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West Indian med. j ; 35(Suppl): 26, April 1986.
Artigo em Inglês | MedCarib | ID: med-5961


Of sixteen patients with MCTD, 10 62 percent) presented with the clinical features of systemic lupus erythematosus (SLE) and 6 (37 percent) with SLE-scleroderma. Ninety-four per cent had a speckled antinuclear factor pattern and 100 percent had IgG deposits in a speckled pattern within the epidermal cell nuclei of the skin. Seventy per cent of these patients had nRNP antibodies. These characteristics are more typical of the mixed connective tissue syndrome than of SLE or scleroderma. The low incidence of Raynaud's phenomenon in our group of patients (18 percent) with MCTD is probably due to the tropical climate. The IgM deposits in the skin of a significant number (67 percent) of the patients with the clinical picture of SLE-scleroderma probably represent an early stage in the development of the disease. The significance of high serum IgA in the clinically diagnosed SLE group is not understood and is now being further investigated. This study strongly suggests that laboratory investigations are of primary importance in distinguishing MCTD from SLE and other forms of collagen vascular diseases (AU)

Humanos , Doenças do Tecido Conjuntivo/fisiopatologia , Lúpus Eritematoso Sistêmico , Escleroderma Sistêmico
West Indian med. j ; 11(2): 138, June 1962.
Artigo em Inglês | MedCarib | ID: med-7530


Details of a family with this disorder are presented. It appears to be transmitted by means of an autosomal dominant gene. The changes include gingival hypertrophy, particularly in the maxilla, increase in the soft tissues of the palate, nose and ears, changes in the nails and digits, excessive joint mobility and pes cavus as well as splenomegaly (AU)

Humanos , Fibromatose Gengival , Doenças Genéticas Inatas , Esplenomegalia , Doenças do Tecido Conjuntivo , Hipertrofia Gengival , Saúde da Família