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West Indian med. j ; 50(Suppl 5): 32-3, Nov. 2001.
Artigo em Inglês | MedCarib | ID: med-137


OBJECTIVE: This study evaluated the relationship between periodontal disease and low birth weight (LBW) in a predominantly black population. METHODS: Using the nested case-control design, we evaluated the periodontal pathogen specific maternal serum IgG levels during pregnancy in relation to birth weight, while controlling for the known risk factors for LBW. RESULTS: There was a significant negative correlation (r= -0.37; p= 0.004) between the birth rate of the infant and Porphyromonas gingivalis (Pg) specific maternal serum IgG levels (LBW group - mean/SE 14.73ñ4.67 ug/ml; p= 0.003). Regression analysis indicated that one unit increase of IgG against Pg in the mother resulted in 5.07g decrease in the birth weight of the infant (p=0.005). CONCLUSION: Our ability to demonstrate a significant difference in the serum IgG levels, against at least one periodontal pathogen (Pg) lends further credibility to the biologic plausibility of the association between poor periodontal health and LBW, and the temporal sequence of this association. (AU)

Lactente , Adulto , Feminino , Humanos , Doenças Periodontais , Recém-Nascido de Baixo Peso , Estudos de Casos e Controles , Afro-Americanos
West Indian med. j ; 50(2): 105-8, Jun. 2001.
Artigo em Inglês | MedCarib | ID: med-351


The tetracyclines are a group of broad-spectrum antimicrobial agents. The first of these compounds, chlortetracycline was isolated from Streptomyces aureofaciens by Benjamin Duggar and introduced into the market in 1948. In 1952, tetracycline was derived semisynthetically from chlortetracycline by removal of its chlorine atom by catalytic hydrogenation. Methacycline, doxycycline and minocycline are all semi-synthetic derivatives. The tetracyclines are closely congeneric derivatives of polycyclic napthacenecarboxamide. The tetracyclines posses a wide range of antimicrobial activity against gram-positive and gram-negative bacteria. In vitro, these drugs are primarily bacteriostatic. Tetracycline have been used extensively as antimicrobial, chemically modified non-antimicrobial properties by Golub. The tetracyclines and their non-antimicrobial, chemically modified analogues have properties that appear to modulate host response by inhibiting the activity of the matrix metalloproteinases that cause collagen destruction. They also inhibit osteoclast function, stimulate osteoblastic bone formation, and regulate angiogenesis.(Au)

Técnicas In Vitro , Humanos , Tetraciclinas/farmacologia , Resistência Microbiana a Medicamentos , Doenças Periodontais/tratamento farmacológico , Metaloproteinase 3 da Matriz/antagonistas & inibidores , /farmacologia , Neovascularização Fisiológica , Osteoclastos/efeitos dos fármacos , Osteogênese/efeitos dos fármacos , Periodontite/tratamento farmacológico
J Periodont Res ; 29(5): 324-7, Sept. 1994.
Artigo em Inglês | MedCarib | ID: med-4788


A national survey was undertaken in 1990 to investigate the periodontal treatment needs in 12 and 15 to 19 year olds residing in urban and rural areas of Antigua. Using the CPITN procedure, examination of 246 12 year old children and 456 adolescents (15 to 19) revealed that the CPITN scores of healthy, gingival bleeding, calculus, 4 or 5 mm and >6mm periodontal pockets were distributed similarly in urban and rural areas. Calculus was the most commonly recorded score, with a prevalence of 46 percent in 12 year olds and 56 percent in 15 -19 year olds. 4 or 5 mm pockets were found in 14 percent of adolescents, affecting on average less than one sextant per subject, but deep pockets were uncommon, 26 percent of 12 year olds and 14 percent of adolescents had priodontally healthy mouths. Scaling and hygiene instructions were the predominant treatment needs in both age groups, but the requirement for complex periodontal care in adolescents was low - 3 percent. (AU)

Humanos , Criança , Adolescente , Doenças Periodontais/epidemiologia , Saúde da População Rural , Saúde da População Urbana , Necessidades e Demandas de Serviços de Saúde/estatística & dados numéricos , Cálculos Dentários/epidemiologia , Índice de Higiene Oral , Índice Periodontal , Bolsa Periodontal/epidemiologia