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West Indian med. j ; 51(1): 4-9, Mar. 2002. ilus, tab
Artigo em Inglês | MedCarib | ID: med-106

RESUMO

One hundred and three consecutive cases of breast cancer in Trinidadian women were evaluated for steriod receptor status and c-erB-2 receptor along with conventional parameters including age, ethnicity, tumour size, histological type and grade, and lymph node status: The molecular markers were studied by immunohistochemistry (IHC) on paraffin sections. Tumour size > 2 cm was seen in 60 percent of the cases. Oestrogen receptor (ER), progestrone receptor (PR) and c-erbB-2 showed 54 percent, 46 percent, and 63 percent positivity, respectively. There was no correlation between c-erbB-2 and steroid receptors. Forty-one percent of cases showed double negativity for steriod receptors (ER-/PR-). No correlation was found between the markers and conventional parameters except for a negative correlation with the tumour grade. The high percentage of c-erbB-2 positivity and the high propotion of steriod receptor negativity suggest a need for studies on adjuvant therapy. Integration of selected markers with conventional parameters could help define sub-groups for treatment and pragnosis (AU)


Assuntos
Adulto , Pessoa de Meia-Idade , Idoso , Feminino , Humanos , Neoplasias da Mama/patologia , Receptores Estrogênicos/análise , Receptores de Progesterona/análise , Receptores de Esteroides/análise , Receptor ErbB-2/diagnóstico , Trinidad e Tobago/etnologia , Imuno-Histoquímica/estatística & dados numéricos , Parafina/diagnóstico , Estudos de Casos e Controles , Biomarcadores Tumorais , Biomarcadores/análise
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