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Exp Pathol Jena ; 18(4): 245-53, 1980.
Artigo em Inglês | MedCarib | ID: med-3186


In magnesium deficient rats with a clinical picture of protein malnutrition, pancreatic changes typical of protein malnutrition were expected. However, in rats fed for four weeks on a low magnesium diet (protein content 25 percent), light and electron microscopic studies revealed that the ascinar cells of the pancreas were packed with zymogen granules, suggesting a disturbance in the discharge (rather than in the production) of the pancreatic enzymes. The mitochondria and the lumina of the RER were swollen. The nuclei had an irregular outline, the chromatin was aggregated into irregular granules and the nucleolemma of the nucleolus was fibrillar. It was suggested that the disturbance in the release of pancreatic enzymes might cause a maldigestion of the dietary protein, which eventually would lead to the condition of protein malnutrition in the magnesium deficient rats. The disturbance of exocytosis in the pancreas of magnesium deficient rats might be due to the preferential use of all the available magnesium for protein (enzymes) synthesis so that there were no magnesium ions left for the energy dependent discharge of the zymogen granules (AU).

21003 , Masculino , Ratos , Deficiência de Magnésio/patologia , Pâncreas/ultraestrutura , Núcleo Celular/ultraestrutura , Grânulos Citoplasmáticos/ultraestrutura , Mitocôndrias/ultraestrutura , Retículo Endoplasmático/ultraestrutura , Complexo de Golgi/ultraestrutura , Junções Intercelulares/ultraestrutura , Microscopia Eletrônica , Ribossomos/ultraestrutura
Pediatr Res ; 12(3): 167-70, Mar. 1978.
Artigo em Inglês | MedCarib | ID: med-10407


Muscle tissue obtained by needle biopsy from the quadriceps femoris of eight malnourished and eight recovered children were examined histologically. In both groups about two-thirds of the total nuclear count was due to muscle nuclei. The remaining one-third was made up of vascular, nerve, and interstitial cells and isolated nuclei in similar proportions in the two groups. A significantly greater percentage of muscle nuclei consisted of myogenic cells in recovered children as compared to malnourished children(20.7 ñ 6.4 vs. 2.6 ñ 1.4 percent)(AU)

Humanos , Lactente , Pré-Escolar , Masculino , Feminino , Núcleo Celular/ultraestrutura , Desnutrição Proteico-Calórica/patologia , Vasos Sanguíneos/ultraestrutura , DNA/análise , Músculos/análise , Fibras Nervosas/ultraestrutura , Desnutrição Proteico-Calórica/metabolismo
Br J Dis Chest ; 68: 202-6, July 1974.
Artigo em Inglês | MedCarib | ID: med-8776


The clinical, radiological and pathological features of fibroxanthomatous pseudotumour of the lung in a 17-year-old Jamaican female Negro are described. The patient was symptom-free 4 years after treatment by conservative surgery. The condition is extremely rare. Its aetiology and pathogenesis are discussed. (Summary)

Humanos , Adolescente , Feminino , Fibroma , Neoplasias Pulmonares , Peso Corporal , Brônquios/patologia , Broncografia , Núcleo Celular , Colágeno/análise , Tosse/etiologia , Citoplasma , Eosinófilos , Fibroma/diagnóstico , Fibroma/patologia , Fibroma/cirurgia , Hemoptise/etiologia , Histiócitos , Pulmão/patologia , Pulmão/diagnóstico por imagem , Neoplasias Pulmonares/cirurgia , Linfócitos , Plasmócitos , Tomografia
J Clin Pathol ; 24(6): 520-3, Sept. 1971.
Artigo em Inglês | MedCarib | ID: med-14443


The ultrastructure of a glumous tumour is described, and the implications of the findings with regard to the histogenesis of this type of tumour are briefly discussed (Summary)

Humanos , Pessoa de Meia-Idade , Masculino , Tumor Glômico/patologia , Nucléolo Celular , Núcleo Celular , Citoplasma , Complexo de Golgi , Microscopia Eletrônica , Mitocôndrias , Miofibrilas , Punho