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1.
Artigo em Inglês | MedCarib | ID: med-17415

RESUMO

OBJECTIVE. Colon cancer is the most common malignancy found in the developed countries. Cancer initiation and progression is known to be associated with the formation of reactive oxygen species, formed in excess in the gastrointestinal tract. The aim of the study was to assess the levels of protein thiols and thiobarbituric acid reactive substances (TBARS) in patients with colon cancer. MATERIAL AND METHODS. Serum samples were obtained from 60 subjects (M and F, mean age 50ñ15 years), 30 of which were from colon cancer patients and 30 from healthy individuals. All the serum samples were analyzed for carcinoembryonic antigen (CEA), protein thiols and TBARS. RESULTS. The levels of protein thiols were significantly lower in colon cancer patients (p<0.001) than in the healthy controls. The TBARS levels in colon cancer patients were moderately high (p<0.05) in comparison with those of the controls. CONCLUSIONS. Low levels of protein thiols and elevated TBARS of colon cancer patients support the hypothesis that colon cancer is associated with reactive oxygen species. Therefore protein thiols and TBARS may serve as additive non-invasive biochemical markers of oxidative stress in colon cancer and this hypothesis needs to be further investigated.


Assuntos
Humanos , Neoplasias do Colo/complicações , Neoplasias do Colo/patologia , Substâncias Reativas com Ácido Tiobarbitúrico/análise , Substâncias Reativas com Ácido Tiobarbitúrico/química , Substâncias Reativas com Ácido Tiobarbitúrico/toxicidade
2.
West Indian med. j ; 50(2): 144-7, Jun. 2001. tab
Artigo em Inglês | MedCarib | ID: med-343

RESUMO

Lipomas of the colon are uncommon but cause diagnostic difficulty when they are symptomatic. The clinical and pathological features of 17 cases of colonic lipomas diagnosed at the University Hospital of the West Indies between 1970 and 1999 are reported. Ten cases were symptomatic, two of these being diagnosed with adult intussusception. Six patients had incidental lipomas in bowel resected for other patholgoy while one lipomas was diagnosed an sigmoidoscopy. Increased awareness of these lesions will enhanced pre-operative diagnostic accuracy.(Au)


Assuntos
Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Idoso , Lipoma/epidemiologia , Neoplasias do Colo/epidemiologia , Jamaica/epidemiologia , Neoplasias do Colo/diagnóstico , Lipoma/diagnóstico
4.
West Indian med. j ; 42(suppl.3): 23, Nov. 1993.
Artigo em Inglês | MedCarib | ID: med-5470

RESUMO

Familial occurrence of colorectal carcinoma in the absense of polyposis is an uncommon but well-documented entity. Although colonic carcinoma is relatively uncommon in the developing world, 3 families with clustering of this tumour have been identified in Trinidad. In this first reporat of familial colonic cancer from the West Indies, the families were (one each) of African, Chinese and East Indian origin. There was slight male predominance (M:F = 1.2:1). Early onset of the disease and poor prognosis were uniform features, with average age at death being 45.4 years. The right colonic involvement synchronously or metachronously occurred in the remainder. An aggressive policy of surveillance in affected members and screening in asymptomatic relatives should favourably alter the prognosis in such stricken families (AU)


Assuntos
Humanos , Masculino , Feminino , Adulto , Neoplasias do Colo/epidemiologia , Trinidad e Tobago
5.
West Indian med. j ; 42(Suppl. 1): 54, Apr. 1993.
Artigo em Inglês | MedCarib | ID: med-5100

RESUMO

Twenty-two consecutive patients with obstructing left colonic carcinoma underwent resection of the tumour and colocolic anastomosis, without intra-operative colonic lavage. There were two wound infections (9 per cent) but no anastomotic leaks or intra-abdominal abscesses. One death occurred 12 hours following surgery. At postmortem, the cause was attributed to myocardial infarction. The average duration of hospitalization was 8 days. Emergency surgery on the obstructed left colon can be safely carried out without intra-operative colonic lavage (AU)


Assuntos
Humanos , Neoplasias do Colo/cirurgia , Neoplasias do Colo/cirurgia , Irrigação Terapêutica
6.
Artigo em Inglês | MedCarib | ID: med-17115

RESUMO

Thirty-two consecutive cases of left-sided colonic obstruction are presented. Thirty cases were managed by primary resection and anastomosis without colostmy. No anastomotic leakage occurred. This procedure allowed significant conservation of material and personnel resources with minimal patient morbidity (AU)


Assuntos
Humanos , Colostomia , Neoplasias do Colo Sigmoide/cirurgia , Neoplasias do Colo/cirurgia , Anastomose Cirúrgica/métodos , Colo/lesões , Colo/cirurgia , Pseudo-Obstrução do Colo , Países em Desenvolvimento
8.
West Indian med. j ; 38(4): 213-6, Dec. 1989.
Artigo em Inglês | MedCarib | ID: med-14338

RESUMO

Four hundred and nine colonoscopic examinations were performed in 335 patients over a 12-year period in Jamaica. The main indications were suspected polyps (34 percent), rectal bleeding (22 percent), and suspected carcinoma (11 percent). Total colonoscopy was performed in 33 percent of cases. The ascending colon and hepatic flexure were examined in a further 25 percent, and the transverse colon in another 21 percent. Endoscopic examination of the suspected abnormal area was possible in all cases. In 142 examinations, no abnormality was detected, reflecting a false positive Barium enema in some. Polyps were found in 135 examinations, diverticula in 69 and carcinoma in 13. There were no complications. Colonoscopy was more sensitive and specific than Barium enema. The barium enema findings were incorrect in 91 of 224 examinations (41 percent). Colonoscopy is a safe and accurate procedure which enables improved patient management (AU)


Assuntos
Humanos , Masculino , Feminino , Lactente , Pré-Escolar , Criança , Adolescente , Pessoa de Meia-Idade , Adulto , Idoso , Colonoscopia , Doenças do Colo/diagnóstico , Sulfato de Bário/diagnóstico , Neoplasias do Colo/diagnóstico
9.
West Indian med. j ; 32(1): 48-9, Mar. 1983.
Artigo em Inglês | MedCarib | ID: med-11445

RESUMO

A case of carcinoma of the colon in childhood is reported, There was remarkable absence of gastro-intestinal symptoms. Reasons for the poor prognosis in this condition are discussed as well as the possibilities for improving survival (AU)


Assuntos
Adolescente , Feminino , Humanos , Adenocarcinoma/patologia , Neoplasias do Colo/patologia , Adenocarcinoma/diagnóstico , Neoplasias do Colo/diagnóstico , Metástase Neoplásica , Trinidad e Tobago
10.
Assoc Gen Pract Jamaica Newsl ; 2(3): 152-5, Dec. 1982.
Artigo em Inglês | MedCarib | ID: med-10517

RESUMO

Primary prevention has too often been elusive and mythical with regard to the activities of a physician. Colorectal cancer appears too often as an exceptionally opportunity. New information about the epidemiology, the development of a better method of testing for occult blood and the flexible fiberoptic endoscopic has made mass screening for precursors of an early stage of cancer of the colon practical and cost effective (AU)


Assuntos
Humanos , Prevenção Primária , Neoplasias do Colo/diagnóstico , Neoplasias do Colo/etiologia , Neoplasias do Colo/patologia , Neoplasias do Colo/prevenção & controle , Neoplasias Retais/diagnóstico , Neoplasias Retais/etiologia , Neoplasias Retais/patologia , Neoplasias Retais/prevenção & controle , Análise Custo-Benefício , Protocolos Clínicos , Educação de Pacientes como Assunto , Jamaica
11.
West Indian med. j ; 18(3): 152-60, Sept. 1969.
Artigo em Inglês | MedCarib | ID: med-10851

RESUMO

Carcinoma of the colon and rectum has a low incidence in Jamaica. The patients with this disease seen at the University Hospital between 1952 and 1966, have been studied. Apart from a higher proportion of rectal cases, and a different frequency of symptoms, the pattern of the disease is similar to that found elsewhere. The prognosis in these cases is poor, but comparable with other reports. Factors which may determine the poor prognosis, are outlined (AU)


Assuntos
Adolescente , Adulto , Idoso , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Pessoa de Meia-Idade , Neoplasias do Colo/epidemiologia , Neoplasias Retais/epidemiologia , Neoplasias do Colo/diagnóstico , Neoplasias Retais/diagnóstico , Jamaica
12.
Dis Colon Rectum ; 12(5): 357-63, Sept.-Oct. 1969.
Artigo em Inglês | MedCarib | ID: med-12281

RESUMO

Two conditions seem necessary for better results in the treatemnt of colorectal cancer in Jamaica: dissemination to the public information about the early signs and symptoms of cancer, and a greater alertness by the medical profession in the interpretation of the patient's gastointestinal complaints. (Summary)


Assuntos
Humanos , Criança , Adolescente , Adulto , Pessoa de Meia-Idade , Idoso , Feminino , Neoplasias do Colo/epidemiologia , Neoplasias Retais/epidemiologia , Fatores Etários , Neoplasias do Colo/complicações , Neoplasias do Colo/mortalidade , Neoplasias do Colo/patologia , Neoplasias do Colo/cirurgia , Hospitalização , Jamaica , Recidiva Local de Neoplasia , Neoplasias Retais/mortalidade , Neoplasias Retais/patologia , Neoplasias Retais/cirurgia , Fatores Sexuais , Jamaica
13.
Surg Gynecol Obstet ; 122(2): 261-3, Feb. 1966.
Artigo em Inglês | MedCarib | ID: med-12983

RESUMO

In the 650 patients with acute intestinal obstruction treated in the past 11 years at the University College Hospital of the West Indies in Jamaica, obstruction due to hernia, adhesions, or intussusception occurred in 2 of every 3 patients. Obstructions due to malignant lesions were infrequently seen and those due to diverticulitis and mesentric vascular occlusion were not encountered. The overall mortality rate was 8.4 per cent. Gangrenous obstructions were associated with a high mortality. Strangulated abstructions, in which intestinal resection was unnecessary, were attended by a lower mortality than simple obstruction. The most important factors influencing mortality were found to be the age of the patient, the mortality being highest at the extremes of life, and the duration of the delay in seeking medical attention.(Summary)


Assuntos
Humanos , Aderências Teciduais/complicações , Neoplasias do Colo/complicações , Hérnia/complicações , Obstrução Intestinal/etiologia , Intussuscepção/complicações , Jamaica
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