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In. The University of the West Indies, Faculty of Medical Sciences. Faculty of Medical Sciences, Research Day. St. Augustine, Caribbean Medical Journal, March 21, 2019. .
Não convencional em Inglês | MedCarib | ID: biblio-1025491

RESUMO

Objective: To perform in-vitro quality control testing of different brands of 400 mg Ibuprofen conventional tablet as per the pharmacopoeia standard and compare them to those are available in hospitals and pharmacies in Trinidad. Design and Methodology: The four popular brands (A, B, C, D) of Ibuprofen conventional tablet of 400 mg strength were chosen. The Ibuprofen tablets were obtained from government hospital pharmacies as well as from local private pharmacies. The in-vitro evaluation tests-friability, weight variation, disintegration time, dissolution and drug assay tests were performed as per the United States Pharmacopoeia. Results: The results showed that all the tablets passed the uniformity of weight (<± 5%), friability (<1%), disintegrated in less than 30 minutes (Ibuprofen coated tablets) and drug assays showed that the amount of drugs varied between 90-100%. The Invitro dissolution study in phosphate buffer pH 7.2 showed that about 95% drug release in 30 minutes. Conclusion: The results of all these parameters of different brands Ibuprofen of tablets were in the pharmacopoeia limits so it could be concluded that marketed pharmaceutical tablets of Ibuprofen of these brands satisfy quality control limits of pharmacopoeia.


Assuntos
Humanos , Masculino , Feminino , Controle de Qualidade , Ibuprofeno , Trinidad e Tobago , Região do Caribe/etnologia
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