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1.
Lancet ; 2(8093): 764-7, Oct 7 1978.
Artigo em Inglês | MedCarib | ID: med-14435

RESUMO

The cow is a ruminant, and cow's milk has evolved to promote bacterial growth in the upper small bowel; whereas human milk has evolved to discourage bacterial growth. Examinations of the constituents of the two milks shows that their differences can be accounted for in terms of this difference in function. Children who are fed a calf's diet tend to develop a rumen. This may lead to chronic diarrhoea and malnutrition and may be a factor in diarrhoea ascribed to cow's-milk-protein allergy and lactose intolerance (Summary)


Assuntos
Humanos , Lactente , 21003 , Feminino , Toxinas Bacterianas/efeitos adversos , Nutrição do Lactente , Intestino Delgado/microbiologia , /efeitos adversos , Leite Humano/fisiologia , Bovinos , Diarreia Infantil/etiologia , Hipersensibilidade Alimentar/etiologia , Transtornos da Nutrição do Lactente/etiologia , Intolerância à Lactose/etiologia , /análise , /fisiologia , Leite Humano/análise , Rúmen , Desmame
2.
Trop geogr med ; 28(4): 336-8, Dec. 1976.
Artigo em Inglês | MedCarib | ID: med-8323

RESUMO

The incidence of intolerance and by inference intestinal lactase deficiency was investigated by means of the oral lactose tolerance test in 30 East Indians born in Trinidad but of Indian heritage. Twenty showed flat curves (67 percent) and twenty had cramps and diarrhoea following the lactose load (67 percent). In India milk consumption is less than in Trinidad. Since all subjects were of the same racial origin the findings are interpreted as suggesting that lactase deficiency among East Indians is inherited on a genetic basis. (Summary)


Assuntos
Humanos , Adolescente , Adulto , Pessoa de Meia-Idade , Masculino , Feminino , Intolerância à Lactose/epidemiologia , Teste de Tolerância a Lactose , Glicemia , Grupos Étnicos , Índia/etnologia , Trinidad e Tobago
3.
Zeist; Centraal Instituut voor voedingsonderzoek TNO; R 4923; 1976. 89 p. maps, tab, gra.(Centraal Instituut voor voedingsonderzoek TNO - Rapport, R 4923).
Monografia em Nl | MedCarib | ID: med-2139

RESUMO

Report of a study concerning the practical meaning of hypolactasia (lactose-intolerance) in Surinamese Bushnegro children. At 2 boarding schools in the Surinamese interior, during the school year 1974 to 1975, each child was supplied daily with ca. 200 ml of milk. At one boarding school this was normal skimed milk and at the other lactose-free skimmed milk. The nutritional status was measured, both in the beginning and at the end of the school year, but no significant differences were found. Lactose-free milk had no better effect than the normal milk. There was also no improvement in the amount of hypolactasia. Thus, racial differences in the prevalence of hypolactasia seemed to have a genetic basis. Therefore, it is not caused by an adaptation to milk consumption. Combined results of weight tests proved that lactose-intolerance and milk-intolerance are not the same. It is concluded that normal, healthy Bushnegro children do tolerate and utilize milk in normal quantities


Assuntos
Criança , Resumo em Inglês , Humanos , Estudo Comparativo , Hipersensibilidade a Leite , Intolerância à Lactose , Teste de Tolerância a Lactose , Suriname , Nutrição da Criança
5.
West Indian med. j ; 22(3): 154, Sept. 1973.
Artigo em Inglês | MedCarib | ID: med-6173

RESUMO

Deficiency of intestinal lactase is widespread among otherwise healthy non-Caucasian adults. Limited available data suggest that very young children in some racial groups also may be affected. In a rural Jamaican district of Elderslie, where poverty, disease, and malnutrition are commonplace, dried skim milk was introduced as a food supplement for weanling children. These children, previously unaccustomed to milk-drinking responded to this new lactose source with frequent episodes of diarrhoea. To determine whether lactase deficiency might contribute to the apparent milk tolerance, a systematic study of lactose absorption was undertaken. Of the 600 children under 4 in the district, 94 were selected randomly for study. Capillary blood was drawn at 0, 15, 30, and 60 minutes after ingestion of 2 gms/kg of lactose. The Ames Reflection Meter/Dextrostix system was used to determine blood glucose. With a blood glucose rise of 25 mg percent or less as the criterion, 53 (56 percent) of the 94 children proved unable to absorb lactose. While two-thirds of the chilren under 12 months absorbed lactose, only one-third of those older enjoyed a similar capacity (p < .05). 9 of the 53 malbsorbers were being breast-fed at time of study. Similar tests in Kingston revealed 14 of 20 urban children were lactose malabsorbers. Neither sex, anthroponmetric status, milk consumption, symptoms of lactose intolerance, nor duration of breast-feeding correlated with lactose absorption. 52 of the original 53 malabsorbers at Elderslie were re-tested 6 months later and 11 (12 percent) displayed normal blood glucose rises. Particular important is the additional observation that this absorptive defect is at least sometimes reversible. Further study is required to relate these phenomena to other aspects of intestinal function and to determine their nutritional significance in children whose diet is marginal (AU)


Assuntos
Humanos , Criança , Intolerância à Lactose , Jamaica , Transtornos da Nutrição Infantil
6.
Br J Dermatol ; 86: 226-37, 1972.
Artigo em Inglês | MedCarib | ID: med-9515

RESUMO

The clinical features and investigations relating to gastrointestinal function are presented in 12 cases of juvenile dermatitis herpetiformis seen over a period of 2 years in Jamaica. None of the children had evidence of steatorrhoea. Jejunal biopsy in 10 cases showed normal mucosa in 1, ridging and convolutions in 8 and a flat mucosa in 1. Electronmicroscopical changes are also described. Lactase deficiency malnutrition in infancy or at the time of biopsy. An interesting feature was relapse following iodine contrast media used during jejunal biopsy and a high incidence of iodine in drinking water in some parts of Jamaica. (AU)


Assuntos
Humanos , Lactente , Pré-Escolar , Criança , Masculino , Feminino , Dermatite Herpetiforme , /anatomia & histologia , /fisiologia , Biópsia , Jamaica , Testes Hematológicos , /análise , Dissacarídeos , Jejuno/anatomia & histologia , Microscopia Eletrônica , Vesícula/tratamento farmacológico , Doença Celíaca , Anemia , Enteropatias Parasitárias , Dermatite Herpetiforme/prevenção & controle , Iodo/efeitos adversos , Transtornos Nutricionais/complicações , Intolerância à Lactose
7.
Trop geogr med ; 23: 54-9, 1971. tab
Artigo em Inglês | MedCarib | ID: med-2187

RESUMO

Complaints which may be due to lactose intolerance are common in Surinam. A preliminary investigation was carried out, after oral loading with lactose, for the increase of glucose blood levels in several population groups. This was minimal in Bushnegroes: 3 mg/100 ml. Among urban Creoles the average maximum increase was 14 mg. In Creole and East-indian children, having some milk, it was 16 and 12 mg/100 ml respectively. In a control group of Dutch soldiers the average maximum was 33 mg. These observations tally with reports from several tropical regions. They suggest a measure of caution in administering milk to non-adapted children.(AU)


Assuntos
Lactente , Humanos , Resumo em Inglês , Criança , Lactente , Intolerância à Lactose , Suriname
8.
Zeist; Central Institute for nutrition and food research TNO; 1971. 23 p. tab.
Monografia em Inglês | MedCarib | ID: med-2190

RESUMO

Critical analysis of information on all relevant studies with regard to prevalence, seriousness of the problem and public health significance in Latin America. A correct definition of the concepts milk intolerance, lactose intolerance and lactase deficiency is essential. In Latin America little work on lactose intolerance has been done, but incidental investigations showed a high percentage. Further studies are recommended, and these should be directed particularly towards the practical significance of lactose intolerance. Results from studies in Suriname are also included


Assuntos
Humanos , Resumo em Inglês , Intolerância à Lactose , Hipersensibilidade a Leite , Suriname
9.
Clin Sci ; 39(2): 305-18, Aug. 1970.
Artigo em Inglês | MedCarib | ID: med-8772

RESUMO

The ability of malnourished children to absorb lactose, sucrose and glucose was tested by perfusing the jejunum. Intestinal motility was measured simultaneously in a perfused segment by a dye dilution technique. These tests were repeated on the same children after 6-16 weeks of treatment. There was a significant correlation between the rate of hydrolysis of disaccharide perfusing the jejunum and the level of disaccharidase activity within the jejunal mucosa. All ten malnourished children had dimished glucose absorption, eight had reduced lactose and six had impaired sucrose hydrolysis and absorption. Children with the most severe mucosal damage had the lowest rate of sugar absorption. The malabsorption of disaccharide was related to the impairment of hydrolysis and not to the malabsorption of the monosaccharide products. Primary hypermotility of the intestine was not a feature of the malnourished group. Water absorption from all infusions occurred only in the treated group. Water entry into the intestinal lumen in the malnourished group was greatest with the most poorly absorbed sugars. The mean transit time of fluid passing down the intestine was inversely correlated with the sugar remaining unabsorbed within the lumen. Treating the malnourished child in hospital produced an increase in glucose, lactose and sucrose absorption. The generalized nature of the malabsorption and the reversibility of the defects suggests that lactose intolerance in these children is related to the nutritional state and not to a genetic predisposition to lactase deficiency. (Summary)


Assuntos
Humanos , Lactente , Carboidratos/metabolismo , Motilidade Gastrointestinal , Transtornos da Nutrição do Lactente/metabolismo , Intestino Delgado , Síndromes de Malabsorção/etiologia , Biópsia , Diarreia/etiologia , Glucose/metabolismo , Intubação Gastrointestinal , Jejuno , Intolerância à Lactose , Matemática , Métodos , Perfusão , Potássio/análise , Sacarose/metabolismo , Fatores de Tempo , Água/metabolismo , Jamaica
11.
West Indian med. j ; 17(3): 125, June, 1968.
Artigo em Inglês | MedCarib | ID: med-7290

RESUMO

Several reporters with divers explanations have been given for the intolerance to milk which sometimes occurs in cases of ulcerative colitis idiopathic steatorrhea and after partial gastrectomy. Intestinal disaccharidase deficiency has been a subject of increasing interest and intense investigation. Santini et al. demonstrated that disaccharide activity of the human small bowel can be measured in specimens of intestinal mucosa obtained by peroral biopsy. In this paper intestinal mucosal disaccharide activities (lactase, maltase, sucrase) were carried out by the method of Dahlquist on 3 patients who had milk intolerance in association with ulcerative colitis, idiopathic steatorrhea and a partial gastrectomy respectively. Lactose tolerance tests were also done on these patients. Low intestinal lactase activities and abnormal disaccharide loading tests were found in all patients. Withdrawal of milk resulted in a subsidence of diarrhoea. It is concluded that mucosal enzymes deficiency states are important factors in the causation of milk intolerance and exacerbation of diarrhoea in these conditions (AU)


Assuntos
Humanos , Intolerância à Lactose , Absorção Intestinal , Dissacaridases
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