1.
Org Biomol Chem
; 12(35): 6794-9, 2014 Sep 21.
Artículo
en Inglés
| MEDLINE
| ID: mdl-25065821
RESUMEN
α-Helix mediated protein-protein interactions are of major therapeutic importance. As such, the design of inhibitors of this class of interaction is of significant interest. We present methodology to modify N-alkylated aromatic oligoamide α-helix mimetics using 'click' chemistry. The effect is shown to modulate the binding properties of a series of selective p53/hDM2 inhibitors.