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Br Med J ; 283(6283): 5-7, July 4, 1981.
Artigo em Inglês | MedCarib | ID: med-12580


Leucocyte sodium and potassium content and concentrations were measured along with ouabain-sensitive and ouabain-insensitive rate constants for sodium efflux in 14 controls and 20 black patients with essential hypertension. Leucocyte sodium content was significantly increased in the patients (mean 101.1 ñ 7.8 mmol/kg dry solids v 74.5 ñ 7.6 mmol/kg dry solids; p<0.05), whereas the rate constants for sodium efflux were not significantly reduced. There was no difference between the two groups in cell potassium values. The increase in leucocyte sodium content in the presence of normal rate constants for sodium efflux suggests an increase in membrane permeability to sodium, which might be important in the pathogenesis of essential hypertension. (AU)

Humanos , Adulto , Pessoa de Meia-Idade , Hipertensão/sangue , Leucócitos/metabolismo , Sódio/sangue , Potássio/sangue , Transporte Biológico Ativo , Jamaica , Cinética , Água/metabolismo
Kingston; s.n; June 1980. 388 p. tab.
Tese em Inglês | MedCarib | ID: med-13633


There is a need for data on cellular electrolytes and sodium pump activity in many models of hypertension because it has become evident that if sodium is involved in hypertension, it is at the cellular level that it is important. This study was designed to measure leucocyte sodium, potassium, and rate constants for sodium efflux, total and ouabain insensitive, in animal and human hypertension. In Goldblatt-2-kidney hypertension, leucocyte electrolytes and rate constants were undisturbed. In Goldblatt-1-kidney hypertension, leucocyte, sodium content unchanged, potassium concentration was depressed, and the rate constant for total sodium efflux was lower. The passive efflux represented by the ouabain insensitive efflux, remained the same. In Goldblatt-1-kidney rats drinking 1 percent saline leucocyte sodium content fell while rate constant for total sodium efflux was increased. Ouabain insensitive efflux was unchanged. In DOCA hypertension, leucocyte sodium content was marginally elevated while the rate constant for total sodium efflux was also increased. Passive efflux was unchanged. Leucocytes from patients with essential hypertension had a high sodium content and concentration, and normal potassium content. Potassium concentration was depressed because of a higher cell water. Total sodium efflux rate constant was unchanged as was ouabain insensitive efflux. In pre-eclampsia, leucocyte sodium content and concentration were elevated while potassium content and concentration were depressed. The rate constant for total sodium efflux was lower while ouabain insensitive efflux was the same. These abnormalities disappeared six months after delivery. These findings are consistent with a hypothesis that cellular sodium is important in the pathogenesis of hypertension, but that there are at least two schemata for its involvement in the various models. (AU)

Humanos , Ratos , Hipertensão , Sódio/metabolismo , Hipertensão/induzido quimicamente , Hipertensão Renovascular/induzido quimicamente , Pré-Eclâmpsia/metabolismo , Potássio/metabolismo , Ouabaína , Leucócitos/metabolismo , Eletrólitos/metabolismo
Pediatr Res ; 12(7): 767-70, Jul. 1978.
Artigo em Inglês | MedCarib | ID: med-9917


Leukocyte potassium has been measured in normal subjects and in malnourished children with and without edema both on admission and during recovery. In nonedematous malnourished children the potassium content was low (328mmol/kg dry solids) and took 2-3 weeks of rehabilitation to return to normal (374 mmol/kg dry solids). Leukocytes from edematous children had normal intracellular potassium values. However, 5 days on a maintenance diet reduced the intracellular potassium in the children with kwashiorkor to a value similar to that found in marasmus. Plasma potassium was significantly lower in kwashiorkor (3.43) than in marasmus (4.74). The relationship between external potassium and internal potassium in normal leukocytes was measured (fig.1) and the values found severe malnutrition compared with normal. It was found that in nonedematous malnutrition intracellular potassium was low compared to the predicted value, whereas in kwashiorkor, although the mean values were normal, no relationship between external potassium and intracellular potassium could be demonstrated. It is concluded that in the leukocyte malnutrition alters either the passive permeability of the membrane to potassium or the active transport of potassium of both.(AU)

Humanos , Lactente , Leucócitos/análise , Potássio/sangue , Desnutrição Proteico-Calórica/sangue , Transporte Biológico , Líquido Intracelular/análise , Kwashiorkor/sangue , Potássio/metabolismo , Espaço Extracelular/análise
Am J Clin Nutr ; 30(9): 1478-81, Sept. 1977.
Artigo em Inglês | MedCarib | ID: med-10380


Intracellular electrolytes and sodium transport were measured in leukocytes obtained from malnourished children. In the presence of edema, leukocyte sodium and potassium were raised. The total flux and the glycoside-sensitive portion were increased. Loss of edema was associated with reductions in all these measurements. In marasmus, glycoside-sensitive sodium efflux was reduced compared to recovered values. Sodium was increased and potassium reduced. It is concluded that at least two defects in sodium transport may occur in protein energy malnutrition, an increased passive permeability in kwashiorkor and a reduced active transport for sodium in marasmus. (AU)

Humanos , Criança , Leucócitos/metabolismo , Potássio/sangue , Desnutrição Proteico-Calórica/sangue , Sódio/sangue , Transporte Biológico/efeitos dos fármacos , Edema/complicações , Glicosídeos/farmacocinética , Kwashiorkor/sangue , Desnutrição Proteico-Calórica/complicações , Desnutrição Proteico-Calórica/dietoterapia
Br Med J ; 1(6020): 1254-5, May 1976.
Artigo em Inglês | MedCarib | ID: med-10777


Sodium and potassium levels in plasma and leucocytes and the sodium efflux rate constants of leucocytes were measured in patients with congenital heart disease not on treatment, patients with valvular heart disease being treated with digoxin and conventional diuretics showed low cellular potassium levels, low sodium levels. Patients given triamterene showed a rise in potassium levels in plasma and cells and in the sodium efflux rate constant (AU)

Humanos , Cardiopatias Congênitas/sangue , Doenças das Valvas Cardíacas/sangue , Leucócitos/metabolismo , Potássio/sangue , Sódio/sangue , Triantereno/farmacologia , Digoxina/administração & dosagem , Digoxina/uso terapêutico , Diuréticos/uso terapêutico , Doenças das Valvas Cardíacas/tratamento farmacológico , Leucócitos/efeitos dos fármacos