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Arch Pathol ; 89(6): 507-20, June 1970.
Artigo em Inglês | MedCarib | ID: med-13138


Electron microscopic observations in humans veno-occlusive disease (VOD) of the liver are presented for the first time . Marked endothelial damage was seen in the sinusoids and subterminal and terminal hepatic veins, accompanied by extravasation of erthrocytes into Disse's space and naked hepatocytes showing a reduction in microvilli. Endothelial damage was seen in all zones of the liver. At the level of terminal hepatic veins, the closed structure of these vessels, absence of fenestrations, existence of a basement membrane, and the presence of collagen and connective tissue cells in the wall provide resistance to erthrocytes and cellular debris tracking up Disse's space. These factors tend to result in narrowing of the lumen where the sinusoid enters the vein. Parenchymal cell alterations, at the time of the biopsies, included dilation of bile canaliculi, abundant glycogen, and nuclear invaginations.(AU)

Humanos , Lactente , Pré-Escolar , Masculino , Feminino , Veias Hepáticas/patologia , Doença Hepática Induzida por Substâncias e Drogas/patologia , Fígado/irrigação sanguínea , Fígado/patologia , Intoxicação por Plantas/patologia , Alcaloides/envenenamento , Biópsia , Jamaica , Cirrose Hepática/induzido quimicamente , Cirrose Hepática/patologia , Testes de Função Hepática , Microscopia Eletrônica , Pirrolidinas/envenenamento , Doenças Vasculares/patologia
Acta Histochem ; 37(2): 369-78, 1970.
Artigo em Inglês | MedCarib | ID: med-15813


Histochemical changes in the liver of rats, treated with the pyrrolizidine alkaloidal constituent of Crotalaria fulva, indicated primarily damage of the hepatic parenchymal cells. The observed differences in activity of enzymes suggested functional inpairment of the cell membrane, mitochondria, endoplasmatic reticulum, and lysosomes in the liver cells. In large doses, fulvine produced a hyaline droplet degeneration in the epithelium of the proximal convoluted tubules of the kidney. Stability of the mitochondrial and changes in activity of the lysosomal enzymes would imply a functional adaptation, rather than primary damage of the epithelium.(AU)

Ratos , 21003 , Masculino , Alcaloides/toxicidade , Compostos Heterocíclicos/toxicidade , Nefropatias/metabolismo , Nefropatias/patologia , Hepatopatias/metabolismo , Hepatopatias/patologia , Fosfatase Ácida/metabolismo , Adenosina Trifosfatases/metabolismo , Fosfatase Alcalina/metabolismo , Complexo IV da Cadeia de Transporte de Elétrons/metabolismo , Esterases/metabolismo , Glucose-6-Fosfatase/metabolismo , Glutamato Desidrogenase/metabolismo , Histocitoquímica , Nefropatias/enzimologia , Túbulos Renais/efeitos dos fármacos , Fígado/efeitos dos fármacos , Hepatopatias/induzido quimicamente , Hepatopatias/enzimologia , Necrose , Succinato Desidrogenase/metabolismo
West Indian med. j ; 15(1): 34-9, Mar. 1966.
Artigo em Inglês | MedCarib | ID: med-10792


The lesions produced in rats and goats by oral doses of Crotalaria preparations include early hepato-cellular damage and later veno-occlusive disease. The effects of repeated dosages seem to be cumulative. Extracts prepared from fresh leaves are considerably more toxic than that from dried leaves (AU)

21003 , Ratos , Alcaloides/toxicidade , Oclusão Vascular Mesentérica/etiologia , Fígado/patologia , Estações do Ano , Jamaica , Intoxicação por Plantas