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West Indian med. j ; 43(3): 89-92, Sept. 1994.
Artigo em Inglês | MedCarib | ID: med-7758


A retrospective analysis of 26 children with neuroblastic tumours treated at the University Hospital of the West Indies (UHWI) between 1970 and 1991 was undertaken to evaluate factors affecting prognosis. The peak incidence was between 48 months and 60 months of age, and 75 percent of the deaths occurred in children older than 3 years. The abdomen was the most common site of the tumours 79 percent of which were from the adrenal gland and carried a dismal outcome. Other sites were thoracic, pelvic and cervical. Extra-adrenal tumours have a good outcome even when the histology is unfavourable; 92 percent of the tumours were in Stages III or IV at the time of initial presentation. Stage IV disease accounted for all but one of the deaths. Of the 8 children with favourable histology (ganglioneuroma or well-differentiated ganglioneuroblastoma), only one (12.5 percent) died, whereas of the remaining 18 cases with unfavourable histology (neuroblastoma and undifferentiated ganglioneuroblastoma), eleven (61 percent) died. When managed by surgery alone or with adjuvant chemo- and/or radio-therapy, only 36.4 percent succumbed while all 4 children with chemotherapy only died. Ten children are alive without disease for more than three years post-therapy. A scoring system was designed which takes into account the factors influencing the outcome in neuroblastic tumours, namely, age, location, stage and histological types of the tumours and therapy. All the children with a score of 21 or less survived, whereas all those with scores of 22 or above succumbed. This underlines the multifactorial influences on the final outcome of neuroblastic tumours (AU)

Humanos , Pré-Escolar , Criança , Prognóstico , Neuroblastoma , Neuroblastoma/terapia , Evolução Fatal , Índice de Gravidade de Doença
West Indian Dental J ; 1(1): 15-17, July 1994.
Artigo em Inglês | MedCarib | ID: med-7723


Malignant neoplasm of the jaws metastatic from primary sit elsewhere in the body do not constitute a numerically large group of lesions. A report of a metastatic neuroblastoma of the adrenal gland to the mandible of a one-year-old infant is described. The tumour was readily diagnosed based on detailed history, clinical examination, roentgenographic features and histologic features. The treatment was that of radiotherapy of the jaw lesion, followed by chemotherapy (AU)

Lactente , Neuroblastoma/terapia , Neoplasias Mandibulares/secundário , Neoplasias Mandibulares/terapia , Neoplasias das Glândulas Suprarrenais
West Indian med. j ; 31(3): 149-52, Sept. 1982.
Artigo em Inglês | MedCarib | ID: med-11378


The first case of neuroblastoma in an adult seen at University Hospital of the West Indies has been reported. The diagnosis was suspected at laparotomy and confirmed by biopsy. Treatment by radiotherapy and chemotherapy produced a temporary regression, but the patient died from metastases one year after the diagnosis was established (AU)

Adulto , Humanos , Masculino , Neuroblastoma/diagnóstico por imagem , Neoplasias Retroperitoneais/diagnóstico por imagem , Jamaica
West Indian med. j ; 30(4): 215-8, Dec. 1981.
Artigo em Inglês | MedCarib | ID: med-11317


A case of paratesticular neuroblastoma in a 2-year old boy is described. The tumour appears to be a primary lesion rather than a metastasis. No previously reported cases of this unusual condition could be found in the literature. Possible explanation for the occurrence of the tumour in the scrotum is given (AU)

Humanos , Masculino , Pré-Escolar , Neoplasias dos Genitais Masculinos/patologia , Neuroblastoma/patologia , Neoplasias dos Genitais Masculinos/cirurgia , Neuroblastoma/cirurgia , Jamaica
West Indian med. j ; 16(2): 120, 1967.
Artigo em Inglês | MedCarib | ID: med-7318


Neuroblastoma arises from the adrenal medulla and sympathetic nervous system and is mainly a disease of infancy and childhood. This is a malignant tumour which presents in many different ways and which on histological examination shows small dark round cells, sometimes gathered into "rosettes". neuroblastoma spreads easily. The primary site is usually retroperitoneal; these present with an abdominal mass due either to the primary neoplasm or to hepatic metastases. Skeletal metastasis occurs eventually and may be the presenting feature. Investigations in suspected cases should include skeletal radiological survey, marrow puncture and the estimation of urinary catecholamines and their metabolites. Fourteen Jamaican patients with this disease are reviewed. There was a delay in diagnosis in five patients and these patients are discussed in more detail. Six patients were not offered treatment and the other eight patients were treated in a variety of ways all with poor results. Emphasis is placed on the necessity for early diagnosis which depends largely on a high index of suspicion in children with a vague chronic pyrexial illness. The most useful current method of management is presented. (AU)

Criança , Humanos , Neuroblastoma , Jamaica