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Int Braz J Urol ; 482022 Apr 10.
Article En | MEDLINE | ID: mdl-35373955

Breast cancer (BC) is mainly considered a disease in women, but male BC (MaBC) accounts for approximately 1.0% of BC diagnoses and 0.5% of malignant neoplasms in the western population. The stigmatization of MaBC, the fact that men are less likely to undergo regular health screenings, and the limited knowledge of health professionals about MaBC contribute to men being diagnosed at more advanced stages. The aim of this article is to increase the visibility of MaBC among urologists, who have more contact with male patients. This review highlights key points about the disease, the risk factors associated with MaBC, and the options for treatment. Obesity and increased population longevity are among the important risk factors for MaBC, but published studies have identified family history as extremely relevant in these patients and associated with a high penetrance at any age. There is currently no screening for MaBC in the general population, but the possibility of screening in men at high risk for developing BC can be considered. The treatment of MaBC is multidisciplinary, and, because of its rarity, there are no robust clinical studies evaluating the role of systemic therapies in the management of both localized and metastatic disease. Therefore, in current clinical practice, treatment strategies for men with breast cancer are extrapolated from information arising from studies in female patients.

Genet Mol Biol ; 45(1): e20210172, 2022.
Article En | MEDLINE | ID: mdl-35112701

Admixed populations have not been examined in detail in cancer genetic studies. Here, we inferred the local ancestry of cancer-associated single nucleotide polymorphisms (SNPs) and haplotypes of a highly admixed Brazilian population. SNP array was used to genotype 73 unrelated individuals aged 80-102 years. Local ancestry inference was performed by merging genotyped regions with phase three data from the 1000 Genomes Project Consortium using RFmix. The average ancestry tract length was 9.12-81.71 megabases. Strong linkage disequilibrium was detected in 48 haplotypes containing 35 SNPs in 10 cancer driver genes. All together, 19 risk and eight protective alleles were identified in 23 out of 48 haplotypes. Homozygous individuals were mainly of European ancestry, whereas heterozygotes had at least one Native American and one African ancestry tract. Native-American ancestry for homozygous individuals with risk alleles for HNF1B, CDH1, and BRCA1 was inferred for the first time. Results indicated that analysis of SNP polymorphism in the present admixed population has a high potential to identify new ancestry-associated alleles and haplotypes that modify cancer susceptibility differentially in distinct human populations. Future case-control studies with populations with a complex history of admixture could help elucidate ancestry-associated biological differences in cancer incidence and therapeutic outcomes.

BMC Public Health ; 22(1): 255, 2022 02 08.
Article En | MEDLINE | ID: mdl-35135522

BACKGROUND: Since the 1980s, when dengue was reintroduced in Brazil, outbreaks and epidemics caused by different arbovirus strains transmitted by vector mosquitoes such as Aedes aegypti have been an annual occurrence. The aim of this study was to evaluate the behavioural change of high school students and teachers who participated in an educational intervention for the prevention and vector control of arboviral diseases. METHODS: In this school-based intervention, a self-reported questionnaire was used in a pre-post intervention methodology to assess environmental risk factors, sociodemographic variables and to measure attitudes and behaviours. In all, 883 high school students and teachers from the city of Campina Grande, in the state of Paraíba, northeastern Brazil, participated. The e-health intervention consisted of a competition between schools to comply with preventive actions via content production for social networks, and the monitoring was performed over a period of three months through the ZikaMob software developed by the researchers. RESULTS: Out of the 883 survey participants, 690 were students ranging in age from 14 to 41 years, with an average of 17 ± 2 years; and 193 were teachers from 22 to 64 years old, averaging 38 ± 9 years. The analysis of the data shows that significant differences in most of the target behaviours were apparent after the intervention, with an increase of about 10% in the performance of inspection actions; a 7% greater separation of recyclables and a 40% increase in the screening of windows among students. Students showed lower fear of, and a lower self-perception of the risk of, acquiring arboviruses than teachers on average. CONCLUSIONS: ZikaMob is an innovative strategy with the potential to be replicated in any location that has an internet network and can involve an unlimited number of participants.

Aedes , Arbovirus Infections , Arboviruses , Dengue , Adolescent , Adult , Animals , Arbovirus Infections/epidemiology , Arbovirus Infections/prevention & control , Brazil/epidemiology , Dengue/epidemiology , Dengue/prevention & control , Humans , Middle Aged , Mosquito Vectors , Young Adult
BMC Geriatr ; 22(1): 110, 2022 02 09.
Article En | MEDLINE | ID: mdl-35139805

BACKGROUND: Among the oldest old, aged 80 years and over, the prevalence of disability is higher than in other age groups and can be considered a predictor of mortality. OBJECTIVE: To evaluate how psychosocial aspects and support networks influence the disability of these oldest-old individuals, performing a comparison between two longevous populations, one living in one of the poorest regions of Brazil, in the backlands of Paraíba, and another living in one of the largest urban centres in Latin America. METHOD: A cross-sectional study in which 417 oldest-old persons aged 80 years and older were interviewed, with data collected through the "Health, Welfare and Ageing" survey conducted in two Brazilian cities. Disability was assessed by reporting the need for assistance in Activities of Daily Living (ADLs) and Instrumental Activities of Daily Living (IADLs). Bivariate and multiple analyses were performed using R statistical software. RESULTS: Food insufficiency in the first years of life had negative repercussions on the disability of oldest old people living in the northeast. On the other hand, in this region, older people have a higher rate of support and live longer with their peers, which may contribute to reducing feelings of loneliness, depressive symptoms, and worse self-perception of health. In the Southeast, financial constraints, subjective poverty, and unmet needs may favour the development of functional limitations between long-lived people. CONCLUSION: Our findings indicate that regional differences in Brazil may influence the disability of older people aged 80 and older. In northeast Brazil, having no partner may contribute to disability for ADLs and IADLs; while, in the longevous population of São Paulo, having a worse self-rated health may contribute to disability for IADLs.

Activities of Daily Living , Disabled Persons , Aged , Aged, 80 and over , Aging , Brazil/epidemiology , Cross-Sectional Studies , Humans
Inquiry ; 59: 469580221086922, 2022.
Article En | MEDLINE | ID: mdl-35341376

PURPOSE: The aim of this research was to investigate the extent to which socioeconomic and regional differences in Brazil may influence the quality of life. To this end, we examined factors associated with health-related quality of life in two populations of oldest-old people, aged 80 and over: one from the Northeast of Brazil and the other from the Southeast. METHODS: 417 participants aged 80 and over were interviewed face-to-face, 179 from Brejo dos Santos, one of the poorest regions in the Northeast; and 238 from São Paulo, one of the largest urban metropolises in Southeast Brazil. Data, which included socioeconomic and demographic factors, health status, and health-related quality of life, were collected using a structured questionnaire. The dependent variable was determined by the completion rate of the 12-item Short Form Survey and analyzed using multiple logistic regression. RESULTS: Although the population of São Paulo had four times as many long-lived women than men, had better literacy levels, used more medications, and presented a greater prevalence of symptoms suggestive of depression in comparison to the Northeast's population, no difference was observed in the proportion of good physical components among the two populations, 54.3% in Brejo dos Santos' oldest-old and 50.4% in São Paulo's (P = .6272). Quality and quantity of sleep were factors that most affected the health-related quality of life among the oldest-old of Northeast. CONCLUSION: Factors associated with health-related quality of life were different among the oldest-old people of the two locations, thereby corroborating the heterogeneous nature of the longevous population.

Quality of Life , Sleep , Aged, 80 and over , Brazil/epidemiology , Cross-Sectional Studies , Female , Humans , Male , Surveys and Questionnaires
J Infect Dev Ctries ; 15(11): 1744-1749, 2021 11 30.
Article En | MEDLINE | ID: mdl-34898505

INTRODUCTION: Central line-associated bloodstream infections are the second most frequent infection in intensive care units. It represents an adverse event of significant magnitude, thus threatening the patient safety. The aim of this study was to analyze the historical trend of central line-associated bloodstream infections in patients in intensive care units, the rate of infection, central venous catheter utilization ratio, type of pathogen and their antimicrobial resistance pattern. METHODOLOGY: This ecological study was performed at 42 intensive care units from a state capital of the Midwest region of Brazil. Central line-associated bloodstream infections notifications were collected from two databases, the Municipal Coordination for Patient Safety and Infection Control at Healthcare Services, from 2012-2016, and the FormSUS (National Health System Data Processing Company), from 2014-2016. RESULTS: The incidence of central line-associated bloodstream infections was high and stationary in the period (incidence rate of 2.3 to 3.2 per 1,000 catheter days, central venous catheter utilization ratio average 56,9%). The most frequent microorganisms were coagulase-negative Staphylococcus, Klebsiella pneumoniae, Acinetobacter spp. and Pseudomonas aeruginosa. Resistance to 3rd and 4th generation cephalosporins and carbapenems were detected among Gram-negative bacteria, and resistance to oxacillin among Gram-positive bacteria. CONCLUSIONS: Central line-associated bloodstream infections incidence rates were high, however the historical trend remained stationary in adult intensive care units. Infections were mostly caused by coagulase-negative Staphylococcus, K. pneumoniae, Acinetobacter spp. and Pseudomonas aeruginosa, including multi-drug resistant organisms. These findings point to the need of educational strategies addressing the adherence to established preventive measures and to the rational use of antimicrobials.

Catheter-Related Infections/epidemiology , Intensive Care Units/statistics & numerical data , Adult , Bacteremia/microbiology , Brazil/epidemiology , Catheter-Related Infections/microbiology , Central Venous Catheters/adverse effects , Central Venous Catheters/statistics & numerical data , Cross Infection/microbiology , Drug Resistance, Microbial , Humans , Incidence
SMAD, Rev. eletrônica saúde mental alcool drog ; 17(4): 54-62, out.-dez. 2021. ilus
Article Pt | LILACS, INDEXPSI | ID: biblio-1347841

OBJETIVO: descrever o padrão de consumo de substâncias psicoativas entre pessoas idosas sob a ótica da complexidade. Método: qualitativo do tipo estudo de caso múltiplo, realizado com onze pessoas idosas no domicílio/serviço de saúde; os dados foram coletados através de documentos, observação assistemática e entrevista semiestruturada; foram analisados de forma geral, analítica e teórica por meio da comparação dos casos; teve como eixo teórico a complexidade, sendo aprovado pelo comitê de ética em pesquisa. RESULTADOS: quanto ao padrão de consumo de substâncias psicoativas foram achados dois temas: encontro com a substância, que identificou pessoas idosas utilizando substâncias lícitas e ilícitas, e formas de consumo; consequências e motivações do consumo e/ou abandono das drogas. São consequências as perdas materiais/econômicas e criminalidade e motivações a socialização e fuga do estresse/ansiedade. Os idosos que pararam ou diminuíram o consumo aderiram à estratégia de redução de danos. CONCLUSÃO: evidenciou-se o consumo de substâncias psicoativas por pessoas idosas, verificando-se espaço para o sucesso de intervenções de saúde/enfermagem com a criação de ações/programas de abordagem específica para redução de danos.

OBJECTIVE: to describe the pattern of consumption of psychoactive substances among older adults from the perspective of complexity. METHOD: a qualitative survey of the multiple-case study type, carried out with eleven older adults at their homes and/or at a health service; data was collected through documents, unsystematic observation and semi-structured interview; they were analyzed in a general, analytical and theoretical way by comparing the cases; its theoretical axis was complexity, being approved by the research ethics committee. RESULTS: regarding the pattern of consumption of psychoactive substances, two themes were found: encounter with the substance, which identified older adults using legal and illegal substances, and forms of consumption; consequences and motivations of drug use and/or abandonment. Consequences are material/economic losses and crime, and motivations for socialization and escape from stress/anxiety. The older adults who stopped or reduced their consumption adhered to the harm reduction strategy. CONCLUSION: the consumption of psychoactive substances by older adults was evidenced, with space for the success of health/nursing interventions, with the creation of actions/programs with a specific approach to harm reduction.

OBJETIVO: describir el patrón de consumo de sustancias psicoactivas en personas mayores desde la perspectiva de la complejidad. MÉTODO: estudio cualitativo, de tipo caso múltiple, realizado con once ancianos en el domicilio/servicio de salud; los datos se recopilaron a través de documentos, observación no sistemática y entrevista semiestructurada; se analizaron de forma general, analítica y teórica comparando los casos; su eje teórico fue la complejidad, siendo aprobado por el comité de ética en investigación. RESULTADOS: en cuanto al patrón de consumo de sustancias psicoactivas, se encontraron dos temas: contacto con la sustancia, que identificó a personas mayores que consumen sustancias legales e ilegales, y formas de consumo; consecuencias y motivaciones del consumo y/o abandono de las drogas. Las consecuencias son pérdidas materiales/económicas y delitos, y motivaciones para socializar y escapar del estrés/ansiedad. Las personas mayores que suspendieron o disminuyeron su consumo se adhirieron a la estrategia de reducción de daños. CONCLUSIÓN: se evidenció el consumo de sustancias psicoactivas por los adultos mayores, con espacio para el éxito de las intervenciones de salud/enfermería, con la creación de acciones/programas con un enfoque específico de reducción de daños.

Humans , Aged , Psychotropic Drugs , Health of the Elderly , Substance-Related Disorders , Dissociative Disorders
Front Cell Infect Microbiol ; 11: 701930, 2021.
Article En | MEDLINE | ID: mdl-34336723

We performed a detailed analysis of immunophenotypic features of circulating leukocytes and spleen cells from cynomolgus macaques that had been naturally infected with Trypanosoma cruzi, identifying their unique and shared characteristics in relation to cardiac histopathological lesion status. T. cruzi-infected macaques were categorized into three groups: asymptomatic [CCC(-)], with mild chronic chagasic cardiopathy [CCC(+)], or with moderate chronic chagasic cardiopathy [CCC(++)]. Our findings demonstrated significant differences in innate and adaptive immunity cells of the peripheral blood and spleen compartments, by comparison with non-infected controls. CCC(+) and CCC(++) hosts exhibited decreased frequencies of monocytes, NK and NKT-cell subsets in both compartments, and increased frequencies of activated CD8+ T-cells and GranA+/GranB+ cells. While a balanced cytokine profile (TNF/IL-10) was observed in peripheral blood of CCC(-) macaques, a predominant pro-inflammatory profile (increased levels of TNF and IFN/IL-10) was observed in both CCC(+) and CCC(++) subgroups. Our data demonstrated that cardiac histopathological features of T. cruzi-infected cynomolgus macaques are associated with perturbations of the immune system similarly to those observed in chagasic humans. These results provide further support for the validity of the cynomolgus macaque model for pre-clinical research on Chagas disease, and provide insights pertaining to the underlying immunological mechanisms involved in the progression of cardiac Chagas disease.

Chagas Disease , Trypanosoma cruzi , Animals , CD8-Positive T-Lymphocytes , Humans , Macaca fascicularis , Spleen
Rev Bras Enferm ; 74(6): e20200867, 2021.
Article En, Pt | MEDLINE | ID: mdl-34431934

OBJECTIVES: to identify the risk and degree of risk of suicide in nursing students of a public institution in the countryside of Pernambuco, Brazil. METHODS: this was a cross-sectional, quantitative research conducted with 150 students. For data collection, a sociodemographic questionnaire and the instrument, M.I.N.I. - Brazilian version 5.0.0 - Module C - Risk of suicide were used. Statistical analyses were performed with IBM(® )SPSS(®), version 23. RESULTS: 53.3% of nursing students had a risk of suicide, of which 20.7% had a high risk. Moreover, 22.67% reported previous suicide attempt. It is noteworthy that students without a partner have a higher risk of suicide (56.8%) than those with a partner (29.4%). CONCLUSIONS: it is perceived the need to develop programs that identify students at risk of suicide in higher education institutions, in order to raise awareness of the problem and implement policies to promote mental health in the academia.

Students, Nursing , Brazil/epidemiology , Cross-Sectional Studies , Humans , Mental Health , Suicide, Attempted
Inquiry ; 58: 469580211007264, 2021.
Article En | MEDLINE | ID: mdl-33834861

OBJECTIVE: To evaluate the association between socioeconomic factors, health status, and Functional Capacity (FC) in the oldest senior citizens in a metropolis and a poor rural region of Brazil. METHOD: Cross-sectional study of 417 seniors aged ≥80 years, data collected through Brazil's Health, Well-being and Aging survey. FC assessed by self-reporting of difficulties in Activities of Daily Living (ADLs) and Instrumental Activities of Daily Living (IADLs). Chi-square tests and multiple logistic regression analyses were performed using "R" statistical software. RESULTS: Socioeconomic and demographic inequalities in Brazil can influence FC in seniors aged 80 years and older. Comparatively, urban long-lived people had a higher prevalence of difficulties for ADLs and rural ones showed more difficulties for IADLs. Among urban oldest seniors, female gender and lower-income were correlated with difficulties for IADLs. Among rural oldest seniors, female gender, stroke, joint disease, and inadequate weight independently were correlated with difficulties for ADLs, while the number of chronic diseases was associated with difficulties for IADLs. CONCLUSION: Financial constraints may favor the development of functional limitations among older seniors in large urban centers. In poor rural areas, inadequate nutritional status and chronic diseases may increase their susceptibility to functional decline.

Activities of Daily Living , Health Status Disparities , Brazil/epidemiology , Cross-Sectional Studies , Female , Humans , Socioeconomic Factors
Acta sci., Health sci ; 43: e54789, Feb.11, 2021.
Article En | LILACS-Express | LILACS | ID: biblio-1367908

The Brazilian nation has rich population diversity, and this makes it responsible for guaranteeing the social rights of all. In this perspective, this research seeks to categorize which are the main challenges in access to health that the rural populations face and to understand how the execution of this health care is carried out by professionals from the perspective of rural people. This is a cross-sectional study with a qualitative approach, carried out at the Nossa Senhora Aparecida Settlement, located in the municipality of Pesqueira (Pernambuco state) in 2018. The results demonstrate that the challenges facedby settled families are due to the difficulty of access to health services. In view of this, the rural population chooses to keep their cultural practices focused on their health alive. Therefore, it is common to use herbal medicines and mystics related to religious beliefs in self-care practices. It was concluded that the current public policies have gaps in their implementation, especially in terms of accessibility, security, health education, equity and respect for cultural differences. In addition, there is precariousness at the national level of studies focused on the health determinants and determinants of the rural population, which makes it necessary that more research be carried out so that new public policies can emerge.

Article En | LILACS-Express | LILACS | ID: biblio-1357735

OBJECTIVE: To compare active and sedentary older adults regarding functional capacity, risk of falling, and chronic pain in a population assisted by telemonitoring during the pandemic lockdown. METHODS: This analytical, cross-sectional study included 104 older adults who were telemonitored during the COVID-19 lockdown by a team from a Brazilian Unified Health System outpatient clinic specializing in geriatrics and gerontology. A structured interview was used to collect data. Following normality testing with the Shapiro-Wilk test, Student's t-test was used for group comparisons. Associations were analyzed using the χ2 test, and the odds ratio was calculated in a 2x2 table of sedentarism and falls in the last six months. The data were analyzed using SPSS version 26.0, with p ≤ 0.05 considered significant. RESULTS: The 57 active older adults had a lower rate of continuous medication use (24.84 vs 27.62%), fewer falls (50 vs 32.11%), less pain (12.31 vs 3.83%), and greater independence in basic activities of daily living (44.39 vs 26.46%). CONCLUSIONS: Older adults who were physically active in the midst of social distancing had better functional capacity in basic activities of daily living, fewer falls, and less pain than their sedentary peers. Independence in instrumental activities of daily living did not differ significantly between the groups.

comparar idosos ativos e sedentários no que diz respeito à capacidade funcional, risco de quedas e dores crônicas dentro de uma população em distanciamento físico, atendida por telemonitoramento. METODOLOGIA: estudo analítico, transversal, de abordagem quantitativa com 104 idosos que vivenciavam a pandemia da COVID-19 em distanciamento físico, acompanhados por telemonitoramento pela equipe de um ambulatório especializado em geriatria e gerontologia pertencente ao Sistema Único de Saúde e classificados em dois grupos comparados. Para as comparações por grupos, utilizou-se do teste t de Student, seguindo análise prévia de parametrização pelo teste de Shapiro-Wilk. A análise de associação foi realizada pelo teste χ2 e em proporções 2x2 calculou-se a razão de chances (Odds Ratio), entre ser sedentário e quedas nos últimos seis meses. Estatística realizada no Statistical Package for the Social Sciences versão 26.0, adotando significância com valor de p ≤ 0,05. Para coleta de dados, utilizou-se um roteiro de entrevista estruturada. RESULTADOS: 57 idosos ativos utilizavam menor quantidade de medicamentos de uso contínuo (24,84 vs 27,62%), apresentavam menos quedas (50 vs 32,11%) e dor (12,31 vs 3,83%), e eram mais independentes para atividades básicas de vida diária (44,39 vs 26,46%). CONCLUSÕES: idosos praticantes de exercício físico durante a pandemia da COVID-19 apresentaram melhor capacidade funcional no que diz respeito às atividades básicas de vida diária, redução na ocorrência de quedas e dor quando comparados aos idosos sedentários na mesma condição. Não se observou diferença significativa para independência nas atividades instrumentais de vida diária entre tais idosos.

Rev. patol. trop ; 50(4)2021. tab
Article En | LILACS | ID: biblio-1353266

Given the potential for morbidity and mortality of ventilator-associated pneumonia (VAP), the profile of these infections in adult intensive care units was evaluated in the city of Goiânia. Data were collected from a secondary base in the Department of Prevention and Control of Infection in Health Services, of the Municipal Health Department of Goiânia, from 2014 to 2016, in private (82.7%), public (17.2%), and philanthropic (6.0%) health care services. The rate of use of mechanical ventilation did not change significantly over the three years (32.6%). However, there was a decrease in the mean of VAP incidence density, and in 2016 there was a reduction of 7% in the 90th percentile. These reductions highlight the benefit of the implementation and adherence to bundles by the multidisciplinary team.

Pneumonia , Respiration, Artificial , Ventilators, Mechanical , Delivery of Health Care , Control , Pneumonia, Ventilator-Associated , Intensive Care Units
Rev. bras. enferm ; 74(6): e20200867, 2021. tab
Article En | LILACS-Express | LILACS, BDENF | ID: biblio-1288410

ABSTRACT Objectives: to identify the risk and degree of risk of suicide in nursing students of a public institution in the countryside of Pernambuco, Brazil. Methods: this was a cross-sectional, quantitative research conducted with 150 students. For data collection, a sociodemographic questionnaire and the instrument, M.I.N.I. - Brazilian version 5.0.0 - Module C - Risk of suicide were used. Statistical analyses were performed with IBM(® )SPSS(®), version 23. Results: 53.3% of nursing students had a risk of suicide, of which 20.7% had a high risk. Moreover, 22.67% reported previous suicide attempt. It is noteworthy that students without a partner have a higher risk of suicide (56.8%) than those with a partner (29.4%). Conclusions: it is perceived the need to develop programs that identify students at risk of suicide in higher education institutions, in order to raise awareness of the problem and implement policies to promote mental health in the academia.

RESUMEN Objetivos: identificar el riesgo y el grado de riesgo de suicidio en estudiantes de enfermería de una institución pública del interior de Pernambuco, Brasil. Métodos: una investigación transversal, cuantitativa, realizada con 150 estudiantes. Para la recolección de datos, un cuestionario sociodemográfico y el M.I.N.I. - versión brasileña 5.0.0 - Módulo C - Riesgo de suicidio. Los análisis estadísticos se realizaron en IBM (®) SPSS (®) , versión 23. Resultados: el 53,3% de los estudiantes de enfermería tenían riesgo de suicidio; de estos, el 20,7% estaban en alto riesgo. Además, el 22,67% informó de un intento de suicidio previo. Es de destacar que los estudiantes sin pareja tienen un mayor porcentaje de riesgo de suicidio (56,8%) que los que tienen pareja (29,4%). Conclusiones: existe la necesidad de desarrollar programas que identifiquen a los estudiantes en riesgo de suicidio en las instituciones de educación superior para generar conciencia sobre el problema e implementar políticas para promover la salud mental en la academia.

RESUMO Objetivos: identificar o risco e o grau de risco de suicídio em estudantes de enfermagem de uma instituição pública do interior de Pernambuco, Brasil. Métodos: tratou-se de uma pesquisa transversal, quantitativa, realizada com 150 estudantes. Para a coleta de dados utilizou-seum questionário sociodemográfico e o instrumento, M.I.N.I. - versão brasileira 5.0.0- Módulo C - Risco de Suicídio. As análises estatísticasforam realizadas no IBM® SPSS®, versão 23. Resultados: 53,3% dos estudantes de enfermagem apresentaram risco de suicídio; desses, 20,7% tinham alto risco. Ademais, 22,67% relataram tentativa de suicídio anterior. Destaca-se que os estudantes sem companheiro apresentam maior percentual de risco de suicídio (56,8%) do que os com companheiro (29,4%). Conclusões: percebe-se a necessidade do desenvolvimento de programas que identifiquem estudantes com risco de suicídio nas instituições de ensino superior, para a conscientização do problema e a implementação de políticas de promoção da saúde mental no meio acadêmico.

Rev. bras. psicanál ; 54(4): 210-228, out.-dez. 2020. ilus
Article Pt | LILACS-Express | LILACS, INDEXPSI | ID: biblio-1288956

RESUMO Pretendemos aqui discutir as peculiaridades da clínica em saúde pública junto a crianças e suas famílias durante a pandemia, considerando os impasses impostos pelo isolamento social e o acolhimento oferecido, mostrando a potência dos atendimentos online. Em contexto público já precário antes da covid-19, enfatizamos a valorização do trabalho clínico e da discussão psicanalítica para colaborar para a saúde institucional no oferecimento de nossos serviços à comunidade. Apresentam-se vinhetas clínicas ilustrativas.

ABSTRACT We intend here to discuss the peculiarities of the community health clinical services with children and their families during the pandemic, considering the impasses imposed by social isolation and the containment offered, showing the power of online sessions. In a public context already precarious before covid-19, we emphasize the relevance of clinical work and psychoanalytic discussion to collaborate for institutional health in offering our services to the community. Clinical vignettes are presented.

RESUMEN Aquí tenemos la intención de discutir las peculiaridades de la clínica de salud pública con los niños y sus familias durante la pandemia, teniendo en cuenta los interrogantes impuestos por el aislamiento social y la recepción ofrecida, mostrando el poder del trabajo en línea. En un contexto público ya precario antes de covid-19, enfatizamos la valorización del trabajo clínico y la discusión psicoanalítica para colaborar por la salud institucional en la oferta de nuestros servicios a la comunidad. Se presentan viñetas clínicas ilustrativas.

RESUMÉ On a l'intention de discuter ici les singularités de la clinique en santé clinique auprès des enfants et leurs familles pendant la pandémie, toute en considérant les impasses imposées par la distanciation sociale et les accueils offerts, et en démontrant la puissance des soins en ligne. Dans un contexte public déjà précaire avant le covid-19, nous soulignons la mise en valeur du travail clinique et de la discussion psychanalytique pour contribuer à la santé institutionnelle en offrant nos services à la communauté. On présente des vignettes cliniques pour illustrer.

Sci Rep ; 10(1): 19591, 2020 11 11.
Article En | MEDLINE | ID: mdl-33177582

Chagas drug discovery has been hampered by a lack of validated assays to establish treatment efficacy in pre-clinical animal models and in patients infected with T. cruzi. Reduced levels of parasite secreted antigens in the blood of infected hosts could be used to demonstrate treatment efficacy. A published proteomic study of parasite secreted antigens identified the hypothetical protein Tc_5171 as a secreted antigen. In this report, we developed Tc_5171 specific antibodies and showed that the native protein was expressed by the three life cycle stages of the parasite. Anti-peptide antibodies were able to detect the parasite antigen in blood of infected mice during the acute and the chronic phase of infection. Benznidazole treatment of infected mice significantly reduced their blood antigen levels. Of clinical significance, patients diagnosed with Chagas disease, either asymptomatic or with cardiac clinical symptoms had significantly higher Tc_5171 antigen levels compared to endemic controls. Pair-wise analysis, before and after Benznidazole treatment, of patients with asymptomatic Chagas disease showed a significant reduction in antigen levels post treatment. Taken together, our results indicate that Tc_5171 could be used as a novel biomarker of Chagas disease for diagnosis and to assess treatment efficacy.

Antigens, Protozoan/blood , Chagas Disease/parasitology , Trypanosoma cruzi/immunology , Adolescent , Adult , Aged , Animals , Antibodies, Protozoan/immunology , Antigens, Protozoan/genetics , Antigens, Protozoan/metabolism , Biomarkers/blood , Chagas Disease/blood , Chagas Disease/drug therapy , Humans , Macaca mulatta , Mice , Mice, Inbred C3H , Mice, Inbred C57BL , Middle Aged , Nitroimidazoles/pharmacology , Trypanocidal Agents/pharmacology
Food Res Int ; 137: 109722, 2020 11.
Article En | MEDLINE | ID: mdl-33233291

There is a need for searching new microalgae species, and the most suitable strategy to increase the cost-effectiveness of a microalgae culture system is to use resources of low costs, such as residues. This study aimed to evaluate the cultivation of microalgae isolated from the Brazilian Northeast region (Lagerheimia longiseta, Monoraphidium contortum, and Scenedesmus quadricauda) in an alternative medium of low cost (biocompost of discarded fruits and vegetables) with a view to possible applications in the food industry. Microalgae cultivated in the conventional synthetic medium was used as control. The cultivation of microalgae in the alternative medium allowed suitable cell growth, and improved the antioxidant activity and the levels of monounsaturated fatty acid and polyunsaturated fatty acid compared to the synthetic medium. The cultivation of S. quadricauda and L. longiseta species in the alternative medium resulted in increased protein content and/or total phenolic content, and improved health indices (lower levels of atherogenic, thrombogenic, and hypercholesterolemic saturated fatty acids indices, and higher levels of desired fatty acids index) compared to cultivation in synthetic medium. The cultivation of M. contortum in the alternative medium contributed to the production of higher lipid content, mainly saturated fatty acid (palmitic acid), which contributed negatively to the health indices. This study proved that S. quadricauda and L. longiseta microalga species from freshwaters have significant potential for distinct applications in functional food industries, and the biocompost of discarded fruits and vegetables is a suitable medium for microalgae cultivation.

Microalgae , Biofuels , Biomass , Brazil , Fruit , Vegetables
Sci Rep ; 10(1): 15573, 2020 09 23.
Article En | MEDLINE | ID: mdl-32968083

This paper deals with the frequency and structure of first-cousin marriages, by far the most important and frequent type of consanguineous mating in human populations. Based on the analysis of large amounts of data from the world literature and from large Brazilian samples recently collected, we suggest some explanations for the asymmetry of sexes among the parental sibs of first-cousin marriages. We suggest also a simple manner to correct the method that uses population surnames to assess the different Wright fixation indexes FIS, FST and FIT taking into account not only alternative methods of surname transmission, but also the asymmetries that are almost always observed in the distribution of sexes among the parental sibs of first-cousins.

Consanguinity , Marriage , Brazil/epidemiology , Family , Female , Humans , Male , Surveys and Questionnaires