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Clin Sci ; 92(2): 153-8, Feb. 1997.
Artigo em Inglês | MedCarib | ID: med-2311


Chronic leg ulceration is a major cause of morbidity in patients with homozygous sickle cell disease; the ulcers commonly resolve on bed rest. We have therefore compared the cutaneous vascular response to dependency in three groups of eight patients with sickle cell disease (those with an active ulcer, with an ulcer scar and with no history of ulceration) and in eight subjects with normal haemoglobin and no history of leg ulceration. We monitored with a laser Doppler flowmeter, the change in red cell (erythocyte) flux induced in the skin of the leg, at two sites proximal to the malleoli, with the leg horizontal and 5 and 10 min after moving the leg to the dependent position. With the leg horizontal, mean cutaneous red cell flux was was substantially higher in normal cells of patients with sickle cell disease than in normal subjects and was higher still at the site of the ulcer scar. On dependency, red cell flux fell not only in normal subjects but also in the patients with the sickle cell disease. The fall in red cell flux in normal skin of patients with sickle cell disease was smaller than in normal subjects when considered as a percentage of the control values, but in absolute terms the falls in red cell were similar in sickle cell patients normal subjects. By contrast, the fall in red cell flux at the ulcer/scar site was greater than in normal skin from sickle cell patients. We propose that high resting perfusion is important in patients with sickle cell disease to maintain normal integrity of cutaneous tissue and that pronounced vasoconstriction on dependency hinders the healing and encourages recurrence of the leg ulcers (AU)

Adulto , Masculino , Humanos , Úlcera da Perna/etiologia , Traço Falciforme/complicações , Postura , Vasoconstrição , Doença Crônica , Eritrócitos/fisiologia , Fluxometria por Laser-Doppler , Microcirculação , Perfusão , Úlcera da Perna/sangue , Traço Falciforme/sangue , Pele/irrigação sanguínea , Cicatrização
Clin Radiol ; 29(2): 119-24, Mar. 1978.
Artigo em Inglês | MedCarib | ID: med-12684


The position of the clinical apex beat projected on chest radiographs was compared to different points on the cardiac outline which have been regarded as the radiological apex. Good correlation was found between the clinical apex and the most lateral point of the left cardiac border, but not with the cardiophrenic angle of the lower end of the long diameter of the heart. The mid-clavicular line cannot be used to define the upper limit of the normal sized heart on radiographs as in clinical practice, because in many of the subjects the heart extended outside the mid-clavicular line (AU)

Humanos , Criança , Coração/anatomia & histologia , Coração/diagnóstico por imagem , Postura , Jamaica
Obstet Gynecol ; 34(4): 495-7, Oct. 1969.
Artigo em Inglês | MedCarib | ID: med-14369


A simple method of achieving face-down position for the vaginal repair of certain types of vesicovaginal fistula is described and its advantages mentioned. It is particularly useful for bladder-neck, juxta-urethal and large midvaginal fistulas, since it readily affords adequate exposure. It does require the use of endotracheal intubation by an experienced anesthesiologist (AU)

Humanos , Feminino , Postura , Fístula Vesicovaginal/cirurgia , Intubação Intratraqueal , Métodos