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J Nat Prod ; 61(10): 1302-3, Oct. 1998.
Artigo em Inglês | MedCarib | ID: med-1371


As the result of a structurally guided isolation to identify lead compounds for the treatment of opportunistic infections of AIDS, the dihydrochloride salt of a new symmetrical pyrrole analogues (2 and 3) were isolated from the Caribbean sponge Agelas conifera collected from Belize. The structure of debromosceptrin was identified by analysis of spectral data. 15N spectral data assignments were made for compounds 1-3. Compounds 2 and 3 showed marginal inhibition of Mycobacterium tuberculosis (Au)

21003 , Antituberculosos/isolamento & purificação , Poríferos/química , Pirróis/isolamento & purificação , Antituberculosos/química , Antituberculosos/farmacologia , HIV/efeitos dos fármacos , Testes de Sensibilidade Microbiana , Estrutura Molecular , Mycobacterium tuberculosis/efeitos dos fármacos , Espectroscopia de Ressonância Magnética , Pirróis/química , Pirróis/farmacologia
Am J Trop Med Hyg ; 55(1): 1-11, July 1996.
Artigo em Inglês | MedCarib | ID: med-3156


More than 18 million persons in the the world are estimated to have been infected with human immunodefeiciency virus (HIV), the cause of the acquired immunodeficiency syndrome (AIDS). As immunodeficiency progresses, these persons become susceptible to a wide variety of opportunistic infections (OIs). The spectrum of OIs varies among regions of the world. Tuberculosis is the most common serious OI in sub-Saharan Africa and is also more common in Latin America and in Asia than in the United States. Bacterial infections such as toxoplasmosis, cryptosporidiosis, and isosporaisis are also common in Latin America. Fungal infections, including cryptococcosis and Penicillium marneffei infection, appear to be prevalent in Southeast Asia. Despite limited health resources in these regions, some measures that are recommended to prevent OIs in the United States may be useful for prolonging and improving the quality of life of HIV-infected persons. These include trimethoprim-sulfamethoxazole to prevent Pneumocystis carinii pneumonia, toxoplasmosis, and bacterial infections; isoniazid to prevent tuberculosis; and 23-valent pnemococcal vaccine to prevent disease due to Streptococcus pneumoniae. Research is needed to determine the spectrum of OIs and the efficacy of various prevention measures in resource-poor nations, and health officials need to determine a minimum standard of care for HIV-infected persons. An increasing problem in the developing world, HIV/AIDS should receive attention comparable to other tropical diseases (AU).

Humanos , Infecções Oportunistas Relacionadas com a AIDS , Anti-Infecciosos , Antituberculosos , Vacinas Bacterianas , Quimioterapia Combinada , Isoniazida , Sulfametizol , Trimetoprima , Pesquisa , África , Ásia , Países em Desenvolvimento , América Latina/epidemiologia , Região do Caribe/epidemiologia