RESUMEN
BACKGROUND: Melatonin might be beneficial to coronavirus disease 2019 (COVID-19) patients in terms of both prevention and treatment. We investigated how melatonin affected various clinical and laboratory results in COVID-19 patients. METHODS: PubMed, Scopus, Cochrane Library and Web of Science databases were utilized for searching eligible articles fulfilling our inclusion criteria up to December 2022. We used random effect model in case of significant heterogeneity; in other cases, a fixed model was applied. RevMan was used for meta-analysis. RESULTS: We included 11 studies in our review. Clinical improvement rate was found to be statistically significantly higher in patients taking melatonin than in the control group (OR: 5.09; 95% CI: 2.60-9.96, p â< â0.001). Patients receiving melatonin showed a non-significant difference in mortality rate compared to the control group (OR: 0.37; 95% CI: 0.07-1.81, p â= â0.22). However, in the randomized controlled trials subgroup, melatonin-treated patients showed significantly lower mortality than did the controls (OR: 0.17; 95% CI: 0.08-0.38, p â< â0.001). CRP level was statistically significantly lower due to melatonin treatment (weighted mean difference [WMD] â= â-9.85; 95% CI: -18.54 to -1.16, p â= â0.03). Length of hospital stay was statistically significantly shorter in patients taking melatonin compared to controls (WMD â= â-4.05; 95% CI: -5.39 to -2.7, p â< â0.001). CONCLUSION: Melatonin was found to have substantial effects on COVID-19 patients when used as adjuvant therapy, enhancing clinical improvement and decreasing time to recovery with a shorter length of hospital stay and a shorter duration of mechanical ventilation.
Asunto(s)
COVID-19 , Melatonina , Humanos , Melatonina/uso terapéutico , Tiempo de InternaciónRESUMEN
A hydatid cyst is a parasitic infection that can occur in multiple organs of the body, mostly in the liver. The ovary is one of the very rare locations for those cysts. Case presentation: The authors report a case of a 43-year-old woman with a primary hydatid cyst, the patient presented with left lower quadrant abdominal pain for 2 months. Ultrasound of the abdomen showed evidence of a multivesicular, fluid-containing cystic lesion in the left adnexa. The mass was excised and a hysterectomy with total left salpingo-oophorectomy was performed. Histopathology confirmed it to be a hydatid cyst. Clinical discussion: The clinical presentation of an ovarian hydatid cyst can differ, ranging from asymptomatic for years to dull pain if it compresses on the neighbouring organs or tissues, it may even cause a systemic immunological reaction if it ruptures. Conclusion: Cyst excision when possible is the best treatment, percutaneous sterilization techniques, and drug therapy may also be applied in certain cases.
