Management of ectopic intestinal variceal bleeding following pancreatic transplant: Two cases.

Ectopic variceal bleeding is a potentially under recognized source of gastrointestinal (GI) hemorrhage. While vascular complications following pancreatic transplant are relatively common, the development of symptomatic ectopic venous varices has rarely been reported. We report two patients with a remote history of simultaneous kidney pancreas transplant (SPK) presenting two decades after transplant with an occult GI bleed. In both cases, a lengthy diagnostic course was required. The varices were treated with coil embolization via transhepatic approach. Our findings add to the limited literature on this topic and aid in the recognition, diagnosis, and management of this unusual presentation.

Biomass-Derived Provenance Dominates Glacial Surface Organic Carbon in the Western Himalaya.

The origin, transport pathway, and spatial variability of total organic carbon (OC) in the western Himalayan glaciers are poorly understood compared to those of black carbon (BC) and dust, but it is critically important to evaluate the climatic role of OC in the region. By applying the distribution of OC activation energy; 14C activity; and radiogenic isotopes of 208Pb/204Pb, 207Pb/204Pb, and 206Pb/204Pb in glacial debris and atmospheric particulate matter (PM10 size fraction), we demonstrate that 98.3 ± 1.6 and 1.7 ± 1.6% of OC in western Himalayan glaciers are derived from biomass and petrogenic sources, respectively. The δ13C and N/C composition indicates that the biomass is a complex mixture of C3 vegetation and autochthonous photoautotrophic input modified by heterotrophic microbial activity. The data set reveals that the studied western Himalayan glacier has negligible contributions from fossil-fuel-derived particles, which contrasts to the central and eastern Himalayan glaciers that have significant contributions from fossil fuel sources. We show that this spatial variability of OC sources relates to regional differences in air mass transport pathways and precipitation regimes over the Himalaya. Moreover, our observation suggests that biomass-derived carbon could be the only primary driver of carbon-induced glacier melting in the western Himalaya.

Conceptual Design of a Body Bag for Preventing Infections and Safe Disposal of Deceased from COVID-19 Virus.

The Covid-19 virus pandemic is leading to a large number of deaths. There are forecasts that there will be an exponential increase in the number of such deaths across the globe because of this deadly virus. To arrest the spread of the virus in this situation, the supply of medical materials including PPE and body bags (also known as human remains pouch or cadaver bag) should be designed to stop the spread of the Covid-19 virus. Conventional body bags have shortcomings, which need to be addressed by a refined redesigning and use of appropriate materials to adequately match the requirements in the current Covid-19 situation. Current designs of the body bags do not allow the family member's sentiments towards the deceased and to cater to the desire of the family members to view the face of the deceased without exposing them to a strong possibility of infection from the cadaver. This is, therefore, a very traumatic experience to the family and in many cases, the cadaver is not handled with respect due to the unavailability of safe design body bags, which also exposes health workers to avoidable risk from the infections. Technopark@iitk has proposed an integrated 5-layer body bag to tackle this situation for Covid-19 deceased such that it is (1) leak-proof, (2) impermeable/water-proof, (3) strong enough for the purpose, (4) ergonomically designed, and (5) has provision to view the face of the dead body for family viewing before cremation/burial. This new design would keep the handling of the deceased body to a minimum during transportation from the hospital/site of death to a mortuary, and then to the home of the deceased/burial ground/crematorium, where it may be disposed-off along with the body in it, in a respectable manner, without putting people involved to the risk of infection.

Development of Autonomous Advanced Disinfection Tunnel to Tackle External Surface Disinfection of COVID-19 Virus in Public Places.

This paper describes a robust autonomous disinfection tunnel to disinfect external surfaces of COVID-19 virus such as clothes and open body sections in public places such as airports, office complexes, schools, and malls. To make the tunnel effective and highly efficient, it has been provided with two chambers with three disinfection processes. Due to the multiple processes, the possibility of neutralizing the virus is quite high and higher than other solutions available at this point for this purpose. Chamber 1 sprays the solution of a disinfectant on the person. This solution can be either a dilute solution of approved chemical or any Ayurvedic/herbal disinfectant. Once the person enters chamber 2, he/she is exposed to hot air at 70 °C along with far-ultraviolet C rays (207-222 nm). Both chambers function autonomously by detecting a person in a chamber using ultrasonic sensors. The proposed tunnel is developed under industry-academia collaboration jointly by Technopark@iitk and ALIMCO under the ambit of the Ministry of Human Resources Development and the Ministry of Social Justice and Empowerment, respectively. The tunnel is referred to as the 'Techno Advanced Disinfection Tunnel' (TADT).

Design and Development of a Portable Disinfectant Device.

With over 7 million people infected globally and over 5 lakh deaths reported worldwide by COVID-19 virus, World Health Organization (WHO) has declared it as a pandemic. India is also suffering badly because of the current crisis, with more than 4 lakh people infected and 13000 deaths reported as on 20th June 2020. There is no respite in sight as of now as the numbers continue to increase exponentially with each passing day. The only possible control to the virus is the availability of a vaccine, which will take a few months to be available to masses. Till then, the global economy has to start reopening slowly with several precautionary measures in place as advised by the WHO, such as mandatory wearing of masks in public places, frequent hand washing, practising good personal hygiene, and social distancing. Recently, the government of India (GoI) has also opened its economy with all the precautionary measures in place. Disinfecting of places of work, modes of transport, hospitals, and common areas is emerging as a mammoth challenge. With the objective of arresting the spread of COVID-19 virus and providing an efficient solution to the above problem, a portable disinfectant device is designed. Undertaken as an Industry-academia collaboration, it is a joint initiative between Technopark@iitk (IIT Kanpur Research and Technology Park) and Industry. The novelty of this device lies in its innovative design that combines spraying of sanitising liquid and UV light-based disinfection methodologies. For this, the device uses two separate disinfection systems: (1) the pump-nozzle assembly for spraying the disinfectant, and (2) UV-C radiations to increase the virus kill efficiency.

Toxicity and mutagenicity of exhaust from compressed natural gas: Could this be a clean solution for megacities with mixed-traffic conditions?

Despite intensive research carried out on particulates, correlation between engine-out particulate emissions and adverse health effects is not well understood yet. Particulate emissions hold enormous significance for mega-cities like Delhi that have immense traffic diversity. Entire public transportation system involving taxis, three-wheelers, and buses has been switched from conventional liquid fuels to compressed natural gas (CNG) in the Mega-city of Delhi. In this study, the particulate characterization was carried out on variety of engines including three diesel engines complying with Euro-II, Euro-III and Euro-IV emission norms, one Euro-II gasoline engine and one Euro-IV CNG engine. Physical, chemical and biological characterizations of particulates were performed to assess the particulate toxicity. The mutagenic potential of particulate samples was investigated at different concentrations using two different Salmonella strains, TA98 and TA100 in presence and absence of liver S9 metabolic enzyme fraction. Particulates emitted from diesel and gasoline engines showed higher mutagenicity, while those from CNG engine showed negligible mutagenicity compared to other test fuels and engine configurations. Polycyclic aromatic hydrocarbons (PAHs) adsorbed onto CNG engine particulates were also relatively fewer compared to those from equivalent diesel and gasoline engines. Taken together, our findings indicate that CNG is comparatively safer fuel compared to diesel and gasoline and can offer a cleaner transport energy solution for mega-cities with mixed-traffic conditions, especially in developing countries.

Emissions from diesel versus biodiesel fuel used in a CRDI SUV engine: PM mass and chemical composition.

The diesel tailpipe emissions typically undergo substantial physical and chemical transformations while traveling through the tailpipe, which tend to modify the original characteristics of the diesel exhaust. Most of the health-related attention for diesel exhaust has focused on the carcinogenic potential of inhaled exhaust components, particularly the highly respirable diesel particulate matter (DPM). In the current study, parametric investigations were made using a modern automotive common rail direct injection (CRDI) sports utility vehicle (SUV) diesel engine operated at different loads at constant engine speed (2400 rpm), employing diesel and 20% biodiesel blends (B20) produced from karanja oil. A partial flow dilution tunnel was employed to measure the mass of the primary particulates from diesel and biodiesel blend on a 47-mm quartz substrate. This was followed by chemical analysis of the particulates collected on the substrate for benzene-soluble organic fraction (BSOF) (marker of toxicity). BSOF results showed decrease in its level with increasing engine load for both diesel and biodiesel. In addition, real-time measurements for organic carbon/elemental carbon (OC/EC), and polycyclic aromatic hydrocarbons (PAHs) (marker of toxicity) were carried out on the diluted primary exhaust coming out of the partial flow dilution tunnel. PAH concentrations were found to be the maximum at 20% rated engine load for both the fuels. The collected particulates from diesel and biodiesel-blend exhaust were also analyzed for concentration of trace metals (marker of toxicity), which revealed some interesting results.