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West Indian med. j ; 44(1): 20-23, Mar. 1995.
Artigo em Inglês | MedCarib | ID: med-7232


Homozygous sickle-cell (SS) disease is associated with retardation of physical and sexual development but most Jamaican children commence their adolescent growth spurt before 16 years of age. Analysis of growth from children in the Jamaican Cohort Study noted extreme growth retardation , defined as an absence of the adolescent growth spurt and pre-pubertal sexual development (Tanner stage 1 or 2) at age 16 years, in 8/52 (15 percent) SS boys. These and two boys from the general sickle-cell clinic with a similar growth pattern provided a study group of 10 boys who were investigated for a possible endocrine explanation for their extreme retardation of physical maturation. A sub-optimal testosterone response (<10 nmol/l) to human chorionic gonadotrophin and an exaggerated gonadotrophin hormone releasing hormone was consistent with poor testicular function in 5 boys. Retardation of adolescent growth and development is common in boys wit SS disease but, when extreme, requires early investigation to identify potentially correctable mechanisms (AU)

Humanos , Masculino , Adolescente , Testosterona/deficiência , Anemia Falciforme/complicações , Puberdade Tardia/etiologia , Homozigoto , Transtornos do Crescimento/etiologia , Estatura , Maturidade Sexual
Arch Intern Med ; 141(10): 1295-7, Sept. 1981.
Artigo em Inglês | MedCarib | ID: med-12586


Results of a questionnaire study of 91 Jamaican patients with homozygous sickle cell (SS) disease and 59 Jamaican control subjects of similar socioeconomic status indicated a mean delay of 2.3 years in age at menarche and of 3.9 years in age at first pregnancy in SS disease. The mean interval between first sexual exposure and pregnancy was similar in the two groups. The delay in age at first pregnancy in SS disease resulted partly from the delay in puberty, but it also resulted from a further delay in first sexual exposure, with a mean interval between menarche and first sexual exposure of 2.6 and 4.4 years in control subjects and patients, respectively. Physical and social factors that related to this delay were reflected in the higher prevalence of casual unions in patients; this finding implied lesser sexual exposure. Although the similar interval between first sexual exposure and pregnancy did not suggest a lesser fertility in patients with SS disease, the number of infants born to patients with SS disease was less at all ages compared with Jamaican standards. This finding might reflect lesser fertility subsequent to the first pregnancy. (AU)

Humanos , Gravidez , Adolescente , Adulto , Pessoa de Meia-Idade , Idoso , Feminino , Fertilidade , Anemia , Anemia Falciforme/fisiopatologia , Maturidade Sexual , Homozigoto , Idade Materna , Menarca , Fatores Socioeconômicos , Jamaica