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Hypertension ; 15((6 pt 2)): 803-9, June 1990.
Artigo em Inglês | MedCarib | ID: med-8762


We have recently reported that there are significant genetic influences on the population variation in blood pressure in black twins in Los Angeles. The present cross-sectional study was undertaken to replicate these findings in a black twin population that lives in a different biosocial environment. We chose the Caribbean island nation of Barbados, where 96 percent of the population is black, the literacy rate is 99 percent, and the access to health care is guaranteed. The goals were 1) to test the feasibility of twin studies in blood pressure research in a developing country and 2) to estimate the relative contribution of genes and environment to blood pressure variability in blacks in the Caribbean. The names of 200 twin sets were obtained with the assistance of community resources including a twin club, by media advertisement, and by asking people at public blood pressure screenings if they knew any twins. By using these methods, we identified 200 sets of twins. Of these, 37.5 percent (75/200) met our criteria for study. Although 97 percent of the sets of twins (73/75) said they were willing to participate, only 69 percent (52/75) were able to be scheduled during the 1 week of the study when the full team of investigators was in Barbados. Of those scheduled, 83 percent (43/52) were examined. Examination included medical history, physical examination, recumbent blood pressure measurements by two observers, anthropometric measurements, 24-hour urine collections for sodium and potassium tests, and blood tests for zygosity. (ABSTRACT TRUNCATED AT 250 WORDS) (AU)

Humanos , Adulto , Pessoa de Meia-Idade , Masculino , Feminino , Pressão Arterial , Doenças em Gêmeos/etnologia , Barbados , Eletrólitos/urina , Análise Fatorial , Natriurese , Gêmeos Dizigóticos , Gêmeos Monozigóticos
Clin Sci Mol Med ; 53(6): 523-7, 1977.
Artigo em Inglês | MedCarib | ID: med-12299


Patients with sickle-cell anaemia were unable to increase free water reabsorption (TcH2O) in response to intravenous hypertonic sodium chloride solution. Ethacrynic acid caused a brisk natriuresis in patients with sickle-cell anaemia but fractional sodium excretion was lower in these patients. These findings could be explained by abnormal function of the loop of Henle.(AU)

Humanos , Adulto , Anemia Falciforme/metabolismo , Diurese/efeitos dos fármacos , Ácido Etacrínico/farmacologia , Cloreto de Sódio/farmacologia , Natriurese/efeitos dos fármacos , Sódio/urina
Am J Med Sci ; 263(3): 137-41, Mar. 1972.
Artigo em Inglês | MedCarib | ID: med-7190


A patient with diabetes mellitus treated with the sulfonylurea chlorpropamide developed the syndrome of inappropriate secretion of antidiuretic hormone. The mode of clinical presentation was one suggesting a central nervous system disorder. A clinical study of the patient's response to chlorpropamide was carried out. Headache, systolic hypertension, serum hypo-osmality, hyponatremia, urine hyperosmolality, fall in urinary output and continued renal excretion of sodium were demonstrated, confirming the initial diagnosis (AU)

Humanos , Feminino , Clorpropamida/efeitos adversos , Hiponatremia/induzido quimicamente , Vasopressinas/metabolismo , Doenças do Sistema Nervoso Central/induzido quimicamente , Clorpropamida/uso terapêutico , Diabetes Mellitus/tratamento farmacológico , Natriurese , Transtornos Urinários/induzido quimicamente , Concentração Osmolar , Síndrome , Fatores de Tempo