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Br J Nutr ; 32(2): 189, 1974.
Artigo em Inglês | MedCarib | ID: med-5059


Total lysosmal hydrolase activities were measured in liver, gastrocnemius muscle and plasma of malnourished and normal rats between 3 and 8 weeks of age. Concurrently, the DNA and protein contents of the livers and muscles were determined. Increased amounts of acid hydrolase activities were found to be associated with subnormal protein: DNA ratios in the tissues of malnourished rats. It was concluded that lysosmal enzymes may be involved in protein catabolism during malnutrition (AU)

21003 , Ratos , Transtornos Nutricionais , Lisossomos , Fosfatase Ácida , Deficiência de Proteína , Catepsinas , Peso Corporal , Fígado , Músculos
Am J Pathol ; 59(1): 161-80, Apr. 1970.
Artigo em Inglês | MedCarib | ID: med-15809


Hypoglycin is a toxic amino acid found in the unripe ackee fruit. The ackee is a popular item of diet in Jamaica and has been proposed as a cause of the so-called vomiting sickness. Hypoglycin is thought to act by inhibiting the oxidation of long-chain fatty acids, uncoupling oxidative phosphorylation, and interfering with gluconeogenesis. Hypoglycin was given intraperitoneally to rats in a dose of 10 mg/100 g, and samples of liver taken at hourly intervals up to 5 hr were studied with the electron microscope and compared with controls. The major ultrastructural findings in the hypoglycin-treated rats were progressive mitochondrial swelling with loss of granules and pallor of the matrix, followed by incorporation into autophagic vacuoles. These findings correlate well with the reported biochemical mechanisms.(AU)

21003 , Masculino , Ciclopropanos/toxicidade , Fígado/patologia , Modelos Animais de Doenças , Ácidos Graxos/metabolismo , Injeções Intraperitoneais , Gluconeogênese , Fígado/metabolismo , Hepatopatias/induzido quimicamente , Mitocôndrias Hepáticas , Lisossomos , Microscopia Eletrônica , Oxirredução , Jamaica