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West Indian med. j ; 39(3): 186-9, Sept. 1990.
Artigo em Inglês | MedCarib | ID: med-14321


This paper describes a 9-year-old girl with primary hypophossphatemic ricketts, an uncommon cause of bowed legs. A simple screening for patients presenting with bowed legs is suggested and the importance of using age-related standards for comparison of biochemical results is emphasized (AU)

Humanos , Criança , Feminino , Hipofosfatasia/complicações , Raquitismo/etiologia , Osteotomia , Fosfatos/uso terapêutico , Vitamina D/uso terapêutico
Br J Surg ; 64(2): 129-33, Feb. 1977.
Artigo em Inglês | MedCarib | ID: med-12441


Whole body protein turnover was measured in 11 patients before and after elective orthopaedic operations by giving 15N-glycine orally every 4 hours for 32 hours. The patients were maintained throughout on a constant protein intake. In two control subjects a comparison was made between intermittent dosage and continuous infusion of 15N-glycine for the estimation of total turnover. With intermittent dosage the 15N abundance in urinary urea reached a constant level after about 24 hours. Rates of total protein synthesis and breakdown were calculated from the 15N abundance at the plateau level. After surgery there was a moderate increase in urinary N output. The apparent N balance (intake - urinary N) was -0.25 ñ 1.31 g/d (mean ñ s.d.) before operation and =7.51 ñ 4.5g/d/ after operation. The rate of protein synthesis fell from 3.83 ñ 0.73g kg-1d-1 before operation to 2.94 ñ 0.83 g kg-1d-1 after operation. This difference is statistically significant (0.05 > p > 0.01). There was no significant change in the rate of protein breakdown. The possibility remains that a block in protein synthesis, probably mainly in muscle, may be partly responsible for the so-called 'catabolic' loss of nitrogen after injury, but this has not been proved. (AU)

Humanos , Adulto , Pessoa de Meia-Idade , Idoso , Masculino , Feminino , Ortopedia , Proteínas/metabolismo , Artrodese , Fêmur/cirurgia , Articulação do Quadril/cirurgia , Prótese Articular , Músculos/metabolismo , Nitrogênio/metabolismo , Osteotomia , Ureia/urina
J Bone Joint Surg ; 45B(2): 320-5, May 1963.
Artigo em Inglês | MedCarib | ID: med-14478


Twenty-eight cases of the infantile and three cases of the adolescent type of tibia vara occurring in West Indian Negroes are reported. The condition is characterised by failure of growth of the postero-medial part of the upper tibial epiphysis. The deformity produced is acute varus at the upper tibia with medial torsion and eventually flexion of the diaphysis on the epiphysis. These deformities are considered to be due to a vicious circle set up by considerable alteration of the lines of force on the medial portion of the upper tibial epiphysial line (Summary)

Humanos , Lactente , Pré-Escolar , Criança , Masculino , Feminino , Osso e Ossos/anormalidades , Deformidades do Pé/etiologia , Tíbia/diagnóstico por imagem , Osteotomia , Biópsia/instrumentação , Índias Ocidentais , Afro-Americanos , Joelho/diagnóstico por imagem