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1.
Arch Dis Child ; 72(3): 227-9, March 1995.
Artigo em Inglês | MedCarib | ID: med-5894

RESUMO

Chronic hypersplenism in homozygous sickle cell (SS) disease markedly increases haemolysis and the resulting erythropoietic expansion is likely to have a high metabolic cost. Splenectomy for hypersplenism in SS disease is followed by highly significant changes in haematological indices and an increase in height, but not weight, velocity. This pattern is similar to that observed in the trichuris dysentery syndrome after treatment, and differs from the increase in both height and weight velocity that follow nutritional supplementation of severely malnourished children. It is postulated that accelerated linear growth after the reduction in erythropoietic stress may implicate a specific nutrient deficiency in hypersplenic children with SS (AU)


Assuntos
Humanos , Masculino , Feminino , Pré-Escolar , Criança , Crescimento , Hiperesplenismo/cirurgia , Traço Falciforme/complicações , Peso Corporal , Estatura , Índices de Eritrócitos , Testes Hematológicos , Hiperesplenismo/sangue , Hiperesplenismo/fisiopatologia , Traço Falciforme/sangue , Traço Falciforme/fisiopatologia , Traço Falciforme/cirurgia , Esplenectomia
4.
Am J Clin Nutr ; 58(5): 622-6, Nov. 1993.
Artigo em Inglês | MedCarib | ID: med-8342

RESUMO

The present investigation was undertaken to assess the efficacy of oral iron supplementation during pregnancy by using a gastric delivery system (GDS). Three hundred seventy-six pregnant women between 16 and 35 years of age and 14 and 22 weeks gestation were selected if mild anemia was present (hemoglobin concentration 80-110 g/l). The participants were randomly assigned to one of three study groups given no iron, two FeSO4 tablets (100 mg FE) daily, or one GDS capsule (50 mg Fe) daily. Blood was obtained initially and after 6 and 12 weeks for measurement of red blood cell and iron indexes, including serum transferrin receptor. There was a significant and comparable improvement in hematologic and iron-status measurements in the two group of women given iron whereas iron deficiency evolved in women given no iron supplement. We conclude that by elimating gastrointestinal side effects and reducing the administration frequency of an iron supplement to once daily, a GDS offers significant advantages for iron supplementation of pregnant women. (AU)


Assuntos
Humanos , Gravidez , Adolescente , Adulto , Feminino , Ferro/administração & dosagem , Administração Oral , Anemia/tratamento farmacológico , Cápsulas , Sistemas de Medicação , Testes Hematológicos , Ferro/metabolismo
5.
J Clin Lab Immunol ; 6(1): 57-60, July 1981.
Artigo em Inglês | MedCarib | ID: med-9332

RESUMO

The role of haemolysis in producing deficient complement function in homozygous sickle cell disease was studied by measuring indices of complement activation and of haemolysis in 30 asymptomatic patients. Plasma concentration of C3d (an index of increased C3 turnover) was elevated in 40 percent of patients and modest decreases in serum concentration of C3 and functionally (haemolytically) active factor B were found. There was a positive correlation between C3d and plasma haemoglobin concentration (r = 0.56, p less than 0.005). Reticulocyte count and foetal haemoglobin concentration also contributed to variation in C3d, though to a lesser extent than plasma haemoglobin. Intravascular haemolysis in sickle cell disease may produce activation of complement and thus cause partial depletion of functional factor B and C3. This may reduce the immune function of the alternative pathway. (AU)


Assuntos
Humanos , Adolescente , Adulto , Pessoa de Meia-Idade , Masculino , Feminino , Anemia Falciforme/imunologia , Ativação do Complemento , Hemoglobinas/análise , Traço Falciforme/imunologia , Proteínas do Sistema Complemento/análise , Complemento C3/análise , Testes Hematológicos , Hemólise , Análise de Regressão , Traço Falciforme/sangue
6.
Br J Haematol ; 41(1): 83-93, Jan. 1979.
Artigo em Inglês | MedCarib | ID: med-12985

RESUMO

Clinical and haematological features in 41 patients with sickle cell-᧠thalassaemia (S᧠thalassaemia) and in 123 age-sex matched controls with homozygous sickle cell (SS) disease were compared. Persistence of splenomegaly was more common and fetal loss less common in S᧠thalassaemia but other clinical features were similar in the two genotypes. Total haemoglobin, Hb A2, PCV, CCV, and red cell count were significantly higher and MCV, MCH, MCHC,and ISC counts significantly lower in Sá§thalassaemia. Proportional reticulocyte counts were significantly lower in S᧠thalassaemia but there was a difference in absolute reticulocyte counts. Persistence of splenomegaly and low ISC counts are compatible with decreased intravascular sickling which may result from the lower mean cell haemoglobin S concentration in S᧠thalassaemia. If beneficial effects of a low MCHC can be confirmed then a carefully monitored trial of iron deficiency in SS disease may be a logical experimental procedure.(AU)


Assuntos
Humanos , Pré-Escolar , Criança , Adolescente , Adulto , Pessoa de Meia-Idade , Masculino , Feminino , Anemia Falciforme/complicações , Traço Falciforme/complicações , Talassemia/complicações , Anemia Falciforme/sangue , Anemia Falciforme/genética , Traço Falciforme/sangue , Traço Falciforme/genética , Talassemia/sangue , Talassemia/genética , Hemoglobina Fetal/análise , Genótipo , Testes Hematológicos , Esplenomegalia/etiologia
7.
West Indian med. j ; 22(3): 155, Sept. 1973.
Artigo em Inglês | MedCarib | ID: med-6172

RESUMO

A longitudinal study of health and growth of 270 Kingston infants was carried out from birth to 1-year of age. The infants were all born at University Hospital and were from predominantly lower socio-economic backgrounds. Haemoglobin levels were estimated 7 times during the year, mean corpuscular haemoglobin concentration 3 times, and serum iron levels and haemoglobin electro-phoresis once when the infants were 10 months old. The stool of approximately 50 percent of the infants was examined for parasites at 10 months of age. The incidence of abnormal haemoglobins was 39 (14.4 percent). 4 infants had haemoglobin SS and their health and progress is reported. Data for children with haemoglobin AS appeared to be similar to that for children with haemoglobin AA. The 33 infants with birth weights below 2.5 kgm had lower mean levels for haemoglobin, serum iron and percentage saturation of transferrin than infants with birth weigh over 2.5 kgm. The following results refer to 220 singleton infants with birth weights over 2.5 kgm. and with Hb AA or AS. The mean Hg levels from 3 months of age were lower than normal values reported from developed countries. The incidence of Hb level below 10 gms. per 100 ml. varied from 20 to 50 percent between 3 and 12 months of age. Mean values for serum irons, the percentage saturation of transferrin and the mean corpuscular haemoglobin concentration were all lower than normal and were all significantly correlated with Hb levels at 10 months of age. Several factors were examined for an association with Hb level. Hb changed with age with a steep fall from birth to 3 months of age and a slight dip at 8 months of age. Males had lower Hb levels than females. Infants with birth weights between 2.5 and 3 kgm. had lower Hb levels at 3 months of age. The prevalence of parasites was 11 percent, comprising 8 percent Giardia lamblia, 2 percent Ascaris lumbricoides and 1 percent Trichuris trichiura. No hookworm was found. Possible explanations for the high incidence of anaemia are discussed (AU)


Assuntos
Humanos , Lactente , Testes Hematológicos/estatística & dados numéricos , Bem-Estar do Lactente , Desenvolvimento Infantil , Jamaica , Hemoglobinas , Hemoglobinas Anormais , Hemoglobina Falciforme , Parasitos , Fatores Socioeconômicos , Classe Social , Ganho de Peso
8.
Br J Dermatol ; 86: 226-37, 1972.
Artigo em Inglês | MedCarib | ID: med-9515

RESUMO

The clinical features and investigations relating to gastrointestinal function are presented in 12 cases of juvenile dermatitis herpetiformis seen over a period of 2 years in Jamaica. None of the children had evidence of steatorrhoea. Jejunal biopsy in 10 cases showed normal mucosa in 1, ridging and convolutions in 8 and a flat mucosa in 1. Electronmicroscopical changes are also described. Lactase deficiency malnutrition in infancy or at the time of biopsy. An interesting feature was relapse following iodine contrast media used during jejunal biopsy and a high incidence of iodine in drinking water in some parts of Jamaica. (AU)


Assuntos
Humanos , Lactente , Pré-Escolar , Criança , Masculino , Feminino , Dermatite Herpetiforme , /anatomia & histologia , /fisiologia , Biópsia , Jamaica , Testes Hematológicos , /análise , Dissacarídeos , Jejuno/anatomia & histologia , Microscopia Eletrônica , Vesícula/tratamento farmacológico , Doença Celíaca , Anemia , Enteropatias Parasitárias , Dermatite Herpetiforme/prevenção & controle , Iodo/efeitos adversos , Transtornos Nutricionais/complicações , Intolerância à Lactose
9.
West Indian med. j;12(2): 117-23, June 1963.
em Inglês | MedCarib | ID: med-10593

RESUMO

The modification of Westergren's Method for measuring erythrocyte sedimentation rate, using blood preserved with E.D.T.A. and diluted with citrate solution was found to give results similar to those of the classical Westergren Method. Wintrobe's Method gave fairly satisfactory results in most but not all cases. The tubes should be read at 45 minutes rather than at one hour (AU)


Assuntos
Humanos , Técnicas In Vitro , Sedimentação Sanguínea , Testes Hematológicos/métodos
10.
West Indian med. j ; 11(2): 135, June 1962.
Artigo em Inglês | MedCarib | ID: med-7541

RESUMO

Thirteen cases of severe coagulation disorders occuring during the past 5 years and investigated at the Government Pathological Laboratory, Jamaica are discussed. Nine of these were hemophilias, one had Christmas disease and three further cases which presented complicated aberrations are discussed in detail. Of this latter group one had multiple congenital deficiency of prothrombin complex (i.e. prothrombin factor VII and factor X) and the other two, who were siblings, had multiple anomalies (anti-hemophilic globulin deficiency, a circulating anti-coagulant acting as a thrombo-plastin inhibitor as well as a plasma thromboplastin antecedent deficiency) (AU)


Assuntos
Humanos , Transtornos da Coagulação Sanguínea/diagnóstico , Testes Hematológicos , Hemofilia A , Hemofilia B , Protrombina
11.
Br J Haematol ; 7(3): 373-81, July 1961.
Artigo em Inglês | MedCarib | ID: med-14535

RESUMO

A large family is described in which the inheritance of a gene responsible for high levels of foetal haemoglobin (the F gene) and its interaction with the gene for haemoglobin-S is followed through three generations. Four cases of SF combination are reported. An example of the the CF combination is described. Evidence is produced that the F gene is situated at the same locus as the S and C genes and the gene for classical thalassaemia, and that it is therefore an allele of them. As an altenative explanation it is suggested that the high levels of foetal haemoglobin may not result from direct gene action but may be due to a failure of inheritance of normal haemoglobin following a deletion at the A-S-C locus (or a mutation lethal for beta-chain production), with a consequent revival of the dormant mechanism of foetal haemoglobin synthesis. Sickle-cell anaemia and the SF combination are phenotypically indistinguishable, and the difficulties in explaining the very marked clinical difference between them are discussed (Summary)


Assuntos
Humanos , Pré-Escolar , Criança , Adolescente , Adulto , Pessoa de Meia-Idade , Idoso , Hemoglobina Fetal/genética , Família , Hemoglobina A/genética , Hemoglobina C/genética , Alelos , Hemoglobina Falciforme/genética , Testes Hematológicos/métodos , Afro-Americanos , Relações Familiares , Jamaica
12.
Blood ; 17(2): 166-81, Feb. 1961.
Artigo em Inglês | MedCarib | ID: med-9609

RESUMO

Data are presented on seven cases of thalassemia major (six of whom were negroes) and 32 cases ofthalassemia minor of whom eight had high levels (20-26 per cent) of fetal hemoglobin. Two families with hemoglobin H disease are presented, in whom the presence of thalassemia minor could be demonstrated. The mode of inheritance of hemoglobin H disease is discussed. Two families with an inherited double A2 fraction of hemoglobin are presented. In one of these thalassemia was also found, in the other ellitocytos is occured concurrently. On the basis of these findings the existence of at least five different types of thalassemia is postulated. A study on 93 healthy students suggests a high incidence (above 3 per) of thalassemia minor in the West Indies. (Summary)


Assuntos
Humanos , Lactente , Pré-Escolar , Criança , Adolescente , Adulto , Pessoa de Meia-Idade , Idoso , Masculino , Feminino , Talassemia/epidemiologia , Índias Ocidentais , Jamaica , Talassemia/diagnóstico , Testes Hematológicos/métodos , Grupos Étnicos , Consanguinidade , Hemoglobina Fetal
13.
Blood ; 13(4): 359-66, Apr. 1958.
Artigo em Inglês | MedCarib | ID: med-14530

RESUMO

Two cases of sickle-cell thalassemia disease are described in young women of mixed Chinese and African parentage. On hemoglobin electrophoresis, a complete suppression of hemoglobin A was found, giving a picture indistinguishable from that seen in sickle-cell anemia. The findings in these two cases are contrasted with those in other examples of this disease which we have studied in Jamaica. The importance of these findings in relation to the diagnosis of sickle cell anaemia is discussed (Summary)


Assuntos
Humanos , Adolescente , Adulto , Masculino , Feminino , Talassemia/etnologia , Anemia Falciforme , Consanguinidade , Testes Hematológicos , Fragilidade Osmótica , Eletroforese/instrumentação , Hemoglobina Fetal
14.
Blood ; 13(6): 559-68, 1958.
Artigo em Inglês | MedCarib | ID: med-9540

RESUMO

Three generations of a Jamaican family of African extraction are desribed, in several members of which an abnormal gene is carried. This gene produces high levels of fetal hemoglobin unassociated with the usual stigmata of thalassemia. It is found in all three generations of the family associated with hemoglobin A only and is also found in at least two members of the family interacting with hemoglobin S. In the latter combination little or no disability results. The mode of inheritance of this abnormal gene is discussed, and reasons are put forward for a possible protective effect of high fetal hemogobin levels due to inhibition of sickling. The findings in the cord blood of the youngest child, including an unusually high percentage of sickling, are discussed, together with follow-up studies to the age of 25 weeks.(AU)


Assuntos
Humanos , Gravidez , Recém-Nascido , Lactente , Pré-Escolar , Criança , Adolescente , Adulto , Pessoa de Meia-Idade , Idoso , Masculino , Feminino , Hemoglobinopatias , Talassemia , Hemoglobina C , Hemoglobina Fetal , Hemoglobina Falciforme , Hemoglobina A , Família , Testes Hematológicos , Fragilidade Osmótica , Hemólise , Cloreto de Sódio , Células Sanguíneas/análise , Jamaica , Sangue Fetal/análise
15.
West Indian med. j ; 5(4): 247-55, Dec. 1956.
Artigo em Inglês | MedCarib | ID: med-12885

RESUMO

The literature on abnormal haemoglobins is briefly reviewed. The laboratory findings on 39 cases of sickle cell anaemia (genotype S-S), 14 of whom were adults, and on 13 cases of sickle cell-haemoglobin C disease (genotype S-C), are presented and discussed. Two family studies are included, in one of which three cases of sickle cell-haemoglobin C disease were found. (AU)


Assuntos
Humanos , Lactente , Pré-Escolar , Criança , Adolescente , Adulto , Pessoa de Meia-Idade , Masculino , Feminino , Hemoglobinas Anormais/análise , Eletroforese em Papel/métodos , Testes Hematológicos/métodos , Doença da Hemoglobina SC , Anemia Falciforme , Jamaica
16.
West Indian med. j;3(2): 104-7, June 1954.
Preprint em Inglês | MedCarib | ID: med-10383

RESUMO

Normal Jamaicans were found to have a low M.C.H.C. and albuminglobulin ratio as judged by normal European standards (AU)


Assuntos
Humanos , Masculino , Feminino , Proteínas Sanguíneas/análise , Hemoglobinas/análise , Testes Hematológicos , Jamaica/etnologia
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