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Stormwater runoff contains dissolved organic carbon (DOC) and potentially toxic elements (PTEs). Interactions between DOC and PTEs can impact PTE speciation and mobility, but are not fully understood. Soil samples were collected from a vegetated bioretention bed to investigate the effects of DOC (0, 15, and 50 mg-C/L) on the desorption of 10 PTEs captured by the soil media: Mn, Fe, Co, Cu, Zn, As, Cd, Sn, Sb, and Pb. In the absence of DOC, the desorbed PTE concentration from bioretention media into the aqueous phase ranking was as follows: Fe > Mn â¼ Zn > Cu > Pb > Sb > As > Co > Sn â¼ Cd. Increased DOC concentrations resulted in a reduction of the soil-water distribution coefficient (Kd) values. The greatest shift in Kd was observed for Cu and lowest for Sb. The PTE sorption capacities were lower for surficial soil samples (lower Kd) compared to the deep soil samples. Overall, the desorbed PTE (average midchannel 55.7 µg/g) fraction accounted for <1.1 % of the total extracted PTEs (5364 µg/g), and while this is a small percentage of the total, this is the fraction that is mobile. The extracted PTE fractions revealed that DOC reduced the organic matter-bound and carbonate-bound fractions. The PTE desorption trends suggest that reducing DOC in stormwater runoff could be an effective measure to mitigate the release of PTEs into the environment.
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Mechanical analysis of the stress and strains developed in the coils were calculated for a ten coil 1.5 T MRI magnet design with magnesium diboride (MgB2) wire protected with Coupling Loss Induced Quench (CLIQ). The temperature distribution inside the coils was first simulated in MATLAB to solve the governing heat and circuit equations. Simulations were performed on the magnet, in which each coil was divided into two subsections, with two CLIQ units while the capacitor ranged from 5 to 20 mF and the initial charging voltage ranged from 2.6 kV to 1.3 kV in order to keep the total stored energy in the CLIQ system constant. The wire's filamentary twist pitch remained constant at 5 cm for all simulations. The exported temperature distribution was expanded to form a representative unit cell (RUC) representing the wire composite and then imported into ANSYS to calculate the 1st principle strain in the MgB2 filament and shear stress across the epoxy for the coils. A peak temperature of 191 K occurred inside the coil with the initial quench when the CLIQ unit had a 20 mF capacitor charged to 1.3 kV. According to the mechanical simulations, the largest resulting peak strain in the wire was 0.034%, and peak shear stress was 44 MPa.
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Conceptual designs of 1.5 and 3.0 T full-body magnetic resonance imaging (MRI) magnets using conduction cooled MgB2 superconductor are presented. The sizes, locations, and number of turns in the eight coil bundles are determined using optimization methods that minimize the amount of superconducting wire and produce magnetic fields with an inhomogeneity of less than 10 ppm over a 45 cm diameter spherical volume. MgB2 superconducting wire is assessed in terms of the transport, thermal, and mechanical properties for these magnet designs. Careful calculations of the normal zone propagation velocity and minimum quench energies provide support for the necessity of active quench protection instead of passive protection for medium temperature superconductors such as MgB2. A new 'active' protection scheme for medium Tc based MRI magnets is presented and simulations demonstrate that the magnet can be protected. Recent progress on persistent joints for multifilamentary MgB2 wire is presented. Finite difference calculations of the quench propagation and temperature rise during a quench conclude that active intervention is needed to reduce the temperature rise in the coil bundles and prevent damage to the superconductor. Comprehensive multiphysics and multiscale analytical and finite element analysis of the mechanical stress and strain in the MgB2 wire and epoxy for these designs are presented for the first time. From mechanical and thermal analysis of our designs we conclude there would be no damage to such a magnet during the manufacturing or operating stages, and that the magnet would survive various quench scenarios. This comprehensive set of magnet design considerations and analyses demonstrate the overall viability of 1.5 and 3.0 T MgB2 magnet designs.
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The spatial organization of membrane-bound ligands is thought to regulate receptor-mediated signaling. However, direct regulation of receptor function by nanoscale distribution of ligands has not yet been demonstrated, to our knowledge. We developed rationally designed DNA origami nanostructures modified with ligands at well-defined positions. Using these 'nanocalipers' to present ephrin ligands, we showed that the nanoscale spacing of ephrin-A5 directs the levels of EphA2 receptor activation in human breast cancer cells. Furthermore, we found that the nanoscale distribution of ephrin-A5 regulates the invasive properties of breast cancer cells. Our ligand nanocaliper approach has the potential to provide insight into the roles of ligand nanoscale spatial distribution in membrane receptor-mediated signaling.
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Nanotecnología , Receptores de Superficie Celular/metabolismo , Endocitosis , LigandosRESUMEN
When a breast lump is detected through palpation, mammography or ultrasonography, the final test for characterization of the tumour, whether it is malignant or benign, is biopsy. This is invasive and carries hazards associated with any surgical procedures. The present work was undertaken to study the feasibility for such characterization using non-invasive electrical impedance measurements and machine learning techniques. Because of changes in cell morphology of malignant and benign tumours, changes are expected in impedance at a fixed frequency, and versus frequency of measurement. Tetrapolar impedance measurement (TPIM) using four electrodes at the corners of a square region of sides 4 cm was used for zone localization. Data of impedance in two orthogonal directions, measured at 5 and 200 kHz from 19 subjects, and their respective slopes with frequency were subjected to machine learning procedures through the use of feature plots. These patients had single or multiple tumours of various types in one or both breasts, and four of them had malignant tumours, as diagnosed by core biopsy. Although size and depth of the tumours are expected to affect the measurements, this preliminary work ignored these effects. Selecting 12 features from the above measurements, feature plots were drawn for the 19 patients, which displayed considerable overlap between malignant and benign cases. However, based on observed qualitative trend of the measured values, when all the feature values were divided by respective ages, the two types of tumours separated out reasonably well. Using K-NN classification method the results obtained are, positive prediction value: 60%, negative prediction value: 93%, sensitivity: 75%, specificity: 87% and efficacy: 84%, which are very good for such a test on a small sample size. Study on a larger sample is expected to give confidence in this technique, and further improvement of the technique may have the ability to replace biopsy.
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Inteligencia Artificial , Neoplasias de la Mama/clasificación , Neoplasias de la Mama/patología , Análisis por Conglomerados , Impedancia Eléctrica , Electrodos , Femenino , HumanosRESUMEN
We report the first few-mode compatible optical add/drop multiplexer (OADM) that enables add/drop functionality for mode division multiplexed (MDM) superchannels. The OADM is comprised of two cascaded free-space thin-film filters with 5° incident angle. The transmission of MDM superchannel CO-OFDM signals via the OADM is investigated. The experimental result shows that the OSNR penalties for add, drop and through ports are 2.6, 2.4, 0.7 dB, respectively for 3x318 Gb/s superchannels.
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Dispositivos Ópticos , Procesamiento de Señales Asistido por Computador/instrumentación , Telecomunicaciones/instrumentación , Diseño Asistido por Computadora , Diseño de Equipo , Análisis de Falla de EquipoRESUMEN
We report successful transmission of dual-LP(11) mode (LP(11a) and LP(11b)), dual polarization coherent optical orthogonal frequency-division multiplexing (CO-OFDM) signals over two-mode fibers (TMF) using all-fiber mode converters. Mode converters based on mechanically induced long-period grating with better than 20 dB extinction ratios are realized and used for interfacing single-mode fiber transmitter and receivers to the TMF. We demonstrate that by using 4×4 MIMO-OFDM processing, the random coupling of the two LP(11) spatial modes can be successfully tracked and equalized with a one-tap frequency-domain equalizer. We achieve successful transmission of 35.3 Gb/s over 26-km two-mode fiber with less than 3 dB penalty.
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In addition to the dimensions of time, frequency, complex constellation, and polarization, spatial mode can be the fifth dimension to be explored for modulation and multiplexing in optical fiber communications. In this paper, we demonstrate successful transmission of 107-Gb/s dual-mode and dual-polarization coherent optical orthogonal frequency-division multiplexing (CO-OFDM) over a 4.5-km two-mode fiber. A mechanically-induced LP01/LP11 mode converter is used as the mode selective element in a spatial-mode multiplexed system.
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Tecnología de Fibra Óptica/instrumentación , Refractometría/instrumentación , Procesamiento de Señales Asistido por Computador/instrumentación , Telecomunicaciones/instrumentación , Diseño Asistido por Computadora , Diseño de Equipo , Análisis de Falla de EquipoRESUMEN
High-order modulation formats and advanced error correcting codes (ECC) are two promising techniques for improving the performance of ultrahigh-speed optical transport networks. In this paper, we present record receiver sensitivity for 107 Gb/s CO-OFDM transmission via constellation expansion to 16-QAM and rate-1/2 LDPC coding. We also show the single-channel transmission of a 428-Gb/s CO-OFDM signal over 960-km standard-single-mode-fiber (SSMF) without Raman amplification.
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Microondas , Fibras Ópticas , Telecomunicaciones/instrumentación , Diseño de Equipo , Procesamiento de Señales Asistido por ComputadorRESUMEN
Transmitter and receiver IQ imbalance causes image interference that degrades performance in high capacity and high spectral efficiency optical orthogonal frequency division multiplexing (OFDM) schemes. Digital compensation is an attractive method to relax component specifications. In this paper we report the details of a hybrid compensation method for IQ imbalance compensation, comprising of orthogonal training symbol-based method for transmitter-side compensation and an iterative image reduction-based method for receiver-side imbalance compensation. We demonstrate performance improvement using the hybrid method in presence of frequency dependent imbalance by both simulation and back-to-back direct detection optical OFDM experiment. We report on the tolerable limit of transmitter IQ imbalance under presence of carrier frequency offset.