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1.
Rev Infirm ; 69(260-261): 31-32, 2020.
Artigo em Francês | MEDLINE | ID: mdl-32600593

RESUMO

Originating in China in November 2019, the wave of infection caused by the new coronavirus Sars-CoV-2 is sweeping across the planet through human contact and fast, global, mass travel. Health professionals on every level are fighting relentlessly against Covid-19, this deadly, invisible yet real enemy. The public, increasingly worried, expect them to protect it against the disease and death. Perceived by most people as a line of defence against the pandemic, health professionals are supported and treated as heroes. Some people howeverfear tthat they may be possible contamination agents.


Assuntos
Atitude Frente a Saúde , Infecções por Coronavirus/epidemiologia , Infecções por Coronavirus/terapia , Pessoal de Saúde , Pandemias , Pneumonia Viral/epidemiologia , Pneumonia Viral/terapia , China/epidemiologia , Infecções por Coronavirus/transmissão , Coragem , Humanos , Transmissão de Doença Infecciosa do Profissional para o Paciente , Pneumonia Viral/transmissão
3.
Zhonghua Jie He He Hu Xi Za Zhi ; 43(6): 520-524, 2020 Jun 12.
Artigo em Chinês | MEDLINE | ID: mdl-32486559

RESUMO

Objective: To explore the end criteria of forced vital capacity(FVC) curve in adults. Methods: A multicenter cross-sectional study was performed in Zhongshan Hospital Affiliated to Fudan University, the First Affiliated Hospital of Fujian Medical University, and the Third Affiliated Hospital of Inner Mongolia Medical University from January 2017 to August 2017. A consecutive sample of subjects who completed the spirometry test and FVC curves met end criteria of no volume change (<0.025 L) for ≥ 1 s were qualified in this study. Subjects were divided into a normal group (n=610), an obstructive group (n=536), and a restrictive group(n=306) according to pulmonary function test results. The FET values in different groups were compared. The side effects in the 3 groups and the diagnostic accuracy, specificity and security of different FET in the obstructive group were assessed. Results: The FET values of the normal group, the obstructive group, and the restricted group were (4.00±1.07) s, (8.08±1.56) s and (2.97±0.76) s respectively, and the 95% CI of FET in the 3 groups were between 3.88-4.12 s, 7.02-10.14 and 2.21- 3.73 s (F=2 263.80, P<0.01). When the exhalation platform was used as the standard of FVC curve, the adverse reaction rate in the normal group and the restricted group were 1.1% and 1.3% respectively, lower than the rate of 17.2% in the obstructive group (χ(2)=92.73, χ(2)=48.49 respectively; all P<0.05). In the obstructive group, 7 s as the ending criterion had similar incidence of adverse reactions to 6 s (χ(2)=0.01, P=0.93). With further extension of expiration time, the incidence of adverse reactions increased significantly. In the obstructive group, the sensitivity of FEV(1)/FEV(7) was 99.25%, higher than that at FEV(1)/FEV(6) (χ(2)=4.06, P=0.04), and the specificity of diagnosis was very similar and 100%. Conclusions: FET was variable in subjects with different lung function status. It is not appropriate to use a fixed FET≥ 6 s as the end criterion of spirometry for adults. For patients with normal lung function or restrictive lung function defect, exhalation platform should be used as the end of exhalation standard. For patients with obstructive lung function defect, an FET of up to 7 s is appropriate.


Assuntos
Espirometria/estatística & dados numéricos , Capacidade Pulmonar Total/fisiologia , Capacidade Vital/fisiologia , Adulto , China , Estudos Transversais , Humanos , Programas de Rastreamento/métodos , Valor Preditivo dos Testes , Sensibilidade e Especificidade
4.
Zhonghua Jie He He Hu Xi Za Zhi ; 43(6): 525-531, 2020 Jun 12.
Artigo em Chinês | MEDLINE | ID: mdl-32486560

RESUMO

Objective: To analyze the clinical features and the results of the whole exome sequencing (WES) of a Chinese family containing both pulmonary sarcoidosis patients and healthy members, and to find potent genes and variants that may be involved in the pathogenesis of sarcoidosis. Methods: Three patients with pulmonary sarcoidosis and 1 healthy member was included from a Chinese Han family in the north of China diagnosed in November 2016, which characterized as 2 consecutive generations including 2 males and 1 female, aged from 23 to 69 years old. The proband is Ⅱ-6. Pulmonary sarcoidosis was diagnosed by clinical features, imaging and pathological findings, and clinical data such as family history were collected. Whole blood samples were taken and WES (Illumina NovaSeq S2) was performed. The pathogenicity analysis and gene annotation analysis were performed by ExAC, SIFT, Polyphenv2, Metascape databases. Results: It was found that 27 genes were highly pathogenic in the database filtering result. After gene annotation analysis, we found that ZC3H12A gene can negatively regulate the differentiation of Th17 cells, which may be involved in the onset of pulmonary sarcoidosis. Sanger sequencing confirmed the c.1361 A>G variant in 3 sarcoidosis patients but normal in healthy member. Conclusions: In patients with familial pulmonary sarcoidosis, the genetic background could regulate immune response which is one of the pathogenic mechanisms of sarcoidosis. The whole exome test and gene ontology analysis showed that Ⅱ-2, Ⅱ-6 and Ⅲ-1 pulmonary sarcoidosis patients in this family were all shared the same variant on ZC3H12A gene, which played a pivotal role in differentiation of Th17 cells and is a potent pathogenesis gene in this Chinese pulmonary sarcoidosis family.


Assuntos
Grupo com Ancestrais do Continente Asiático/genética , Sarcoidose Pulmonar/genética , Adulto , Idoso , China , Exoma , Feminino , Predisposição Genética para Doença , Estudo de Associação Genômica Ampla , Humanos , Masculino , Pessoa de Meia-Idade , Linhagem , Ribonucleases , Sarcoidose Pulmonar/etnologia , Fatores de Transcrição , Sequenciamento Completo do Exoma/métodos , Adulto Jovem
5.
Zhongguo Zhong Yao Za Zhi ; 45(10): 2239-2248, 2020 May.
Artigo em Chinês | MEDLINE | ID: mdl-32495576

RESUMO

To analyze the development of coronavirus disease 2019(COVID-19), this study systematically retrieved relevant Chinese and English literatures from both CNKI and Web of Science database platforms by bibliometric research method and CiteSpace 5.5.R2 software to obtain information and visualize relevant literatures. A total of 695 Chinese and 446 English literatures were included in this paper. Statistics showed that China had published most of the literatures and established close cooperation with the United States and the United Kingdom. Through the analysis, Tongji Medical College of Huazhong University of Science and Technology and its affiliated hospitals published the largest number of the publications. Moreover, the highly productive journals including Journal of Traditional Chinese Medicine and The Lancet covered eight major fields, such as medicine, medical virology, radiation medicine, infectious disease, and traditional Chinese medicine. Besides, a total of 35 special COVID-19 funds were recently established to subsidize these studies. The key words and themes analysis indicated that protein structure of COVID-19, receptor targets and mechanisms of action, integration of traditional Chinese and Western medicine, screening and development of antiviral drugs from traditional Chinese medicine and Western medicine, vaccine research as well as epidemiological characteristics and prediction are current study hotspots. This study provides a reference for researchers to rapidly master main study directions of COVID-19 and screen out relevant literatures.


Assuntos
Betacoronavirus , Bibliometria , Infecções por Coronavirus , Pandemias , Pneumonia Viral , China , Humanos , Reino Unido , Estados Unidos
6.
Zhongguo Zhong Yao Za Zhi ; 45(10): 2265-2274, 2020 May.
Artigo em Chinês | MEDLINE | ID: mdl-32495579

RESUMO

In December 2019, an outbreak of viral pneumonia began in Wuhan, Hubei Province, which caused the spread of infectious pneumonia to a certain extent in China and neighboring countries and regions, and triggered the epidemic crisis. The coronavirus disease 2019(COVID-19) is an acute respiratory infectious disease listed as a B infectious disease, which is managed according to standards for A infectious disease. Traditional Chinese medicine and integrated traditional Chinese and Western medicine have played an active role in the prevention and control of this epidemic. China's ethnomedicine has recognized infectious diseases since ancient times, and formed a medical system including theory, therapies, formula and herbal medicines for such diseases. Since the outbreak of the COVID-19 epidemic, Tibet Autonomous Region, Qinghai Province, Inner Mongolia Autonomous Region, Xinjiang Uygur Autonomous Region and Chuxiong Autonomous Prefecture of Yunnan, Qiandongnan Autonomous Prefecture of Guizhou have issued the prevention and control programs for COVID-19 using Tibetan, Mongolian, Uygur, Yi and Miao medicines. These programs reflect the wisdom of ethnomedicine in preventing and treating diseases, which have successfully extracted prescriptions and preventive measures for the outbreak of the epidemic from their own medical theories and traditional experiences. In this paper, we summarized and explained the prescriptions and medicinal materials of ethnomedicine in these programs, and the origin of Tibetan medicine prescriptions and Mongolian medicine prescriptions in ancient books were studied. These become the common characteristics of medical prevention and treatment programs for ethnomedicine to formulate therapeutic programs under the guidance of traditional medicine theories, recommend prescriptions and prevention and treatment methods with characteristics of ethnomedicine, and focus on the conve-nience and standardization. However, strengthening the support of science and technology and the popularization to the public, and improving the participation of ethnomedicine in national public health services and the capacity-building to deal with sudden and critical diseases are key contents in the development of ethnomedicine in the future.


Assuntos
Betacoronavirus , Infecções por Coronavirus/tratamento farmacológico , Pneumonia Viral/tratamento farmacológico , China , Humanos , Medicina Tradicional , Pandemias , Tibet
7.
Zhongguo Zhong Yao Za Zhi ; 45(10): 2291-2295, 2020 May.
Artigo em Chinês | MEDLINE | ID: mdl-32495582

RESUMO

2019 novel coronavirus(2019-nCoV) has occurred for 2 months, and seriously affected the people's health in the world. Therefore, scientific prevention and control strategies and effective intervention measures are the only ways to solve the world problem. In the determination of intervention measures, not only the effectiveness evaluation, but also accessibility, treatment cost, inventory and production capacity and other relevant sociological issues shall be considered, especially in low and middle-income countries and regions. With the introduction of clinical epidemiological experiment design and evidence-based medicine evidence evaluation into the evaluation of curative effect of traditional Chinese medicine(TCM), TCM has officially entered the studies of syndrome regularity of new public health emergencies(such as SARS and influenza) clearly diagnosed by modern medicine for many years, as well as the development of relevant guidelines, consensus and paths. The results of curative effect show that TCM could significantly alleviate symptoms, control disease and tendency, reduce the occurrence of critical illness, and improve the clinical efficacy and the prognosis and quality of life of patients, which fully reflects the consciousness and self-confidence of traditional Chinese medicine workers. For the evidence-based evaluation of TCM intervention in new public health emergencies, the basic principles and general methods of clinical epidemiology and evidence-based medicine shall be followed to obtain high-quality evidence; besides, we shall also fully realize that clinical scientific study is carried out with the epidemic treatment as the primary task. The scientific hypothesis comes from the clinical problems unsolved. The scientific study conclusions aim to give feedbacks to clinical diagnosis and treatment regimens. The core elements of clinical trials are population(P), intervention(I), control(C), outcome(O), which are abbreviated as "PICO". The evaluation of intervention measures for new public health emergencies with traditional Chinese medicine shall have clear study objectives and a high quality, with a correct analysis method as the guarantee of real and reliable results. Then, the selection of patients, the de-finition of intervention measures and control measures, the development of end-point indicators, the clinical quality control under special epidemics, the data verification, and the data analysis methods to be adopted are all characteristics and key points that need special consideration. It is suggested that scientific experimental design, rigorous collection and scientific data analysis shall be conducted to reflect the therapeutic value of traditional Chinese medicine, so that the study results could be adopted and shared, and become the scientific evidence for China and even the global to republish the diagnosis and treatment regimens.


Assuntos
Betacoronavirus , Infecções por Coronavirus , Medicamentos de Ervas Chinesas , Medicina Tradicional Chinesa , Pandemias , Pneumonia Viral , China , Emergências , Medicina Baseada em Evidências , Humanos , Saúde Pública , Qualidade de Vida
8.
Ann Palliat Med ; 9(3): 1198-1205, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32498535

RESUMO

BACKGROUND: Nursing quality is an integral part of health care quality and one of key performance indicators (KPIs) for health care management. The Plan-Do-Check-Act (PDCA) cycle is a management tool for continuous improvement of a business's products or processes. It can be applied to standardize nursing management and thus improve the nursing quality and increase the survival rate of patients. This study assessed the value of the PDCA cycle in standardizing nursing management in an intensive care unit (ICU) for patients with severe coronavirus disease 2019 (COVID-19). METHODS: The status quo of the ICU was analyzed, and the relevant issues and countermeasures were proposed. The PDCA cycle was applied to standardize the nursing management in the ICU. RESULTS: Nine measures were proposed and applied to improve the management of the COVID-19 ICU: defining the clean or contaminated areas, use of self-designed shoe storage cabinets, defining staff roles and responsibilities, establishing the staffing structure, staff training, placing items at fixed locations, improving shift handover, use of bulletin boards for listing key points, and use of reserved drugs cabinets. The virus contamination awareness, professional skills, awareness of duties and responsibilities, and quality and performance of nursing were remarkably improved 2 weeks after the implementation of the above countermeasures. CONCLUSIONS: The PDCA cycle helps to standardize nursing management in COVID-19 ICU by developing and applying effective nursing management approaches.


Assuntos
Infecções por Coronavirus/enfermagem , Enfermagem de Cuidados Críticos/organização & administração , Enfermagem de Cuidados Críticos/normas , Unidades de Terapia Intensiva/organização & administração , Pneumonia Viral/enfermagem , Garantia da Qualidade dos Cuidados de Saúde/métodos , China/epidemiologia , Infecções por Coronavirus/epidemiologia , Humanos , Pesquisa em Administração de Enfermagem , Pesquisa em Avaliação de Enfermagem , Pandemias , Pneumonia Viral/epidemiologia
9.
Arq Bras Cardiol ; 114(5): 817-822, 2020 06 01.
Artigo em Inglês, Português | MEDLINE | ID: mdl-32491073

RESUMO

Coronavirus disease 2019 (COVID-19) is a global pandemic affecting the world, seen in more than 1,300,000 patients. COVID-19 acts through the angiotensin-converting enzyme 2 (ACE2) receptor. Cardiovascular comorbidities are more common with COVID-19, and nearly 10% of cases develop myocarditis (22% of critical patients). Further research is needed to continue or discontinue ACE inhibitors and angiotensin receptor blockers, which are essential in hypertension and heart failure in COVID-19. Intensive research is promising for the treatment and prevention of COVID-19.


Assuntos
Betacoronavirus , Doenças Cardiovasculares/epidemiologia , Infecções por Coronavirus/epidemiologia , Pneumonia Viral/epidemiologia , Antagonistas de Receptores de Angiotensina/metabolismo , Animais , Antirreumáticos/uso terapêutico , Antivirais/uso terapêutico , Doenças Cardiovasculares/enzimologia , Doenças Cardiovasculares/mortalidade , China/epidemiologia , Cloroquina/uso terapêutico , Comorbidade , Infecções por Coronavirus/tratamento farmacológico , Infecções por Coronavirus/enzimologia , Infecções por Coronavirus/mortalidade , Humanos , Hipertensão/enzimologia , Hipertensão/epidemiologia , Pandemias , Peptidil Dipeptidase A/metabolismo , Pneumonia Viral/tratamento farmacológico , Pneumonia Viral/enzimologia , Pneumonia Viral/mortalidade
10.
Sci Total Environ ; 727: 138678, 2020 Jul 20.
Artigo em Inglês | MEDLINE | ID: mdl-32498187

RESUMO

Due to rapid urbanization and a growing population, the tropical forest in southwestern China has experienced a dramatic shrinkage, which threatens its biodiversity and imposes limitations to sustainable development. Spatiotemporal change analysis and ecological sensitivity assessment are the important prerequisites for investigating the relationship between eco-environmental quality and human activities. In this study, the tropical forest and other land cover types in Jinghong, China were firstly classified by a machine learning classification algorithm (support vector machine, SVM) with 7 pairs of remote sensing (RS) data (from 1989 to 2018). Then the spatiotemporal change patterns were analyzed. The ecological sensitivity was evaluated based on an index system method (ISM) in which a weighted combination of eleven indicators were produced using an analytic hierarchy process (AHP) method and GIS. Meanwhile four individual sensitivity indicators, including biodiversity sensitivity (BS), water resources sensitivity (WRS), geological hazard sensitivity (GHS) and soil erosion sensitivity (SES) were assessed respectively to create a multi-perspective understanding of the entire ecological sensitivity. The results suggest that the tropical forest experienced a continual decrease from 5631.78 km2 in 1999 to 4216.23 km2 in 2018 with an average change rate of -1.49%. The decreased area was mainly encroached on by human settlements and agriculture, particularly in the south of Jinghong. Furthermore, it could be seen that urbanization is the key driver for the changes to ecological sensitivity with both positive and negative impacts. In Jinghong, the region covered by a tropical forest has a relatively higher comprehensive ecological sensitivity (CES) than that of an urban area. This work shows RS and GIS to be powerful tools providing profound insights to researchers with regard to the spatiotemporal evolution of tropical forests and ecological sensitivity. The results are significant for improving policies in order to keep a sustainable balance in regional ecosystem management.


Assuntos
Conservação dos Recursos Naturais , Florestas , Agricultura , China , Humanos
11.
Sci Total Environ ; 727: 138690, 2020 Jul 20.
Artigo em Inglês | MEDLINE | ID: mdl-32498188

RESUMO

The spatiotemporal associations between the emissions and environmental toxicities of polycyclic aromatic hydrocarbons (PAHs) in lake still remain an issue. Here, we focused on the suspended particulate matter (SPM)-bound PAHs in Lake Chaohu, China to quantitatively estimate their spatiotemporal toxicities from different sources. A source-based quantitative method, positive matrix factorization (PMF)-benzo[a]pyrene-based toxic equivalency (TEQBaP) model, was applied. Firstly, we investigated the spatiotemporal characteristics of SPM-bound PAHs. The concentrations of Σ21 PAHs ranged from 1646 to 19267 ng·g-1. Low-ring PAHs were found to have the highest fractions. T-distributed stochastic neighbor embedding (t-SNE)-partitioning around medoid (PAM) technic revealed significantly spatiotemporal variation characteristics of SPM-bound PAHs in Lake Chaohu. Season, location (west or east lake zone), and sample classification (estuary or lake) together governed the patterns. Then, their potential sources were apportioned. Our results found that diagnostic ratios did not work perfectly. However, 3 factors were separated by PMF model. Unburned petroleum (F1), biomass, coal and gasoline combustion (F2), and diesel, straw combustion (F3) were the main sources of PAHs, accounting for 36.16%, 48.96% and 14.88%, respectively. The patterns of the source profiles were season-dependent. Finally, the toxicity of SPM-bound PAHs from different sources were predicted by PMF-TEQBaP model, and the model predictions were satisfactorily acceptable. Overall, predicted Σ19 TEQBaP of SPM-bound PAHs in Lake Chaohu ranged from 20.8 to 947.9 ng·g-1. Benzo[e]pyrene (BeP), benzo[a]pyrene (BaP) and benzo[b]fluoranthene (BbF) were the main toxic species. Temporally, PAH toxicity posed significantly seasonal differences. F3 had primary contributions to Σ19 TEQBaP. Cutting the diesel consumption and using cleaner energy substitutes were suggested to reduce the PAH toxicity in Lake Chaohu. Overall, we expected this study could give new insights into the spatiotemporal associations between the sources and toxicities of SPM-bound PAHs in lake ecosystem.


Assuntos
Lagos , China , Ecossistema , Monitoramento Ambiental , Material Particulado , Hidrocarbonetos Policíclicos Aromáticos
12.
Sci Total Environ ; 727: 138691, 2020 Jul 20.
Artigo em Inglês | MEDLINE | ID: mdl-32498189

RESUMO

Data on chlorophenoxy herbicides (CPHs) in drinking water from China are scarce. This study was designed to describe the occurrence of CPHs in drinking water in China. In June 2019, drinking water samples including 789 tap water and 95 groundwater samples were collected from 31 provinces in mainland China and Hong Kong. Raw source, treated, and tap water samples (n = 20, 20, and 170, respectively) in Wuhan, Central China were also analyzed. 2,4-dichlorophenoxyacetic acid (2,4-D) and 2-methyl-4-chlorophenoxyacetic acid (MCPA) were found in 71.2% and 74.9% of the samples nationwide, respectively. The cumulative concentration of CPHs (ΣCPHs) in tap water in China was up to 125 ng/L (median: 1.38 ng/L), and regional variations were found for ΣCPHs. The highest median ΣCPHs (3.95 ng/L) was found in Northeast China, followed by Central (3.40), South (2.71), East (2.43), Southwest (1.58), North (0.42), and Northwest China (0.30). The median ΣCPHs in groundwater was approximately five times lower than that in tap water. In addition, ΣCPHs were found in all the raw source water samples collected in Wuhan, Central China (median: 6.69 ng/L, range: 2.66-43.1 ng/L). The removal of 2,4-D and MCPA during conventional drinking water treatment was not efficient, removing approximately 0.91% and 17.4%, respectively. In a water plant with advanced treatment, they were efficiently removed. Seasonal variations were found in ΣCPHs in tap water from Wuhan, with the highest found in July (median: 21.2 ng/L), and the lowest in October (1.96 ng/L). The intake of CPHs via water ingestion was estimated as below 5 ng/kg-bw/day, much lower than the reference doses for 2,4-D (5 µg/kg-bw/day) and MCPA (4 µg/kg-bw/day). This is the first study to demonstrate the fate of CPHs during drinking water treatment and seasonal variations of CPHs in water from Wuhan, China. Moreover, this study provides an overview of ΣCPHs in tap water for many areas in China.


Assuntos
Ácido 2-Metil-4-clorofenoxiacético , Água Subterrânea , Ácido 2,4-Diclorofenoxiacético , China , Água Potável , Poluentes Químicos da Água
13.
Sci Total Environ ; 727: 138739, 2020 Jul 20.
Artigo em Inglês | MEDLINE | ID: mdl-32498192

RESUMO

Whether or not the completely destroyed ecosystem would follow a succession trajectory towards the surrounding forest ecosystem after restoration remains debatable. Here, a comprehensive dataset of thirty-five ecosystem functions were measured on five reclaimed opencast coal mine forest plots (two Robinia pseudoacacia - Pinus tabuliformis mixed forests with different technosol conditions: RPT and RPM; one R. pseudoacacia - Ulmus pumila - Ailanthus altissima mixed forest: RUA; one Picea meyeri - Picea wilsonii - Hippophae rhamnoides mixed forest: PPH; one R. pseudoacacia monoculture forest: RM) and one natural forest plot (Populus simonii monoculture forest: PM) in Pingshuo opencast coal mine, Shanxi Province, China. These functions were employed to examine the reclamation effects among plots in terms of four management scenarios (i.e., biomass productivity, carbon sequestration, general biodiversity conservation and nutrient accumulation) and to determine the affinities between reclaimed ecosystem and its native counterpart according to Bray Curtis Distance Algorithm. The results showed that after 20-23 years of succession, thirty-five ecosystem functions differed among plots and eight highest ecosystem functions were found in RPT and RPM (P < 0.05). In scenarios of biomass productivity, carbon sequestration, general biodiversity conservation and nutrient accumulation scenarios, RPM scored 0.645, 0.470, 0.467 and 0.578, respectively. Accordingly, RPT scored 0.458, 0.447, 0.405 and 0.515, respectively. Consequently, RPT and RPM had the highest scores in the four management objectives compared to other plots. With regard to the ecosystem affinities, RPT was analogous to RPM. Similarly, RUA and PPH resembled PM and RM, respectively. Overall, the pioneer tree species determined the reclamation quality in the dump in the long term, which could be referred as the "trigger effect" in the succession trajectory in reclaimed ecosystem, and the reclaimed coal mine ecosystem diverged from the surrounding ecosystem and reached a new self-sustaining state after 20-23 years of succession.


Assuntos
Ecossistema , Robinia , China , Carvão Mineral , Mineração , Solo , Fatores de Tempo , Árvores
14.
Sci Total Environ ; 727: 138558, 2020 Jul 20.
Artigo em Inglês | MEDLINE | ID: mdl-32498208

RESUMO

Stable isotopes in wood lignin methoxyl groups (δ2HLM and δ13CLM values) have been suggested as valuable complementary paleoclimate proxies. In permafrost forests, tree growth is influenced by multiple factors, however temperature appears to have the strongest impact on tree growth and, therefore, on carbon cycling. To test whether δ2HLM and δ13CLM values of trees from permafrost regions might record climate parameters, two dominant tree species (Larix gmelinii, larch, and Pinus sylvestris var. mongolica, pine) collected from a permafrost forest in China's Greater Hinggan Mountains, were investigated. The two tree species larch and pine covered time spans of 1940 to 2013 and 1870 to 2013, respectively. Results showed significant correlations of pine and larch δ2HLM values and larch δ13CLM values with temperatures and in particular with the mean temperature of the growing season from April to August. However, only weak correlations of δ2HLM and δ13CLM values with moisture conditions, such as precipitation amount and relative humidity were observed. In addition, species specificity in the climate response was most obvious for δ13CLM values. Compared to a temperature reconstruction based on tree ring width, pine δ2HLM-based reconstruction showed strongest spatial correlations with regional temperature. Therefore, δ2HLM values might be a promising proxy to reconstruct growing-season temperatures in permafrost regions.


Assuntos
Pergelissolo , China , Florestas , Lignina , Temperatura , Árvores , Madeira
15.
J Glob Health ; 10(1): 011005, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32509294

RESUMO

Background: Corona Virus Disease 2019 (COVID-19) is spreading around the world currently, seriously threatening people's health and global security as an international public health emergency. The objective of this study is to summarize China's countermeasures and experience in response to the COVID-19 emergence in order to serve as a warning for the global COVID-19 prevention and control, and further provide some suggestions for global fighting to COVID-19. Methods: Content analysis, expert consultation, and high frequency word analysis were applied in this study. Relevant data and information were collected from official websites, the experience accumulated in China during the fighting to the novel coronavirus, and suggestions from some experts. Results: As of March 29, 2020, China had accumulated 82 419 confirmed diagnoses, and the mortality rate was 4.01%; in the mean time, the global had accumulated 596 042 confirmed diagnoses, and the mortality rate was 4.76%. Although the mortality of COVID-19 was not so high, its harmfulness couldn't be ignored. Ten facts during COVID-19 epidemic in China were summarized in the study, including: the COVID-19 is highly contagious and can be spread through many channels; although elderly people and people with underlying diseases are susceptible, young people can also be victims; isolation is the most effective way to reduce the risk of COVID-19, and secondary disasters induced by COVID-19 should be emphasized in advance. High frequent words of experts' suggestions mainly includes: material, prevention and control, pathogeny, propaganda, education, hygiene, technology, medical care, overall planning, policy, panic, etc. The main concerns of experts are from four aspects: publicity and education, various subjects, medical materials and law construction. Conclusions: COVID-19 is a new infectious disease worldwide, and its infectious source, transmission route, susceptible population, and therapy are not clear. In the face of the COVID-19 epidemic, no country can stand alone to maintain its own safety. People from all over the world should put aside their difference in ideology, religious belief, politics, economy, and culture, and only by global cooperation and globally unified actions, can we successfully overcome COVID-19 in the end.


Assuntos
Infecções por Coronavirus/epidemiologia , Infecções por Coronavirus/prevenção & controle , Saúde Global , Pandemias/prevenção & controle , Pneumonia Viral/epidemiologia , Pneumonia Viral/prevenção & controle , China/epidemiologia , Humanos
16.
Theranostics ; 10(14): 6113-6121, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32483442

RESUMO

Rationale: To retrospectively analyze serial chest CT and clinical features in patients with coronavirus disease 2019 (COVID-19) for the assessment of temporal changes and to investigate how the changes differ in survivors and nonsurvivors. Methods: The consecutive records of 93 patients with confirmed COVID-19 who were admitted to Wuhan Union Hospital from January 10, 2020, to February 22, 2020, were retrospectively reviewed. A series of chest CT findings and clinical data were collected and analyzed. The serial chest CT scans were scored on a semiquantitative basis according to the extent of pulmonary abnormalities. Chest CT scores in different periods (0 - 5 days, 6 - 10 days, 11 - 15 days, 16 - 20 days, and > 20 days) since symptom onset were compared between survivors and nonsurvivors, and the temporal trend of the radiographic-clinical features was analyzed. Results: The final cohort consisted of 93 patients: 68 survivors and 25 nonsurvivors. Nonsurvivors were significantly older than survivors. For both survivors and nonsurvivors, the chest CT scores were not different in the first period (0 - 5 days) but diverged afterwards. The mortality rate of COVID-19 monotonously increased with chest CT scores, which positively correlated with the neutrophil-to-lymphocyte ratio, neutrophil percentage, D-dimer level, lactate dehydrogenase level and erythrocyte sedimentation rate, while negatively correlated with the lymphocyte percentage and lymphocyte count. Conclusions: Chest CT scores correlate well with risk factors for mortality over periods, thus they may be used as a prognostic indicator in COVID-19. While higher chest CT scores are associated with a higher mortality rate, CT images taken at least 6 days since symptom onset may contain more prognostic information than images taken at an earlier period.


Assuntos
Betacoronavirus , Infecções por Coronavirus/diagnóstico por imagem , Pneumonia Viral/diagnóstico por imagem , Adulto , Fatores Etários , Idoso , China/epidemiologia , Infecções por Coronavirus/sangue , Infecções por Coronavirus/mortalidade , Progressão da Doença , Feminino , Humanos , Contagem de Leucócitos , Contagem de Linfócitos , Masculino , Pessoa de Meia-Idade , Neutrófilos , Pandemias , Pneumonia Viral/sangue , Pneumonia Viral/mortalidade , Prognóstico , Estudos Retrospectivos , Fatores de Risco , Nanomedicina Teranóstica , Tórax/diagnóstico por imagem , Tomografia Computadorizada por Raios X
19.
Shanghai Kou Qiang Yi Xue ; 29(1): 69-74, 2020 Feb.
Artigo em Chinês | MEDLINE | ID: mdl-32524125

RESUMO

PURPOSE: To compare the differences of influence of mothers' different socio-demographic background, their oral health status and feeding behavior on their one-month-old infants' risk of dental caries between Shanghai and Kunming, and to explore the factors affecting infants' risk of dental caries in different regions. METHODS: One-month-old infants and their mothers from Huangpu district of Shanghai and Xishan district of Kunming were recruited in the study. Oral plaque samples of mothers and their infants were collected to assess their risk of dental caries. Statistical analysis was performed using SPSS 22.0 software package, and multivariate logistic regression analysis was used to screen the factors affecting the risk of infantile rickets in Shanghai and Kunming. RESULITS: A total of 165 mother-child pairs in Shanghai and 161 mother-child pairs in Kunming participated in the survey, and the proportion of infants who were at high risk of caries was 10.3% and 6.2%, respectively. The result of multivariate logistic analysis indicated that the infants whose mother smoked before pregnancy (OR=6.9, P=0.030) and attained lower education level (OR=6.1, P=0.035) had higher risk of caries in Shanghai; while in Kunming, the infants whose mother had higher DMFS values were at higher risk of caries (OR=1.1, P=0.031). CONCLUSIONS: Factors affecting one-month-old infants' risk of caries in Shanghai and Kunming were pre-pregnancy maternal cigarette smoking, mother's lower education level and mother's dental caries status, respectively.


Assuntos
Cárie Dentária , Placa Dentária , Criança , China , Feminino , Humanos , Lactente , Mães , Gravidez , Inquéritos e Questionários
20.
Shanghai Kou Qiang Yi Xue ; 29(1): 85-88, 2020 Feb.
Artigo em Chinês | MEDLINE | ID: mdl-32524128

RESUMO

PURPOSE: To investigate the category and prevalence rate of denture-related oral mucosal lesions (DML) in 185 patients with removable denture and analyze the influencing factors. METHODS: A total of 185 patients with removable denture who visited the department of stomatology of our hospital from October 2015 to June 2018 were investigated by questionnaire. DML types and locations were recorded in detail, and patients were followed up after treatment. Based on the data of this study, the differences of DML reports in other regions of China were analyzed by comparing the results searched from databases. SPSS 17.0 software package was used for statistical analysis. RESULTS: In this study, the DML prevalence rate was 42.7%, significantly higher in male patients than in female patients (54.17% vs 35.40%, P<0.05). DML was more common in complete denture wearers than that in partial denture wearers (66.67% vs 31.20%, P<0.05). The categories of DML were as followed (prevalence rate from high to low): denture stomatitis (54.43%), traumatic ulcer (34.18%), inflammatory hyperplasia (6.33%), and angular cheilitis (5.06%). CONCLUSIONS: DML is affected by multiple factors. Among them, denture related factors include denture type, denture wearing time, denture lasting time and cleaning method. DML is more influenced by the type of denture than the wearing time. Gender, ethnicity and systemic diseases may affect the prevalence of DML, but further studies are needed. The results of domestic studies in various regions cannot objectively reflect the current prevalence rate of DML, thus a multi-center epidemiological investigation is needed.


Assuntos
Prótese Parcial Removível , Doenças da Boca , Estomatite sob Prótese , China , Prótese Total , Prótese Parcial , Feminino , Humanos , Masculino
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