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1.
Complement Ther Med ; 46: 217-222, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31519282

RESUMO

Chromotherapy is a method of treatment that uses wavelengths in the visible region for curing different diseases and medical conditions. Recent advances in photobiology and the speciality of Photobiomodulation are uncovering the cellular and molecular effects of visible range electromagnetic radiation. We discuss the reported effects of visible range radiation on cells (in vitro and in vivo) and the attempted explanations of the underlying processes with regard to therapeutic effects. Some of the important advances in this area are reviewed, especially the effects of visible light on bacteria, enzymes and the use of visible light for wound healing and treatment of psychiatric diseases for the purpose of explaining the therapeutic implications of chromotherapy. We highlight the correlation of wavelengths used between recently uncovered mechanisms of photobiology and conventional chromotherapy. The elucidation of mechanisms of the cellular and molecular interaction of light will help in deciphering the scientific background of chromotherapy and will help in the application of this alternative therapeutic treatment to many other diseases.


Assuntos
Cromoterapia/métodos , Animais , Humanos , Luz , Transtornos Mentais/terapia , Radioterapia/métodos , Cicatrização/efeitos dos fármacos
2.
Trials ; 20(1): 472, 2019 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-31370871

RESUMO

BACKGROUND: There is increasing recognition of the need to stabilize sleep-wake cycles in individuals with major mental disorders. As such, clinicians and researchers advocate the use of interventions targeted at sleep and circadian dysrhythmias as an adjunct to the standard treatments offered for acute illness episodes of a broad range of diagnoses. To determine the trans-diagnostic generalizability of chronotherapy, we explore the benefits of admitting individuals with an acute illness episode to a psychiatric inpatient unit where changes in light exposure are integrated into the therapeutic environment. METHODS/DESIGN: A two-arm, pragmatic effectiveness, randomized controlled treatment trial, where individuals admitted for acute inpatient psychiatric care will be allocated to a ward with blue-depleted evening light or to a ward with the same layout and facilities but lacking the new lighting technology. The trial will test whether the experimental lighting conditions offer any additional benefits beyond those associated with usual treatment in an acute psychiatric inpatient unit. The main objectives are to examine any differences between groups in the mean duration of hospitalization in days. Additional analyses will compare group differences in symptoms, functioning, medication usage, and side effects and whether length of stay is associated with stability of sleep-wake cycles and circadian rhythms. Ancillary investigations should determine any benefits according to diagnostic subgroups and potential drawbacks such as any adverse effects on the well-being of professionals working across both wards. DISCUSSION: This unit offers a unique opportunity to explore how exposure to different lighting conditions may modify sleep-wake cycles and how any changes in sleep-wake cycle may impact on the clinical and functional outcomes of individuals experiencing an acute episode of a severe mental disorder that requires inpatient care. The findings could influence the future design of hospital units offering care to patients with mental or physical disorders. TRIAL REGISTRATION: ClinicalTrials.gov, ID: NCT03788993 . Retrospectively registered on 28 December 2018.


Assuntos
Cronoterapia , Cromoterapia , Iluminação , Transtornos Mentais/terapia , Quartos de Pacientes , Sono , Doença Aguda , Cronoterapia/efeitos adversos , Cromoterapia/efeitos adversos , Humanos , Transtornos Mentais/diagnóstico , Transtornos Mentais/fisiopatologia , Transtornos Mentais/psicologia , Noruega , Admissão do Paciente , Ensaios Clínicos Pragmáticos como Assunto , Fatores de Tempo , Resultado do Tratamento
3.
World J Surg Oncol ; 16(1): 222, 2018 Nov 12.
Artigo em Inglês | MEDLINE | ID: mdl-30419911

RESUMO

BACKGROUND: To observe the effect of red light phototherapy (RLPT) on radioactive dermatitis (RD) caused by radiotherapy in patients with head and neck cancer (HNC). METHODS: Sixty patients with HNC admitted to our hospital were randomly divided into experimental group and control group, 30 patients in each group. The control group received routine daily care during radiotherapy treatment. In the experimental group, in addition to routine daily care during radiotherapy treatment, photon therapy apparatus RLPT was added, 10 min/time, 2 times/day, and lasted until the end of radiotherapy. The pain and conditions of the patients' skin were assessed daily, and the skin pain and dermatitis grades of the two groups were compared. RESULTS: In terms of the reaction degree of RD, experimental group was mainly grade 0-2, and control group was mainly grade 2-3, with a significant difference (P < 0.05). In terms of skin pain, according to the pain records at week 2, 3, and 4, the pain degree increased with time. However, the score of wound pain in experimental group was significantly lower than that in control group, and there was a significant difference between the two groups (P < 0.05). CONCLUSIONS: The application of RLPT in the treatment of RD can help accelerate wound healing and significantly shorten healing time. It can not only reduce wounds pain of patients, promote inflammation and ulcer healing, but also ensure the smooth progress of patients' radiotherapy and improve their quality of lives, which is worth popularization and application in the clinical practice.


Assuntos
Cromoterapia/métodos , Neoplasias de Cabeça e Pescoço/radioterapia , Manejo da Dor/métodos , Radiodermatite/terapia , Adulto , Idoso , Cromoterapia/instrumentação , Estudos de Viabilidade , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Dor/diagnóstico , Dor/etiologia , Medição da Dor , Qualidade de Vida , Radiodermatite/etiologia , Radiodermatite/patologia , Pele/patologia , Pele/efeitos da radiação , Resultado do Tratamento , Cicatrização/efeitos da radiação
4.
Behav Brain Res ; 348: 267-275, 2018 08 01.
Artigo em Inglês | MEDLINE | ID: mdl-29684473

RESUMO

OBJECTIVES: Exposure to light can have acute alerting and circadian phase-shifting effects. This study investigated the effects of evening exposure to blue-enriched polychromatic white (BEL) vs. polychromatic white light (WL) on sleep inertia dissipation the following morning in older adults. METHODS: Ten healthy older adults (average age = 63.3 yrs; 6F) participated in a 13-day study comprising three baseline days, an initial circadian phase assessment, four days with 2-h evening light exposures, a post light exposure circadian phase assessment and three recovery days. Participants were randomized to either BEL or WL of the same irradiance for the four evening light exposures. On the next mornings at 2, 12, 22 and 32 min after each wake time, the participants completed a 90-s digit-symbol substitution test (DSST) to assess working memory, and objective alertness was assessed using a wake EEG recording. DSST and power density from the wake EEG recordings were compared between the two groups. RESULTS: DSST performance improved with time awake (p < 0.0001) and across study days in both light exposure groups (p < 0.0001). There was no main effect of group, although we observed a significant day x group interaction (p = 0.0004), whereby participants exposed to BEL performed significantly better on the first two mornings after light exposures than participants in WL (post-hoc, p < 0.05). On those days, the BEL group showed higher EEG activity in some of the frequency bins in the sigma and beta range (p < 0.05) on the wake EEG. CONCLUSION: Exposure to blue-enriched white light in the evening significantly improved DSST performance the following morning when compared to polychromatic white light. This was associated with a higher level of objective alertness on the wake EEG, but not with changes in sleep or circadian timing.


Assuntos
Cognição/efeitos da radiação , Fototerapia/métodos , Idoso , Atenção/efeitos da radiação , Ritmo Circadiano , Cor , Cromoterapia/métodos , Feminino , Humanos , Luz , Iluminação/métodos , Masculino , Memória de Curto Prazo/fisiologia , Memória de Curto Prazo/efeitos da radiação , Pessoa de Meia-Idade , Sono , Vigília
5.
J Cosmet Dermatol ; 17(2): 176-183, 2018 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-28755402

RESUMO

BACKGROUND: Striae distensae (SD) are a common dermatologic problem that plagues many people. Although there are many therapeutic modalities have been used to treat SD, effective method has been disappointing for striae Alba. AIMS: To evaluate the clinical and histopathologic efficacy and safety of the 2940-nm erbium yttrium aluminum garnet (Er:YAG) ablative fractional laser (AFL) with recombinant bovine basic fibroblast growth factor (rb-bFGF) and light-emitting diode-red light (LED-RL) for the treatment of striae alba. PATIENTS AND METHODS: Thirty volunteers with striae distensae alba were enrolled. The subjects completed treatments with the 2940-nm Er:YAG AFL 6 times at 4-week intervals. Following this treatment, the subjects were required to spray rb-BFGF for 1 week at home. They then received LED-RL once every 7 days for three sessions between the two laser treatments. Two independent investigators evaluated clinical improvement at pretreatment and 1, 3, 6, and 12 months post-treatment, patients also provided self-assessments of clinical improvement. Two biopsies were obtained from two subjects, both of the same sites of striae alba, one before the first treatment and one 6 months after the last session. RESULTS: All 30 subjects demonstrated clinical improvement after treatment. Skin biopsies after treatment showed an increase in epidermal thickness, dermal thickness, and collagen and elastin density when compared to that at the baseline. CONCLUSIONS: The combination of the 2940-nm Er:YAG laser with rb-bFGF and LED-RL for the treatment of striae alba was a safe and effective approach for improving the appearance of striae alba.


Assuntos
Cromoterapia , Fator 2 de Crescimento de Fibroblastos/uso terapêutico , Lasers de Estado Sólido/uso terapêutico , Estrias de Distensão/patologia , Estrias de Distensão/terapia , Adulto , Animais , Bovinos , Terapia Combinada/efeitos adversos , Terapia Combinada/métodos , Edema/etiologia , Eritema/etiologia , Feminino , Humanos , Masculino , Projetos Piloto , Estudos Prospectivos , Proteínas Recombinantes/uso terapêutico , Adulto Jovem
6.
Clin Dermatol ; 35(2): 183-189, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28274357

RESUMO

The treatment of acne and acne scarring with lasers and light-based and energy-based technologies has become an integral component of our therapeutic arsenal. Lasers including infrared wavelengths and pulsed dye lasers; light devices including blue light, red light, and broadband light; and photodynamic therapy with aminolevulinic acid and methylaminolevulinic acid have been shown to be effective in the treatment of acne vulgaris. The optimal outcomes are achieved with photodynamic therapy combined with medical therapy. Acne scarring has been best treated with lasers, including nonablative infrared lasers, fractional nonablative and ablative laser resurfacing, and most recently needle-based radiofrequency devices.


Assuntos
Acne Vulgar/terapia , Cicatriz/terapia , Terapia a Laser/métodos , Fotoquimioterapia/métodos , Cromoterapia/métodos , Humanos
7.
Photodermatol Photoimmunol Photomed ; 33(1): 4-13, 2017 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-27943458

RESUMO

The innumerable intricacies associated with chronic wounds have made the development of new painless, noninvasive, biophysical therapeutic interventions as the focus of current biomedical research. Red and near-infrared light-induced photobiomodulation therapy appears to emerge as a promising drug-free approach for promoting wound healing, reduction in inflammation, pain and restoration of function owing to penetration power in conjunction with their ability to positively modulate the biochemical and molecular responses. This review will describe the physical properties of red and near-infrared light and their interaction with skin and highlight their efficacy of wound repair and regeneration. Near-infrared (800-830 nm) was found to be the most effective and widely studied wavelength range followed by red (630-680 nm) and 904 nm superpulsed light exhibiting beneficial photobiomodulatory effects on impaired dermal wound healing.


Assuntos
Luz , Fototerapia , Fenômenos Fisiológicos da Pele/efeitos da radiação , Pele/efeitos da radiação , Cicatrização/efeitos da radiação , Animais , Cor , Cromoterapia , Humanos , Terapia de Luz Pulsada Intensa , Pele/metabolismo
8.
Prog Nucl Magn Reson Spectrosc ; 96: 58-72, 2016 08.
Artigo em Inglês | MEDLINE | ID: mdl-27573181

RESUMO

In human nutritional science progress has always depended strongly on analytical measurements for establishing relationships between diet and health. This field has undergone significant changes as a result of the development of NMR and mass spectrometry methods for large scale detection, identification and quantification of metabolites in body fluids. This has allowed systematic studies of the metabolic fingerprints that biological processes leave behind, and has become the research field of metabolomics. As a metabolic profiling technique, NMR is at its best when its unbiased nature, linearity and reproducibility are exploited in well-controlled nutritional intervention and cross-sectional population screening studies. Although its sensitivity is less good than that of mass spectrometry, NMR has maintained a strong position in metabolomics through implementation of standardisation protocols, hyphenation with mass spectrometry and chromatographic techniques, accurate quantification and spectral deconvolution approaches, and high-throughput automation. Thus, NMR-based metabolomics has contributed uniquely to new insights into dietary exposure, in particular by unravelling the metabolic fates of phytochemicals and the discovery of dietary intake markers. NMR profiling has also contributed to the understanding of the subtle effects of diet on central metabolism and lipoprotein metabolism. In order to hold its ground in nutritional metabolomics, NMR will need to step up its performance in sensitivity and resolution; the most promising routes forward are the analytical use of dynamic nuclear polarisation and developments in microcoil construction and automated fractionation.


Assuntos
Líquidos Corporais/química , Dieta , Metabolômica , Ressonância Magnética Nuclear Biomolecular/métodos , Avaliação Nutricional , Biomarcadores/análise , Biomarcadores/sangue , Biomarcadores/urina , Cromoterapia/métodos , Comportamento Alimentar , Humanos , Lipoproteínas/análise , Lipoproteínas/sangue , Lipoproteínas/metabolismo , Lipoproteínas/urina , Espectrometria de Massas/métodos , Polifenóis/análise , Polifenóis/sangue , Polifenóis/metabolismo , Polifenóis/urina
9.
Med Tr Prom Ekol ; (4): 36-40, 2016.
Artigo em Russo | MEDLINE | ID: mdl-27396151

RESUMO

Complex treatment using naphthalane applications with nonselective chromotherapy covered 64 engine operators of locomotive crews, aged 40-69 years, having 1-3 stage knee osteoarthrosis. Findings are that optimized treatment schedules effectively reduce intensity of pain, improve functional state of the joints involved, increase life quality of the patients, have no side effects. Comparative analysis of the treatment results showed that efficiency of combined naphthalane and nonselective chromotherapy exceeds isolated naphthalane effects.


Assuntos
Cromoterapia/métodos , Naftalenos/farmacologia , Doenças Profissionais/terapia , Osteoartrite/terapia , Ferrovias , Adulto , Idoso , Humanos , Masculino , Pessoa de Meia-Idade , Naftalenos/administração & dosagem , Doenças Profissionais/tratamento farmacológico , Osteoartrite/tratamento farmacológico
10.
Med Tr Prom Ekol ; (2): 6-11, 2016.
Artigo em Russo | MEDLINE | ID: mdl-27164744

RESUMO

The article covers treatment results of 90 patients with primary glaucoma simplex of stage 1 and 2 (137 eyes). The authors proved that using a specified magnetotherapy method, when compared to regular medical therapy, causes more fast and marked regression in clinical symptoms and improvement of vision in patients with primary glaucoma simplex of stages 1 and 2.


Assuntos
Cromoterapia/métodos , Glaucoma de Ângulo Aberto/terapia , Oftalmologia/métodos , Estimulação Magnética Transcraniana/métodos , Idoso , Terapia Combinada , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
11.
Proc Natl Acad Sci U S A ; 113(19): 5239-44, 2016 May 10.
Artigo em Inglês | MEDLINE | ID: mdl-27114521

RESUMO

Evidence suggests that light and circadian rhythms profoundly influence the physiologic capacity with which an organism responds to stress. However, the ramifications of light spectrum on the course of critical illness remain to be determined. Here, we show that acute exposure to bright blue spectrum light reduces organ injury by comparison with bright red spectrum or ambient white fluorescent light in two murine models of sterile insult: warm liver ischemia/reperfusion (I/R) and unilateral renal I/R. Exposure to bright blue light before I/R reduced hepatocellular injury and necrosis and reduced acute kidney injury and necrosis. In both models, blue light reduced neutrophil influx, as evidenced by reduced myeloperoxidase (MPO) within each organ, and reduced the release of high-mobility group box 1 (HMGB1), a neutrophil chemotactant and key mediator in the pathogenesis of I/R injury. The protective mechanism appeared to involve an optic pathway and was mediated, in part, by a sympathetic (ß3 adrenergic) pathway that functioned independent of significant alterations in melatonin or corticosterone concentrations to regulate neutrophil recruitment. These data suggest that modifying the spectrum of light may offer therapeutic utility in sterile forms of cellular injury.


Assuntos
Cromoterapia/métodos , Cor , Corticosterona/sangue , Traumatismo por Reperfusão/prevenção & controle , Traumatismo por Reperfusão/fisiopatologia , Animais , Relação Dose-Resposta à Radiação , Proteína HMGB1/sangue , Testes de Função Renal , Testes de Função Hepática , Masculino , Melatonina/sangue , Camundongos , Camundongos Endogâmicos C57BL , Peroxidase/sangue , Doses de Radiação , Traumatismo por Reperfusão/diagnóstico , Índice de Gravidade de Doença , Resultado do Tratamento
12.
Pediatr Res ; 79(2): 308-12, 2016 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-26484622

RESUMO

BACKGROUND: Blue light with peak emission around 460 nm is the preferred treatment of neonatal hyperbilirubinemia. However, studies using fluorescent light tubes have suggested that turquoise light with peak emission at 490 nm may be more efficient. At present, the predominant light source for phototherapy is light emitting diodes (LEDs). Hence, the aim of this study was to compare the bilirubin-reducing effect in jaundiced neonates treated either with turquoise or with blue LED light with peak emission at 497 or 459 nm, respectively, with equal irradiance on the infants. METHODS: Infants with gestational age ≥33 wk and uncomplicated hyperbilirubinemia were randomized to either turquoise or blue LED light and were treated for 24 h. The mean irradiance footprint at skin level was 5.2 × 10(15) and 5.1 × 10(15) photons/cm(2)/s, respectively. RESULTS: Forty-six infants received turquoise light and 45 received blue light. The median (95% confidence interval) decrease of total serum bilirubin was 35.3% (32.5; 37.3) and 33.1% (27.1; 36.8) for infants treated with turquoise and blue lights, respectively. The difference was nonsignificant (P = 0.53). The decrease was positively correlated to postnatal age and negatively to birth weight. CONCLUSION: Using LED light of equal irradiance, turquoise and blue lights had equal bilirubin-reducing effect on hyperbilirubinemia of neonates.


Assuntos
Bilirrubina/sangue , Cromoterapia/instrumentação , Icterícia Neonatal/terapia , Fatores Etários , Biomarcadores/sangue , Peso ao Nascer , Cromoterapia/efeitos adversos , Dinamarca , Regulação para Baixo , Desenho de Equipamento , Feminino , Humanos , Recém-Nascido , Icterícia Neonatal/sangue , Icterícia Neonatal/diagnóstico , Masculino , Fatores de Tempo , Resultado do Tratamento
13.
Dermatology ; 231(1): 24-34, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26044167

RESUMO

BACKGROUND: Blue light irradiation reduces the proliferation of keratinocytes and modulates T-cell immune response in vitro and has been shown to reduce the severity of psoriasis vulgaris (Pv) in two clinical trials. OBJECTIVE: Evaluation of safety and efficacy of long-term UV-free blue light treatment at home for mild Pv. METHODS: Forty-seven patients with mild Pv were randomized for receiving high-intensity blue light treatment (HI: 453 nm LED, 200 mW/cm(2), n = 24) and low-intensity treatment (LI: 453 nm LED, 100 mW/cm(2), n = 23) of one Pv plaque for 12 weeks. A contralateral control plaque remained untreated. RESULTS: Patient compliance and satisfaction were high. The primary endpoint, change from baseline (CfB) of the Local Psoriasis Severity Index, revealed a significant improvement of the target compared to the control plaques (ΔCfB for the HI group: -0.92 ± 1.10, p = 0.0005; for the LI group: -0.74 ± 1.18, p = 0.0064). CONCLUSION: UV-free blue light home treatment is safe and improves Pv plaques.


Assuntos
Cromoterapia/métodos , Psoríase/terapia , Adulto , Idoso , Cromoterapia/efeitos adversos , Método Duplo-Cego , Feminino , Humanos , Hiperpigmentação/etiologia , Masculino , Pessoa de Meia-Idade , Cooperação do Paciente , Satisfação do Paciente , Estudos Prospectivos , Índice de Gravidade de Doença , Fatores de Tempo , Adulto Jovem
14.
Artigo em Inglês | MEDLINE | ID: mdl-25817261

RESUMO

In this work, the separation and purification of fumigaclavine C (FC), an ergot alkaloid with strong anti-inflammatory activity from fermented mycelia of Aspergillus fumigatus was systematically evaluated. Among the eight tested resins, the non-polar resin D101 displayed the best adsorption and desorption based on of static adsorption and desorption tests. Adsorption isotherms were constructed on D101 resin and fitted well to the Freundlich model. Dynamic adsorption and desorption tests on a column packed with D101 resin have been investigated for optimization of chromatographic parameters. Under optimized conditions, the contents of FC increased from 7.32% (w/w) in the crude extract to 67.54% in the final product with a recovery yield of 90.35% (w/w) via one run. Furthermore, a lab scale-up separation was carried out, in which the FC content and recovery yield were 65.83% and 90.13%, respectively. These results demonstrated that this adsorption-desorption strategy by using D101 resin was simple and efficient, thus showing potential for large scale purification and preparation of FC in the future.


Assuntos
Aspergillus fumigatus/metabolismo , Cromoterapia/métodos , Alcaloides de Claviceps/isolamento & purificação , Alcaloides Indólicos/isolamento & purificação , Micélio/química , Resinas Sintéticas/química , Adsorção , Aspergillus fumigatus/química , Cromoterapia/instrumentação , Alcaloides de Claviceps/metabolismo , Fermentação , Alcaloides Indólicos/metabolismo , Micélio/metabolismo , Porosidade
15.
Artigo em Russo | MEDLINE | ID: mdl-25314761

RESUMO

This article gives evidence of the effectiveness of chromo- and laser therapy (using infrared and green wavelenth radiation) in combination with basal pharmacotherapy in the patients presenting with combined pathology. The analysis of the data obtained indicates that the proposed approach makes it possible to accelerate normalization of the clinical characteristics, reduce arterial pressure, improve the parameters of external respiration, and increase the duration of remission periods.


Assuntos
Cromoterapia/métodos , Hipertensão , Terapia com Luz de Baixa Intensidade/métodos , Doença Pulmonar Obstrutiva Crônica , Adulto , Idoso , Feminino , Humanos , Hipertensão/complicações , Hipertensão/fisiopatologia , Hipertensão/terapia , Masculino , Pessoa de Meia-Idade , Doença Pulmonar Obstrutiva Crônica/complicações , Doença Pulmonar Obstrutiva Crônica/fisiopatologia , Doença Pulmonar Obstrutiva Crônica/terapia , Indução de Remissão
16.
Bipolar Disord ; 16(8): 894-8, 2014 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-25264124

RESUMO

OBJECTIVE: Available pharmacological treatment of mania is insufficient. Virtual darkness therapy (blue light-blocking treatment by means of orange-tinted glasses) is a promising new treatment option for mania. The basis for this might be the recently identified blue light-sensitive retinal photoreceptor, which is solely responsible for light stimulus to the circadian master clock. This is the first case report describing the clinical course of a closely monitored, hospitalized patient in a manic episode first receiving clear-lensed, and then blue light-blocking glasses. METHODS: A 58-year-old Caucasian man, with bipolar I disorder and three previous manic episodes, was hospitalized during a manic episode. In addition to pharmacological treatment, he was treated with clear-lensed glasses for seven days, then one day without glasses, followed by six days of blue light-blocking glasses. During the entire observational period, he wore an actigraph with internal light sensors. RESULTS: Manic symptoms were unaltered during the first seven days. The transition to the blue-blocking regime was followed by a rapid and sustained decline in manic symptoms accompanied by a reduction in total sleep, a reduction in motor activity during sleep intervals, and markedly increased regularity of sleep intervals. The patient's total length of hospital stay was 20 days shorter than the average time during his previous manic episodes. CONCLUSIONS: The unusually rapid decline in symptoms, accompanied by uniform sleep parameter changes toward markedly increased regularity, suggest that blue-blockers might be targeting a central mechanism in the pathophysiology of mania that needs to be explored both in clinical research and in basic science.


Assuntos
Transtorno Bipolar/terapia , Cromoterapia , Luz , Privação Sensorial , Sono/efeitos da radiação , Óculos , Humanos , Masculino , Pessoa de Meia-Idade , Células Fotorreceptoras de Vertebrados/fisiologia
17.
Anal Bioanal Chem ; 406(4): 957-69, 2014 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-23748592

RESUMO

Countercurrent chromatography (CCC) is an attractive separation method because the analytes are partitioned between two immiscible liquid phases avoiding problems related to solid stationary phase. In recent years, this technique has made great progress in separation power and detection potential. This review describes coupling strategies involving high speed CCC (HSCCC) or centrifugal partition chromatography (CPC). It includes on-line extraction-isolation, hyphenation with mass spectrometry (MS) and nuclear magnetic resonance (NMR) detectors, multidimensional CCC (MDCCC), two-dimensional CCC (2D-CCC), on-line coupling with liquid chromatography (LC), and biological tests, and innovative off-line developments. The basic principles of each method are presented and applications are summarized.


Assuntos
Centrifugação/tendências , Distribuição Contracorrente/tendências , Animais , Centrifugação/instrumentação , Centrifugação/métodos , Cromoterapia/instrumentação , Cromoterapia/métodos , Cromoterapia/tendências , Distribuição Contracorrente/instrumentação , Distribuição Contracorrente/métodos , Humanos , Peptídeos/análise , Peptídeos/isolamento & purificação , Extratos Vegetais/análise , Extratos Vegetais/isolamento & purificação
18.
Biostatistics ; 14(4): 792-806, 2013 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-23743206

RESUMO

Estimation of the period length of time-course data from cyclical biological processes, such as those driven by the circadian pacemaker, is crucial for inferring the properties of the biological clock found in many living organisms. We propose a methodology for period estimation based on spectrum resampling (SR) techniques. Simulation studies show that SR is superior and more robust to non-sinusoidal and noisy cycles than a currently used routine based on Fourier approximations. In addition, a simple fit to the oscillations using linear least squares is available, together with a non-parametric test for detecting changes in period length which allows for period estimates with different variances, as frequently encountered in practice. The proposed methods are motivated by and applied to various data examples from chronobiology.


Assuntos
Relógios Biológicos/fisiologia , Ritmo Circadiano/fisiologia , Interpretação Estatística de Dados , Análise de Regressão , Animais , Arabidopsis/crescimento & desenvolvimento , Cromoterapia/métodos , Neoplasias Colorretais/tratamento farmacológico , Simulação por Computador , Humanos , Pneumopatias/tratamento farmacológico , Camundongos , Proteínas Circadianas Period/uso terapêutico , Temperatura Cutânea/efeitos dos fármacos
19.
Artigo em Russo | MEDLINE | ID: mdl-24640656

RESUMO

A series of investigations have demonstrated the anti-inflammatory, bactericidal, analgesic, and vegetocorrective effects of extraocular selective polarized chromotherapy using blue and red light and the possibility to optimize autonomous regulation with the help of this technique. The results of the study confirmed the high clinical effectiveness and safety of the method being considered for the treatment of acute respiratory diseases, chronic tonsillitis, cervical dorsopathies, and vegetative dysfunction.


Assuntos
Cromoterapia/métodos , Nasofaringite/terapia , Infecções Respiratórias/terapia , Tonsilite/terapia , Criança , Pré-Escolar , Terapia Combinada , Feminino , Humanos , Lactente , Masculino , Nasofaringite/complicações , Nasofaringite/tratamento farmacológico , Infecções Respiratórias/complicações , Infecções Respiratórias/tratamento farmacológico , Staphylococcus aureus/isolamento & purificação , Tonsilite/tratamento farmacológico , Tonsilite/microbiologia , Resultado do Tratamento
20.
Artigo em Russo | MEDLINE | ID: mdl-23096039

RESUMO

The objective of the study was to work out a method of color and rhythm therapy (CRT) for correction of mental and autonomic disorders in children with diabetes mellitus type I. The elaboration of the method was based on the results of examination of 62 patients, aged 7-16 years. In addition, a psychometric assessment of anxiety (the Spielberger-Khanin test), stress resistance and communicative abilities (the Luscher color test), depression (the scale of Saint-Petersburg Bekhterev's Psychoneurological Research Institute) and autonomic dysfunctions (the Vein's questionnaire) was performed. CRT was conducted with the apparatus"Color-rhythm" that allows to perform stimulation with the light of specified length. The high effectiveness of CRT in the correction of mental and autonomic disorders depending on the character of disorders and effects of separate photic stimuli (red or yellow, green and blue), sequence and rhythm of their presentation is demonstrated. The choice of automatic working regime of the apparatus is proved to be optimal.


Assuntos
Doenças do Sistema Nervoso Autônomo/terapia , Cromoterapia/métodos , Diabetes Mellitus Tipo 1/complicações , Transtornos Mentais/terapia , Adolescente , Doenças do Sistema Nervoso Autônomo/etiologia , Criança , Cromoterapia/instrumentação , Diabetes Mellitus Tipo 1/fisiopatologia , Diabetes Mellitus Tipo 1/psicologia , Feminino , Humanos , Masculino , Transtornos Mentais/etiologia , Resultado do Tratamento
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