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Diabetes;35(3): 324-7, Mar. 1986.
Preprint em Inglês | MedCarib | ID: med-14078


The effect of morphine (0.1 mg/kg) on insulin secretion stimulated by oral, intraduodenal, or intravenous administration of glucose was studied in seven healthy volunteers. When glucose was given intravenously, morphine had no effect on plasma glucose, insulin, glucose-dependent insulinotropic polypeptide (GIP), or pancreatic glucagon. Following oral glucose, morphine slowed gastric emptying and reduced plasma concentrations of glucose, insulin, and GIP. During intraduodenal infusion of glucose, insulin concentrations of plasma were also decreased by morphine, an effect best explained by decreased small intestinal transit with delayed absorption of glucose and delayed release of GIP. We conclude that clinically relevant doses of morphine have no direct effect on insulin secretion and that the changes observed were secondary to slowed gastric emptying and small intestinal transit (AU)

Humanos , Adolescente , Adulto , Masculino , Feminino , Motilidade Gastrointestinal/efeitos dos fármacos , Insulina/metabolismo , Morfina/farmacologia , Glicemia/análise , Duodeno , Peptídeos Semelhantes ao Glucagon/sangue , Esvaziamento Gástrico/efeitos dos fármacos , Polipeptídeo Inibidor Gástrico/sangue , Glucose/administração & dosagem , Glucose/farmacologia , Infusões Parenterais , Insulina/sangue , Neurotensina/sangue
West Indian med. j ; 19(4): 259, Dec. 1970.
Artigo em Inglês | MedCarib | ID: med-6357


There is little evidence at present on which to base the assumption that gastric emptying is slowed during pregnancy. The present study was designed to obtain further information. The emptying of a 750ml 'meal' of water or saline (100meq/L) was measured in several groups of Jamaican women using a double sampling technique. Since the basic pattern of emptying in both pregnant and non-pregnant subjects was exponential, the rate of emptying could be described in terms of half-life. The mean half-life of both water and saline meals was significantly longer in the pregnant subjects with heartburn than in the non-pregnant and the other pregnant women. In the pregnant without heartburn there was no evidence of impaired gastric emptying of either meal. During labour the pattern of emptying was altered, and an exponential relationship between volume of gastric contents and time was not indicated. A comparison of the volume of gastric contents thirty minutes after imbibtion of either meal indicated a considerable slowing of gastric emptying during labour. The rate of emptying of both meals was virtually the same in labour, whereas in the other groups the saline meal emptied more rapidly than the water meal. In several women tested within 48 hours of delivery there was a returned to rapid exponential emptying. These studies support the suggestion that a slowing of gastric emptying might contribute to the sensation of heartburn in pregnancy, but do not provide any evidence of a generalized impairment of gastric emptying pregnancy. There is clear evidence that gastric emptying is slowed in labour, confirming the impressions based on clinical observations of the vomitus of women in labour. It is further concluded that the "duodenal brake", which can be triggered by the presence of water in the duodenum does not operate during labour due possibly to the high level of inhibition already present (AU)

Humanos , Feminino , Gravidez , Esvaziamento Gástrico , Trabalho de Parto
J Obstet Gynaecol Br Commonw ; 77(1): 37-41, Jan. 1970.
Artigo em Inglês | MedCarib | ID: med-14515


Gastric emptying time was measured in non-pregnant, pregnant and labouring women. The results suggest an explanation for previously conflicting studies and support the suggestion that slowing of gastric emptying contributes to heartburn in pregnancy. However, there was no clear evidence that in pregnant women generally gastric emptying is impared. Gastric emptying times during labour were shown to be prolonged and the pattern of emptying altered (Summary)

Humanos , Feminino , Esvaziamento Gástrico/fisiologia , Trabalho de Parto , Gravidez , Grupos Controle