Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Mais filtros










Filtros aplicados
Base de dados
Tipo de estudo
Intervalo de ano de publicação
1.
N Engl J Med ; 295(9): 461-7, Aug. 1976.
Artigo em Inglês | MedCarib | ID: med-13116

RESUMO

We identified methylenecyclopropylacetic acid, a known metabolite of hypoglycin A, in the urine of two patients with Jamaican vomiting sickness. Excretion of unusual dicarboxylic acids such as 2-ethylmalonic, 2-methylsuccinic, glutaric, adipic and dicarboxylic acids with eight and 10 carbon chains were also detected in both patients. The amounts of these dicarboxylic acids were 70 to 1000 times higher than normal. These metabolities have also been identified in urine of hypoglycin-treated rats. This evidence links hypoglycin A to Jamaican vomiting sickness as its causative agent. Urinary excretion of short-chain fatty acids was also increased up to 300 times higher than normal. These results indicate that, despite their clinical and histological similarities, the cause and biochemical mechanisms of Jamaican vomiting sickness differ distinctly from those of Reye's syndrome in which these abnormal urinary metabolities are not appreciably increased.(AU)


Assuntos
Humanos , Pré-Escolar , Ratos , 21003 , Feminino , Intoxicação por Plantas , Vômito/etiologia , Hipoglicinas/envenenamento , Ciclopropanos/metabolismo , Diagnóstico Diferencial , Ácidos Dicarboxílicos/urina , Ácidos Graxos Voláteis/sangue , Ácidos Graxos Voláteis/urina , Doenças Transmitidas por Alimentos/etiologia , Doenças Transmitidas por Alimentos/urina , Gluconeogênese , Hidroxiácidos/urina , Hipoglicemia/etiologia , Jamaica , Síndrome de Reye/diagnóstico , Toxinas Biológicas/metabolismo , Valeratos/urina
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA