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Am J Phys Anthropol ; 81(4): 555-62, Apr. 1990.
Artigo em Inglês | MedCarib | ID: med-8760


The sera of a sample of 204 Creoles from Trinidad were tested for the presence of polmorphic gene complexes occurring on immunoglobulin light and heavy-chain molecules including the allotypic markers IGKC 1, IGHA2 1 and 2, IGHG1 A, X, F, and Z, and IGHG3 G, G5, B0, B1, B3, B4, B5, C3, C5, S, and T. Nine IGHG (GM) haplotypes occur in polymorphic frequencies (greater than .01) in this population, including known African, Asian, Caucasian, and Amerindian marker haplotypes. Significant differences (P less than .01) were found in the frequency distributions of three IGHI (GM) haplotypes and the frequency of IGKC*1 in these data and data from Creole populations of Belize and St. Vincent. The Creoles of Trinidad and St. Vincent are more similar in IGHG (GM) haplotype distributions than are Trinidad and Belize populations. Previous testing has revealed no significant differences between St. Vincent and Belize Creoles at the Ig allotypic loci. Analysis of migration patterns in the Caribbean suggests that different rates of Asian migration have maintained regional diversity at these loci, while continuous gene flow from the eastern Caribbean to Trinidad has had a relative homogenising effect on the gene pools of this area. (AU)

Humanos , Alótipos de Imunoglobulina/genética , Variação Genética , Distribuição de Qui-Quadrado , Haplótipos , Fenótipo , Trinidad e Tobago
Int J Lepr Other Mycobact Dis ; 57(2): 465-71, June 1989.
Artigo em Inglês | MedCarib | ID: med-10029


Our recent segregation analysis, carried out on 27 large pedigrees from a Caribbean island (Desirade), has shown the presence of recessive major gene(s) controlling susceptibility to leprosy per se and nonlepromatous leprosy, respectively. Linkage analysis was performed between each of these two detected genes and each of five markers typed in the Desirade population: HLA, ABO, Rhesus, Gm and Km. No positive significant lod score was observed. However, for leprosy per se close linkage was excluded with Rhesus and Gm (and also with ABO and HLA, considering a lower value for the frequency of the gene controlling susceptibility to leprosy per se). The highest lod score, although not significant, was obtained between the gene for nonlepromatous leprosy and ABO. Our overall results, joined with previous studies and experimental data, suggest that the gene controlling susceptibility to leprosy per se and that controlling susceptibility to nonlepromatous leprosy might be different, acting at successive stages of the immune response to infection with Mycobacterium leprae. (AU)

Humanos , Marcadores Genéticos , Hanseníase/genética , Hanseníase Virchowiana/genética , Ligação Genética , Sistema ABO de Grupos Sanguíneos/genética , Suscetibilidade a Doenças , Antígenos HLA/genética , Alótipos de Imunoglobulina/genética , Alótipos Gm de Imunoglobulina/genética , Sistema do Grupo Sanguíneo Rh-Hr/genética , Índias Ocidentais