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WEST INDIAN MED. J ; 45(1): 28-30, Mar. 1996.
Artigo em Inglês | MedCarib | ID: med-4686


Plasma fibronectin (Fbn) was assessed daily in 9 men admitted to the cardiology care unit for uncomplicated acute myocardial infarction (AMI). In a control group of twenty healthy men, plasma Fbn was 0.290ñ 0.0417g/l-1 (meanñSD). In 6 hypertensive AMI patients, Fbn levels were increased to a maximum of 0.461ñ0.0294 g/l-1 at day five (5.5 ñ 0.84 days) and returned to the range of the control group values 56 ñ 32.8 afterwards. Three normotensive patients had higher Fbn results without returning to the control group range at the end of the hospitalization (0.734 ñ 0.209 gl-1). Plasma Fbn could in part be implicated in the repair process and/or in the limitation of the cardiac necrosis extension. Moreover, it seems that a link exists between plasma Fbn kinetics and hypertension and/or normotension during uncomplicated AMI. (AU)

Adulto , Humanos , Masculino , Fibronectinas/metabolismo , Infarto do Miocárdio/metabolismo , Hipertensão/metabolismo , Fibronectinas/sangue , Infarto do Miocárdio/sangue , Nefelometria e Turbidimetria
West Indian med. j ; 43(suppl.1): 18, Apr. 1994.
Artigo em Inglês | MedCarib | ID: med-5429


A single assay of maternal fibronectin level is not specific enough to predict adverse foetal outcome, but daily measurement of maternal fibronectin level and a time-relate analysis allow a good prediction of the disease. In predicting adverse foetal outcome, these measurements complement the information provided by the physical methods of evaluation of the foetal status such as Doppler, ehcography or cardiotocography. The daily profile of plasma fibronectin level during hypertensive pregnancies shows a bi-phasic pattern: an early increase in fibronectin is followed by a decrease or at least a plateau preceding delivery. This last observation is consistent with a protective role of fibronectin as emphasised by Frolich and Bathia (AU)

Humanos , Gravidez , Recém-Nascido , Fibronectinas/diagnóstico , Hipertensão/diagnóstico , Resultado da Gravidez