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West Indian med. j ; 50(2): 105-8, Jun. 2001.
Artigo em Inglês | MedCarib | ID: med-351


The tetracyclines are a group of broad-spectrum antimicrobial agents. The first of these compounds, chlortetracycline was isolated from Streptomyces aureofaciens by Benjamin Duggar and introduced into the market in 1948. In 1952, tetracycline was derived semisynthetically from chlortetracycline by removal of its chlorine atom by catalytic hydrogenation. Methacycline, doxycycline and minocycline are all semi-synthetic derivatives. The tetracyclines are closely congeneric derivatives of polycyclic napthacenecarboxamide. The tetracyclines posses a wide range of antimicrobial activity against gram-positive and gram-negative bacteria. In vitro, these drugs are primarily bacteriostatic. Tetracycline have been used extensively as antimicrobial, chemically modified non-antimicrobial properties by Golub. The tetracyclines and their non-antimicrobial, chemically modified analogues have properties that appear to modulate host response by inhibiting the activity of the matrix metalloproteinases that cause collagen destruction. They also inhibit osteoclast function, stimulate osteoblastic bone formation, and regulate angiogenesis.(Au)

Técnicas In Vitro , Humanos , Tetraciclinas/farmacologia , Resistência Microbiana a Medicamentos , Doenças Periodontais/tratamento farmacológico , Metaloproteinase 3 da Matriz/antagonistas & inibidores , /farmacologia , Neovascularização Fisiológica , Osteoclastos/efeitos dos fármacos , Osteogênese/efeitos dos fármacos , Periodontite/tratamento farmacológico
West Indian med. j ; 17(4): 250, Dec. 1968.
Artigo em Inglês | MedCarib | ID: med-7551


Osteoclasts are frequently, perhaps invariably, associated with resorbing surfaces of bone. Studies have been carried out in animals stained intra-vitally with alizarin red, supravitally with neutral red, and in controls, to determine criteria for resorption and the frequency of association of osteoclasts with this process. In these experiments, a constant association was found between the presence of osteoclasts may be utilised as "target areas" in order to test factors affecting osteoclast function (AU)