , Sulfapiridina/análise , Sulfapiridina/química , Sulfaquinoxalina/análise , Sulfaquinoxalina/química
10.
Vet Q ; 16(1): 33-7, 1994 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-8009816

RESUMO

To get a better insight into the oral bioavailability of sulphonamides in ruminants, sulphamethoxydiazine (pKa 7.0), sulphathiazole (pKa 7.2), and sulphamoxole (pKa 7.4) were administered to dwarf goats (n = 5). The drugs were given at 2-week intervals by the intravenous or intraruminal route at a dose of 100 mg per kg body weight. After IV injection, the mean half-life (t1/2 beta in h +/- SEM) was 0.80 +/- 0.10 h, 2.35 +/- 0.38 h, and 3.36 +/- 1.25 h, for sulphathiazole, sulphamoxole, and sulphamethoxydiazine, respectively and the mean distribution volume (Vd beta) was 0.23 +/- 0.05 l/kg, 0.23 +/- 0.04 l/kg, and 0.33 +/- 0.02 l/kg. After intraruminal administration, the mean bioavailability varied from 86.0 +/- 11.8% for sulphamethoxydiazine to 46.6 +/- 4.3% for sulphamoxole, and 52.6 +/- 7.2% for sulphathiazole. The elimination half-life was significantly prolonged, probably due to a low rate of drug absorption from the gastrointestinal tract. In contrast to chloramphenicol, the sulphonamides studied were stable when incubated in rumen fluid at 39 degrees C.


Assuntos
Cabras/metabolismo , Sulfameter/farmacocinética , Sulfamoxol/farmacocinética , Sulfatiazóis/farmacocinética , Administração Oral , Animais , Disponibilidade Biológica , Esquema de Medicação , Feminino , Meia-Vida , Injeções Intravenosas/veterinária , Absorção Intestinal , Intubação Gastrointestinal/veterinária , Masculino , Taxa de Depuração Metabólica , Rúmen , Sulfameter/administração & dosagem , Sulfamoxol/administração & dosagem , Sulfatiazol , Sulfatiazóis/administração & dosagem
11.
Rev Med Chir Soc Med Nat Iasi ; 96(1-2): 57-64, 1992.
Artigo em Romano | MEDLINE | ID: mdl-1410926

RESUMO

Cicatrol ointment with the formula: argentic sulphamethoxydiasine 1 g, bentonite hydrogel 12.5% for 100 g is manufactured at the Microproduction Laboratory of the Faculty of Pharmacy of Iasi. The one-year physicochemical determinations of the aspect, colour, homogeneity, pH, rheological behaviour and relative viscosity, content in argentic sulphamethoxydiasine as well as "in vitro" antimicrobial activity of Cicatrol showed a good stability and gel properties enabling an uniform and long-term contact with the wound. The clinical investigations carried out until now in patients with burns, varicose ulcers, trophic shank ulcers, superficial phlebitis with atonic ulcerations or wounds with multiple sites revealed its remarkable therapeutic value. As compared to other similar products, Cicatrol by its aseptic properties favours the scarring of any type of wound, a normal skin, without keloid scars being obtained, it also being well tolerated.


Assuntos
Ácido Pantotênico/química , Sulfameter/química , Queimaduras/tratamento farmacológico , Carboximetilcelulose Sódica , Fenômenos Químicos , Físico-Química , Combinação de Medicamentos , Avaliação de Medicamentos , Estabilidade de Medicamentos , Glicerol , Humanos , Concentração de Íons de Hidrogênio , Úlcera da Perna/tratamento farmacológico , Testes de Sensibilidade Microbiana , Pomadas , Ácido Pantotênico/farmacologia , Ácido Pantotênico/uso terapêutico , Compostos de Prata , Sulfameter/farmacologia , Sulfameter/uso terapêutico , Úlcera Varicosa/tratamento farmacológico , Viscosidade
13.
Arch Gynecol Obstet ; 247(4): 215-7, 1990.
Artigo em Inglês | MEDLINE | ID: mdl-2221996

RESUMO

This is a report of a pregnant woman who became pancytopenic in the second trimester following pyrimethamine administration. The patient recovered on steroid, antibiotics, transfusion, folic acid and folinic acid therapy, and the pregnancy was uneventful afterwards. The patient was delivered of a healthy term-infant.


Assuntos
Pancitopenia/induzido quimicamente , Complicações Hematológicas na Gravidez/induzido quimicamente , Complicações Infecciosas na Gravidez/tratamento farmacológico , Pirimetamina/efeitos adversos , Sulfameter/efeitos adversos , Toxoplasmose/tratamento farmacológico , Adulto , Quimioterapia Combinada , Feminino , Humanos , Recém-Nascido , Masculino , Gravidez , Pirimetamina/administração & dosagem , Sulfameter/administração & dosagem
15.
Biochem Med Metab Biol ; 39(2): 158-67, 1988 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-3132187

RESUMO

The interactions of aflatoxin B1 (AFB1) with vitamin K, phenylbutazone, and sulfamethoxine were investigated in albino rats. Vitamin K (5 mg/kg) was able to completely suppress the increase in whole blood clotting time caused by AFB1 (25 micrograms/kg). Phenylbutazone (50 mg/kg) and sulfamethoxine (50 mg/kg) also significantly (P less than 0.05) lowered the increased clotting time caused by AFB1. Equilibrium dialysis was performed on rat plasma (4 mg/ml protein content) to investigate the displacement of AFB1 (3 micrograms) from its bound form by vitamin K (250 micrograms), phenylbutazone (2500 micrograms), and sulfamethoxine (2500 micrograms). Phenylbutazone and sulfamethoxine significantly (P less than 0.05) displaced AFB1 from rat plasma protein. Histopathological examinations performed on the liver, kidneys, and spleen of control and treated rats showed that none of the drugs used appeared to offer any significant organ protection against AFB1 except in the spleen.


Assuntos
Aflatoxinas/metabolismo , Fenilbutazona/metabolismo , Sulfameter/metabolismo , Sulfanilamidas/metabolismo , Vitamina K/metabolismo , Aflatoxina B1 , Aflatoxinas/farmacologia , Animais , Coagulação Sanguínea/efeitos dos fármacos , Proteínas de Transporte/metabolismo , Interações Medicamentosas , Feminino , Masculino , Fenilbutazona/farmacologia , Ratos , Sulfameter/farmacologia , Vitamina K/farmacologia
16.
Pharmazie ; 42(8): 511-3, 1987 Aug.
Artigo em Alemão | MEDLINE | ID: mdl-3432328

RESUMO

The stability of sulphamethoxydiazine (1) in HCl (1 mol/l) under elevated temperature was investigated. Isolated decomposition products further served as standards for the selection of HPLC conditions. Three types of stationary phases were tested: Pragosil 5, MicroPak CN-10, MicroPak CH-10. The selection of mobile phases was made in such a way as to be able to inject 1 hydrolysate in HCl (1 mol/l) directly or after simple dilution. Detection was performed with an UV detector at the wavelength of 226 nm. A column packed with MicroPak CN-10 was selected to investigate the process of 1 decomposition. The method made it possible to quantify 1 in the course of hydrolysis and to illustrate the process of decomposition. On the basis of continuous examination of the development of decomposition products during the stability study it was possible to consider the chemism of the decomposition reaction.


Assuntos
Sulfameter/análise , Sulfanilamidas/análise , Cromatografia Líquida de Alta Pressão , Estabilidade de Medicamentos , Hidrólise , Espectrofotometria Ultravioleta , Sulfameter/isolamento & purificação
17.
Czech Med ; 9(3): 157-61, 1986.
Artigo em Inglês | MEDLINE | ID: mdl-3095075

RESUMO

Internal distribution of 2-sulphanilamido-5-methoxypyrimidine (SM) 100 mg/kg in rats is characterized by a corticopapillary gradient. The papilla/cortex ratio of SM concentration averaged 2.25 +/- 0.34. Furosemide (5 mg/kg) elicited a significant corticopapillary gradient decrease for SM. Corticopapillary gradients for SM and sodium showed a positive correlation (r = 0.45; p less than 0.001). After furosemide corticopapillary gradient for SM averaged 1.4 +/- 0.22. Unilateral nephrectomy alone induced no significant difference in the corticopapillary gradient for SM compared with controls. Corticopapillary gradient for SM was significantly lower in unilaterally nephrectomized rats than in controls when furosemide was given after 24 hours or 7 or 14 days. The results suggest that SM concentration was significantly higher in the medulla than in the cortex; furosemide led to a significant decrease of corticopapillary gradient for SM against controls; the corticopapillary gradient for SM did not significantly change after unilateral nephrectomy; the effect of furosemide on corticopapillary gradient for SM was more pronounced in rats after unilateral nephrectomy than in controls.


Assuntos
Furosemida/farmacologia , Rim/metabolismo , Sulfameter/metabolismo , Sulfanilamidas/metabolismo , Animais , Rim/efeitos dos fármacos , Masculino , Nefrectomia , Ratos , Ratos Endogâmicos , Sódio/metabolismo
19.
Hepatogastroenterology ; 31(5): 199-200, 1984 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-6510880

RESUMO

Two cases of severe sulfonamide liver injury are described. In one patient, fulminant liver failure developed after two days of taking sulfamethoxazole-trimethoprim. The patient was treated with resin hemoperfusion and recovered completely. Another patient became jaundiced after using sulfamethoxydiazine for ten days. Very severe intrahepatic cholestasis developed and cleared up only after high-dose prednison treatment. Marked hyperbilirubinemia persisted for four months and aminotransferase activity had not normalized ten months after the onset of the disease.


Assuntos
Doença Hepática Induzida por Substâncias e Drogas , Sulfameter/efeitos adversos , Sulfanilamidas/efeitos adversos , Combinação Trimetoprima e Sulfametoxazol/efeitos adversos , Trimetoprima/efeitos adversos , Adulto , Anti-Infecciosos Urinários/efeitos adversos , Combinação de Medicamentos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
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