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1.
J Med Virol ; 59(4): 541-6, Dec. 1999.
Artigo em Inglês | MedCarib | ID: med-746

RESUMO

Mother-to-child transmission of human T-cell lymphotrophic virus type 1 (HTLV-I) is primarily due to prolonged breast-feeding (>6 months) in the post-natal period. Most infant infections are not identifiable until 12-18 months of age by available whole virus Western blot serologic tests because of their inability to distinguish passively transferred maternal antibody from infant antibody. We investigated two methods to assess more accurately the time of infant infection. In prospectively collected serial biospecimens, HTLV-I-specific immunoglobulin (Ig) isotypes of IgM and IgA were determined by Western blot and HTLV-I proviral DNA was detected by polymerase chain reaction (PCR). IgA and IgG reactivity was assessed in periodic serum samples from 16 HTLV-I-seropositive children while IgM reactivity was observed in 100 percent of children at 24 months of age and 73 percent of children at 6-12 months of age; however, this could represent maternal and not infant antibody. Both IgA and IgM reactivity were insensitive indicators of infection, with only 50 percent of children showing reactivity at 24 months of age. PCR testing was performed in biospecimens obtained from 11 of these children. An estimated median time of infection of 11.9 months was determined by PCR, which was similar to the median time to infection determined by whole virus Western blot (12.4 months; P=0.72). PCR Tests support a median time to infection that is similar to that estimated by whole virus Western blot. (AU)


Assuntos
Adulto , Pré-Escolar , Feminino , Humanos , Recém-Nascido , Lactente , Aleitamento Materno , Transmissão Vertical de Doença Infecciosa , Vírus Linfotrópico T Tipo 1 Humano/imunologia , Infecções por HTLV-I/transmissão , DNA Viral/análise , Estudo de Avaliação , Vírus Linfotrópico T Tipo 1 Humano/isolamento & purificação , Infecções por HTLV-I/imunologia , Infecções por HTLV-I/virologia , Anticorpos Anti-HTLV-I/sangue , Imunoglobulina A/sangue , Imunoglobulina M , Jamaica , Reação em Cadeia da Polimerase/métodos , Estudos Prospectivos , Provírus , Fatores de Tempo
2.
Lupus ; 8(3): 210-4, 1999.
Artigo em Inglês | MedCarib | ID: med-1306

RESUMO

Anticardiolipin and anti-beta2GP1 antibodies were measured in 50 patients with HTLV-1-associated Myelopathy-Tropical Spastic Paraparesis (HAM-TSP) and the results were compared with those obtained for 34 HTLV-1-positive and 35 HTLV-1-negative controls, as well as 128 SLE patients. aCL but not anti-beta2GP1 was associated with HTLV-I infection. aCL was more prevalent than anti-beta2GP1 (32 percent vs. 8 percent) and was not associated with anti-beta2GP1 in HAM-TSP. IgA was the dominant isotype of aCL and anti-beta2GP1. The data suggest that tin HAM-TSP, IgA aCL are frequent and are associated with HTLV-1 infection.(Au)


Assuntos
Humanos , Anticorpos Anticardiolipina/sangue , Anticorpos Antifosfolipídeos/sangue , Glicoproteínas/imunologia , Paraparesia Espástica Tropical/imunologia , Estudos de Casos e Controles , Infecções por HTLV-I/imunologia , Imunoglobulina A/sangue , Isotipos de Imunoglobulinas/sangue , Lúpus Eritematoso Sistêmico/imunologia
4.
Am J Trop Med Hyg ; 55(5): 474-6, Nov. 1996.
Artigo em Inglês | MedCarib | ID: med-2385

RESUMO

The enzyme-linked immunosorbant assay was used to investigate long term changes in serum immunoglobulin G1 (IgG1), IgG4, IgE, and IgA against Strongyloides stercoralis phosphate-buffered saline-soluble filariform larval antigens in eight Jamaican patients treated with ivermectin. Patients were followed for periods of between 170 and 542 days. Based on repeated formalin-ether concentration and agar plate culture, all patients were found to be uninfected up to 18 months following chemotherapy. Generally, all antibody isotype levels decreased following treatment, although there was considerable heterogeneity among patients. In a single patient with hyperinfection, the decrease in IgG4 was marginal and may represent a treatment failure. Reduction in serum antibody isotype responses to S. stercoralis following treatment may be used to assess the effectiveness of ivermectin in treating endemic strongyloides (AU)


Assuntos
21003 , Humanos , Anti-Helmínticos/uso terapêutico , Anticorpos Anti-Helmínticos/análise , Ivermectina/uso terapêutico , Strongyloides stercoralis/efeitos dos fármacos , Strongyloides stercoralis/imunologia , Estrongiloidíase/tratamento farmacológico , Estrongiloidíase/epidemiologia , Estrongiloidíase/imunologia , Imunoglobulina A/análise , Imunoglobulina E/análise , Imunoglobulina G/análise , Fatores de Tempo
5.
Lupus ; 4(2): 138-41, Apr. 1995.
Artigo em Inglês | MedCarib | ID: med-4703

RESUMO

A retrovirus human T cell lymphotropic virus type I (HTLV-I), is an essential but not a sufficient aetiological factor for tropical spastic paraparesis (TSP). Because some TSP patients have biological false positive tests for trepomemal infections (BFP-STS), we used EISA to study BFP-STS and anticardiolipin antibodies in 42 Jamaican TSP patients. The data indicate that in TSP anticardiolipin antibodies accur in about 26 percent of patients, are associated with biological false positive treponemal serology, are relatively restricted to the IgA isotype and may be induced by HTLV-I or other non-treponemal infections. (Au)


Assuntos
Adulto , Humanos , Feminino , Masculino , Técnicas In Vitro , Imunoglobulina A , Anticorpos Antifosfolipídeos , Paraparesia Espástica Tropical , Vírus Linfotrópico T Tipo 1 Humano , Retroviridae , Manifestações Neurológicas , Vírus Linfotrópico T Tipo 1 Humano/patogenicidade , Infecções por Treponema/epidemiologia , Ensaio de Imunoadsorção Enzimática , Sífilis/diagnóstico , Região do Caribe
6.
West Indian med. j ; 32(3): 140-6, Sept. 1983.
Artigo em Inglês | MedCarib | ID: med-11427

RESUMO

Forty-one amniotic fluid samples were tested by single radial immunodiffusion, using Hyland plates for the demonstration of IgG, IgA, IgD, IgM and C3. All of the immunoglobulins except IgM could be detected throughout gestation. There was a tendency to increase during mid-pregnancy and thereafter to decrease toward term. IgM was detected in only 5 samples (12.2 percent) obtained at term. The literature is reviewed with particular emphasis on IgD, IgM and C3 in amniotic fluid (AU)


Assuntos
Feminino , Humanos , Gravidez , Líquido Amniótico/imunologia , Complemento C3/análise , Imunoglobulinas/análise , Imunoglobulina A/análise , Imunoglobulina D/análise , Imunoglobulina G/análise , Imunoglobulina M/análise , Jamaica
7.
Clin Chim Acta ; 125(1): 81-7, Oct. 13, 1982.
Artigo em Inglês | MedCarib | ID: med-12397

RESUMO

Serum immunoglobulin levels (IgA, IgG, and IgM) have been assayed in a representative sample of children (aged 1-7 years) with homozygous sickle cell disease and in age/sex-matched control children with a normal haemoglobin genotype, followed from birth in a prospective cohort study. In SS disease, significant elevation of IgA occurred from the age of two years and of IgG from the age of six years. IgM levels were not significantly different in the two genotypes. The mechanisms contributing to these changes in immunoglobulins are currently unclear as is their clinical significance.(AU)


Assuntos
Humanos , Lactente , Pré-Escolar , Criança , Masculino , Feminino , Anemia Falciforme/imunologia , Imunoglobulinas/análise , Envelhecimento , Eletroforese das Proteínas Sanguíneas , Sangue Fetal/imunologia , Genótipo , Imunoglobulina A/análise , Imunoglobulina G/análise , Imunoglobulina M/análise
8.
Arch Dis Child ; 53(5): 426-8, May 1978.
Artigo em Inglês | MedCarib | ID: med-14777

RESUMO

Two cases of infantile cortical hyperostosis are reported. Both had raised immunoglobulins. Particularly remarkable were the IgA and IgM levels, a finding infrequently reported (AU)


Assuntos
Humanos , Lactente , Masculino , Hiperostose Cortical Congênita/imunologia , Imunoglobulinas/análise , Hiperostose Cortical Congênita/diagnóstico por imagem , Imunoglobulina A/análise , Imunoglobulina M/análise
9.
Ann Trop Med Parasitol ; 66(3): 369-73, Sept. 1972.
Artigo em Inglês | MedCarib | ID: med-13057

RESUMO

An investigation was made of the immunological status of matched groups of patients with Schictosoma mansoni infection in St. Lucia, one group with hepatosplenic disease and the other with only intestinal disease. No impairment of humoral or cellular immunity was detected in either group. IgG and IgM levels were above normal range and were higher in the patients with intestinal disease, but only the difference between groups in IgG level was statistically significant. In their reaction to specific schistisome antigens and ability to develop delayed hypersensitivity, the groups were about equal. (AU)


Assuntos
Humanos , Criança , Adolescente , Masculino , Feminino , Imunidade Celular , Imunoglobulinas/análise , Schistosoma mansoni/imunologia , Esquistossomose/imunologia , Hepatomegalia/etiologia , Hepatomegalia/imunologia , Hipersensibilidade Tardia , Imunoglobulina A/análise , Nitrobenzenos , Esquistossomose/complicações , Albumina Sérica/análise , Soroglobulinas/análise , Testes Cutâneos , Esplenomegalia/etiologia , Esplenomegalia/imunologia , Santa Lúcia , Imunoglobulina G/análise , Imunoglobulina M/análise
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