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Braz. j. biol ; 83: e249104, 2023. tab
Article En | MEDLINE, LILACS, VETINDEX | ID: biblio-1339389

Abstract The present study was designed to evaluate the strength of association of raised plasma homocysteine concentration as a risk factor for coronary heart disease independent of conventional risk factor. It was a case control study conducted at Punjab Institute of Cardiology Lahore. A total of 210 subjects aged 25 to 60 years comprising of 105 newly admitted patients of CHD as cases and 105 age and sex matched healthy individuals with no history of CHD as control were recruited for the study. Fasting blood samples were obtained from cases and controls. Plasma homocysteine was analyzed by fluorescence polarization immunoassay (FPIA) method on automated immunoassay analyzer (Abbott IMX). Total cholesterol, triglyceride and HDL cholesterol were analyzed using calorimetric kit methods. The concentration of LDL cholesterol was calculated using Friedewald formula. The patients were also assessed for traditional risk factors such as age, sex, family history of CVD, hypertension, smoking and physical activity, and were compared with control subjects. The collected data was entered in SPSS version 24 for analysis and interpretation.The mean age in controls and experimental groups were 43.00± 8.42 years and 44.72± 8.59 years with statistically same distribution (p- value= 0.144). The mean plasma homocysteine for cases was 22.33± 9.22 µmol/L where as it was 12.59±3.73 µmol/L in control group. Highly significant difference was seen between the mean plasma level of homocysteine in cases and controls (p˂0.001).Simple logistic regression indicates a strong association of coronary heart disease with hyperhomocysteinemia (OR 7.45), which remained significantly associated with coronary heart disease by multivariate logistic regression (OR 7.10, 95%C1 3.12-12.83, p=0.000). The present study concludes that elevated levels of Plasma homocysteine is an independent risk factor for coronary heart disease independent of conventional risk factors and can be used as an indicator for predicting the future possibility for the onset of CVD.

Resumo O presente estudo foi desenhado para avaliar a força da associação da concentração elevada de homocisteína no plasma como um fator de risco para doença cardíaca coronária independente do fator de risco convencional. Foi um estudo de caso-controle realizado no Punjab Institute of Cardiology Lahore. Um total de 210 indivíduos com idade entre 25 e 60 anos, compreendendo 105 pacientes recém-admitidos de CHD como casos e 105 indivíduos saudáveis ​​pareados por idade e sexo sem histórico de CHD como controle, foi recrutado para o estudo. Amostras de sangue em jejum foram obtidas de casos e controles. A homocisteína plasmática foi analisada pelo método de imunoensaio de polarização de fluorescência (FPIA) em analisador de imunoensaio automatizado (Abbott IMX). Colesterol total, triglicerídeos e colesterol HDL foram analisados ​​usando métodos de kit calorimétrico. A concentração de colesterol LDL foi calculada pela fórmula de Friedewald. Os pacientes também foram avaliados para fatores de risco tradicionais, como idade, sexo, história familiar de DCV, hipertensão, tabagismo e atividade física, e foram comparados com indivíduos de controle. Os dados coletados foram inseridos no SPSS versão 24 para análise e interpretação. A média de idade nos grupos controles e experimentais foi de 43,00 ± 8,42 anos e 44,72 ± 8,59 anos com distribuição estatisticamente igual (p-valor = 0,144). A homocisteína plasmática média para os casos foi de 22,33 ± 9,22 µmol / L, enquanto no grupo controle foi de 12,59 ± 3,73 µmol / L. Diferença altamente significativa foi observada entre o nível plasmático médio de homocisteína em casos e controles (p ˂ 0,001). A regressão logística simples indica uma forte associação de doença cardíaca coronária com hiper-homocisteinemia (OR 7,45), que permaneceu significativamente associada com doença cardíaca coronária por multivariada regressão logística (OR 7,10, 95% C1 3,12-12,83, p = 0,000). O presente estudo conclui que níveis elevados de homocisteína plasmática são fator de risco independente para doença cardíaca coronária, independentemente dos fatores de risco convencionais, e pode ser usado como um indicador para prever a possibilidade futura de aparecimento de DCV.

Humans , Adult , Middle Aged , Coronary Disease/embryology , Hyperhomocysteinemia/diagnosis , Hyperhomocysteinemia/epidemiology , Case-Control Studies , Risk Factors , Fasting
Oxid Med Cell Longev ; 2022: 6687626, 2022.
Article En | MEDLINE | ID: mdl-35340212

Background and Aims: Elevated serum uric acid (SUA) is associated with an increased risk of nonalcoholic fatty liver disease (NAFLD); however, whether this association is causal is undetermined. Methods: Each participant from the Dongfeng-Tongji cohort study based on 27,009 retirees was interviewed face-to-face following a clinical examination. Covariance, logistic regression analysis, and instrumental variables were used to assess associations between SUA and (severity of) NAFLD and the causal link. Results: Among 8,429 subjects free of NAFLD at baseline, 2,007 participants developed NAFLD after 5 years of follow-up. The multivariable-adjusted odds ratio (OR) for NAFLD for individuals in the fourth quartile of SUA level versus those in the first was 1.71 (95% CI: 1.45-2.01, P for trend <0.001) and was more dramatic in women or normal-weight persons. Furthermore, SUA was materially associated with greater mean markers of hepatic necroinflammation and greater probabilities of fibrosis. In genetic analyses, both single nucleotide polymorphisms (rs11722228 to SLC2A9 and rs2231142 to ABCG2) were pronouncedly associated with increased SUA concentrations, ranging from 0.19 to 0.22 mg/dl. No significant associations were observed between SNPs and potential confounders. No association was observed between the SUA-increasing allele and NAFLD, with an OR of 0.98 (95% CI: 0.90-1.08) per genetic score. This was not significantly different (P = 0.25) from what was expected (1.03, 95% CI: 1.03-1.03). Conclusions: SUA was positively associated with NAFLD incidence especially in female and normal-weight individuals and the suspected progression risk of newly developed NAFLD. However, the Mendelian randomization analyses lend no causal evidence, suggesting high SUA as a marker and not a cause of NAFLD.

Non-alcoholic Fatty Liver Disease , Uric Acid , Cohort Studies , Female , Glucose Transport Proteins, Facilitative , Humans , Non-alcoholic Fatty Liver Disease/genetics , Odds Ratio , Risk Factors
J Nerv Ment Dis ; 210(4): 257-263, 2022 04 01.
Article En | MEDLINE | ID: mdl-35212665

ABSTRACT: We aimed to explore the prevalence and determinants of severe COVID-19 disease and mortality in patients with schizophrenia in this study. We conducted a retrospective observational study of 1620 patients with schizophrenia. Of the 1620 patients, 52 (3.2%) tested positive for SARS-CoV-19. Among SARS-CoV-2-positive patients, 40 patients were hospitalized, and 17 patients required intensive care unit admission due to COVID-19 (76.9% and 32.7%, respectively). Severe COVID-19 disease was noted in 17 patients (32.7%) requiring intubation. In the logistic regression analysis, antipsychotic dose, and comorbidity score were independently associated with a greater risk of severe COVID-19 disease in patients with schizophrenia. Our study suggests that factors such as age, sex, comorbidities, and a daily antipsychotic dose may have effects on the poor outcome of SARS-CoV-2 disease in schizophrenia patients. In addition, the current findings propose that mortality may be associated with an older age, comorbidity score, and a longer duration of psychiatric disease among the SARS-CoV-2-positive patients with schizophrenia. However, the findings of our study should be verified in prospective and larger sample studies.

COVID-19 , Schizophrenia , COVID-19/epidemiology , Comorbidity , Demography , Hospitalization , Humans , Prospective Studies , Retrospective Studies , Risk Factors , SARS-CoV-2 , Schizophrenia/epidemiology
Artif Organs ; 46(4): 597-605, 2022 Apr.
Article En | MEDLINE | ID: mdl-34951495

BACKGROUND: M101 is an extracellular hemoglobin isolated from a marine lugworm and is present in the medical device HEMO2 life®. The clinical investigation OXYOP was a paired kidney analysis (n = 60) designed to evaluate the safety and performance of HEMO2 life® used as an additive to preservation solution in renal transplantation. The secondary efficacy endpoints showed less delayed graft function (DGF) and better renal function in the HEMO2 life® group but due to the study design cold ischemia time (CIT) was longer in the contralateral kidneys. METHODS: An additional analysis was conducted including OXYOP patients and patients from the ASTRE database (n = 6584) to verify that the decrease in DGF rates observed in the HEMO2 life® group may not be due solely to the shorter CIT but also to HEMO2 life® performance. Kaplan-Meier estimate curves of cumulative probability of achieving a creatinine level below 250 µmol/L were generated and compared in both groups. A Cox model was used to test the effect of the explanatory variables (use of HEMO2 life® and CIT). Finally, a bootstrap strategy was used to randomly select smaller samples of patients and test them for statistical comparison in the ASTRE database. RESULTS: Kaplan-Meier estimate curves confirmed the existence of a relation between DGF and CIT and Cox analysis showed a benefit in the HEMO2 life® group regardless of the associated CIT. Boostrap analysis confirmed these results. CONCLUSIONS: The present study suggested that the better recovery of renal function observed among kidneys preserved with HEMO2 life® in the OXYOP study is a therapeutic benefit of this breakthrough innovative medical device.

Cold Ischemia , Kidney Transplantation , Cold Ischemia/adverse effects , Cold Ischemia/methods , Delayed Graft Function , Graft Survival , Hemoglobins , Humans , Kidney/physiology , Kidney Transplantation/adverse effects , Kidney Transplantation/methods , Prospective Studies , Risk Factors
Horm Metab Res ; 54(2): 84-93, 2022 Feb.
Article En | MEDLINE | ID: mdl-35130569

Long-term glycemic fluctuation has been associated with cardiovascular risk in patients with type 2 diabetes mellitus (T2DM). However, the findings are inconsistent. We performed a meta-analysis to summarize the association between parameters of long-term glycemic variability and risk of cardiovascular events in T2DM patients. Medline, Embase, and Web of Science databases were searched for longitudinal follow-up studies comparing the incidence of cardiovascular events in T2DM patients with higher or lower long-term glycemic variability. A random-effect model incorporating the potential heterogeneity among the included studies was used to pool the results. Twelve follow-up studies with 146 653 T2DM patients were included. The mean follow-up duration was 4.9 years. Pooled results showed that compared to those with the lowest glycemic variability, patients with the highest glycemic variability had significantly increased risk of cardiovascular events, as evidenced by the standard deviation of glycated hemoglobin [HbA1c-SD: relative risk (RR)=1.44, 95% confidence interval (CI): 1.23 to 1.69, p<0.001; I2=70%], HbA1c coefficient of variation (HbA1c-CV: RR=1.46, 95% CI: 1.19 to 1.79. p<0.001; I2=83%), standard deviation of fasting plasma glucose (FPG-SD: RR=1.33, 95% CI: 1.07 to 1.65, p=0.009; I2=0%), and FPG coefficient of variation (FPG-CV: RR=1.29, 95% CI: 1.01 to 1.64, p=0.04; I2=47%). In conclusion, increased long-term glycemic variability may be an independent risk factor for cardiovascular events in T2DM patients.

Cardiovascular Diseases , Diabetes Mellitus, Type 2 , Blood Glucose , Cardiovascular Diseases/epidemiology , Cardiovascular Diseases/etiology , Diabetes Mellitus, Type 2/complications , Fasting , Glycated Hemoglobin A/analysis , Humans , Risk Factors
Horm Metab Res ; 54(2): 104-112, 2022 Feb.
Article En | MEDLINE | ID: mdl-35130571

Some studies have suggested that diabetes may be a risk factor for osteoarthritis. However, whether prediabetes is also associated with osteoarthritis has not been comprehensively examined. We performed a meta-analysis to evaluate the relationship between prediabetes and osteoarthritis. This meta-analysis included relevant observational studies from Medline, Embase, and Web of Science databases. A random-effect model after incorporation of the intra-study heterogeneity was selected to pool the results. Ten datasets from six observational studies were included, which involved 41 226 general adults and 10 785 (26.2%) of them were prediabetic. Pooled results showed that prediabetes was not independently associated with osteoarthritis [risk ratio (RR): 1.07, 95% confidence interval (CI): 1.00 to 1.14, p=0.06, I2=0%]. Sensitivity limited to studies with adjustment of age and body mass index showed consistent result (RR: 1.06, 95% CI: 0.99 to 1.14, p=0.09, I2=0%). Results of subgroup analyses showed that prediabetes was not associated with osteoarthritis in cross-sectional or cohort studies, in studies including Asian or non-Asian population, or in studies with different quality scores (p for subgroup difference>0.10). Besides, prediabetes was not associated with osteoarthritis in men or in women, in studies with prediabetes defined as impaired fasting glucose, impaired glucose tolerance, or HbA1c (approximately 39-46 mmol/mol). Moreover, prediabetes was not associated with overall osteoarthritis, and knee or hip osteoarthritis. Current evidence does not support that prediabetes is independently associated with osteoarthritis in adult population.

Glucose Intolerance , Osteoarthritis , Prediabetic State , Adult , Blood Glucose/metabolism , Cross-Sectional Studies , Female , Glycated Hemoglobin A/analysis , Humans , Male , Observational Studies as Topic , Osteoarthritis/complications , Osteoarthritis/epidemiology , Prediabetic State/complications , Prediabetic State/epidemiology , Prediabetic State/metabolism , Risk Factors
Clin Exp Nephrol ; 26(1): 22-28, 2022 Jan.
Article En | MEDLINE | ID: mdl-34342776

BACKGROUND: Cytomegalovirus (CMV) is a herpes virus that causes latent infections, and its reactivation due to immunosuppression can cause fatal complications. CMV reactivation is a complication frequently occurring in patients with kidney disease who require immunosuppressive therapy, and, therefore, this study retrospectively examined its risk factors. METHODS: Patients who received immunosuppressive therapy and underwent the CMV antigenemia test (CMV antigenemia: C7-HRP) for the treatment of primary nephritis (minimal change disease, membranous nephropathy, membranoproliferative glomerulonephritis, focal glomerulosclerosis, and IgA nephropathy) and anti-neutrophil cytoplasmic autoantibody (ANCA)-associated nephritis diagnosed at Saiseikai Kurihashi Hospital from January 2014 to December 2019 were recruited as study participants. Risk factors of CMV reactivation were examined using univariable and multivariable analyses. RESULTS: Among the 64 patients (36 men and 28 women; median age, 72 years) included, 34 had primary nephritis (20 minimal disease changes, 10 membranous nephropathy, 1 membranoproliferative glomerulonephritis, 1 focal glomerulosclerosis, and 2 IgA nephropathy) and 30 had ANCA-associated nephritis. Regarding glucocorticoid (GC), 43 patients received oral GC therapy, whereas 21 received GC pulse therapy. CMV reactivation participants showed significant differences in age, ANCA-associated nephritis, hemoglobin level, lymphocyte count, maximum GC dosage, and hemodialysis in univariable analysis. Multivariate analysis showed significantly lower lymphocyte counts in CMV-reactivated patients, but no significant difference in other factors. CONCLUSION: In patients with kidney disease, who require immunosuppressive therapy, CMV reactivation risk is high in patients with low lymphocyte count, and monitoring CMV during the treatment course could lead to early diagnosis and treatment of CMV disease.

Cytomegalovirus , Kidney Diseases , Aged , Female , Humans , Kidney Diseases/diagnosis , Male , Retrospective Studies , Risk Factors , Virus Activation
J. Health Biol. Sci. (Online) ; 10(1): 1-6, 01/jan./2022.
Article Pt | LILACS | ID: biblio-1366907

Objetivos: estabelecer diagnóstico diferencial das demências em ambulatório de geriatria no Distrito Federal, calculando-se sua prevalência por meio de exame clínico e avaliação multifuncional. Método: estudo longitudinal, retrospectivo, com amostra de pessoas com 60 anos ou mais residentes no Distrito Federal-Brasil, com déficit cognitivo caracterizado por Transtorno Neurocognitivo (TNC) Maior (demência), cadastradas durante os anos de 2010 a 2018. A coleta de dados foi realizada em prontuários para selecionar e avaliar o perfil do idoso com diagnóstico de TNC seguida de avaliação geriátrica ampla e avaliação multifuncional. A análise de dados foi realizada com o cálculo da prevalência, estatística descritiva e índice V de Cramer. Resultados: 158 indivíduos conseguiram concluir todas as avalições. 52,5% possuem de 80 a 89 anos, 62,5% são mulheres e 62,7% caucasianos, 50,6% viúvos e 47,5% analfabetos. A prevalência inicial de Doença de Alzheimer (DA) foi de 45,6%, reduzindo-se para 35,4% após um período de acompanhamento e a demência vascular (DV) foi de 34,2%, inicialmente, e 45,6% ao final. Utilizou-se o Coeficiente V de Cramer, em que se encontrou uma relação fraca de fatores de risco com os diagnósticos das demências apresentados. Conclusão: DV foi a mais prevalente na área estudada. Entende-se ser a maior frequência de DA esteja relacionada à avaliação superficial uma vez que esse tipo de demência é mundialmente mais frequente

Objetivos: estabelecer diagnóstico diferencial das demências em ambulatório de geriatria no Distrito Federal, calculando-se sua prevalência por meio de exame clínico e avaliação multifuncional. Método: estudo longitudinal, retrospectivo, com amostra de pessoas com 60 anos ou mais residentes no Distrito Federal-Brasil, com déficit cognitivo caracterizado por Transtorno Neurocognitivo (TNC) Maior (demência), cadastradas durante os anos de 2010 a 2018. A coleta de dados foi realizada em prontuários para selecionar e avaliar o perfil do idoso com diagnóstico de TNC seguida de avaliação geriátrica ampla e avaliação multifuncional. A análise de dados foi realizada com o cálculo da prevalência, estatística descritiva e índice V de Cramer. Resultados: 158 indivíduos conseguiram concluir todas as avalições. 52,5% possuem de 80 a 89 anos, 62,5% são mulheres e 62,7% caucasianos, 50,6% viúvos e 47,5% analfabetos. A prevalência inicial de Doença de Alzheimer (DA) foi de 45,6%, reduzindo-se para 35,4% após um período de acompanhamento e a demência vascular (DV) foi de 34,2%, inicialmente, e 45,6% ao final. Utilizou-se o Coeficiente V de Cramer, em que se encontrou uma relação fraca de fatores de risco com os diagnósticos das demências apresentados. Conclusão: DV foi a mais prevalente na área estudada. Entende-se ser a maior frequência de DA esteja relacionada à avaliação superficial uma vez que esse tipo de demência é mundialmente mais frequente

Dementia , Alzheimer Disease , Women , Dementia, Vascular , Geriatric Assessment , Public Health , Prevalence , Risk Factors , Neurocognitive Disorders , Geriatrics , Persons
Rev. urug. enferm ; 17(1): 1-14, jun. 2022.
Article Pt | LILACS, BDENF | ID: biblio-1362990

A laparotomia consiste no acesso cirúrgico aos órgãos da cavidade abdominal, quando classifica-da como urgente apresenta-se quando há necessidade de se explorar a dimensão de lesões abdominais ou para investigar e tratar patologias desconhecidas. Por vezes, tal procedimento apresenta complicações onde há a necessidade de uma relaparotomia. O objetivo deste estudo foi descrever a ocorrência da laparotomia de urgência e fatores de risco associados à relaparotomia. Trata-se de um estudo retrospectivo, analítico e de caráter quantitativo, realizado em hospital de urgência e emergência do estado de Pernambuco. A amostra foi composta por 120 prontuários. Os resultados apresentaram perfis de risco distintos. Para a laparotomia houve a prevalência do sexo masculino, idade <50 anos, com o etilismo sendo um hábito de vida considerado fator de risco relevante e o desfecho clínico mais comum foi a alta hospitalar. Já no caso da relaparotomia, houve prevalência no sexo feminino, idade >50 anos, sendo a idade elevada considera um fator de risco para complicações, como fatores de risco clínico, o tabagismo e a hipertensão arterial prevaleceram, a classificação do ASA III e IV também se mostrou relevante e o desfecho clínico mais representativo foi o óbito. Em ambos os perfis, a causa inicial se mostrou signifi cativa para a diferença no desfecho clínico dos prontuários analisados. Conhecer a ocorrência da laparotomia de urgência e os fatores de risco para relaparotomias proporciona a equipe multiprofissional dos serviços de saúde um conhecimento prévio para que haja o planejamento adequado da assistência e a implantação de medidas preventivas.

Laparotomy consists of surgical access to the organs of the abdominal cavity, when classified as urgent, it appears when there is a need to explore the dimension of abdominal injuries or to investigate and treat unknown pathologies. Sometimes, this procedure presents complications where there is a need for a relaparotomy. the aim of this study was to describe the occurrence of emergency laparotomy and risk factors associated with relaparotomy. this is a retrospective, analytical and quantitative study carried out in an emergency hospital in the state of Pernambuco. The sample consisted of 120 medical records. The results showed different risk profiles. For laparotomy, there was a prevalence of males, age <50 years, with alcoholism being a life habit considered a relevant risk factor and the most common clinical outcome was hospital discharge. In the case of relaparotomy, there was a prevalence in females, age> 50 years, with high age considered a risk factor for complications, as clinical risk factors, smoking and arterial hypertension prevailed, the classification of ASA III and IV it also proved to be relevant and the most representative clinical outcome was death. In both profiles, the initial cause was significant for the difference in the clinical outcome of the analyzed medical records. Knowing the occurrence of emergency laparotomy and the risk factors for relaparotomy provides the multidisciplinary team of health services with prior knowledge so that there is adequate planning of care and the implementation of preventive measures.

La laparotomía consiste en el acceso quirúrgico a los órganos de la cavidad abdominal, cuando se clasifica como urgente, aparece cuando es necesario explorar la dimensión de las lesiones abdominales o investigar y tratar patologías desconocidas. A veces, este procedimiento presenta complicaciones donde existe la necesidad de una relaparotomía. El objetivo de este estudio fue describir la aparición de laparotomía de emergencia y los factores de riesgo asociados con la relaparotomía. Este es un estudio retrospectivo, analítico y cuantitativo realizado en un hospital de emergencia en el estado de Pernambuco. La muestra consistió en 120 registros médicos. Los resultados mostraron diferentes perfi les de riesgo. Para la laparotomía, hubo una prevalencia de varones, edad <50 años, siendo el alcoholismo un hábito de vida considerado un factor de riesgo relevante y el resultado clínico más común fue el alta hospitalaria. En el caso de la relaparotomía, hubo una prevalencia en las mujeres, edad > 50 años, con la edad alta considerada un factor de riesgo de complicaciones, ya que prevalecieron los factores de riesgo clínico, el tabaquismo y la hipertensión arterial, la clasificación de ASA III y IV también demostró ser relevante y el resultado clínico más representativo fue la muerte. En ambos perfiles, la causa inicial fue significativa para la diferencia en el resultado clínico de los registros medicos analizados. Conocer la aparición de laparotomía de emergencia y los factores de riesgo de la relaparotomía proporciona al equipo multidisciplinario de servicios de salud conocimientos previos para que hay a una planificación adecuada de la atención y la implementación de medidas preventivas.

Humans , Brazil , Risk Factors , Emergency Medicine , Abdominal Injuries , Laparotomy
Comput Intell Neurosci ; 2022: 4745534, 2022.
Article En | MEDLINE | ID: mdl-35498212

Background: Adjacent segment degeneration (ASD) has been considered as a serious complication from changes in the biological stress pattern after spinal fusion. The sagittal balance significantly associated with lumbar loading is largely dependent on L5-S1 segment. However, the evidence indicating risk factors for radiological and symptomatic ASD after minimally invasive transforaminal interbody fusion (MIS-TLIF) remains insufficient. Methods: This single-central retrospective study recruited patients with lumbosacral degeneration receiving MIS-TLIF at the L5-S1 level from January 2015 to December 2018. The targeted variables included demographic information, radiological indicators, surgery-related parameters, and patient-reported outcomes (PROs) extracted from the electronic medical system by natural language processing. In these patients, a minimum of 3-year follow-up was done. After reviewing the preoperative and postoperative follow-up digital radiographs, patients were assigned to radiological ASD group (disc height narrowing ≥3 mm, progressive slipping ≥3 mm, angular motion >10°, and osteophyte formation >3 mm), symptomatic ASD group, and control group. We identified potential predictors for radiological and symptomatic ASD with the service of stepwise logistic regression analysis. Results: Among the 157 consecutive patients treated with MIS-TLIF in our department, 16 cases (10.2%) were diagnosed with radiological ASD at 3-year follow-up. The clinical evaluation did not reveal suspicious risk factors, but several significant differences were confirmed in radiological indicators. Multivariate logistic regression analysis showed postoperative PI, postoperative DA, and ∆PI-LL in radiological ASD group were significantly different from those in control group. Nevertheless, for patients diagnosed with simultaneously radiological and symptomatic ASD, postoperative DA and postoperative PT as risk factors significantly affected the clinical outcome following MIS-TLIF. Conclusion: In this study, while approximately 10% of lumbosacral degenerations develop radiographic ASD, prognosis-related symptomatic ASD was shown not to be a frequent postoperative complication. Postoperative PI, postoperative DA, and mismatched PI-LL are risk factors for radiological ASD, and postoperative DA and postoperative PT are responsible for the occurrence of symptomatic ASD following MIS-TLIF. These radiological risk factors demonstrate that restoration of normal sagittal balance is an effective measure to optimize treatment strategies for secondary ASD prevention.

Lumbar Vertebrae , Spinal Fusion , Humans , Lumbar Vertebrae/diagnostic imaging , Lumbar Vertebrae/surgery , Minimally Invasive Surgical Procedures/adverse effects , Retrospective Studies , Risk Factors , Spinal Fusion/adverse effects
Front Endocrinol (Lausanne) ; 13: 853473, 2022.
Article En | MEDLINE | ID: mdl-35498421

Objective: The objective of the study was to explore the effect of insulin resistance on pregnancy outcomes in patients with polycystic ovary syndrome (PCOS) from the first embryo transfer cycle. Design: This was a single-center, retrospective, observational cohort study. Patients: Included in the study were women with PCOS for the first embryo transfer. Main Outcome Measures: Early miscarriage rate and macrosomia rate were the main outcome measures. Results: With increased HOMA-IR, the early miscarriage rate (7.14, 13.21, and 16.22%, respectively; P = 0.039), macrosomia rate (5.78, 11.79, and 17.58%, respectively; P = 0.026) and the incidence of gestational diabetes (GDM) (10.00, 14.50, and 25.67% respectively; P = 0.002) significantly increased, while the live birth rate markedly decreased (63.03, 55.27, and 47.88%, respectively; P = 0.004). No significant difference was found in clinical pregnancy rate, late miscarriage rate, low birthweight rate and baby gender ratio (all P >0.05). After adjusting for confounding factors, HOMA-IR was an independent risk factor of early miscarriage rate and macrosomia rate. Conclusion: Insulin resistance is an independent risk factor for early miscarriage and macrosomia in PCOS patients during the first embryo transfer cycle. It is essential to give more attention before and after pregnancy for PCOS women with high HOMA-IR.

Abortion, Spontaneous , Diabetes, Gestational , Insulin Resistance , Polycystic Ovary Syndrome , Embryo Transfer , Female , Fetal Macrosomia , Humans , Infant , Male , Polycystic Ovary Syndrome/complications , Pregnancy , Retrospective Studies , Risk Factors , Weight Gain
Vasc Health Risk Manag ; 18: 319-327, 2022.
Article En | MEDLINE | ID: mdl-35498559

Objective: To study the association between sublingual varices (SV) and cardiovascular (CVD) risk factors. Methods: A total of 989 consecutive dental patients aged 55-84 years participated in the study, which applied a survey about risk factors, diseases and medications. Digital photos of the lateral borders of the tongue, height, weight, waist, hip and blood pressure were registered, and blood samples were analyzed. Those with SV were compared with those without SV (nSV). Results: Those with SV had more hypertension 41.8% vs 27.0% (p<0.0001), a higher systolic blood pressure (BP) 139.5 (SD 18.6) mmHg vs 134.3 (SD 18.8) mmHg (95% CI -7.73 ─ -2.72), more diabetes type 2 (DM-2) 7.4% vs 3.8% (p=0.014), a higher fasting plasma glucose 5.9 (SD 1.5) mmol/L vs 5.7 (SD 1.0) mmol/L (95% CI -0.42 ─ -0.05), more dyslipidemia 24.1% vs 17.7% (p=0.018), lower HDL 1.6 vs 1.7 (p=0.003), a greater waist circumference 97.0 cm vs 93.9 cm (95% CI -4.66 ─ -1.46), a greater waist/hip ratio 0.92 cm/cm vs 0.90 cm/cm (95% CI -0.03 ─ -0.01), and a higher BMI 26.6 kg/m2 vs 26.0 kg/m2 (95% CI -1.11 ─ -0.03). The following associations with SV were found in multivariate analysis: hypertension OR=1.6 (95% CI 1.19 ─2.13), a high systolic BP OR =1.5 (95% CI 1.11 ─2.13), a high fP-glucose OR= 1.8 (95% CI 1.03 ─3.21), a low HDL OR= 1.8 (95% CI 1.15 ─2.92), a greater waist circumference OR= 1.68 (95% CI 1.10 ─2.58), a greater waist/hip ratio OR=2.21 (95% CI 1.36 ─3.58), and a higher BMI OR=1.05 (95% CI 1.02 ─1.09). Conclusion: This study shows an association between SV and a high BP, a high fP-glucose, hypertension, diabetes mellitus type 2, dyslipidemia, abdominal obesity, older age and smoking.

Cardiovascular Diseases , Diabetes Mellitus, Type 2 , Hypertension , Varicose Veins , Cardiovascular Diseases/diagnosis , Cardiovascular Diseases/epidemiology , Diabetes Mellitus, Type 2/diagnosis , Diabetes Mellitus, Type 2/epidemiology , Heart Disease Risk Factors , Humans , Hypertension/diagnosis , Hypertension/epidemiology , Risk Factors , Varicose Veins/diagnosis , Varicose Veins/epidemiology
Span J Psychol ; 25: e17, 2022 May 02.
Article En | MEDLINE | ID: mdl-35499095

Callous Unemotional (CU) traits are associated with different environmental risk factors, such as negative stressful life events (SLE). The most common studied SLE associated with CU trait has been childhood maltreatment, but less is known about how other SLE impact the development of CU traits. Therefore, this work examines risk factors, personal factors (executive functioning), and mental health outcomes associated with the trajectories of Callous Unemotional (CU) traits and Stressful Life Events (SLE) in a community sample of children. A cohort of 377 preschoolers were followed up between ages 3 and 10. Several risk factors and outcomes for three trajectory groups (high CU/SLE; high CU/low SLE; and the reference group with low CU/SLE) were analyzed by using multiple post-hoc comparisons. We hypothesized that children with high CU/SLE would face more contextual risk factors, more executive functioning difficulties and more mental health problems than children with high CU/low SLE or the reference group. At the age of 3, children who showed high CU/SLE faced more early contextual adversity, including socioeconomic difficulties and maternal antisocial behavior than the other groups of children. At the age of 10, children with high CU/SLE presented more peer problems and higher psychopathology symptoms than the reference group, but no differences on mental health outcomes in comparison to the high CU/low SLE group. These results have potential implications for clinical practice and studies attempting to identify different CU subtypes in children.

Conduct Disorder , Lupus Erythematosus, Systemic , Child , Child, Preschool , Conduct Disorder/diagnosis , Conduct Disorder/epidemiology , Conduct Disorder/psychology , Copper , Humans , Outcome Assessment, Health Care , Risk Factors
Intern Med ; 61(9): 1353-1359, 2022.
Article En | MEDLINE | ID: mdl-35491176

Objective This study assessed the risk factors of mortality from foreign bodies in the respiratory tract using the Japan Collaborative Cohort Study for the Evaluation of Cancer Risk data. Methods Data of 110,585 participants 40-79 years old living in 45 areas in Japan were collected between 1988 and 2009. Mortality from foreign bodies in the respiratory tract was assessed in a multivariable-adjusted analysis using a Cox proportional hazard regression model. Results Among all participants, 202 deaths occurred from foreign bodies in the respiratory tract. In the multivariable-adjusted model, older age [50-59 (hazard ratio, 4.93; 95% confidence interval, 1.91-12.74), 60-69 (hazard ratio, 14.96, 6.01-37.25) and 70-79 (hazard ratio, 53.81; 95% confidence interval, 21.44-135.02) years old compared to 40-49 years old], male sex (hazard ratio, 2.34; 95% confidence interval, 1.54-3.54), a history of apoplexy (hazard ratio, 7.04; 95% confidence interval, 4.24-11.67) and the absence of a spouse (hazard ratio, 1.56; 95% confidence interval, 1.05-2.32) were associated with an increased risk of mortality from foreign bodies in the respiratory tract. Conclusions Older age, male sex, medical history of apoplexy and the absence of a spouse were potential risk factors of mortality from foreign bodies in the respiratory tract. Especially in elderly men, social connections, such as cohabitation or relationships, may be important for ensuring the early detection of asphyxia and preventing death due to foreign bodies in the respiratory tract.

Foreign Bodies , Stroke , Adult , Aged , Aged, 80 and over , Cohort Studies , Humans , Japan/epidemiology , Male , Middle Aged , Respiratory System , Risk Factors , Young Adult
Rinsho Ketsueki ; 63(4): 277-285, 2022.
Article Ja | MEDLINE | ID: mdl-35491217

Thrombotic thrombocytopenic purpura (TTP) is an extremely rare and fatal thrombotic disorder characterized by impaired enzyme activity of von Willebrand factor cleaving protease, also known as ADAMTS13. Immune-mediated TTP (iTTP) is an acquired form of TTP caused by the production of auto-antibodies against ADAMTS13. The pathophysiology of autoimmune disorders is multifactorial, with several human leukocyte antigen (HLA) alleles identified as a genetic risk factor for autoimmune diseases known as susceptible HLA. In the early 2010s, three distinct European groups revealed that DRB1*11 is one of the most susceptible alleles in acquiring iTTP among Caucasians based on HLA typing data. Several in silico predictions for allele-restricted ADAMTS13 epitopes against T cells are made in this context, followed by an in vitro validation employing mass spectrometry using eluted peptides and T-cell assays. However, similar analyses in a genetically distinct Japanese population have not yet been conducted. We used next-generation sequencing to perform HLA typing for 52 Japanese patients with iTTP from 19 institutes. Our detailed analysis revealed that the specific allele DRB1*08:03 was identified as a genetic risk factor for iTTP in Japanese patients, but there were no statistically significant differences in the allele frequency of DRB1*11 between iTTP and healthy controls.

Purpura, Thrombotic Thrombocytopenic , Alleles , Disease Susceptibility/complications , Histocompatibility Testing/adverse effects , Humans , Purpura, Thrombotic Thrombocytopenic/genetics , Risk Factors
Cancer Discov ; 12(5): OF7, 2022 May 02.
Article En | MEDLINE | ID: mdl-35491632

Pre-hematopoietic stem cell transplantation (HSCT) chemotherapy creates a permissive niche in the brain for peripheral macrophage engraftment.

Hematopoietic Stem Cell Transplantation , Brain , Humans , Macrophages , Risk Factors
Ann Parasitol ; 68(1): 61-70, 2022.
Article En | MEDLINE | ID: mdl-35491672

The morbidity indicators and risk factors of urinary schistosomosis in school-age children were ascertained in three Senatorial Districts of Cross River State (CRS). A cross-sectional study conducted between April 2015 and March 2016. Seven hundred and seventy-seven (777) urine samples were randomly collected from selected children and examined for ova of Schistosoma haematobium, using a modified filtration system. Commercial reagent strips were employed for the detection of haematuria and proteinuria. Chi-square test was used to determine the statistical differences between the data in subgroups and the results from specimen examinations. S. haematobium ova was observed in 13 (1.7%) of the 777 participants examined. Ninety (11.6%) children showed haematuria, and 137 (17.6%) showed proteinuria. Infection varied significantly across the age-groups (P<0.05). Males 11 (2.4%) were more infected than females 2 (0.6%) (P<0.05). The age group 9-12 years accounted for the highest mean ova count (7.33±2.1) in urine samples analysed. Female participants had a higher mean ova count (7.50±0.71) than male participants (6.18±1.66). Age, gender and the habit of fetching water from streams were significant risk factors for urinary schistosomiasis. It is evident from this study that S. haematobium infection is still endemic in the three Senatorial Districts of CRS, despite periodic chemotherapy.

Hematuria , Rivers , Child , Cross-Sectional Studies , Female , Hematuria/diagnosis , Humans , Male , Morbidity , Nigeria/epidemiology , Prevalence , Proteinuria/diagnosis , Risk Factors
Front Public Health ; 10: 835092, 2022.
Article En | MEDLINE | ID: mdl-35493371

Background: This study aimed to investigate the Aspergillus species distribution, antifungal sensitivities, clinical characteristics, and risk factors of patients with invasive aspergillosis (IA) in a tertiary teaching hospital in Anhui Province. Methods: In the present study, 156 Aspergillus isolates were collected from patients admitted to a 2,800-bed comprehensive hospital between January 2019 and April 2021. The epidemiology of Aspergillus species was well-examined, and its antifungal susceptibility was specifically measured by the microbroth dilution method. The risk factors of patients with IA were documented and analyzed intensively. In addition, gene sequencing was employed to determine gene mutations of cytochrome P450 14-α sterol demethylase-Aspergillus (cyp51A) associated with azole resistance among Aspergillus fumigatus. Results: The Aspergillus species distribution was dominated by A. fumigatus (56.41%), Aspergillus flavus (20.51%), and Aspergillus niger (15.38%) locally. In particular, all Aspergillus species showed very low minimum inhibitory concentrations (MICs, ≤ 0.5 µg/ml) for azoles and echinocandins, slightly high MICs (1.66-2.91 µg/ml) for amphotericin B, and exceptionally high MICs (>64 µg/ml) for flucytosine. Azole-resistant rate of Aspergillus species in this local region reached up to 5.79%. Correlation analyses of multiple antifungals indicate a significant MIC relevance between isavuconazole and voriconazole (Pearson correlation coefficient was 0.81, P < 0.0001). The clinical risk factors for patients with IA were found primarily to be pulmonary diseases (P = 0.007) and patients' age (P < 0.001). Notably, three mutant loci (TR46/Y121F/T289A) of the cyp51A gene were identified in azole-resistant A. fumigatus. Conclusions: The Aspergillus species emerged increasingly, of which A. fumigatus and A. flavus remained the main pathogens for invasive Aspergillus infections in the local region. The vast majority of Aspergillus species exhibited good susceptibility to all the antifungals, except flucytosine. The local occurrence of azole-resistant Aspergillus species grew gradually and needed monitoring in time. Pulmonary diseases and age were likely considered as highly associated risk factors for IA. To our knowledge, the clinically isolated azole-resistant A. fumigatus with TR46/Y121F/T289A mutations identified here were rarely reported in the area of China.

Aspergillosis , Lung Diseases , Antifungal Agents/pharmacology , Aspergillosis/drug therapy , Aspergillosis/epidemiology , Aspergillosis/microbiology , Aspergillus fumigatus/genetics , Azoles/pharmacology , Drug Resistance, Fungal/genetics , Flucytosine , Fungal Proteins/genetics , Humans , Risk Factors
J Diabetes Res ; 2022: 2590415, 2022.
Article En | MEDLINE | ID: mdl-35493606

Both gestational diabetes mellitus (GDM) and pregnancy-induced hypertension (PIH) would influence the gestation significantly. However, the causation between these two symptoms remains speculative. 16,404 pregnant women were identified in Harbin, China, in this study. We investigated and evaluated the causal effect of GDM on PIH based on the Bayes conditional probability. The statistical results indicated that PIH might cause GDM, but not vice versa. Also, this case study demonstrated that the decrease temperature might also cause hypertension during pregnancy, and the prevalence rate of GDM increased with age. However, the prevalence of diabetes did not show a remarkable difference in varied areas and ages. This study could provide some essential information that will help to investigate the mechanism for GDM and PIH.

Diabetes, Gestational , Hypertension, Pregnancy-Induced , Bayes Theorem , China/epidemiology , Diabetes, Gestational/epidemiology , Female , Humans , Hypertension, Pregnancy-Induced/epidemiology , Hypertension, Pregnancy-Induced/etiology , Pregnancy , Risk Factors