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Trans R Soc trop Med Hyg ; 79(5): 641-4, 1985.
Artigo em Inglês | MedCarib | ID: med-9462


The efficacy of multiple and single dose regimens of albendazole on Trichuris trichiura infection was evaluated by counting the number of worms expelled/day from two pair-matched groups of children, for nine days following therapy. The temporal patterns of worm expulsion were similar whether the children received a single 400 mg dose or two consecutive doses: no worms were passed before the second day, or after the sixth day, after intervention, and the maximum worm expulsion rate was attained on the fourth day. A second treatment six days after the first expelled no more worms. The results obtained here resemble those obtained previously with a three-day (600 mg) regimen of mebendazole in a study of heavily infected children. We conclude: that irrespective of dose, benzimidazole carbamates require the gut transit time plus 48 hours to immobilize T. trichiura; and that single dose of albendazole is effective against light infections of T. trichiura but requires further evaluation with high intensity infections.(AU)

Humanos , Pré-Escolar , Criança , Anti-Helmínticos/uso terapêutico , Benzimidazóis/uso terapêutico , Tricuríase/tratamento farmacológico , Benzimidazóis/administração & dosagem , Relação Dose-Resposta a Droga , Fezes/parasitologia , Contagem de Ovos de Parasitas
JAMA ; 203(10): 1408-11, Dec. 4, 1974.
Artigo em Inglês | MedCarib | ID: med-14387


Mebendazole (Vermox), a new broad-spectrum anthelminthic, was used in 107 Bahamian children with trichuriasis, 88 of whom had concomitant ascariasis, in a dose of 100mg twice daily for three days. After treatment, three consecutive daily formalin-ether determinations and stool egg counts by the Stoll method were performed. Egg reduction rates of 97.6 percent and 99.5 percent were obtained for Trichuris trichiura and Ascaris Lumbricoides, respectively. Respective cure rates were 68.2 percent and 98.8 percent. Drug tolerance was excellent and side effects were nil. Mebendazole was confirmed as a safe and easily administered broad-spectrum anthelminthic, particularly useful in trichuriasis (AU)

Humanos , Pré-Escolar , Criança , Adolescente , Masculino , Feminino , Anti-Helmínticos/uso terapêutico , Ascaríase/tratamento farmacológico , Benzimidazóis/uso terapêutico , Carbamatos/uso terapêutico , Tricuríase/tratamento farmacológico , Fatores Etários , Análise de Variância , Anti-Helmínticos/administração & dosagem , Bahamas , Benzimidazóis/administração & dosagem , Benzoatos/administração & dosagem , Benzoatos/uso terapêutico , Carbamatos/administração & dosagem , Química , Avaliação de Medicamentos , Tolerância a Medicamentos , Fezes/parasitologia , Consentimento Livre e Esclarecido , Contagem de Ovos de Parasitas