[Baroreflexes originated in vertebral artery zones upon peripheral vein tonus, systemic arterial blood pressure, and external respiration].

The investigation was intended to study the role ofbaroreceptors ofhemodynamically isolated zone of vertebral arteries in regulation of peripheral veins tonus, arterial pressure and external respiration. Pressure decrease in this vascular reflexogenic zone led to reflex responses of increase in femoral vein tonus, elevation of blood pressure level and stimulation of external respiration. The opposite reflex responses of cardio-respiratory functional system to initial pressure activation of vertebral arteries baroreceptors are observed. Basing on generalization of our own findings and similar physiological and morphological researches of other authors, it is established that afferentation from the vertebral artery zone is a reflexogenic factor of somatic muscles' veins tonus regulation. These reflexes of capacity vessels tonic activity changes are part of cardio-respiratory responses of maintaining the tissue gaseous exchange.

[Hypoxic training -- effective method of raising skin vitality in cases of local plastic operations].

In spite of the complications after expander use the advantages of local plastics predetermine constant return to the method. Systemic use of hypoxic training produces stimulating effect on the skin microcirculation and can be used widely in clinical surgical practice in cases of local plastic operations to prevent possible complications reducing consequences of blood supply disturbance and tissue oxygen provision. The method of hypoxic adaptation let us receive as non-medicamentous mean to prepare for shorter period of time more vital flap.

[The effect of phonational load on parameters of cardiorespiratory system in hypotonic dysphonia].

Cardiointervalometry was used to investigate functional parameters of the cardiorespiratory system during text reading. A total of healthy women aged from 17 to 28 years and 11 women with hypotonic dysphonia 17 to 31 years of age entered the study. Both groups exhibited a low index of parasympathetic component of cardiorhythm regulation in shortening of the RR-interval. Correlation inhalation/expiration has changed with prolongation of inhalation and shortening of expiration in reading in women suffering from hypotonic dysphonia. Parameters of the respiratory cycle at rest did not correlate with relevant parameters in reading text in both groups.

[Desynchronization: mechanisms of development from molecular to systemic levels]. / Desinkhronoz: mekhanizmy razvitiia ot molekuliarno-geneticheskogo do organizmennogo urovnia.

Striking progress in the field of molecular chronobiology has been made during the last years. It renders us to reconsider some traditional viewpoints concerning circadian system functioning. Not only we are able now to explain basic concept of how clock genes pass through transcriptional and post-transcriptional pathways and how circadian system eventually "comes to life" at the cellular level, but we are also in position to speculate on how the whole organism constitutes its space-temporal order and how certain ultradians and infradians could be generated. Herein we propose a concept of multifuctorial genesis of chronomes and suggest terms such as "input rhythm" (or influencing rhythm) and "output rhythm" (or modulated rhythm). We stress on a viewpoint that the majority of investigated variables are multifuctorial by its nature because of vast net of regulatory mechanisms lied down in between the molecular basis of the clock and the output rhythms which are actually measurable by investigators. An attempt to follow down mechanisms of loss in the circadian temporal order (desynchronization) from the molecular level to that of a whole organism has been provided.

[Classification of hypoxia, hypo-, and hypercapnia]. / Klassifikatsii gipoksicheskikh, gipo- i giperkapnicheskikh sostoianii.

The new classifications of hypoxical, hypo- and hypercapnical conditions are elaborated. They take into account the ecological factors in the development of various kinds of exogenic hypoxia, hypercapnia. For the first time the positive sides of physiological hypoxia and hypercapnia are brought in. In all classification til the last days hypoxia was considered as pathological process only. However hypoxia can be met in different physiologic conditions of organism: internal period of fetus development, hard physical work, increased sportsmen activity, hypoxia after hearty meal, hypoxia of aged organism. The same it is possible to say about the hypo- and hypercapnical conditions.

[Role of carotid chemoreceptors in formation of adaptive reactions in animals]. / Rol' karotidnykh khemoretseptorov v formirovanii adaptivnykh reaktsii zhivotnykh.

After surgical denervation of sinocarotid reflexogenic zones and bilateral glomectomy in white laboratory rats oxygen consumption, rectal temperature, rate of cardial contractions and thermoregulatory activity of skeletal muscles display authentic increase. Glomectomy results in decreasing calorigecic effect of noradrenaline. Compensatory increase of thermoregulatory activity of sceletal muscles in response to beta-adrenogenic blocade with inderal in post-glomectomic animals is authentically less, than before inactivation of carotid receptors. In animals after carotid glomectomy resistance to acute hypoxia is clearly reduced. True reduction of number of erythrocytes, of hemoglobin concentration, of hematocrite parameter in post glomectic animals was found, which indicates anemisation phenomena. It was found that glomectomy after adaptation of animals in the mountains of Tien Shan at the height of 3200 m during 30 days didn't substantively change resistance to acute hypoxia. Resistance to acute hypoxia of animals living on mountains (susliks, marmots) is higher than of animals living on plains. Glomectomy performed on animals living on mountain resulted in an insignificant decrease in resistance to acute hypoxia. Resistance to acute hypoxia in postglomectic animals was found to be directly linked with absolute amount of hemoglobin concentration and erythrocyte number. In that way denervation of sinocarotid reflexogenic zones and bilateral glomectomy is an adequate method of comparative research of functions regulation mechanism during formation of adaptive responses in animals in dependence of various factors of external environment in norm, as well, as in pathology.

[Electrophysiological and neurochemical analysis of the biological effects of disturbances of Earth's magnetic field]. / Elektrofiziologicheskii i neirokhimicheskii analiz biologicheskikh éffektov vozmushchenii magnitnogo polia Zemli.

Geomagnetic effects on quantitative characteristics of alpha-rhythm were assessed by shifts in electroencephalograms recorded in 126 essentially healthy human subjects and changes in lipid metabolism in the cortex and white matter in 140 white rats. Indices of the geomagnetic activity were D, H and Z-components. The method of "epoch superposition" revealed an inconsistent alpha-rhythm depression and flattening out of the interhemispheric functional asymmetry against persistently high electrical activity in the right hemisphere, and biochemical asymmetry in consequence of different lipid transformation processes. Spotlighted were some nonspecific adaptive reactions to changes in the environment and stressful agents.

[Specific aspects of hemostasis and lipid peroxidation in thrombocyte membranes during expedition and shift organization of labor]. / Osobennosti distemy gemostaza i perekisnogo okisleniia lipidov membran trombotsitov pri ékspeditsionno-vakhtovoi organizatsii truda.

The aim of the present study is to investigate dynamics of the hemostasis system and structural and functional state of thrombocyte membranes by the LPO and AOD parameters under the conditions of expedition and shift organization of labour of worker tripping from the West Siberia middle latitudes to the Far North. A trend to hypocoagulemia and increases in LPO and AOD reactions were characteristic of the type-1 (adaptive) reaction. The type-2 (hypotensive) reaction included a trend to hypercoagulemia, an increase in LPO and a decrease in AOD reactions in thrombocyte membranes as well as a hypertensive reaction during the whole shift period. The type-3 (asthenic) reaction was described by hypocoagulemia, an increase in the amount of LPO products with a simultaneous decrease in the AOD activity and asthenic sleep disturbance.

[Influence of geomagnetic activity on the cardiorespiratory system in healthy humans]. / Vliianie geomagnitnoi aktivnosti na kardiorespiratonuiu sistemu zdorovykh lits.

Changes in a number of respiration and circulation parameters during magnetic storms of varying intensity were analyzed in 126 normal humans belonging to two age groups: 19-21 yr. old young men and women (29 of each) and 51-53 yr. old men (n = 36) and women (n = 32). Geomagnetic components D, H and Z were used. Systolic pressure, respiration volume, minute respiration volume and peak expiration rate were shown to be the most labile characteristics of the cardiorespiratory system responding by increases on magnetodisturbed days. The parameters under study exhibited sexual and age differences equally on quiescent and magnetodisturbed days. Adaptation to growing tension of the magnetic field of Earth involves the neuroendocrine system and manifests itself by activation of the sympathetic nervous system entailing relative shifts in the cardiorespiratory parameters under study.