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New York; Raven Press; 1990. 484 p.
Monografia em Inglês | MedCarib | ID: med-14136
In. Anon. AIDS: profile of an epidemic. Washington, D.C, Pan American Health Organization, 1989. p.113-9. (Scientific Publication, 514).
Monografia | MedCarib | ID: med-14185
Ann Neurol ; 23(suppl): S174-80, 1988.
Artigo em Inglês | MedCarib | ID: med-12478


Human T-lymphotropic virus type I (HTLV-I) has been associated with adult T-cell leukemia/lymphoma (ATL), a malignancy of mature CD4-positive lymphocytes, and tropical spastic paraparesis (TSP), a demyelinating neurological syndrome. This article describes the clinical and pathological features of ATL and reviews the epidemiology of this disease and of its putative etiological agent, HTLV-I. From what is known about the molecular biology and epidemiology of HTLV-I, hypotheses on the etiology of TSP are proposed, and strategies for studying the neurological syndrome are suggested. (AU)

Humanos , Adulto , Masculino , Feminino , Infecções por Deltaretrovirus/complicações , Leucemia/complicações , Infecções por Retroviridae , Ásia , Doença Crônica , Doenças Hematológicas/etiologia , Infecções por Deltaretrovirus/epidemiologia , Infecções por Deltaretrovirus/fisiopatologia , Deltaretrovirus/fisiologia , Pessoa de Meia-Idade , Doenças do Sistema Nervoso/etiologia , Índias Ocidentais , Paraparesia Espástica Tropical
Int J Cancer ; 38(1): 41-5, July 1986.
Artigo em Inglês | MedCarib | ID: med-13285


Six healthy relatives of 3 adult T-cell leukemia lymphoma (ATLL) patients and 6 members of a Caribbean family immigrant to the UK have been investigated for the presence of HTLV-I and expression of interleukin 2(IL-2) receptors. Serum antibodies to HTLV-I were detected in all but 4 samples. Four to 10 percent of circulating cells from 3/4 seropositive donors studied displayed IL-2 receptors (anti-Tac+) and were shown to be convoluted lymphocytes by light microscopy morphology and immunoelectromicroscopy. After 5 to 28 days in culture, cells from 4 seropositive donors reacted with monoclonal antibodies (MAbs) against the HTLV-I core proteins, p19 and p24, and released retrovirus particles. Simmilar experiments with blood from 3 seronegative donors from the same families and 4 normal controls proved negative. Our findings indicate that seropositive individuals harbour the virus in a population of T-lymphocytes which may then acquire receptors for IL-2. These individuals are at risk of developing ATLL. (AU)

Humanos , Portador Sadio/microbiologia , Leucemia/microbiologia , Infecções por Retroviridae/microbiologia , Anticorpos Antivirais/análise , Portador Sadio/sangue , Células Cultivadas , Reino Unido , Deltaretrovirus/imunologia , Técnicas Imunoenzimáticas , Leucemia/sangue , Linfócitos/imunologia , Linfócitos/ultraestrutura , Receptores de Antígenos de Linfócitos T/imunologia , Receptores Imunológicos/imunologia , Proteínas do Core Viral/análise , Vírion/ultraestrutura , Índias Ocidentais/etnologia
Br Med J ; 290(6477): 1243-6, 1985.
Artigo em Inglês | MedCarib | ID: med-14411


Adult T cell leukaemia/lymphoma was first recognised as a clinical entity in southwest Japan. Subsequently the Caribbean has been found to be another area where the disease is endemic, and sporadic cases have been identified in different parts of the world. The human T cell leukaemia/lymphoma virus (HTLV-1) is causally related to adult T cell leukaemia/lymphoma. A sub-group of HTLV, designated HTLV-111, has recently been isolated from many patients with the acquired immunodeficiency syndrome (AIDS) and preAIDS, and there is now evidence that this variant is the primary cause of AIDS. This is the first report from Trinidad to describe twelve cases of adult T cell leukaemia/lymphoma and 14 of AIDS. All were in patients of African descent. No cases were seen in subjects of East Indian descent, who, like those of African descent, comprise as much as 40 percent of the population

Humanos , Adulto , Pessoa de Meia-Idade , Idoso , Masculino , Feminino , Síndrome de Imunodeficiência Adquirida/epidemiologia , Leucemia/epidemiologia , Infecções por Retroviridae/epidemiologia , Deltaretrovirus , Linfócitos T , Trinidad e Tobago
Artigo em Inglês | MedCarib | ID: med-1594


63 haemodialysis (HD) patients and 63 age and gender matched controls were investigated for hepatitis B surface antigen (HbsAg) and antibodies to hepatitis B virus (anti-HBV), hepatitis C virus (anti-HCV), hepatitis D virus (anti-HDV), human immunodeficiency virus types 1 and 2 (anti-HIV-1 and 2) and human T-cell lymphotropic virus type-1 (anti-HTLV-1). The notable finding was an increase in hepatitis B markers, 34.9 percent in HD patients compared to 19.0 percent in controls (p < 0.02). The seroprevalence of anti-HCV (7.9 percent, p < 0.03) and anti-HTLV-1 (9.5 percent; p < 0.006) was also increased in the patients. Four of the five patients positive for anti-HCV were also seropositive for HBV. Anti-HIV and anti-HDV were not detectable in the HD patients in this study. The possibility of HTLV-1 being transmitted by organ transplantation is raised. The seropositivity rate for hepatitis B and C increased with duration on dialysis, but it is likely that it was related to the number of blood transfusions since 50 percent with no transfusion were HBV seropositive.(AU)

Adulto , Pessoa de Meia-Idade , Idoso , Feminino , Humanos , Masculino , Antígenos de Superfície da Hepatite B/sangue , Infecções por Retroviridae/sangue , Diálise Renal , Vírus da Hepatite B/imunologia , Anticorpos Anti-Hepatite C , Vírus Delta da Hepatite/imunologia , HIV-1/imunologia , HIV-2/imunologia , Anticorpos Anti-HTLV-I/sangue , Jamaica