The Profuse Bleeding Potential of Orbital Epithelioid Hemangioendotheliomas.

Epithelioid hemangioendothelioma is a rare vascular tumor originating from vascular endothelial or pre-endothelial cells. We present the case of a 4-month-old male with a rapidly enlarging left zygomatico-orbital tumor causing mass effect on the eye globe. Examination revealed a large, nontender, solid lesion. CT angiography showed no major feeder or intralesional vessels. Complete surgical excision was performed, which was complicated by life-threatening intraoperative bleeding and successfully controlled with electrocautery. Microscopically, tumor cells exhibited varying morphologies. Immunohistochemistry confirmed the diagnosis of epithelioid hemangioendothelioma (positive for CD31 and CD34, negative for CK AE1/AE3). We also highlight 2 similar case reports with life-threatening bleeding complications. Surgeons should be aware of this condition and optimize surgical preparation, including blood products, to manage potential bleeding complications.

Airway reconstruction: review of an approach to the advanced-stage laryngotracheal stenosis.

INTRODUCTION: The management of laryngotracheal stenosis is complex and is influenced by multiple factors that can affect the ultimate outcome. Advanced lesions represent a special challenge to the treating surgeon to find the best remedying technique. OBJECTIVE: To review the efficacy of our surgical reconstructive approach in managing advanced-stage laryngotracheal stenosis treated at a tertiary medical center. METHODS: A retrospective review of all patients that underwent open laryngotracheal repair/reconstruction by the senior author between 2002 and 2014. Patients with mild/moderate stenosis (e.g. stage 1 or 2), or those who had an open reconstructive procedure prior to referral, were excluded. Patients who had only endoscopic treatment (e.g. laser, balloon dilatation) and were not subjected to an open reconstructive procedure at our institution, were not included in this study. Variables studied included patient demographics, clinical presentation, etiology of the laryngotracheal pathology, the location of stenosis, the stage of stenosis, the type of corrective or reconstructive procedure performed with the type of graft used (where applicable), the type and duration of stent used, the post-reconstruction complications, and the duration of follow-up. Outcome measures included decannulation rate, total number of reconstructive surgeries needed to achieve decannulation, and the number of post-operative endoscopies needed to reach a safe patent airway. RESULTS: Twenty five patients were included, aged 0.5 months to 45 years (mean 13.5 years, median 15 years) with 16 males and 9 females. Seventeen patients (68%) were younger than 18 years. Most patients presented with stridor, failure of decannulation, or respiratory distress. Majority had acquired etiology for their stenosis with only 24% having a congenital pathology. Thirty-two reconstructive procedures were performed resulting in decannulating 24 patients (96%), with 15/17 (88%) pediatric patients and 5/8 (62.5%) adult patients requiring only a single reconstructive procedure. Cartilage grafts were mostly used in children (84% vs. 38%) and stents were mostly silicone made, followed by endotracheal tubes. The number of endoscopies required ranged from 1 to 7 (mean 3). More co-morbidities existed in young children, resulting in failure to decannulate one patient. Adult patients had more complex pathologies requiring multiple procedures to achieve decannulation, with grafting less efficacious than in younger patients. The pediatric patients had double the incidence of granulation tissue compared to adults. The decannulated patients remained asymptomatic at a mean follow-up of 50.5 months. CONCLUSION: The review of our approach to open airway repair/reconstruction showed its efficacy in advanced-stage laryngotracheal stenosis. Good knowledge of a variety of reconstructive techniques is important to achieve good results in a variety of age groups.

Inverted papilloma of the ethmoid sinus Case report and review of the literature.

Importance: Description of a primary inverted papilloma of the ethmoid sinus. This has never been documented before in the literature. Observation: The clinical presentation, along with the radiographic features, gross findings and management will be discussed. Conclusions and Relevance: In contrast to the vast majority of cases that present with nasal complaints, the clinical presentation of an inverted papilloma confined to the ethmoid sinus was incidental. Radiologic findings are nonspecific. Functional endoscopic sinus surgery with total removal of the mass is the therapy of choice to reach a final pathologic diagnosis, prevent recurrence and other sequelae.

Laryngeal findings and acoustic changes in light cigar smokers.

UNLABELLED: The aim of this prospective study was to look at the laryngeal findings and acoustic changes in light cigar smokers in comparison to nonsmokers, in the setting of a voice clinic. A total of 22 cigar smokers and 19 nonsmokers used as controls were enrolled in the study. Demographic data included age, number of years smoking, number of cigars per week, history of allergy, and history of reflux. The confounding effects of allergy and reflux were accounted for in the control group. Subjects underwent laryngeal endoscopy and acoustic analysis. On laryngeal endoscopy, the most common laryngeal finding was thick mucus. There was no significant difference in the prevalence of any of the laryngeal findings in cigar smokers vs. CONTROLS: In comparison with the control group, both the fundamental frequency and habitual pitch were significantly lower in cigar smokers (p value = 0.034 and 0.004, respectively). We conclude that cigar smokers have lower fundamental frequency and habitual pitch compared to nonsmokers.

Submucosal resection of a microcystic oropharyngeal lymphatic malformation using radiofrequency ablation.

Lymphatic malformations (LMs) are uncommon congenital anomalies noted to have a prevalence of 1 per 5000 births and comprise roughly 6% of all pediatric soft tissue lesions. Recently radiofrequency ablation has been described as a surgical option for the treatment microcystic LMs in the oral cavity, more specifically the tongue. The following case describes the use of radiofrequency ablation for the submucosal removal of a large obstructing pharyngeal LM in a 4-year-old female. The mucosal sparing approach and surgical method of extirpation are discussed in detail. To the authors' knowledge this is the first description of a submucosal coblation technique being used as treatment for pharyngeal LMs.

Formant frequency in relation to body mass composition.

OBJECTIVES: This study examines the relationship between total body mass composition and vowel formant frequency and formant dispersion in men. METHODS: A total of 60 healthy male volunteers were recruited. Formant frequencies and dispersions of F1, F2, F3, and F4 for the vowels /ɑː/ and /iː/ were determined using spectrographic analysis. RESULTS: The mean height and weight were 179.17 cm and 80.53 kg, respectively, with fat-free weight averaging to 67.02 kg (65.5% in the extremities vs 16.7% in the trunk). The body mass index (BMI) was 25.5 ± 3.34 kg/m(2). For the vowel /ɑː/, F1 and F4 correlated poorly with weight and trunk fat-free mass. There was also a poor negative correlation between F4 and muscle mass and body fat-free mass (r < 0.36). For the /iː/ vowel, there was a weak negative correlation between F2, F3, and F4 and height (r = -0.260, -0.299, and -0.320, respectively). Similarly, there was a negative correlation between F2 and muscle mass, trunk fat-free mass, and body fat-free mass (r = -0.291, -0.276, and -0.272, respectively). For the vowel /ɑː/, F1-F2 interspace correlated positively with fat weight, fat mass in the extremities, and trunk (r = 0.313, 0.350, and 0.264, respectively), whereas F2-F3 negatively correlated with weight (r = -0.255). For the /iː/ vowel, only F1-F2 negatively correlated with weight and BMI (r = -0.297 and -0.281). CONCLUSION: There is no significant correlation between body mass composition, formant frequencies, and dispersions. All the correlations were poor with r values less than 0.36.

The effect of snoring on voice: a controlled study of 30 subjects.

We conducted a study to determine the prevalence of vocal symptoms in snorers. A total of 30 patients with a history of snoring were investigated for the presence or absence of three vocal symptoms immediately after they awoke from sleep: hoarseness, voice weakness, and other changes in voice quality. All patients were also asked to complete a voice-related quality-of-life (V-RQOL) questionnaire. Findings were compared with those of an age- and sex-matched control group of 30 nonsnorers. The most common vocal symptom in the snoring group was hoarseness, which occurred in 11 patients (36.7%); voice weakness and other voice quality changes were present in 8 snorers each (26.7%). In the control group, the most common vocal symptom was voice weakness, which was present in 7 subjects (23.3%); 5 controls (16.7%) experienced other changes in voice quality, and 3 controls (10.0%) experienced hoarseness. The difference between the prevalence of hoarseness in the two groups was statistically significant (p = 0.030), and the differences in voice weakness and other voice quality changes were not. The mean V-RQOL score was 87.50 ± 26.89 in the snoring group and 96.00 ± 5.82 in the control group-again, not a statistically significant difference. Finally, we found no association between any of the three vocal symptoms and the prevalence of mouth breathing, the level of snoring loudness, and the mean number of snores per minute. We conclude that snorers are more likely to experience hoarseness than are nonsnorers.

Relationship between acoustic parameters and body mass analysis in young males.

PURPOSE: To analyze the correlation between acoustic parameters and body height, weight, and mass composition in young males. MATERIAL: A total of 40 male subjects were included in this study. Each subject underwent acoustic analysis using the Kay Elemetric VISI Pitch (Model 3300, KayPentax, Lincoln Park, NJ) and complete body mass analysis. Pearson correlation was calculated to estimate the strength of the relationship between acoustic parameters and each of the weight analysis variables. RESULTS: The mean age of the male subjects was 24 years with a range between 18 and 40 years. The average weight and height were almost 80 and 180cm, with standard deviation (SD) of 7.42 and 10.46, respectively. The fat weight ranged between 3 and 25kg, with the main concentration being in the extremities, 61.84%±17.4 and less concentrated in the trunk, 16.20% ± 7.6. The mean fundamental frequency was 120.13Hz with an SD of 19.16Hz. The mean Habitual Pitch was 114.16Hz with an SD of 16.55Hz. There was no significant correlation between the acoustic parameters and any of the body composition variables, in particular fat weight and distribution. There was a weak correlation between Shimmer, trunk fat (r value=0.328, P=0.039), and muscle mass (r value=0.326, P=0.038). CONCLUSION: The body mass composition and distribution do not correlate significantly with the fundamental frequency and the Habitual pitch.

Vocal symptoms in women undergoing in vitro fertilization.

OBJECTIVE: The aim of this study was to investigate changes in vocal symptoms in relation to estrogen level in women undergoing in vitro fertilization. MATERIALS AND METHODS: A total of 31 women were enrolled in this study. The following vocal symptoms were investigated: vocal tiring or fatigue, vocal straining, throat clearing, lump sensation, hoarseness, and aphonia (or loss of voice). The severity of these symptoms was graded from 0 to 4, where 0 means absence of the symptom and 3 means severe symptom presence. The frequency of these symptoms was evaluated in the first visit at presentation; second visit, 4 to 5 days after ovarian stimulation; and third visit, 8 to 10 days after stimulation. In the second and third visits, the estradiol levels were measured. RESULTS: The mean age was 32.33 ± 4.80 years. Ten of the 31 patients had at least 1 vocal symptom. The most common vocal symptom in all 3 visits was throat clearing, with an incidence of 22.6% in the first and second visits and 19.4% in the third visit. This was followed by vocal fatigue or tiring and lump sensation, with an incidence of 9.68% for both. The incidence of all the vocal symptoms as well as their severity did not change throughout the visits, except for throat clearing, which has decreased in the third visit but not significantly (22.6% vs 19.4%, P = 1). Subjects with vocal symptoms had lower estradiol level compared with those with no vocal symptoms; however, the difference was not statistically significant (P = .108 and .267, respectively). CONCLUSION: Subjects undergoing in vitro fertilization do not experience changes in their vocal symptoms when present, except for throat clearing. However, those with vocal symptoms have lower levels of estradiol compared with those with no vocal symptoms.