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1.
Vaccine ; 28(33): 5421-5426, Jun. 19 2010. tab, graf
Artigo em Inglês | MedCarib | ID: med-17679

RESUMO

A hamster model was used to determine the efficacy of commercially prepared canine vaccines against Leptospira serovars circulating in Trinidad and to assess the effectiveness of killed whole-cell vaccines prepared from local isolates. The local isolates used for vaccine preparation and challenge were isolates of serovars Copenhageni and Mankarso obtained from a local dog and rodent. Their estimated lethal dose-50 (LD(50)) were 5 and 10 organisms, respectively and clinical signs observed on infection were consistent with leptospirosis. An unvaccinated control group of hamsters and other groups of hamsters that had been vaccinated with 3 doses of (i) in-house whole-cell Copenhageni vaccine, (ii) in-house whole-cell Mankarso vaccine, (iii) commercial vaccine Brand A or (iv) commercial vaccines Brand B were challenged with 1000 times the LD(50) of the respective challenge serovar. The most commonly used commercial vaccine (Brand A) did not offer protection to challenged hamsters, whereas Brand B facilitated the renal carrier state of the Leptospira organism. In contrast the whole-cell vaccines developed from local strains of serovars Copenhageni and Mankarso, protected all hamsters tested from both clinical disease and renal carrier states.


Assuntos
Cricetinae , Animais , Humanos , Leptospirose , Leptospira , Vacinas , Trinidad e Tobago
2.
Rev. panam. salud publica ; 10(3): 149-151, Sept. 2001.
Artigo em Inglês | MedCarib | ID: med-16962

RESUMO

This meeting will review much of the work done in the Central American subregion, in Mexico, and in the Spanish-speaking Caribbean in the field of vaccines and the diseases they prevent. It will review progress achieved, the steps that have to be followed to consolidate the gains that have been made to date, and the strategies that have to be adopted to face the challenges ahead. It will comment on some new initiatives and, based on experiences shared, see how we may advance together (AU)


Assuntos
Humanos , Saúde Pública , Haiti , Imunização , Programas de Imunização , Vacinas
3.
West Indian med. j ; 50(1): 15-6, Mar. 2001.
Artigo em Inglês | MedCarib | ID: med-327

RESUMO

Under the immunization regulations, parents and guardians have equal responsibility to take their children for vaccination "within one year of child's birth or soon after". (AU)


Assuntos
Humanos , Programas de Imunização/economia , Vacina contra Sarampo/efeitos adversos , Vacina contra Caxumba/efeitos adversos , Vacina contra Rubéola/efeitos adversos , Vacinas/efeitos adversos , Resultado do Tratamento , Organização Mundial da Saúde , Fatores de Risco
6.
anon.
Epi News ; 15(2): 1, Nov. 1999.
Artigo em Inglês | MedCarib | ID: med-848
7.
Bull Pan Am Health Organ ; 30(2): 95-105, Jun. 1996.
Artigo em Inglês | MedCarib | ID: med-3167

RESUMO

There is some uncertainty about the extent to which Latin America and the Caribbean have participated in the advances of health-related industrial biotechnology. This article reviews the available literature and seeks to provide an overview of the prevailing situation. In general, national governments and multinational agencies have provided most of the health-related biotechnology investments within this region. Efforts to achieve technology transfers, a subject of prime concern, have been developed by a number of programs including the WHO Special Programme for Research and Training in Tropical Diseases, the UNDP/UNESCO/UNIDO Regional Biotechnology Program for Latin America and the Caribbean; PAHO's Program for the Regional Development of Biotechnology as Applied to Health; the PAHO/WHO Expanded Program of Immunization (EPI); and PAHO's Regional System of Vaccines (SIREVA). Regarding current production capacity, some successful efforts have been made to produce a variety of therapeutic products including recombinant and natural ionterferons, interleukins, insulin, and recombinant streptokinase; but in general the region's current potential in this area is at best incipient and uncertain. However, the region does have a limited ability to make diagnostic products and a well-established capacity for vaccine development. Overall, this picture suggests that the region has the potential to play a small but significant role in health-related biotechnology (AU).


Assuntos
Humanos , Biotecnologia/tendências , Serviços de Saúde/tendências , Produtos Biológicos/biossíntese , Pesquisa , Financiamento Governamental , Agências Internacionais , Transferência de Tecnologia , Vacinas/biossíntese , América Latina , Região do Caribe
8.
In. Levett, Paul N; Fraser, Henry S; Hoyos, Michael D. Medicine and therapeutics update 1990: proceedings of Continuing Medical Education symposia in Barbados, November 1988 & June 1989. St. Michael, University of the West Indies, (Cave Hill). Faculty of Medical Sciences, 1990. p.34-41.
Monografia em Inglês | MedCarib | ID: med-15007

RESUMO

This article looks at the history, development, progress and research of the Human Immunodeficiency Virus (HIV) which causes AIDS. The author reports of the ongoing research into a vaccine for HIV, he examines the viral life cycle and indicates the points at which the virus can be attacked, and classifies antiviral strategies


Assuntos
HIV , Infecções por HIV/classificação , Infecções por HIV/diagnóstico , Infecções por HIV/tratamento farmacológico , Infecções por HIV/epidemiologia , Infecções por HIV/história , Infecções por HIV/terapia , HIV-2/análise , HIV-2/classificação , HIV-2/crescimento & desenvolvimento , HIV-2/isolamento & purificação , HIV-2/patogenicidade , HIV-1/análise , HIV-1/classificação , HIV-1/crescimento & desenvolvimento , HIV-1/isolamento & purificação , HIV-1/patogenicidade , Sistema Imunitário/patologia , HIV , Complexo Relacionado com a AIDS/diagnóstico , Complexo Relacionado com a AIDS/tratamento farmacológico , Complexo Relacionado com a AIDS/etnologia , Complexo Relacionado com a AIDS/etiologia , Complexo Relacionado com a AIDS/história , Complexo Relacionado com a AIDS/terapia , Complexo Relacionado com a AIDS/transmissão , Vacinas/administração & dosagem , Vacinas/efeitos adversos , Vacinas/análise , Vacinas/classificação , Vacinas/diagnóstico , Vacinas/imunologia , Vacinas/farmacologia , Vacinas Virais/administração & dosagem , Vacinas Virais/efeitos adversos , Vacinas Virais/classificação , Vacinas Virais/diagnóstico , Vacinas Virais/farmacologia , Vacinas Virais/uso terapêutico , Soropositividade para HIV , Produtos do Gene tat/análise , Produtos do Gene tat/classificação , Produtos do Gene tat/diagnóstico , Produtos do Gene tat/uso terapêutico
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