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J Clin Lab Immunol ; 13(3): 129-32, Mar. 1984.
Artigo em Inglês | MedCarib | ID: med-7214


The subpopulations of mononuclear cells and the lymphocyte proliferative capacity following mitogen stimulation were studied in 22 patients with homozygous sickle cell (SS) disease and 25 controls with a normal haemoglobin (AA) genotype. The total number of lymphocytes in peripheral blood samples was higher in SS patients compared to controls. Expressed as a percentage of total lymphocytes, the number of B lymphocytes (detected by membrane immunoglobulin Fluorescence) was normal and of T lymphocytes (identified by sheep erythocyte rosetting) was slightly reduced in SS disease. Expressed in absolute numbers, both B and T lymphoctes were increased. Lymphocyte proliferation measured by tritium labelled thymidine incorporation following stimulation with phytohaemaeglutin A and concanavalin A was normal. Following pokeweed mitogen stimulation, thymidine incorporation was significantly increased in SS disease although normal when expressed as a stimualtion index. These results do not suggest a major defect in cell mediated immunity in sickle cell disease. The number of circulating monocytes was increased in SS disease and correlated inversely with the number of reticulocyytes (r= -0.58, p < 0.005) (AU)

Humanos , Masculino , Feminino , Técnicas In Vitro , Adolescente , Adulto , Pessoa de Meia-Idade , Anemia Falciforme/imunologia , Ativação Linfocitária , Anemia Falciforme/sangue , Linfócitos B , Contagem de Leucócitos , Mitógenos/farmacologia , Monócitos , Reticulócitos , Linfócitos T , Jamaica