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West Indian med. j ; 7(1): 44-52, Mar. 1958.
Artigo em Inglês | MedCarib | ID: med-12835

RESUMO

It has long been supposed that malnutrition predisposes the liver to injury. An attempt has been made to characterize this vulnerable state in biochemical terms. A diet deficient in protein causes the liver cell to lose a large proportion of its cytoplasmic protein and ribonucleic acid. It is suggested that this might lead to a disturbance in the amount or pattern of enzymes, which could have serious metabolic consequences. To test this hypothesis, measurements were first made of a number of single-enzyme systems, e.g. dehydrogenases transaminase choline esterase, cytochrome oxidase, cytochromec reductase. Only choline esterase was reduced in activity in the malnourished liver; the other enzymes were well preserved. Preliminary evidence suggests that more complex systems,involving a chain of enzymes, may be more easily damaged. (AU)


Assuntos
Humanos , Lactente , Ratos , Fígado/enzimologia , Transtornos Nutricionais , Deficiência de Proteína/enzimologia , Jamaica , Colinesterases/metabolismo , NADH Desidrogenase/metabolismo , Oxirredutases/metabolismo , Complexo IV da Cadeia de Transporte de Elétrons/metabolismo , Succinato Desidrogenase/metabolismo
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