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Humans , Male , Female , Middle Aged , Aged , Aged, 80 and over , Osteomyelitis/diagnosis , Chronic Disease , Skin Ulcer/complications , Chronic Pain/complications , Osteomyelitis/therapy , Inflammation/complications , Skin/injuries , Skin/pathology , Hyperkeratosis, Epidermolytic/complications , Interdisciplinary Research/organization & administration
Objective: High-grade anal intraepithelial neoplasia is considered a precursor of anal cancer. It is necessary to identify risk factors for AIN in women who could benefit from screening. Material and methods: For this retrospective study, we recruited women who underwent anal cytology screening over a 6-year period. We analyzed data on sexual habits, substance use, and the association with sexually transmitted infections, human papillomavirus infection, and HIV infection. We also analyzed HPV-related anogenital neoplasms. The groups were compared according to the cytology results. Results: Dysplasia was detected in 56 of 105 women and was confirmed as high-grade in 33.9%. The variables associated with abnormal anal cytology findings were higher educational level (p=0.031), ≥2 HPV-associated cancers (p=0.031), and a history of genital herpes (p=0.001) were associated with abnormal anal cytology. Neither anal sex nor high-risk anal HPV was associated with anal dysplasia. Abnormal cytology was more common in HIV-positive women. Conclusions: Anal screening is necessary because anal atypia is common in women. Genital herpes was associated with atypia, which could be explained by the synergistic effect of both infections simultaneously. Although high-risk HPV and HIV infection are risk factors for anal dysplasia, prospective studies are needed to design new screening algorithms
Objetivo: las neoplasias intraepiteliales de ano de alto grado son precursores de cáncer de ano .Son necesarios estudios que estimen factores de riesgo de NIA en mujeres que se beneficiarían del cribado. Material y métodos: estudio de cohortes retrospectivas de mujeres a las que se les tomó una citología anal en un periodo de 6 años. Analizamos hábitos sexuales, tóxicos, asociación con ITS, virus de papiloma y VIH, neoplasias en relación con VPH y comparamos las dos poblaciones de acuerdo al resultado de la prueba. Resultados: cincuenta y seis mujeres de 105 presentaron algún grado de atipia. En el 33,9% de ellas fue informada de alto grado. El nivel de estudios superior (p=0,031), dos o más patologías oncogénicas por VPH (p=0,031) y el herpes genital (p=0,001) se relacionaron con la atipia anal. Ni el sexo anal ni el VPH de alto riesgo se relacionaron con la positividad de la prueba. En las mujeres VIH positivas la atipia anal fue más frecuente. Conclusiones: la atipia anal es frecuente en las mujeres por lo que el despistaje citológico estaría justificado. El herpes genital se asoció con la atipia, lo que se explicaría por el efecto sinérgico de los dos virus. Aunque la patología genital por VPH de alto riesgo y el VIH en mujeres son factores de riego de NIA, son necesarios estudios en los que apoyen nuevos protocolos de despistaje
Humans , Female , Adult , Middle Aged , Rectal Neoplasms/diagnosis , Papillomavirus Infections/pathology , Precancerous Conditions/pathology , Early Detection of Cancer/methods , Retrospective Studies , Rectal Neoplasms/pathology , Herpes Genitalis/pathology , HIV Infections/pathology , Sexually Transmitted Diseases/pathology , Risk Factors
BACKGROUND: Painful sunburns at any age are one of the main risk factors for skin cancer. OBJECTIVES: To determine the prevalence and predictors of sunburn among beachgoers. METHODS: A cross-sectional health survey was conducted at the beach during the summer. Adults >18 years with an understanding of Spanish were interviewed using a questionnaire about behaviours, attitudes and knowledge related to sun exposure at the beach. A descriptive analysis was performed, and a log-binomial regression model was used to determine predictors of sunburn. RESULTS: The survey was completed by 1054 beachgoers, with a mean age of 43.8 (SD: 18.7) years, 61.2% women, skin phototypes i (13.6%), ii (22.3%), iii (34.0%) and iv (30.2%). 46.9% of responders reported at least one painful sunburn during the previous summer. Age, sex, education, skin phototype, midday sun exposure, sun protection habits, attitudes towards tanning and knowledge about skin cancer were identified as independent predictors of sunburn. CONCLUSIONS: It is necessary to develop photoprotection campaigns aimed at beachgoers, particularly in young people, men, those with skin phototypes I-III and secondary or university education. Educational strategies should be aimed at discouraging sun exposure at midday, changing attitudes towards tanning and improving knowledge about skin cancer.
Sunbathing , Sunburn/epidemiology , Adult , Female , Humans , Male , Middle Aged , Prevalence , Spain/epidemiology , Sunburn/etiology
Radiotherapy is a widely recognised treatment for non-melanoma skin cancer. We report three cases of radiation-induced skin ulcers in which hyperbaric oxygen therapy was administered in 90-min sessions, 5 days a week at 2.4 absolute atmospheres in a multiplace hyperbaric chamber. Hyperbaric oxygen therapy is an outpatient treatment that does not displace other classical treatments and may be used as an adjunct therapy.
Carcinoma, Squamous Cell/radiotherapy , Hyperbaric Oxygenation , Radiotherapy/adverse effects , Skin Neoplasms/radiotherapy , Skin Ulcer/etiology , Skin Ulcer/therapy , Aged , Female , Humans , Male , Middle Aged
Beach activities and outdoor sports are risk factors for developing skin cancer. Skateboarding is among the most popular sports among adolescents. The aim was to analyse the sun exposure habits and sun protection practices of skaters, in comparison with corresponding sun exposure and protection practices on the beach. This cross-sectional study is based on health surveys carried out into sun exposure and protection practices among young skateboarders. The study population was composed of 102 skaters, of whom 84 (82.4 %) were male. Fifty-eight (56.8 %) of the participants reported having suffered at least one sunburn event the previous summer. Eighty-seven (91.6 %) said they practiced outdoor sports more than 90 days per year, while only six (6.1 %) spent this long at the beach. Forty-nine (52.1 %) practiced outdoor sports for 5 or more hours a day compared to 42 (43.3 %) who spent comparable periods at the beach. A long-sleeved shirt was worn more frequently during sports than at the beach. Keen skaters are a risk group for the development of skin cancer due to excessive sun exposure, high rates of sunburn and scant use of sun protection measures. Specific educational and behavioural interventions should be aimed at this risk group.
Adolescent Behavior/psychology , Skating/physiology , Sunburn/prevention & control , Sunscreening Agents/therapeutic use , Ultraviolet Rays/adverse effects , Adolescent , Cross-Sectional Studies , Female , Health Surveys , Humans , Male , Risk Factors , Skating/trends , Skin Neoplasms/prevention & control , Spain , Time Factors , Water Sports
INTRODUCCIÓN: La neoplasia intraepitelial anal de alto grado (NIAAG) está en aumento en determinados grupos de riesgo y en su etiopatogenia están implicados algunos genotipos del virus del papiloma humano (VPH). El cribado de la NIAAG contempla el uso sistemático de la citología anal y más recientemente el genotipado de VPH. Nuestro objetivo fue determinar la sensibilidad y especificidad de ambas herramientas diagnósticas en la identificación de NIAAG. MATERIAL Y MÉTODO: Estudio de correlación entre los hallazgos citológicos y microbiológicos con respecto a la biopsia anal de una cohorte de pacientes con conductas de riesgo de desarrollar neoplasia intraepitelial anal atendidos en la consulta de infecciones de transmisión sexual del área de Dermatología del Hospital Costa del Sol desde enero de 2008 a diciembre de 2014. RESULTADOS: De los 151 pacientes sometidos al cribado, se seleccionaron aquellos pacientes con las tres pruebas de cribado realizadas (citología anal, genotipado y biopsia guiada por anoscopia), 92 en total, de los que el 62% presentaban infección por VIH. La sensibilidad y especificidad para identificar NIAAG fue 52,8 y 85,7% para la citología anal (k: 0,328), y 78 y 62,8% de la presencia de dos o más genotipos oncogénicos VPH (k: 0,417). La detección de VPH oncogénicos permitió clasificar correctamente 23 casos de NIAAG confirmados por biopsia guiada por anoscopia e infradiagnosticados con la citología anal, 14 de ellos con al menos 3 genotipos de riesgo. CONCLUSIÓN: La citología anal ha mostrado una sensibilidad insuficiente para la detección de NIAAG. El genotipado del VPH, aunque como única herramienta de cribado daría lugar a un sobrediagnóstico, es una herramienta que puede complementar el procedimiento de cribado, especialmente con el objetivo de identificar los casos de NIAAG
INTRODUCTION: The incidence of high-grade anal intraepithelial neoplasia (HGAIN) -with an aetiological based on high-risk types of human papillomavirus- is increasing in some high-risk groups. Screening for HGAIN includes routine anal cytology and, more recently, HPV genotyping. The main objective of this study was to determine the sensitivity and specificity of anal cytology and HPV genotyping for the detection of HGAIN. MATERIALS AND METHODS: This is a study to determine the correlation of cytological and microbiological findings with anal biopsy findings in a cohort of patients at high risk of developing AIN referred to the department of sexually transmitted infections of the Hospital Costa del Sol, Spain, between January 2008 and December 2014. RESULTS: Of the 151 patients subjected to screening, a total of 92 patients, all of them with the result of three screening test (anal cytology, genotyping and biopsy) were included in the study. Just under two-thirds (62%) of them were HIV-positive. The sensitivity and specificity of anal cytology to detect HGAIN were 52.8 and 85.7%, respectively (k: 0.328), and 78 and 62.8% to detect two or more HPV oncogenic genotypes (k: 0.417). The detection of oncogenic HPV genotypes allowed the identification of 23 new cases of HGAIN that had been underdiagnosed with anal cytology, with 14 cases containing at least three high-risk genotypes. CONCLUSION: Anal cytology did not show enough sensitivity in HGAIN screening. HPV genotyping has shown to be a useful tool to detect HGAIN cases, although it could lead to an over-diagnosis as a solitary screening procedure
Humans , Anus Neoplasms/diagnosis , Papillomaviridae/pathogenicity , Genotyping Techniques/methods , Cytological Techniques/methods , Carcinoma in Situ/diagnosis , Sensitivity and Specificity , Biopsy/methods , Risk Factors , Mass Screening/methods
INTRODUCTION: The incidence of high-grade anal intraepithelial neoplasia (HGAIN) -with an aetiological based on high-risk types of human papillomavirus- is increasing in some high-risk groups. Screening for HGAIN includes routine anal cytology and, more recently, HPV genotyping. The main objective of this study was to determine the sensitivity and specificity of anal cytology and HPV genotyping for the detection of HGAIN. MATERIALS AND METHODS: This is a study to determine the correlation of cytological and microbiological findings with anal biopsy findings in a cohort of patients at high risk of developing AIN referred to the department of sexually transmitted infections of the Hospital Costa del Sol, Spain, between January 2008 and December 2014. RESULTS: Of the 151 patients subjected to screening, a total of 92 patients, all of them with the result of three screening test (anal cytology, genotyping and biopsy) were included in the study. Just under two-thirds (62%) of them were HIV-positive. The sensitivity and specificity of anal cytology to detect HGAIN were 52.8 and 85.7%, respectively (k: 0.328), and 78 and 62.8% to detect two or more HPV oncogenic genotypes (k: 0.417). The detection of oncogenic HPV genotypes allowed the identification of 23 new cases of HGAIN that had been underdiagnosed with anal cytology, with 14 cases containing at least three high-risk genotypes. CONCLUSION: Anal cytology did not show enough sensitivity in HGAIN screening. HPV genotyping has shown to be a useful tool to detect HGAIN cases, although it could lead to an over-diagnosis as a solitary screening procedure.
Anus Neoplasms/diagnosis , Anus Neoplasms/virology , Carcinoma in Situ/diagnosis , Carcinoma in Situ/virology , Papillomaviridae/genetics , Papillomavirus Infections/diagnosis , Adult , Anus Neoplasms/pathology , Carcinoma in Situ/pathology , Cross-Sectional Studies , Female , Genotype , Genotyping Techniques , Humans , Male , Sensitivity and Specificity , Spain
Health professionals are key agents in healthcare promotion. In the field of skin cancer, they play a crucial role in the development of prevention strategies in the community. This paper aims to describe the sun exposure attitudes and habits of public healthcare professionals in the western Costa del Sol (Spain). A cross-sectional descriptive study was conducted in the Costa del Sol healthcare district to analyse sun exposure and protection practices and habits, and attitudes to tanning and sun protection. The respondents, all healthcare personnel in various professional categories and workplace situations, were asked to complete a self-administered questionnaire. Six hundred forty-three workers in the Costa del Sol healthcare district took part in the study. Of these participants, 450 were healthcare professionals. Of the 450 health professionals, 226 (50.2 %) were nurses or auxiliary nursing staff, and the remaining 224 were doctors. These two groups presented differences regarding habits of sun exposure: 15.3 % of the doctors went to the beach at least 30 days a year, compared to 30.9 % of the nurses (p < 0.001). With respect to workplace situation, there were differences (p < 0.001) between the sunburn events reported by healthcare staff who worked in hospitals (52.4 %) compared to those working in primary healthcare (30.4 %); comparable differences were found with respect to attitudes toward the use of sunscreen creams (p = 0.014). This study identifies two distinct subgroups within healthcare personnel: on one hand, primary healthcare professionals, who are key agents for future policy strategies, and on the other, specialist healthcare professionals, who are more likely to suffer sunburn events and therefore toward whom strategies should be addressed to encourage them to change their sun exposure attitudes and habits and sun protection practices.
Habits , Health Behavior , Health Knowledge, Attitudes, Practice , Health Personnel/psychology , Skin Neoplasms/psychology , Sunburn/psychology , Sunlight/adverse effects , Adult , Cross-Sectional Studies , Female , Humans , Male , Skin Neoplasms/etiology , Skin Neoplasms/prevention & control , Sunburn/etiology , Sunburn/prevention & control , Sunscreening Agents/therapeutic use
Reconstructive surgery in nasal pyramid can be a challenge for surgeons. Moreover this anatomic area is one the most common sites for non-melanoma skin cancer. The "puzzle" flap was described to repair surgical defects located just on the nasal ala affecting melolabial sulcus. We have seen this flap can be also very useful to repair defects located on nasal sidewall and cheek without dysfunctional effects and with a good cosmetic result.
Nose/surgery , Plastic Surgery Procedures/methods , Surgical Flaps , Cheek/surgery , Esthetics , Humans , Nose Neoplasms/surgery
Neonatal lupus erythematosus (NLE) is an autoimmune disease caused by transplacental antibodies that can damage fetal tissue and cause various findings. With the exception of congenital heart block, which can be easily recognized at birth because of neonatal cardiac monitoring during the delivery and immediately after birth, most cases of NLE are recognized within days to weeks of life, but fewer than 10 cases with findings present at birth have been reported. We report the case of a newborn with extensive cutaneous eruption at the time of birth and multisystemic involvement, including hematologic, respiratory, hepatic, and neurologic involvement.
Lupus Erythematosus, Systemic/congenital , Abnormalities, Multiple , Biopsy , Diagnosis, Differential , Humans , Infant, Newborn , Lupus Erythematosus, Systemic/diagnosis , Male
INTRODUCCIÓN: La incidencia de la neoplasia intraepitelial anal está en aumento en determinados grupos con conductas de riesgo, y en su etiopatogenia está implicada la infección por el virus del papiloma humano (VPH). Dentro de los programas de cribado implementados en las últimas décadas se encuentra el uso sistemático de la citología anal y, más recientemente, la detección del VPH mediante captura de híbridos y genotipado. MATERIAL Y MÉTODO: Estudio de cohortes retrospectivo de la población con conductas de riesgo de desarrollar neoplasia intraepitelial anal atendida en la consulta de Infecciones de Transmisión Sexual del área de Dermatología del Hospital Costa del Sol desde enero de 2010 a diciembre de 2012, a la que se le realizó cribado de neoplasia intraepitelial anal mediante toma de citología anal y genotipado de VPH. RESULTADOS: El 50% de la población estudiada tenía infección por VIH. Se encontró una alta frecuencia de displasia anal y presencia de VPH en la citología (82,1%) y genotipado (79%). Se obtuvo una asociación estadísticamente significativa (p < 0,005) entre la presencia de genotipos de VPH de alto riesgo y la presencia de displasia de alto grado en la segunda citología dirigida. El genotipado de VPH permitió identificar 17 casos (22%) de displasia severa infradiagnosticados en la primera citología. CONCLUSIÓN: La citología anal a ciegas puede infradiagnosticar casos de displasia de alto grado. La detección de VPH puede complementar este procedimiento, permitiéndonos identificar aquellos pacientes con mayor riesgo de desarrollar displasia anal de alto grado
INTRODUCTION: The incidence of intraepithelial anal neoplasia is increasing in certain risk behaviour groups, and human papillomavirus (HPV) infection is involved in its pathogenesis. The systematic use of anal cytology, and more recently HPV detection by hybrid capture and genotyping, have been introduced into screening programs in recent decades. MATERIAL AND METHODS: A retrospective cohort study was carried out on individuals with risk behaviours of developing intraepithelial anal neoplasia and who attended Sexually Transmitted Infections clinics in the Dermatology area of the Hospital Costa del Sol from January 2010 to December 2012. The intraepithelial anal neoplasia screening was performed using anal cytology and HPV genotyping. RESULTS: Half (50%) of the study population were HIV positive. A high frequency of anal dysplasia and presence of HPV in cytology (82.1%) and genotype (79%) was found. A statistically significant association (P < .005) was obtained between the presence of high-risk HPV genotypes and the presence of high-grade dysplasia in the second directed cytology. HPV genotyping enabled 17 cases (22%) of severe dysplasia to be identified that were under-diagnosed in the first cytology. CONCLUSION: Cases of high-grade dysplasia can be under-diagnosed by a first anal cytology. Detection of HPV can supplement this procedure, leading to the identification of those patients most at risk of developing high-grade anal dysplasia
Humans , Papillomavirus Infections/diagnosis , Early Detection of Cancer/methods , Anus Neoplasms/epidemiology , Papillomaviridae/isolation & purification , Risk-Taking , Mass Screening , Neoplasms, Glandular and Epithelial/epidemiology , HIV Infections/complications , False Negative Reactions , Retrospective Studies
Periungual warts represent a treatment challenge because of its high recurrence rate and recalcitrance. These are benign lesions produced by the human papilloma virus (HPV) that often do not respond to habitual treatment. Cidofovir is a potent antiviral drug that acts inactivating viral DNA polymerase. Topical cidofovir for the treatment of HPV-related cutaneous and mucous lesions is becoming increasingly common. Our aim was to assess the efficacy and safety of cidofovir cream for the treatment of viral periungual warts. We undertook a retrospective observational study of patients with periungual warts who received treatment with topical cidofovir between January 2010 and December 2013 at the Dermatology Service of the Hospital Costa del Sol, Marbella, Spain. Data were recorded about the rate of treatment response, the adverse effects and recurrences, as well as the characteristics of the patient cohort. We identified 41 patients who had received some previous treatment. The concentration of cidofovir was 3% in all cases, usually applied twice a day (in 37 of the 41 cases). A greater or lesser response was noted in 35 cases. There were six recurrences in the follow-up period. Topical cidofovir seems to be a useful alternative for the therapeutic management of recalcitrant periungual common warts that fail to respond to usual treatment. Our experience with the use of this antiviral agent has been satisfactory, although in our opinion, it should be reserved for specific cases as its economical cost represents an important limitation.
Antiviral Agents/administration & dosage , Cytosine/analogs & derivatives , Nail Diseases/drug therapy , Organophosphonates/administration & dosage , Papillomavirus Infections/drug therapy , Warts/drug therapy , Administration, Topical , Adolescent , Adult , Antiviral Agents/adverse effects , Child , Child, Preschool , Cidofovir , Cytosine/administration & dosage , Cytosine/adverse effects , Female , Humans , Male , Middle Aged , Nail Diseases/diagnosis , Nail Diseases/virology , Organophosphonates/adverse effects , Papillomavirus Infections/diagnosis , Papillomavirus Infections/virology , Recurrence , Remission Induction , Retrospective Studies , Spain , Time Factors , Treatment Outcome , Warts/diagnosis , Warts/virology , Young Adult
INTRODUCTION: The incidence of intraepithelial anal neoplasia is increasing in certain risk behaviour groups, and human papillomavirus (HPV) infection is involved in its pathogenesis. The systematic use of anal cytology, and more recently HPV detection by hybrid capture and genotyping, have been introduced into screening programs in recent decades. MATERIAL AND METHODS: A retrospective cohort study was carried out on individuals with risk behaviours of developing intraepithelial anal neoplasia and who attended Sexually Transmitted Infections clinics in the Dermatology area of the Hospital Costa del Sol from January 2010 to December 2012. The intraepithelial anal neoplasia screening was performed using anal cytology and HPV genotyping. RESULTS: Half (50%) of the study population were HIV positive. A high frequency of anal dysplasia and presence of HPV in cytology (82.1%) and genotype (79%) was found. A statistically significant association (P<.005) was obtained between the presence of high-risk HPV genotypes and the presence of high-grade dysplasia in the second directed cytology. HPV genotyping enabled 17 cases (22%) of severe dysplasia to be identified that were under-diagnosed in the first cytology. CONCLUSION: Cases of high-grade dysplasia can be under-diagnosed by a first anal cytology. Detection of HPV can supplement this procedure, leading to the identification of those patients most at risk of developing high-grade anal dysplasia.
Anus Neoplasms/virology , Carcinoma in Situ/virology , Early Detection of Cancer/methods , Papillomavirus Infections/diagnosis , Tumor Virus Infections/diagnosis , Adult , Anus Neoplasms/epidemiology , Anus Neoplasms/pathology , Anus Neoplasms/prevention & control , Carcinoma in Situ/epidemiology , Carcinoma in Situ/pathology , Carcinoma, Squamous Cell/prevention & control , Female , Genotype , Humans , Male , Papillomaviridae/genetics , Papillomaviridae/isolation & purification , Papillomaviridae/pathogenicity , Papillomavirus Infections/epidemiology , Retrospective Studies , Risk , Risk-Taking , Sexual Behavior , Sexually Transmitted Diseases/epidemiology , Single-Blind Method , Spain/epidemiology , Tumor Virus Infections/epidemiology
En la edad pediátrica existen determinados trastornos cutáneos que pueden afectar a la calidad de vida de los niños y, en especial, de los adolescentes, e incluso representar un obstáculo para su desarrollo psicosocial, como son el vitíligo, el acné, las malformaciones vasculares o las cicatrices posquirúrgicas.Se revisó a un total de 4 pacientes con vitíligo con afectación facial que participaron en el taller de camuflaje de nuestro servicio desde enero hasta diciembre de 2012 con evaluación del impacto de su trastorno cutáneo en la calidad de vida antes y después de la sesión de maquillaje terapéutico.El maquillaje corrector se trata de una técnica complementaria, fácilmente reproducible, económica y no invasiva que puede ser de gran utilidad en el manejo de enfermedades dermatológicas con repercusión en la esfera física y emocional de pacientes en la edad pediátrica
There are certain skin disorders such as vitiligo, acne, vascular malformations and postoperative scars that can affect the quality of life of children and especially adolescents. It can become an obstacle to their psychosocial development. A review was conducted on 4 patients with vitiligo located on face, who took part in a camouflage treatment course from January to December 2012. The impact of the skin disorder on quality of life was assessed before and after the therapeutic make-up sessions. Corrective makeup can be a complementary, reproducible, cost-effective, non-invasive, and useful technique in the management of dermatological diseases that have a physical and emotional impact in childhood
Humans , Male , Female , Child , Adolescent , Vitiligo/psychology , Products for Facial Makeup , Acne Vulgaris/psychology , Cicatrix/psychology , Vascular Malformations/psychology , Quality of Life
There are certain skin disorders such as vitiligo, acne, vascular malformations and postoperative scars that can affect the quality of life of children and especially adolescents. It can become an obstacle to their psychosocial development. A review was conducted on 4 patients with vitiligo located on face, who took part in a camouflage treatment course from January to December 2012. The impact of the skin disorder on quality of life was assessed before and after the therapeutic make-up sessions. Corrective makeup can be a complementary, reproducible, cost-effective, non-invasive, and useful technique in the management of dermatological diseases that have a physical and emotional impact in childhood.
Cosmetics , Vitiligo/nursing , Adolescent , Child , Female , Humans , Male , Quality of Life
Introducción: La neoplasia intraepitelial anal se considera una lesión precursora del carcinoma escamoso anal. La población de mayor riesgo de padecer esta lesión son pacientes inmunodeprimidos, especialmente los infectados por el virus de la inmunodeficiencia humana (VIH), con prácticas de sexo anal. El objetivo de este estudio fue describir los hábitos sexuales de los pacientes atendidos en la consulta de infecciones de transmisión sexual (ITS) en nuestro servicio, a los que se les realizó una citología anal, así como la presencia de otras ITS. Material y métodos: Se realizó un estudio descriptivo de aquellos pacientes a los que, de acuerdo con nuestro protocolo, se les realizó una citología anal entre 2008 y 2011. Asimismo, se realizó una encuesta sobre hábitos sexuales y cribado de otras ITS. Finalmente, se llevó a cabo un estudio descriptivo y analítico bivariado valorando la distribución de la alteración citológica y el grado de displasia anal. Resultados: Se incluyeron un total de 347 citologías anales, con un 48,1% de citologías alteradas. Se encontraron diferencias estadísticamente significativas entre la presencia de condilomas perianales/endoanales, la infección por VIH, la infección por Chlamydia trachomatis y la presencia de alteración citológica. Conclusión: La displasia anal tiene una alta prevalencia en nuestro medio en determinados grupos con hábitos sexuales de riesgo, pero probablemente esté infradiagnosticada por su carácter subclínico y la falta de un protocolo de cribado bien establecido (AU)
Background: Anal intraepithelial neoplasia is considered a precursor lesion of anal squamous carcinoma. The population with increased risk of this conditions are immunocompromised individuals, especially HIV-infected, with anal sex practices. The aim of this study was to describe the sexual habits of patients who were seen in sexually transmitted infections (STIs) consult in our service in whom anal cytology was performed as well as the association of anal dysplasia to other STIs. Material and methods: We performed a retrospective cohort study that included those patients in whom, according to our protocol, anal cytology was performed between 2008 and 2011. Also we conducted a survey on sexual habits and screening for other STIs. Finally, we conducted a descriptive and analytical study assessing bivariate distribution of cytological alterations and grade of anal dysplasia. Results: A total of 347 anal cytologies were performed, and 48.1% were abnormal. Statistically significant differences were found between the presence of condylomata perianal/endoanal, HIV infection, Chlamydia trachomatis infection and the presence of cytologic alterations. Conclusion: There was a high incidence of anal dysplasia in our group of individuals with risky sexual habits; however, it is probably underdiagnosed due to its subclinical nature and lack of a well-established screening protocol (AU)
Humans , Mass Screening/methods , Anus Neoplasms/epidemiology , Early Detection of Cancer/methods , Risk Factors , Health Vulnerability , Carcinoma in Situ/epidemiology , Sexual Behavior , Sexually Transmitted Diseases/epidemiology , Immunocompromised Host , HIV Infections/epidemiology
Plantar warts are a common reason for dermatological consultations and their treatment can occasionally be a challenge. Plantar warts are benign lesions produced by the human papillomavirus (HPV) that often fail to respond to habitual treatment. Cidofovir is a potent antiviral drug that acts competitively, inhibiting viral DNA polymerase. Our aim was to assess the efficacy and safety of cidofovir cream for the treatment of viral plantar warts. We undertook a retrospective observational study of patients with plantar warts who received treatment with topical cidofovir between July 2008 and July 2011 at the Dermatology Service of the Hospital Costa del Sol, Marbella, Spain. Data about the rate of treatment response, the adverse effects, and recurrences, as well as the characteristics of the patient cohort, were recorded. We identified 35 patients who had received some previous treatment. The usual concentration was 3% (in 33 of 35 cases), applied twice a day (in 31 of 35 cases). A greater or lesser response was noted in 28 cases. There were two recurrences. Topical cidofovir seems to be a useful alternative for the therapeutic management of recalcitrant plantar common warts that fail to respond to usual treatment.
Antiviral Agents/administration & dosage , Cytosine/analogs & derivatives , Foot Dermatoses/drug therapy , Organophosphonates/administration & dosage , Warts/drug therapy , Administration, Cutaneous , Adolescent , Adult , Antiviral Agents/adverse effects , Child , Cidofovir , Cytosine/administration & dosage , Cytosine/adverse effects , Drug Administration Schedule , Female , Foot Dermatoses/diagnosis , Foot Dermatoses/virology , Humans , Male , Middle Aged , Organophosphonates/adverse effects , Recurrence , Retrospective Studies , Spain , Time Factors , Treatment Outcome , Warts/diagnosis , Warts/virology , Young Adult
BACKGROUND: Anal intraepithelial neoplasia is considered a precursor lesion of anal squamous carcinoma. The population with increased risk of this conditions are immunocompromised individuals, especially HIV-infected, with anal sex practices. The aim of this study was to describe the sexual habits of patients who were seen in sexually transmitted infections (STIs) consult in our service in whom anal cytology was performed as well as the association of anal dysplasia to other STIs. MATERIAL AND METHODS: We performed a retrospective cohort study that included those patients in whom, according to our protocol, anal cytology was performed between 2008 and 2011. Also we conducted a survey on sexual habits and screening for other STIs. Finally, we conducted a descriptive and analytical study assessing bivariate distribution of cytological alterations and grade of anal dysplasia. RESULTS: A total of 347 anal cytologies were performed, and 48.1% were abnormal. Statistically significant differences were found between the presence of condylomata perianal/endoanal, HIV infection, Chlamydia trachomatis infection and the presence of cytologic alterations. CONCLUSION: There was a high incidence of anal dysplasia in our group of individuals with risky sexual habits; however, it is probably underdiagnosed due to its subclinical nature and lack of a well-established screening protocol.
Anus Neoplasms/diagnosis , Carcinoma in Situ/diagnosis , Carcinoma, Squamous Cell/diagnosis , Early Detection of Cancer , Anus Neoplasms/epidemiology , Anus Neoplasms/pathology , Carcinoma in Situ/epidemiology , Carcinoma in Situ/pathology , Carcinoma, Squamous Cell/epidemiology , Carcinoma, Squamous Cell/pathology , Condoms/statistics & numerical data , Female , HIV Infections/epidemiology , Humans , Male , Retrospective Studies , Risk Factors , Risk-Taking , Sexual Behavior , Sexual Partners , Sexually Transmitted Diseases/epidemiology , Unsafe Sex , Uterine Cervical Dysplasia/epidemiology
