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1.
Emerg Microbes Infect ; 9(1): 949-961, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-32378471

RESUMO

The emergences of coronaviruses have caused a serious global public health problem because their infection in humans caused the severe acute respiratory disease and deaths. The outbreaks of lethal coronaviruses have taken place for three times within recent two decades (SARS-CoV in 2002, MERS-CoV in 2012 and SARS-CoV-2 in 2019). Much more serious than SARS-CoV in 2002, the current SARS-CoV-2 infection has been spreading to more than 213 countries, areas or territories and causing more than two million cases up to date (17 April 2020). Unfortunately, no vaccine and specific anti-coronavirus drugs are available at present time. Current clinical treatment at hand is inadequate to suppress viral replication and inflammation, and reverse organ failure. Intensive research efforts have focused on increasing our understanding of viral biology of SARS-CoV-2, improving antiviral therapy and vaccination strategies. The animal models are important for both the fundamental research and drug discovery of coronavirus. This review aims to summarize the animal models currently available for SARS-CoV and MERS-CoV, and their potential use for the study of SARS-CoV-2. We will discuss the benefits and caveats of these animal models and present critical findings that might guide the fundamental studies and urgent treatment of SARS-CoV-2-caused diseases.


Assuntos
Betacoronavirus/fisiologia , Infecções por Coronaviridae/patologia , Infecções por Coronaviridae/prevenção & controle , Infecções por Coronavirus/patologia , Infecções por Coronavirus/prevenção & controle , Modelos Animais de Doenças , Pandemias/prevenção & controle , Pneumonia Viral/patologia , Pneumonia Viral/prevenção & controle , Pesquisa/tendências , Animais , Humanos , Coronavírus da Síndrome Respiratória do Oriente Médio/fisiologia , Vírus da SARS/fisiologia
7.
Sheng Wu Gong Cheng Xue Bao ; 36(3): 416-425, 2020 Mar 25.
Artigo em Chinês | MEDLINE | ID: mdl-32237536

RESUMO

Phytoremediation is one of the important methods for restoring heavy-metal contaminated soils. Using high-biomass economic plants to restore heavy-metal contaminated soils can have both ecological and economic benefits, with great application prospects. Based on the analysis of current situation and existing problems of phytoremediation, we propose the advantages of high-biomass economic plants in contaminated soil remediation, and summarize the recent advances and mechanisms involved in absorbing heavy metals in high-biomass economic plants. Furthermore, the possible methods for improving the remediation efficiency of high-biomass economic plants are also discussed, to provide insights for improving the economic benefits of phytoremediation and promoting its widespread application in the future.


Assuntos
Metais Pesados , Poluentes do Solo , Biodegradação Ambiental , Biomassa , Metais Pesados/metabolismo , Pesquisa/tendências , Solo
8.
Trends Immunol ; 41(5): 355-359, 2020 05.
Artigo em Inglês | MEDLINE | ID: mdl-32249063

RESUMO

Coronavirus (CoV) disease 2019 (COVID-19) caused by severe acute respiratory syndrome (SARS)-CoV-2 (also known as 2019-nCoV) is threatening global public health, social stability, and economic development. To meet this challenge, this article discusses advances in the research and development of neutralizing antibodies (nAbs) for the prevention and treatment of infection by SARS-CoV-2 and other human CoVs.


Assuntos
Anticorpos Neutralizantes/uso terapêutico , Anticorpos Antivirais/uso terapêutico , Betacoronavirus/imunologia , Infecções por Coronavirus/imunologia , Coronavirus/imunologia , Pneumonia Viral/imunologia , Anticorpos Neutralizantes/imunologia , Anticorpos Antivirais/imunologia , Infecções por Coronavirus/prevenção & controle , Infecções por Coronavirus/terapia , Humanos , Pandemias/prevenção & controle , Pneumonia Viral/prevenção & controle , Pneumonia Viral/terapia , Pesquisa/tendências
11.
Sheng Wu Gong Cheng Xue Bao ; 36(4): 643-651, 2020 Apr 25.
Artigo em Chinês | MEDLINE | ID: mdl-32347059

RESUMO

Cucumber (Cucumis sativus) is an important vegetable crop in the world. Agrobacterium-mediated transgenic technology is an important way to study plant gene functions and improve varieties. In order to further accelerate the transgenic research and breeding process of cucumber, we described the progress and problems of Agrobacterium tumefaciens-mediated transgenic cucumber, from the influencing factors of cucumber regeneration ability, genetic transformation conditions and various additives in the process. We prospected for improving the genetic transformation efficiency and safety selection markers of cucumber, and hoped to provide reference for the research of cucumber resistance breeding and quality improvement.


Assuntos
Agrobacterium tumefaciens , Cucumis sativus , Plantas Geneticamente Modificadas , Transformação Genética , Agrobacterium tumefaciens/metabolismo , Cruzamento , Cucumis sativus/genética , Cucumis sativus/microbiologia , Plantas Geneticamente Modificadas/microbiologia , Pesquisa
12.
Semin Oncol ; 47(1): 56-64, 2020 02.
Artigo em Inglês | MEDLINE | ID: mdl-32229032

RESUMO

Pediatric cancer is a rare disease with a low annual incidence, which presents a significant challenge in being able to collect enough data to fuel clinical discoveries. Big data registry trials hold promise to advance the study of pediatric cancers by allowing for the combination of traditional randomized controlled trials with the power of larger cohort sizes. The emergence of big data resources and data-sharing initiatives are becoming transformative for pediatric cancer diagnosis and treatment. This review discusses the uses of big data in pediatric cancer, existing pediatric cancer registry initiatives and research, the challenges in harmonizing these data to improve accessibility for study, and building pediatric data commons and other important future endeavors.


Assuntos
Big Data , Oncologia/estatística & dados numéricos , Neoplasias/epidemiologia , Pediatria/estatística & dados numéricos , Fatores Etários , Criança , Bases de Dados Factuais , Humanos , Disseminação de Informação , Informática Médica/métodos , Oncologia/tendências , Neoplasias/diagnóstico , Neoplasias/etiologia , Neoplasias/terapia , Pediatria/tendências , Vigilância em Saúde Pública , Sistema de Registros , Pesquisa , Sobrevivência
17.
Stud Health Technol Inform ; 268: 97-112, 2020 Mar 02.
Artigo em Inglês | MEDLINE | ID: mdl-32141882

RESUMO

Maintain Your Brain (MYB)i is a randomised controlled trial (RCT) of multiple online interventions designed to target modifiable risk factors for Alzheimer's disease and dementia. Traditional clinical trial management systems (CTMS) requirements consist of features such as management of the study, site, subject (participant), clinical outcomes, external and internal requests, education, data extraction and reporting, security, and privacy. In addition to fulfilling these traditional requirements, MYB has a specific set of features that needs to be fulfilled. These specific requirements include: (i) support for multiple interventions within a study, (ii) flexible interoperability options with third-party software providers, (iii) study participants being able to engage in online activities via web-based interfaces throughout the trial (from screening to follow-up), (iv) ability to algorithmically personalize trial activities based on the needs of the participant, and (v) the ability to handle large volumes of data over a long period. This paper outlines how the existing CTMSs fall short in meeting these specific requirements. The presented system architecture, development approach and lessons learned in the implementation of the MYB digital platform will inform researchers attempting to implement CTMSs for trials comparable to MYB in the future.


Assuntos
Encéfalo , Doença de Alzheimer , Ensaios Clínicos como Assunto , Humanos , Manutenção , Pesquisa , Fatores de Risco
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