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1.
West Indian med. j ; 49(Supp 2): 33-4, Apr. 2000.
Artigo em Inglês | MedCarib | ID: med-961

RESUMO

OBJECTIVE: To determine plasma lipid concentrations in non-pregnant women, pregnant women, and their infants. DESIGN AND METHODS: A cross-sectional study of non-pregnant and pregnant African-Trinidadian (AT) and Indian-Trinidadian (IT) women was carried out at Mount Hope Hospital, Trinidad. Adult and cord blood samples were collected and birth weights recorded. Plasma triacylglycerol (TAG), phosphatidylcholine (PC) and non-esterified fatty acid concentrations were determined by gas chromatographic analysis. RESULTS: On average, infants born to both AT (n=4) and IT (n=5) women were of lower birthweight than reference standards; medians 3.07 (2.7-4.6) kg and 3.22 (2.58-4.02) kg, respectively. Plasma lipid concentrations in non-pregnant and pregnant women, and umbilical cord were similar for AT and IT women. Plasma concentrations of PC and nonesterified fatty acids (NEFA) were not significantly different between non-pregnant and pregnant women. Median plasma TAG concentration was significantly (p<0.05) greater at term 1.8 (0.6-2.0) mmol/l for AT (n=7); 1.9 (1.5-2.7) mmol/l for IT (n=5) compared with non-pregnant women 0.8 (0.5-1.3) mmol/l for AC; 1.0 (0.5-1.7 mmol/l for EI) n=5/group. Term TAG concentrations were markedly lower than reported previously for Caucasian (2.76 mmol/l). Indian (2.76 mmol/l) and Nigerian (2.7-2.9 mmol/l) women, while values in non-pregnant and pregnant women at 20-22 weeks and 30-34 weeks were comparable. CONCLUSIONS: Since maternal hyperlipidaemia in pregnancy may serve to increase supply of lipids to the foetus during the principal growth phase, low maternal TAG concentrations in late gestation may have contributed to the lower birth weight of these infants. Low birth weight is associated with an increased risk of cardiovascular disease and type 2 diabetes in adults. Therefore, low maternal plasma TAG leading to poor foetal weight gain and impaired growth may represent one potential mechanism which contributes to the high prevalence of heart disease and diabetes in the population of Trinidad.(Au)


Assuntos
Feminino , Humanos , Recém-Nascido , Triglicerídeos/sangue , Estudos Transversais , Trinidad e Tobago , Triglicerídeos/análise , Fosfatidilcolinas/análise , Ácidos Graxos não Esterificados/análise , Peso ao Nascer , Fatores de Risco , Doenças Cardiovasculares/etiologia , Diabetes Mellitus Tipo 2/etiologia
2.
West Indian med. j ; 49(Supp 2): 23, Apr. 2000.
Artigo em Inglês | MedCarib | ID: med-986

RESUMO

The gastrointestinal handling and post absorptive metabolism of [1, 1, 1-13 C] triolein (TO) and [1, 1, 13 C] tripalmitin (TP) were studied in two groups of eight severely malnourished children (5-0 months): on admission (Phase 1), during rapid-catch up growth (Phase 2) and when weight for height had reached 90 percent of the reference (Phase 3). Total excretion of 13 C label in stool (over 3 days) and breath as 13 CO 2 (over 24 hours) were analysed by isotope radio mass spectrometry. Stool 13 C excretion at admission was approximately 10 percent of the administered dose for both trials but varied markedly between subjects, was significantly reduced during rehabilitation in the TO trial (Phase 2:0.5 +or- 1.0; Phase 3: 1.3 +or- 0.9; p<0.05) and tended to decline on the P trial. ANOVA analysis of the magnitude and time course of 13 C excretion in breath (from area under the curve), excretion tended to decrease during rehabilitation in the TO trial but remained unchanged on the TP trial. These results suggest that the efficiency with which dietary triacylglycerol is handled within the gastrointestinal tract is generally impaired in severely malnourished children at admission but improves during rehabilitation.(Au)


Assuntos
Lactente , Humanos , Ácidos Graxos/metabolismo , Transtornos Nutricionais/reabilitação , Fármacos Gastrointestinais/metabolismo , Trioleína/metabolismo , Espectrometria de Massas/estatística & dados numéricos , Modalidades de Secreções e Excreções , Triglicerídeos/metabolismo
3.
West Indian med. j ; 44(Suppl. 2): 40, Apr. 1995.
Artigo em Inglês | MedCarib | ID: med-5739

RESUMO

The Curacao Health Study is a cross-sectional population-based study designed to give insight into the determinants of health on Curacao. This study presents prevalence data for lipid risk factors and interactions with demographic and socio-economic variables. Serum was collected from 1001 (44.5 percent) respondents included in the CHS study. These respondents were representative for all respondents. Cholesterol, HDL-cholesterol and triglycerides were measured and LDL-cholesterol was calculated. Cholesterol levels increased significantly in women > 50 years of age, as did LDL-cholesterol levels. HDL-cholesterol was higher in women than in men (52 ñ 13 mg/dl vs 48 ñ 15 mg/dl). Mean total and LDL-cholesterol levels were comparable to Western European and Northern American populations. Multiple regression indicated that race (Black vs non-Black) did not contribute to cholesterol levels, whereas education, living in the East District, age, and gender did. These associations need further study before definitive conclusions can be drawn. We conclude that lipid risk factors are as prevalent on Curacao as in most Western societies (AU)


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Lipídeos/efeitos adversos , Fatores Socioeconômicos , Colesterol , Triglicerídeos , Fatores de Risco , Curaçao
4.
J Clin Pathol ; 47(12): 1105-7, Dec. 1994.
Artigo em Inglês | MedCarib | ID: med-5861

RESUMO

AIMS: To investigate differences in serum lipid, lipoprotein and apolipoprotein concentrations in pregnant women of different ethnic origin. METHODS: Serum lipid, lipoprotein and apolipoprotein concentrations were measured in 232 women (114 Caucasians, 118 Africans/Afro-Caribbeans), who presented consecutively for screening for gestational diabetes in the third trimester of pregnancy. RESULTS: African/Afro-Caribbean pregnant women had lower serum concentrations of total cholesterol, low density lipoprotein cholesterol, triglycerides, and apolipoprotein B and higher high density lipoprotein cholesterol and Lp(a) lipoprotein concentrations compared with Caucasian women. Apolipoprotein A1 concentrations were similar in the two groups. The differences were not attributable to differences in weight, age, parity, or postload plasma glucose levels. CONCLUSION: Ethnic origin is an important determinant of serum lipid, lipoprotein and apolioprotein concentrations during pregnancy (AU)


Assuntos
Estudo Comparativo , Humanos , Feminino , Adulto , Gravidez/metabolismo , Lipídeos/metabolismo , Triglicerídeos/sangue , Colesterol/sangue , Lipoproteínas/metabolismo , HDL-Colesterol/sangue , LDL-Colesterol/sangue , Apolipoproteínas/sangue
6.
J Natl Med Assoc ; 84: 853-5, 1992.
Artigo em Inglês | MedCarib | ID: med-9445

RESUMO

This study investigates the alteration of serum cholinersterase levels in diabetics and its possible relationship to blood glucose, insulin, triglyceride, and cholesterol levels. Fourteen phasic insulin-dependent diabetes mellitus patients were comapared with 10 insulin-dependent diabetes mellitus, 10 noninsulin-dependent diabetes mellitus, and 10 normal controls. Each group was matched for age, sex, body mass index and duration of diabetes. Mean age was 56.7 ñ 2.5 years; mean body mass index, 24.00 ñ 0.8 kg/mý; and mean duration of diabetes, 14.2 ñ 2.2 years. Serum acetylcholinesterase, insulin, triglyceride, and cholesterol levels as well as fasting blood sugar were all assayed using standard techniques. Results suggest an associated increase of serum acetlycholinesterase with triglyceride levels in diabetics and may point to a possible association between increased serum acetylcholinesterase and vascular complications in Jamaican diabetics. (AU)


Assuntos
Humanos , Pessoa de Meia-Idade , Masculino , Feminino , Acetilcolinesterase/sangue , /enzimologia , Diabetes Mellitus Tipo 2/enzimologia , Glicemia/análise , Colesterol/sangue , /epidemiologia , Diabetes Mellitus Tipo 2/epidemiologia , Triglicerídeos/sangue , Jamaica/epidemiologia
7.
Am J Clin Nutr ; 53(5): 1197-204, May 1991.
Artigo em Inglês | MedCarib | ID: med-12566

RESUMO

Triglycerides, cholesterol, fatty acid composition, and tocopherols were determined in colustrum, transitional milk, and mature milk in St. Lucia. With progress of lactation, triglycerides and percentage medium-chain fatty acids increased whereas tocopherols, cholesterol and percentage long-chain polyunsaturated fatty acids decreased. These changes reflect augmented de novo synthesis of fatty acids (8:0, 10:0, 12:0, and 14:0) in the mammary gland and a tendency of increasing fat-globule size as milk matures. Transitional and mature milks, but particularly colustrum, contained higher concentrations of components considered to be derived from the fat-globule membrane (cholesterol, tocopherols, percentage long-chain polyunsaturated fatty acids) compared with those reported for Western countries. Percentage medium-chain fatty acids in mature milk was two to three times higher than in developed countries. Differences from data from studies in Western countries are discussed in relation to analytical methods and possible consequences for lipid digestion, lipid absorption, growth, and brain development.(AU)


Assuntos
Humanos , Feminino , Ácidos Graxos/análise , Lipídeos/análise , Leite Humano/química , Vitamina E/análise , Colostro/química , Colesterol/análise , Países em Desenvolvimento , Ácidos Graxos Monoinsaturados/análise , Ácidos Graxos Ômega-3/análise , Ácidos Graxos Insaturados/análise , Lactação/metabolismo , Estudos Longitudinais , Triglicerídeos/análise , Santa Lúcia
8.
Am J Clin Nutr ; 52(2): 326-34, Aug. 1990.
Artigo em Inglês | MedCarib | ID: med-12083

RESUMO

We isolated phospholipid (PL) subclasses from milk of women in Dominica and Belize. Fatty acid (FA) compositions of PLs and total lipids were determined. In the total-lipid fraction Dominican milk showed higher relative amounts of medium-chain saturated fatty acids (MC-SAFAs; 6:0-14:0) and 22:6n-3 and lower amounts of long-chain saturated fatty acids (LC-SAFAs) and monounsaturated fatty acids (MUFAs). There was a positive relationship between the MC-SAFA content in total lipids and total PLs. Incorporation of MC-SAFAs in PLs occurred at the expense of LC-SAFAs, MUFAs, polyunsaturated fatty acids (PUFAs), and long-chain PUFAs with o20 carbon atoms (LC-PUFAs oC20). Previous studies from western countries revealed low amounts of MC-SAFAs and high amounts of PUFAs and LC-PUFAs oC20 in milk PLs. Our data show that carbohydrate-rich diets give rise to incorporation of MC-SAFAs in PLs at the expense of PUFAs and LC-PUFAs oC20. The data are discussed in relation to the presumed origin of fat-globule membrane phospholipids. (AU)


Assuntos
Humanos , Feminino , Carboidratos da Dieta/administração & dosagem , Ácidos Graxos/análise , Leite Humano/análise , Fosfolipídeos/análise , Triglicerídeos/análise , Belize , Análise de Regressão , Dominica
9.
West Indian med. j ; 38(Suppl. 1): 25, April 1989.
Artigo em Inglês | MedCarib | ID: med-5696

RESUMO

Fatty acid composition of mature milk from Belize, Curacao, Dominica and Suriname and of colostrum, transitional and mature milk from women in St. Lucia was analyzed by capillary gas chromatography. Remarkable differences and striking similarities were found in fatty acid compositions. The levels of 6:0-12:0, the medium chain fatty acids (MCFA), and 14:0 were high (12:0-16:9 and 9.6-15.0 gm percent respectively) in all 5 countries as compared to reports from European countries. Palmitic acid (16:) levels (20.2-23.6 gm percent were similar to reported levels from other societies. The levels of 22.+c, W3 (docosahexaenoic acid or DHA) were extremely high in Dominica (average 1.15 gm percent) and relatively high (0.25-0.56 gm percent) in other Caribbean countries as compared to reported levels of 0.05-0.23 gm percent in studies from the USA. When a mother is in energy equilibrium or positive energy balance, the fatty acid composition of her breast milk is related to that of her diet, whereas in negative energy balance, it resembles that of her adipose tissue. High levels of DHA in breast milk may be explained by consumption of fish rich in DHA. A high carbohydrate intake leads to a high MCFA content of breast milk, such as seen in all 5 Caribbean countries but especially in Dominica. The levels of MCFAs and 14:0 in breast milk from St. Lucia increased substantially from colostrum to mature milk at the expense of the longer chain fatty acids (AU)


Assuntos
Humanos , Feminino , Gravidez , Leite Humano/química , Triglicerídeos , Ácidos Graxos/análise , Belize , Suriname , Colostro , Comportamento Alimentar , Ácidos Docosa-Hexaenoicos
10.
West Indian med. j ; 33(3): 158-63, Sept. 1984.
Artigo em Inglês | MedCarib | ID: med-11474

RESUMO

Serum total cholesterol (TCHO) and tryglyceride (TG) levels were determined in paired maternal and umbilical cord serum from 120 full-term deliveries at the University Hospital of the West Indies. The median cord serum TG level was found toPbe 0.74 mmol/l, which is much higher than the levels of 0.34-0.52 mmol/l in the studies reprted so far. On the other hand, cord serum TCHO levels of 1.91 mmol/l, and maternal TG and TCHO levels of 1.84 mmol/l and 5.60 mmol/l respectively are within the range of values reported in the literature. Cord serum hypertriglyceridaemia was seen in 7 newborns, all of whom had at least one kind of perinatal stress. A significant elevation of cord serum TG was seen in infants who suffered neonatal jaundice. Further studies are needed to confirm our findings to elucidate their significance (AU)


Assuntos
Feminino , Humanos , Recém-Nascido , Colesterol/sangue , Sangue Fetal/análise , Triglicerídeos/sangue , Complicações do Trabalho de Parto/sangue , Gravidez , Valores de Referência , Jamaica
12.
Am J Clin Nutr ; 27(6): 610-4, June 1974.
Artigo em Inglês | MedCarib | ID: med-13336

RESUMO

Measurements were made of triglyceride concentrations in the liver, serum, and serum lipoproteins in malnourished Jamaican children with fatty liver. The fasting serum triglyceride concentrations of the patients, before treatment, were highly variable, ranging from 55.6 to 353 mg/100ml. The patterns of change for serum triglyceride concentration during treatment were also variable. Patients were grouped according to whether the concentrations of serum triglycerides after recovery were higher than, lower than, or unchanged from, the concentrations before treatment. The three groupings then exhibited concentrations before treatment that fell in discrete ranges, being respectively low, high, or normal. There was no clinical difference among the three groups of patients. There was also no difference in the serum lipoprotein pattern nor in the composition of the serum very low density lipoprotein. The latter did not change during treatment. In most patients the fasting serum triglyceride concentrations before treatment appeared to be correlated with age. The difference between these findings and those reported from other countries are discussed. (AU)


Assuntos
Humanos , Lactente , Fígado Gorduroso/metabolismo , Fígado/metabolismo , Desnutrição Proteico-Calórica/metabolismo , Triglicerídeos/metabolismo , Fatores Etários , Biópsia , Estatura , Peso Corporal , Dietoterapia , Edema/complicações , Ácidos Graxos/metabolismo , Fígado Gorduroso/complicações , Nutrição do Lactente , Jamaica , Lipoproteínas/sangue , Lipoproteínas VLDL/sangue , Desnutrição Proteico-Calórica/complicações , Desnutrição Proteico-Calórica/terapia , Triglicerídeos/sangue
13.
Clin Sci Mol Med ; 51: 475-82, 1976.
Artigo em Inglês | MedCarib | ID: med-5057

RESUMO

The relation between plasma high-density lipoprotein (HDL) cholesterol concentration and multiple coronary-risk factor status has been assessed in fifty-two middle-aged clinically healthy men from urban and rural Jamaica. Rural hill-farmers had a superior exercise performance (assessed by the responses to submaximal test exercise), less body fat, and lower fasting levels for plasma total cholesterol, low-density lipoprotein (LDL) cholesterol, total triglyceride and blood glucose than urban businessmen. Mean plasma HDL cholesterol was considerably higher in farmers then businessmen. Multilinear regression analysis showed HDL cholesterol concentration to be independently and inversely correlated with plasma triglyceride, LDL cholesterol and diastolic blood pressure and that these relationships applied across the urban and rural sub-groups. There was also some evidence that HDL cholesterol concentration increased with stature. When these factors were taken into account, age, ethnic group, adiposity, weight, exercise performance, smoking history and blood glucose made no further significant contribution to the prediction of HDL cholesterol concentration. Thus plasma HDL cholesterol concentration was highest in those subjects with the lowest coronary-risk as predicted by their multiple risk-factor status, an observation which supported other evidence that coronary-risk is inversely related to plasma HDL concentration. The results raise the possibility that coronary risk can be more simply estimated from the plasma HDL cholesterol concentration than from a consideration of other major lipid risk factor and blood pressure (AU)


Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , HDL-Colesterol , Doença das Coronárias , Fatores de Risco , Jamaica , LDL-Colesterol , Triglicerídeos , Fatores de Risco , Fatores Etários
16.
Int J Epid ; 1(2): 157-66, 1972.
Artigo em Inglês | MedCarib | ID: med-1997

RESUMO

The prevalence of diabetes mellitus and significance of related variables are described for a rural Jamaican community. The population of the defined survey area was enumerated by private census and all 696 persons aged 25-64 were requested to participate. A response rate of 77.3 percent was achieved. Blood samples were drawn after respondents and fasted and 1 hour after consumption of a 100 G glucose load (Glucola). Blood tests included blood glucose, serum cholesterol and triglycerides. Anthropometric and blood pressure measurements, a 12 lead electrocardiogram and a PA chest X-ray were taken and a questionaire administered to elicit the occurrence of effort pain. Persons with 1 hour blood glucose levels of 180mg, percent or more were requested to undergo a 3 hour glucose tolerance test. Age specific rates for diabetes rose to 14.5 percent in males aged 45-54 and 17.0 percent in females aged 55-64. The percentage distribution of 1 hour glucose is given by age and sex. No relationship between number of live births and 1 hour blood glucose was found. In a comparison between non-diabetics, newly diagnosed and previously known diabetics, known diabetics of both sex had thicker infrascapular skinfolds, male new and known diabetics had higher cholesterol, and triglycerides increased from non-to known diabetics of both sexes. The validity of intersurvey comparison of diabetes rates is discussed and a alternative presentation of data is recommended. The lack of relationship between the diagnosis of diabetes and cardiovascular disease is also discussed.(AU)


Assuntos
Adulto , Pessoa de Meia-Idade , Masculino , Humanos , Feminino , Diabetes Mellitus/epidemiologia , Glicemia/análise , Pressão Arterial , Colesterol/sangue , Doença das Coronárias/epidemiologia , Eletrocardiografia , Jejum , Teste de Tolerância a Glucose , Glicosúria/epidemiologia , Insulina/sangue , Jamaica , Lipídeos/sangue , População Rural , Pregas Cutâneas , Triglicerídeos/sangue
17.
Kingston; s.n; Oct. 1971. 132 p. ills, tab.
Tese em Inglês | MedCarib | ID: med-13646

RESUMO

The aim of this work was to make an assessment of the role of impaired lipoprotein secretion from the liver in the pathogenesis of the fatty liver caused by protein malnutrition in infants. The only evidence for this role prior to the study was that serum lipid levels were lower than normal in patients with fatty liver. The proposed method for measuring the incorporation of amino acids into the lipoproteins of children with fatty liver was used first with the rat as a model. It was found, in the development of such a model, that there are great variations in the level of liver fat induced by protein depletion in the rat. The variations depend on the age and nutritional state of the animal at the time of introducing the low-protein diet, and depend on the calorie intake while thay are on the diet. It was found that there were always measurable increases in the liver fat content when 70-gram rats were fed a 6 percent casein diet for 7 to 10 days. The use of this model with either single-injection or constant-infusion techniques showed that the incorporation of labelled amino acids into the serum lipoproteins was reduced. The greatest reduction was in the VLDL fraction of the low-density lipoproteins. There was no evidence for any significant contribution to the fatty liver from increased lipogenesis at the time when the defect in lipoprotein synthesis was apparent. The incorporation of methionine-S35 into the low-density lipoproteins of malnourished children was measured; although the changes were not consistent throughout the group studied, there was some evidence that the incorporation of the amino acid into lipoproteins was less when the children were malnourished than when they had recovered. Some modification in the design of future experiments of this type are discussed. Routine measurements of serum triglycerides in the patients during treatment showed that there are some differences between the pattern seen here and that reported elsewhere. The patients had very low triglyceride levels after recovery. These low levels were found to be due to the high fat content of the diet which the patients received during treatment. The changes in serum triglycerides induced by changing the fat content of the diet were found to be more rapid and to be relatively greater than any changes previously reported for adults. No explanation for this is given at present. The unusual patterns for serum triglycerides found during treatment of the malnourished patients with a low-fat diet appeared at first to be inconsistent with reduced synthesis of lipoprotein being associated with the fatty liver; other changes in fat metabolism concurrent with such a defect, however, could account for the unusual patterns.(AU)


Assuntos
Humanos , Lactente , Ratos , Desnutrição Proteico-Calórica/metabolismo , Fígado Gorduroso/metabolismo , Aminoácidos/metabolismo , Triglicerídeos/metabolismo , Lipoproteínas/biossíntese , Lipoproteínas/metabolismo , Metionina , Deficiência de Proteína/induzido quimicamente , Deficiência de Proteína/metabolismo , Leucina/metabolismo , Glicina/metabolismo
18.
West Indian med. j ; 19(2): 119, June 1970.
Artigo em Inglês | MedCarib | ID: med-7491

RESUMO

Fasting serum triglyceride levels from children in our ward who have recovered from malnutrition are about 30 percent of the values reported by others for normal children or similarly recovered patients. Our patients have been treated for malnutrition with a diet containing 60-70 percent of total calories as fat. We have investigated the effects of the dietary fat intake on the fasting level of serum triglycerides by feeding these children a diet containing 30 percent of the calories as fat. Two to 4 days after changing the diet, fasting serum triglycerides rose 200 to 700 percent; thereafter the values stabilized within the normal values usually found in the literature. The rise was accounted for mainly by the d<1.019 lipoprotein triglycerides. Advantage was taken of the wide range of values obtained to study the composition of the d<1.019 lipoprotein. The data obtained support the hypothesis that the components of this lipoprotein fraction are in a constant proportion, thus it would constitute a definite chemical entity. The high sensitivity of infants to changes in the dietary fat intake and the rapidity of this response are being considered in the studies concerning the pathogenic mechanism of the fatty infiltration of the liver produced by protein malnutrition (AU)


Assuntos
Humanos , Criança , Lactente , Gorduras na Dieta , Triglicerídeos , Proteínas Sanguíneas , Transtornos da Nutrição do Lactente , Deficiência de Proteína
19.
West Indian med. j ; 16(2): 124, 1967.
Artigo em Inglês | MedCarib | ID: med-7312

RESUMO

The method of estimating Serum Triglyceride levels have been long and tedious and therefore restricted to specialized centres. Recently a relatively simple method using a miconephelometer has been described by Stone & Thorp of the I.C.I. Laboratories. This report is concerned with our experience with this method during the past six months. The method was applied to 113 patients and the results compared with the cholesterol levels taken at the same time. Seventy-seven patients were from private practice and of these 15 had myocardial infarcts, 18 had angina pectoris and 44 reported for routine checks. 36 were from clinics at U.W.I. (Dr. G. Millers), 12 were diabetics, 12 were hypertensives and 12 had myocardial infarcts. Of the 33 private patients with cardiac ischaemia 2 had high cholesterols and low triglycerides, 12 had high cholesterols and high triglycerides, 13 had low cholesterols and high triglycerides and 6 had low cholesterols and low triglycerides. Thus measuring cholesterol levels alone, as is the custom of most physicians, would have missed 13 or 39 percent of this group who had normal cholesterol but high triglycerides. Of the 44 private patients reporting for routine checks 9 had cholesterols with low triglycerides, 13 had high cholesterols and triglycerides, 9 had low cholesterols and high triglycerides and 13 had low cholesterols and triglycerides. Thus 9 or 22 percent would have been missed if cholesterol levels alone were checked. Of the 12 clinic patients with infarcts only 1 had a slightly high cholesterol level with normal triglycerides; while 3 had elevated triglycerides with normal cholesterol levels. Of the 12 hypertensives 1 had a slightly high cholesterol and 1 a high triglyceride level. Of the 12 diabetics (on treatment) only one had a very slightly elevated cholesterol level. Thus of the 36 U.W.I. clinic patients, 29 were in the normal low cholesterol-low triglyceride range. The higher incidence of abnormal lipids in the private group than in the clinic group is explained on the different income levels and consequently dietary habits of the two groups. It is suggested that this is one of the reasons that ischaemic heart disease is more commonly seen in private practice than in University practice in Jamaica. In 4 patients in whom adequate follow-up was available Atromid-S (chlor-phenoxy iso-butyric ester) was shown to be very effective in lowering elevated triglyceride levels, and as an incidental observation in one diabetic patient, retinal exudates disappeared after 2 months on Arromid-S when both cholesterol and triglycerides were lowered, though the diabetes was still not well controlled. The number are small yet the indications are that triglyceride estimation is a useful addition to cholesterol estimation since many patients have low cholesterol yet high triglyceride levels. There is no promise that correcting the lipids will definitely alter the course of established coronary artery disease but the prophylactic value in people who report for routine checks should be assessed over the years (AU)


Assuntos
Triglicerídeos/análise
20.
Artigo em Inglês | MedCarib | ID: med-173

RESUMO

The aim of this study is to assess the plasma glycaemia of patients attending the diabetes mellitus outpatients' clinics in Trinidad and determine how different plasma glycaemia would affect cardiovascular disease (CVD) risk factors. One hundred and ninety-one patients (64 males, 127 females, mean age 56.6ñ0.8 yr) with Type 2 diabetes mellitus (mean duration 9.2ñ0.6 yr) attending diabetes mellitus clinics from January to April 2000 participated in study. Anthropometric indices (weight, height, waist and hip circumferences) and blood pressure were measured and overnight fasting blood samples were collected for glycated haemoglobin (HbA), glucose, lipids (triglyceride, total cholesterol, LDL-cholesterol, HDL-cholesterol) and creatinine determinations. The patients were categorized into Group 1 ("well controlled"; HbA<7.0 percent) and Group 2 ("poorly controlled"; HbA>7.0 percent). Although the majority (85 percent) of patients were "poorly controlled", there were no significant diferences in the age, duration of diabetes mellitus, body mass index and waist/hip ratios between the two groups of patients (p>0.05). Similarly, the blood presure and (total cholesterol, LDL-cholesterol) levels did not differ between the two groups (p>0.05) although triglyceride (1.4ñ0.1 vs 2.2ñ0.1 mmol/L) levels were higher in patients in Group 2 compared with Group 1 (p<0.05). Multiple linear regression analysis indicates that the levels of blood pressure, lipid and anthropometric parameters were not significantly dependent on the plasma glycaemia of the patients (p>0.05). Analysis of the data has shown that the majority of patients with Type 2 diabetes mellitus attending primary care clinics in Trinidad had poor glycaemic control. The poorly controlled patients had similar levels of CVD risk factors to "well controlled" patients although the former were potentially at greater risk of progressing to cardiovascular disorder than "well controlled" patients. (AU)


Assuntos
Pessoa de Meia-Idade , Feminino , Humanos , Masculino , Diabetes Mellitus Tipo 2/sangue , Hemoglobina A Glicada/análise , Doenças Cardiovasculares/epidemiologia , Lipídeos/sangue , Trinidad e Tobago/epidemiologia , Glicemia , Colesterol/sangue , Estudos de Coortes , Doenças Cardiovasculares/complicações , /complicações , Hipertensão/epidemiologia , Obesidade/epidemiologia , Fatores de Risco , Triglicerídeos/sangue
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